Apoe-ε4 and apoe-491a polymorphisms in individuals with subjective memory loss

Molecular Psychiatry

Volumn 7, Issue 7, 2002, Pages 768-775

  Laws, S M ^a   Clarnette, R M ^a   Taddei, K ^a   Martins, G ^a   Paton, A ^a   Hallmayer, J ^b   Almeida, O P ^a   Groth, D M ^c   Gandy, S E ^d   Forstl H ^e   Martins, R N ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b STANFORD UNIVERSITY   (United States)

^c CURTIN UNIVERSITY   (Australia)

^d NEW YORK UNIVERSITY   (United States)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

491A t; Alzheimer's disease; Apoe 4; Apolipoprotein e; Memory complaints

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

ALZHEIMER DISEASE; ARTICLE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; MEMORY DISORDER; PREDICTION AND FORECASTING; PROMOTER REGION; RISK FACTOR; ADULT; AMNESIA; CONTROLLED STUDY; DNA POLYMORPHISM; FOLLOW UP; GENE FREQUENCY; HOMOZYGOSITY; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MINI MENTAL STATE EXAMINATION; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PSYCHOLOGIC TEST;

ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MEMORY DISORDERS; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS (GENETICS); RISK FACTORS;

EID: 0036025371     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001083     Document Type: Article

References (53)

1. Exploring the etiology of Alzheimer disease using molecular genetics
2. Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician
3. Memory complaint, memory performance and psychiatric diagnosis: A community study
4. Memory complaints in older adults: Fact or fiction
5. The validity of memory complaints by elderly persons
6. Memory complaints in the elderly: A study of 367 community dwelling individuals from 50 to 80 years old
7. A longitudinal study of cognitive function in elderly persons with subjective memory complaints
8. Self reported memory complaints and memory performance in elderly French community residents: Results of the PAQUID research program
9. Association between memory complaints incident Alzheimer's Disease in elderly people with normal baseline cognition
10. Memory complaints of elderly people in a population survey: Variation according to dementia stage and depression
11. A follow-up study of age-associated memory impairment: Neuropsychological predictors of dementia
12. Subjective memory complaints and personality traits in normal elderly subjects
13. Stability of age-associated memory impairment during a longitudinal population-based study
14. Memory complaints and memory impairment in older individuals
15. Complaints of cognitive decline in the elderly: A comparison of reports by subjects and informants in a community survey
16. Do cognitive complaints either predict future cognitive decline or reflect past cognitive decline? A longitudinal study of an elderly community sample
17. Memory complaints as a precursor of memory impairment in older people: A longitudinal analysis over 7-8 years
18. Do subjective memory complaints precede dementia? A three year follow up of patients with supposed 'benign senescent forgetfulness'
19. Memory complaints and impairment in normal, depressed and demented elderly persons identified in a community survey
20. 1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease
21. Subjective memory complaints may announce dementia
22. Subjective memory complaints in the elderly: Depressive symptoms and future dementia
23. Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment
24. Subjective memory assessment and test performance in elderly adults
25. Correlates of memory decline: A 4 year longitudinal study of older adults with memory complaints
26. Clinical characteristics of individuals with subjective memory loss in Western Australia: Results from a cross-sectional survey
27. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
28. ApoE genotypes in Australia: Roles in early and late onset Alzheimer's disease and Down's syndrome
29. Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease
30. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene
31. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
32. Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease
33. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease
34. The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease
35. The effect of education on dementia occurrence in an Italian population with middle to high socioeconomic status
36. Influence of education and occupation on the incidence of Alzhelmer's disease
37. CAMDEX: A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia
38. Evaluation of a mental test score for the assessment of mental impairment in the elderly
39. Restriction of human apolipoprotein E by gene amplification and cleavage with Hla1
40. Apolipoprotein E genotyping by one-stage PCR
41. APOE-epsilon4 is associated with memory decline in cognitively impaired elderly
42. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease
43. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease
44. Age-dependent decline in the apolipoprotein E level in cerebrospinal fluid from control subjects and its increase in cerebrospinal fluid from patients with Alzheimer's disease
45. Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform
46. Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease
47. Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls
48. Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: Correlations with amyloid load in the brain
49. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
50. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease