Wegener's granulomatosis: Antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release - Role of autocrine cell activation

Journal of Leukocyte Biology

Volumn 71, Issue 6, 2002, Pages 996-1004

  Hattar, Katja ^a   Bickenbach, Annette ^a   Csernok, Elena ^b   Rosseau, Simone ^a   Grandel, Ulrich ^a   Seeger, Werner ^a   Grimminger, Friedrich ^a   Sibelius, Ulf ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Autoimmunity; Inflammation; Lipid mediators; Macrophages

Indexed keywords

CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCLONAL ANTIBODY; MYELOBLASTIN; MYELOBLASTIN ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROSTANOID; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; MACROPHAGE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; TISSUE INJURY; WEGENER GRANULOMATOSIS;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; KINETICS; MONOCYTES; NEUTROPHIL ACTIVATION; PROSTAGLANDINS; PROTEASE INHIBITORS; WEGENER GRANULOMATOSIS;

MURINAE;

EID: 0036623121     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Jennette, J. C., Wilkman, A. S., Falk, R. J. (1989) Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am. J. Pathol 135, 921-930.
2. Weiss, M. A., Crissman, J. D. (1989) Renal pathologic features of the kidney in Wegener's Granulomatosis. A review. Semin. Respir. Med. 10, 141-148.
3. Noronha, I. L., Krüger, C., Andrassy, K., Ritz, E., Waldherr, R. (1993) In situ production of TNF-α, IL-1β, and IL-2R in ANCA-positive glomerulonephritis. Kidney Int. 43, 682-693.
4. Cockwell, P., Brooks, C. J., Adu, D., Savage, C. O. S. (1999) Interleukin-8: a pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. Kidney Int. 55, 852-863.
5. Rastaldi, M. P., Ferrario, F., Tunesi, S., Yang, L., D'Amicio, G. (1996) Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin 1α expression in 15 cases of antineutrophil cytoplasmic autoantibody-associated renal vasculitis. Am. J. Kidney Dis. 27, 48-57.
6. Arimura, Y., Minoshima, S., Kamiya, Y., Tanaka, U., Nakabayashi, K., Kitamoto, K., Nagasawa, T., Sasaki, T., Suzuki, K. (1993) Serum myeloperoxidase and serum cytokines in anti-myeloperoxidase antibody-associated glomerulonephritis. Clin. Nephrol. 40, 256-264.
7. Deguchi, Y., Shibata, N., Kishimoto, S. (1990) Enhanced expression of the tumour necrosis factor/cachetin gene in peripheral blood mononuclear cells from patients with systemic vasculitis. Clin. Exp. Immunol. 81, 311-314.
8. Van der Woude, F. J., Rasmussen, N., Lobatto, S., Wiik, A., Permin, H., van Es, L. A., van der Giessen, M., van der Hem, G. K., The, T. H. (1985) Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet I, 425-429.
9. Calafat, J., Goldschmeding, R., Ringeling, P. L., Janssen, H., van der Schott, C. E. (1990) In situ localization by double-labeling immunelectron microscopy of anti-neutrophil cytoplasmic autoantibodies in neutrophils and monocytes. Blood 75, 242-250.
10. Csernok, E., Lüdemann, J., Gross, W. L., Bainton, D. F. (1990) Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's Granulomatosis. Am. J. Pathol. 137, 1113-1120.
11. Gross, W. L., Csernok, E., Flesch, B. (1993) Classic anti-neutrophil cytoplasmic autoantibodies (cANCA), Wegener's autoantigen, and their immunopathogenetic role in Wegener's Granulomatosis. J. Autoimmun. 6, 171-184.
12. Kallenberg, C. G. M., Brouwer, E., Weening, J. J., Cohen Tervaert, J. W. (1994) Anti-neutrophil cytoplasmic antibodies: current diagnostic and pathophysiologic potential. Kidney Int. 46, 1-15.
13. Cohen Tervaert, J. W., van der Woude, F. J., Fauci, A. S., Ambrus, J. L., Velosa, J., Keane, W. F., Meuer, S., Van der Giessen, M., The, T. H., van der Hem, G. K., Kallenberg, C. G. M. (1989) Association between active Wegener's Granulomatosis and anticytoplasmic antibodies. Arch. Intern. Med. 149, 2461-2465.
