Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines

International Journal of Cancer

Volumn 68, Issue 5, 1996, Pages 663-668

  Hala, Monika ^a,b   Hartmann, Bernd L ^a   Bock, Gü̈nther ^a   Geley, Stephan ^a   Kofler, Reinhard ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Institute of General and Experimental Pathology   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

ALLELES; AMINO ACID SEQUENCE; APOPTOSIS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOCORTICOIDS; HUMANS; LEUKEMIA; MOLECULAR SEQUENCE DATA; MUTATION; RECEPTORS, GLUCOCORTICOID; TUMOR CELLS, CULTURED;

EID: 0029807699     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19961127)68:5<663::AID-IJC17>3.0.CO;2-2     Document Type: Article

References (21)

1. ASHRAF, J. and THOMPSON, E.B., Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol. Endocrinoi, 7, 631-642(1993).
2. BOHEN, S.P. and YAMAMOTO, K.R., Isolation of hsp90 mutants by screening for decreased steroid-receptor function. Proc. not. Acad. Sei. (Wash.), 90, 11424-11428 (1993).
3. GELEY, S., FIEGEL, M., HARTMANN, B.L. and KOFLER, R., Genes mediating GC effects and mechanisms of their regulation. Rev. Physiol. Biochem. PhannacoL, 128, 1-97 (1996).
4. GELEY, S., HARTMANN, B.L., HALA, M., STRASSER-WOZAK, E.M.C., KAPELARI, K. and KOFLER, R., Resistance to glucocorticoid-induced apoptosis in human T-ALL CEM-C1 cells is due to insufficient glucocorticoid-receptor expression. Cancer Res. 56 (1996). (In press).
5. HARMON, J.M. and THOMPSON, E.B., Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7. Mol. cell. Biol., 1, 512-521 (1981).
6. HARMON, J.M., THOMPSON, E.B. and BAIONE, K.A., Analysis of glucocortiocid-resistant human leukemic cells by somatic-cell hybridization. Cancer Res., 45, 1587-1593 (1985).
7. HELMBERG, A., FÄSSLER, R., GELEY, S., JÖHRER, K., KROEMER, G. and KOFLER, R., Glucocorticoid-regulated gene expression in the immune system: analysis of glucocorticoid-regulated transcripts from the mouse macrophage-like cell line P388D1..7. Immunol., 145, 4332-4337 (1990).
8. HOLLENBERG, S.M., WEINBERGER, C., ONO, E.S., CERELLI, G., ORO, A., LEBO, R., THOMPSON, E.B., ROSENFELD, M.G. and EVANS, R.M., Primary structure and expression of a functional human glucocorticoidreceptor cDNA. Nature (Loud.), 318, 635-641 (1985).
9. HUGHES, P.M., JR. and CIDLOWSKI, J.A., Regulation of apoptosis in S49 cells.J. SteroidBiochem. mol. Biol., 49, 303-310 (1994).
10. IP, M.M., SHEA, W.K. and ROWAN, B.G., Mutant glucocorticoid receptors in lymphoma. Ami. NYAcad. Sei., 684, 94-115 (1993).
11. KASPERS, G.J.L., PIETERS, R., KLUMPER, E., DEWAAL, F.C. and VEERMAN, A.J.P., Glucocorticoid resistance in childhood leukemia. Leukemia Lymphoma, 13, 187-201 (1994).
12. KRETT, N.L., PILLAY, S., MOALLI, P.A., GREIPP, P.R. and ROSEN, S.T., A variant glucocorticoid-receptor messenger RNA is expressed in multiple-myeloma patients. Cancer Res., 55, 2727-2729 (1995).
13. MOALLI, P.A., PILLAY, S., KRETT, N.L. and ROSEN, S.T., Alternatively spliced glucocorticoid-receptor messenger RNAs in glucocorticoidresistant human multiple-myeloma cells. Cancer Res., 53, 3877-3879 (1993).
14. NORMAN, M.R. and THOMPSON, E.B., Characterization of a glucocorti-coid-sensitive human lymphoid cell line. Cancer Res., 37, 3785-3791 (1977).
15. PALMER, L. A. and HARMON, J.M., Biochemical evidence that glucocprticoid-sensitive cell lines derived from the human leukemic cell line CCRF-CEM express a normal and a mutant glucocorticoid-receptor gene. Cancer Res., 51, 5224-5231 (1991).
16. PALMER, L.A., HUKKU, B. and HARMON, J.M., Human glucocorticoidreceptor-gene deletion following exposure to cancer-chemotherapeutic drugs and chemical mutagens. Cancer Res., 52, 6612-6618 (1992).
17. POWERS, J.H., HILLMAN, A.G., TANG, D.C. and HARMON, J.M., Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells. Cancer Res., 53, 4059-4065(1993).
18. SOUFI, M., KAISER, U., SCHNEIDER, A., BEATO, M. and WESTPHAL, H.M., The DNA- and steroid-binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients. Exp. din. Endocrinol., 103, 175-183 (1995).
19. STRASSER-WOZAK, E.M.C., HATTMANNSTORFER, R., HALA, M., HARTMANN, B.L., FIEOL, M., GELEY, S. and KOFLER, R., Splice-site mutation in the glucocorticoid-receptor gene causes resistance to glucocorticoid-induced apoptosis in a human leukemic cell line. Cancer Res., 55, 348-353 (1995).
20. THOMPSON, E.B., Apoptosis and steroid hormones. Mol. Endocrinol., 8, 665-673 (1994).
21. ZAWYDIWSKI, R., HARMON, J.M. and THOMPSON, E.B., Glucocorticoidresistant human acute-lymphoblastic-leukemic cell line with functional receptor. Cancer Res., 43, 3865-3873 (1983).