Essential role of Plzf in maintenance of spermatogonial stem cells

Nature Genetics

Volumn 36, Issue 6, 2004, Pages 653-659

  Costoya, José A ^a,e   Hobbs, Robin M ^a   Barna, Maria ^a   Cattoretti, Giorgio ^b   Manova, Katia ^a   Sukhwani, Meena ^c   Orwig, Kyle E ^c   Wolgemuth, Debra J ^d   Pandolfi, Pier Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN PLZF; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DNA MICROARRAY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE ZFP145; GENETIC CODE; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERTOLI CELL; SPERMATOGENESIS; SPERMATOGONIUM; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GENE EXPRESSION; MALE; MICE; MICE, KNOCKOUT; SPERMATOGENESIS; SPERMATOGONIA; STEM CELLS; TESTIS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 2642550555     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1367     Document Type: Article

References (30)

1. McLaren, A. Germ and somatic cell lineages in the developing gonad. Mol. Cell. Endocrinol. 163, 3-9 (2000).
2. de Rooij, D.G. Proliferation and differentiation of spermatogonial stem cells. Reproduction 121, 347-354 (2001).
3. Costoya, J.A. & Pandolfi P.P. The role of promyelocytic leukemia zinc finger and promyelocytic leukemia in leukemogenesis and development. Curr. Opin. Hematol. 8, 212-217 (2001).
4. Barna, M. et al. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell. 3, 499-510 (2002).
5. Cook, M. et al. Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc. Natl. Acad. Sci. USA 92, 2249-2253 (1995).
6. Barna, M., Hawe, N., Niswander, L. & Pandolfi, P.P. Plzf regulates limb and axial skeletal patterning. Nat. Genet. 25, 166-172 (2000).
7. Shaknovich, R. et al. The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis. Mol. Cell. Biol. 18, 5533-5545 (1998).
8. v substitution upon postnatal development of germ cells. J. Exp. Zool. 126, 277-296 (1954).
9. Beumer, T.L., Roepers-Gajadien, H.L., Gademan, I.S., Kal, H.B. & de Rooij, D.G. Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse. Biol. Reprod. 63, 1893-1898 (2000).
10. Wrobel, K.H., Bickel, D. & Kujat, R. Immunohistochemical study of seminiferous epithelium in adult bovine testis using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen (PCNA). Cell Tissue Res. 283, 191-201 (1996),
11. Beumer, T.L. et al. Regulatory role of p27kip1 in the mouse and human testis. Endocrinology. 140, 1834-1840 (1999).
12. Narula, A. et al. Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice. Am. J. Pathol. 161, 1723-1734 (2002).
13. Handel, M.A., Cobb, J. & Eaker, S. What are the spermatocyte's requirements for successful meiotic division? J. Exp. Zool. 285, 243-250 (1999).
14. Gown, A.M. & Willingham, M.C. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J. Histochem. Cytochem. 50, 449-454 (2002).
15. Brinster, R.L. & Zimmermann, J.W. Spermatogenesis following male germ-cell transplantation. Proc. Natl. Acad. Sci. USA 91, 11298-11302 (1994).
16. Brinster, R.L. & Avarbock, M.R. Germline transmission of donor haplotype following spermatogonial transplantation. Proc. Natl. Acad. Sci. USA 91, 11303-11307 (1994).
17. Orwig, K.E., Shinohara, T., Avarbock, M.R. & Brinster, R.L. Functional analysis of stem cells in the adult rat testis. Biol. Reprod. 66, 944-949 (2002).
18. Yeyati, P.L. et al. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene 18, 925-934 (1999).
19. McConnell, M.J. et al. Growth suppression by Acute Promyelocytic Leukemia-Associated protein PLZF is mediated by repression of c-myc expression. Mol. Cell. Biol. 23, 9375-9388 (2003).
20. Venables, J.P. & Eperon, I. The roles of RNA-binding proteins in spermatogenesis and male infertility. Curr. Opin. Genet. 9, 346-354 (1999).
21. Andersson, S. Molecular genetics of androgenic 17 beta- hydroxysteroid dehydrogenases. J. Steroid. Biochem. Mol. Biol. 55, 533-534 (1995).
22. Scott, K.L. & Plon, S.E. Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae. Mol. Cell. Biol. 23, 4522-4531 (2003).
23. Inoue, N. et al. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. Hum. Mol. Genet. 8,1201-1207 (1999).
24. Cunningham, D.B., Segretain, D., Arnaud, D., Rogner, U.C. & Avner, P. The mouse Tsx gene is expressed in Sertoli cells of the adult testis and transiently in premeiotic germ cells during puberty. Dev. Biol. 204, 345-360 (1998).
25. Labbaye, C. et al. PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA 1 protein. Oncogene 21, 6669-6679 (2002).
26. Buaas, F.W. et al. ZFP145 is required in adult male germ cells for stem cell self-renewal. Nat. Genet. advance online publication, 23 May 2004 (doi:10.1038/ng1366).
27. Cooke, H.J. & Saunders, P.T. Mouse models of male infertility. Nat. Rev. Genet. 3, 790-801 (2002).
28. Manova, K., Nocka, K., Besmer, P. & Bachvarova, R.F. Gonadal expression of c-kit encoded at the W locus of the mouse. Development. 110, 1057-1069 (1990).
29. Shinohara, T., Orwig, K.E., Avarbock, M.R. & Brinster, R.L. Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells. Proc. Natl. Acad. Sci. USA 97, 8346-8351 (2000).
30. Rajasekhar, V.K. et al. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell. 12, 889-901 (2003).