14. Kerr, G. S., Fleisher, T. A., Hallahan, C. W., Leavitt, R. Y., Fauci, A. S., Hoffman, G. S. (1993) Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with Wegener's granulomatosis. Arthritis Rheum. 36, 365-371.
15. Falk, R. J., Terrell, R. S., Charles, L. A., Jennette, J. C. (1990) Antineutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. USA 87, 4115-4119.
16. Grimminger, F., Hattar, K., Papavassilis, C., Temmesfeld, B., Csernok, E., Gross, W. L., Seeger, W., Sibelius, U. (1996) Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation. J. Exp. Med. 184, 1567-1572.
17. Savage, C. O. S., Pottinger, B. E., Gaskin, G., Pusey, C. D., Pearson, J. D. (1992) Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity towards cultured endothelial cells. Am. J. Pathol. 141, 335-342.
18. Kallenberg, C. G. M., Brouwer, E., Mulder, A. H. L., Stegman, C. A., Weening, J. J., Cohen Tervaert, J. W. (1995) ANCA - pathophysiology revisited. Clin. Exp. Immunol. 100, 1-3.
19. Ferrario, F., Rastaldi, M. P. (1999) Necrotizing crescentic glomerulonephritis in ANCA-associated vasculitis: the role of monocytes. Nephrol. Dial. Trans. 14, 1627-1631.
20. Muller Kobold, A. C., Kallenberg, C. G. M., Cohen Tervaert, J. W. (1999) Monocyte activation in patients with Wegener's Granulomatosis. Ann. Rheum. Dis. 58, 237-245.
21. Ralston, D. R., Marsh, C. B., Lowe, M. P., Wewers, M. D. (1997) Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. J. Clin. Investig. 100, 1416-1424.
22. Casselman, B. L., Kilgore, K. S., Miller, B. F., Warren, J. S. (1995) Antibodies to neutrophil cytoplasmic antigens induce monocyte chemoattractant protein-1 secretion from human monocytes. J. Lab. Clin. Med. 126, 495-502.
23. Beutler, B. (1995) TNF, immunity, and inflammatory disease: lessons of the past decade. J. Investig. Med. 43, 227-235.
24. De Forge, L. E., Kenney, J. S., Jones, M. L., Warren, J. S., Remick, D. G. (1991) Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood. J. Immunol. 148, 2133-2141.
25. Akira, S., Hirano, T., Taga, T., Kishimoto, T. (1990) Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 4, 2860-2867.
26. 2 in nonadherent human monocytes. J. Immunol. 158, 351-358.
27. Pawlowski, N. A., Kaplan, G., Hamill, A. L., Cohn, Z. A., Scott, W. A. (1983) Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures. J. Exp. Med. 158, 393-412.
28. Arbibe, L., Vial, D., Rosinski-Chupin, I., Havet, N., Huerre, M., Vargafting, B. B., Touqui, L. (1997) Endotoxin induced expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs. J. Immunol. 159, 391-400.
29. Charles, L. A., Falk, R. J., Jennette, J. C. (1992) Reactivity of antineutrophil cytoplasmic autoantibodies with mononuclear phagocytes. J. Leukoc. Biol. 51, 65-68.
30. Muller-Kobold, A. C., Kallenberg, C. G. M., Cohen-Tervaert, J. W. (1998) Leukocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's Granulomatosis. Br. J. Rheumatol. 37, 901-907.
31. Ewert, B. H., Jenette, J. C., Falk, R. J. (1991) The pathogenetic role of antineutrophil cytoplasmic autoantibodies. Am. J. Kidney Dis. 18, 188-195.
32. Porges, A. J., Redecha, P. B., Kimberley, W. T., Csernok, E., Gross, W. L., Kimberley, R. P. (1994) Anti-neutrophil cytoplasmic antibodies engage and activate neutrophils via Fc gamma RIIa. J. Immunol. 153, 1271-1280.
33. Macintyre, E. A., Roberts, P. J., Jones, M., van der Schott, C. E., Favalaro, E. J., Tidman, N., Linch, D. C. (1989) Activation of human monocytes occurs on cross-linking monocytic antigens to an Fc receptor. J. Immunol. 142, 2377-2383.
34. Chen, W., Knapp, W., Majdic, O., Stockinger, H., Böhmig, G. A., Zlabinger, G. J. (1994) Co-ligation of CD31 and FcγRII induces cytokine production in human monocytes. J. Immunol. 152, 3991-3997.