Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-α in mediating LTA-induced interleukin-8 generation

Critical Care Medicine

Volumn 34, Issue 3, 2006, Pages 835-841

  Hattar, Katja ^a   Grandel, Ulrich ^a   Moeller, Alexander ^a   Fink, Ludger ^a   Iglhaut, Julia ^a   Hartung, Thomas ^b   Morath, Siegfried ^b   Seeger, Werner ^a   Grimminger, Friedrich ^a   Sibelius, Ulf ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

CD14 antigen; Cytokines; Interleukin 10; Lipoteichoic acid; Neutrophils; Sepsis; Toll like receptors

Indexed keywords

BACTERIAL PROTEIN; CD14 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOTEICHOIC ACID; MESSENGER RNA; NEUTRALIZING ANTIBODY; RECEPTOR ANTIBODY; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL ISOLATION; CYTOKINE RELEASE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; STAPHYLOCOCCUS AUREUS;

ANALYSIS OF VARIANCE; ANTIGENS, CD14; CELLS, CULTURED; CYTOKINES; HUMANS; INTERLEUKIN-10; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; NEUTROPHILS; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TEICHOIC ACIDS; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33644592813     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000202204.01230.44     Document Type: Article

References (45)

1. Van Amersfoort ES, Van Berkel TJC, Kuiper J: Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 2003; 16:379-414
2. Karima RS, Matsumoto S, Highasi H, et al: The molecular pathogenesis of endotoxic shock and organ failure. Mol Med Today 1999; 5:123-132
3. Bellingan G: Inflammatory cell activation in sepsis. Br Med Bull 1999; 55:12-29
4. Lloyd AR, Oppenheim JJ: Poly's lament: The neglected role of the polymorphonuclear leukocyte in the afferent limb of the immune response. Immunol Today 1992; 13:169-172
5. Cassatella MA, Gasperini S, Russo MP: Cytokine expression and release by neutrophils. Ann NY Acad Sci 1997; 832:233-242
6. Cassatella MA: Neutrophil-derived proteins: Selling cytokines by the pound. Adv Immunol 1999; 73:369-505
7. Wright SD, Ramos RA, Tobias PS, et al: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990; 249:1431-1433
8. Haziot AS, Chen E, Ferrero MG, et al: The monocyte differentiation antigen, CD14, in anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol 1988; 141:547-552
9. Yang RB, Mark MR, Gray A, et al: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 1998; 395:284-288
10. Kirschning CJ, Wesche H, Ayres TM, et al: Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998; 188:2091-2097
11. Qureshi ST, Lariviere L, Leveque G, et al: Endotoxin-tolerant mice have mutations in Toll-like receptor 4. J Exp Med 1999; 189: 615-619
12. Shimazu R, Akashi S, Ogata H, et al: MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4. J Exp Med 1999; 189:1777-1782
13. Fischer W, Mannsfeld T, Hagen G: On the basic structure of poly (glycerophosphate) lipoteichoic acids. Biochem Cell Biol 1990; 68:33-43
14. Alkan ML, Beachey EH: Excretion of lipoteichoic acid by group A streptococci: Influence of penicillin on excretion and loss of ability to adhere to human oral mucosal cells. J Clin Invest 1978; 61:671-677
15. Kengatharan KM, De Kimpe S, Robson C, et al: Mechanism for gram-positive shock: Identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure. J Exp Med 1998; 2:305-315
16. Ginsburg I: Role of lipoteichoic acid in infection and inflammation. Lancet Infect Dis 2002; 2:171-179
17. Kawamura N, Imanishi N, Koike H, et al: Lipoteichoic acid-induced neutrophil adhesion via E-Selectin to human umbilical vein endothelial cells (HUVECs). Biochem Biophys Res Commun 1995; 217:1208-1212
18. Bhakdi S, Klonisch T, Nuber P, et al: Stimulation of monokine production by lipoteichoic acids. Infect Immun 1991; 59: 4614-4620
19. Standiford TJ, Arenberg DA, Danforth JM, et al: Lipoteichoic acid induces secretion of interleukin-8 from human blood monocytes: A cellular and molecular analysis. Infect Immun 1994; 62:119-125
