[35S]GTPγS autoradiography reveals a wide distribution of Gi/o-linked ADP receptors in the nervous system: Close similarities with the platelet P2YADP receptor

Journal of Neurochemistry

Volumn 77, Issue 2, 2001, Pages 505-518

  Laitinen, Jarmo T ^a   Uri, Asko ^b   Raidaru, Gerda ^b   Miettinen, Riitta ^c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF TARTU   (Estonia)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

2 Alkythio; Autoreceptor; Gi linked P2Y receptor; Inhibitory heteroreceptor; Lysophosphatidic acid; Oligodendrocyte progenito

Indexed keywords

2 METHYLTHIOADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; AUTORECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PURINE P2Y RECEPTOR; PYRIMIDINE NUCLEOTIDE; UNCLASSIFIED DRUG; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 2 HEXYLTHIO ADOOC(O)ASP2; 2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2-HEXYLTHIO-ADOOC(O)ASP2; 2-METHYLTHIO-ATP; 6 N,N DIETHYL BETA,GAMMA DIBROMOMETHYLENE D ATP; 6-N,N-DIETHYL-BETA,GAMMA-DIBROMOMETHYLENE-D-ATP; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE TRIPHOSPHATASE; DITHIOTHREITOL; DRUG DERIVATIVE; ENZYME INHIBITOR; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; NUCLEOTIDE; P2Y12 PROTEIN, RAT; PURINE P2 RECEPTOR; PURINE P2Y12 RECEPTOR; SULFUR; THIOL REAGENT; XANTHINE DERIVATIVE;

ADRENAL MEDULLA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; MALE; MOLECULAR RECOGNITION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; STEM CELL; TISSUE DISTRIBUTION; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; BRAIN LEVEL; CAPILLARY; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GLIA; GLIOMA; MACROMOLECULE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; SIGNAL TRANSDUCTION; THROMBOCYTE; VASCULAR ENDOTHELIUM; VASCULARIZATION; WISTAR RAT;

ANIMALIA;

ADENINE NUCLEOTIDES; ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ADRENAL MEDULLA; ANIMALS; AUTORADIOGRAPHY; BLOOD PLATELETS; BRAIN; BRAIN CHEMISTRY; CAPILLARIES; CELL LINE; DITHIOTHREITOL; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; GLIOMA; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEUROGLIA; ORGAN SPECIFICITY; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; SULFHYDRYL REAGENTS; SULFUR RADIOISOTOPES; THIONUCLEOTIDES; TUMOR CELLS, CULTURED; URACIL NUCLEOTIDES; XANTHINES;

EID: 0034744564     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00265.x     Document Type: Article

References (62)

1. 35S]thio) triphosphate binding in rat brain
2. 2+, phospholipase. C and mitogen-activated protein kinase
3. A rat G protein-coupled receptor selectively expressed in myelin-forming cells
4. Regulation of cyclic AMP by extracellular ATP in cultured brain capillary endothelial cells
5. Comparative analysis of glutamate transport expression in rat brain using differential double in situ hybridization
6. P2Y receptors, in the middle of the road
7. Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase
8. 2Y-purinoceptors
9. 1 receptor
10. Current status of purinergic signalling in the nervous system
11. 1 receptors
12. +-ATPase: Molar and specific activity, protein determination
13. 2+ wave propagation in dorsal spinal cord astrocytes
14. 2-Thioether 5′-O-(1-thiotriphosphate) adenosine derivatives as new insulin secretagogues acting through P2Y-receptors
15. Towards a revised nomenclature for P1 and P2 receptors
16. ATP modulation of calcium channels in chromaffin cells
17. 1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation
18. 1 receptor, similarities to the platelet ADP receptor
19. Identification of the platelet ADP receptor targeted by antithrombotic drugs
20. 2-(Arylalkylamino) adenosin-5′-uronamides: A new class of highly selective adenosine A2 receptor ligands
21. Antagonists of the platelet P2T receptor, a novel approach to antithrombotic therapy
22. The functions of ATP receptors in the synaptic transmission in the hippocampus
23. P2-receptor-mediated inhibition of noradrenaline release in the rat hippocampus
24. Functional characterization of platelet ADP receptors
25. 35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G protein activation in the chick optic tectum
26. AC-like P2Y receptors in the rat brain white matter
27. Functional evidence for a widespread presence of ADP-selective P2Y receptor in the rat brain
28. 35S]guanosine 5′-(thio)triphosphate autoradiography
29. 3 receptor-dependent activation of G proteins in rat brain tissue sections
30. Comparative biochemical, morphological, and immunocytochemical studies between C-6 glial cells of early and late passages and advanced passages of glial cells derived from aged mouse cerebral hemispheres
31. 2T-receptor antagonists as novel antithrombotic agents
32. 2Y purinoceptor subtypes recruit different Mek activators in astrocytes
33. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
34. 2+-channel-dependent and -independent inhibition of exocytosis by extracellular ATP in voltage-clamped rat adrenal chromaffin cells
35. Different signal transduction pathways are coupled to the nucleotide receptor and the P2Y receptor in C6 glioma cells
36. 32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets
37. ADP receptors on platelets
38. 1 purinergic receptor in neurons and glial cells of the central nervous system
39. 1 receptor antagonists and partial agonists
40. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes, involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway
41. ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells
42. P2Y purinoceptors inhibit exocytosis in adrenal chromaffin cells via modulation of voltage-operated calcium channels
43. Receptor for purines and pyrimidines
44. Characterization of P2 receptors modulating neural activity in rat rostral ventrolateral medulla
45. 1 purinoceptors
46. 1-purinoceptor
47. 1 receptor to phospholipase C
48. 35S]-thio]triphosphate binding
49. 35S]dATP'S binding sites in the adult rat neuraxis
50. Characterisation of putative P2T receptor endogenously expressed in rat glioma and brain microvascular endothelial cell lines
51. P2T purinoceptor antagonists. A QSAR study of some 2-substituted ATP analogues
52. 1 receptor in rat brain capillary endothelial cells of the B7 and B 10 clones
53. P2-receptors controlling neurotransmitter release from postganglionic sympathetic neurones
54. 35S]thio)triphosphate binding stimulated by sphingosine 1-phosphate and lysophosphatidic acid
55. 35S]guanosine-5′-O-(3-thio)triphosphate binding to rodent brain sections as visualized by in vitro autoradiography
56. 2+ channels, role in channel function
57. The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase
58. A1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain
59. ái-linked receptor for ADP
60. ADP is the cognate ligand for the orphan G-protein coupled receptor SP1999
61. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system