20. Sugawara S, Arakaki R, Rikiishi H, et al: Lipoteichoic acid acts as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner. Infect Immun 1999; 67:1623-1632
21. Lotz S, Aga E, Wilde I, et al: Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol 2004; 75:467-477
22. Schwandner R, Dziarski R, Wesche H, et al: Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999; 274:17406-17409
23. Takeuchi O, Hoshino K, Kawai T, et al: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999; 11:443-451
24. Morath S, Geyer A, Spreitzer I, et al: Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations. Infect Immun 2002; 70:938-944
25. Morath S, Geyer A, Hartung T: Structure-function relationship of cytokine induction by lipoteichoic acid. J Exp Med 2001; 193: 393-397
26. Ellingsen E, Morath S, Flo T, et al: Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: Involvement of Toll-like receptors and CD14. Med Sci Monit 2002; 8:149-156
27. Morath S, Stadelmaier A, Geyer A, et al: Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release. J Exp Med 2002; 195:1635-1640
28. Courtney H, Ofec I, Simpson WA, et al: Characterization of lipoteichoic acid binding to polymorphonuclear leukocytes of human blood. Infect Immun 1981; 32:625-631
29. Von Aulock S, Morath S, Hareng L, et al: Lipoteichoic acid from Staphylococcus aureus is a potent stimulus for neutrophil recruitment. Immunobiol 2003; 208:423-422
30. Bone RC: Gram-positive organisms and sepsis. Arch Intern Med 1994; 154:26-34
31. Hattar K, Fink L, Fietzner K, et al: Cell density regulates neutrophil IL-8 synthesis: Role of IL-1RA and sTNFRs. J Immunol 2001; 166:6287-6293
32. Hattar K, Bickenbach A, Csernok E, et al: Wegener's granulomatosis: Anti-proteinase 3 antibodies are potent inductors of monocyte cytokine and prostanoid release: Role of autocrine cell activation. J Leukoc Biol 2002; 71:996-1004
33. Fink L, Seeger W, Ermert T, et al: Real-time quantitative RT-PCR after laser-assisted cell picking. Nat Med 1998; 4:1329-1133
34. Hermann C, Spreitzer I, Schroeder NW, et al: Cytokine induction by purified lipoteichoic acids from various bacterial species: Role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent INF-γ release. Eur J Immunol 2002; 32:541-551
35. Bazzoni F, Cassatella MA, Laudanna C, et al: Phagycytosis of opsonized yeast induces tumor necrosis factor-alpha mRNA accumulation and protein release by human polymorphonuclear leukocytes. J Leuko Biol 1991; 50:223-228
36. Wang P, Wu P, Anthes JC, et al: Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood 1994; 83: 2678-2683
37. Schroeder NWJ, Morath S, Alexander C, et al: Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem 2003; 278: 15587-15594
38. Cassatella MA, Meda L, Bonora S, et al: Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human leukocytes: Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharides. J Exp Med 1993; 178: 2207-2211
39. Howard M, Muchamuel T, Andrade S, et al: Interleukin 10 protects mice from lethal endotoxemia. J Exp Med 1993; 1771:205-208
40. Rongione AJ, Kusske AM, Kwan K, et al: Interleukin-10 protects against lethality of intra-abdominal infection and sepsis. J Gastrointest Surg 2000; 4:70-76
41. Cassatella MA: The neutrophil: One of the cellular targets of interleukin-10. Int J Clin Lab Res 1998; 28:148-161
42. Cassatella MA, Gasperini S, Bovolenta C, et al: Interleukin-10 (IL-10) selectively enhances CIS3/SOC3 mRNA expression in human neutrophils: Evidence for an IL-10 induced pathway that is independent on STAT protein activation. Blood 1999; 94: 2880-2889
43. Flo TH, Halaas O, Lien E, et al: Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not group b streptococci or lipopolysaccharide. J Immunol 2000; 164:2064-2069
44. Lien E, Sellati TJ, Yoshimura A, et al: Toll like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999; 247:33419-33425
45. Kurt-Jones EA, Mandell L, Whitney C, et al: Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin-8 responses in neutrophils. Blood 2002; 100: 1860-1868