The genetic heterogeneity of uterine leiomyomata

Obstetrics and Gynecology Clinics of North America

Volumn 33, Issue 1, 2006, Pages 13-39

  Lobel, Melissa K ^a   Somasundaram, Priya ^a   Morton, Cynthia C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN AGONIST;

CHROMOSOME 6P; CHROMOSOME REARRANGEMENT; CLONAL VARIATION; CYTOGENETICS; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENOTYPE PHENOTYPE CORRELATION; HERITABILITY; HUMAN; NONHUMAN; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; REVIEW; UTERUS MYOMA;

EPIDEMIOLOGIC STUDIES; FEMALE; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KARYOTYPING; LEIOMYOMA; UTERINE NEOPLASMS;

EID: 33644524366     PISSN: 08898545     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ogc.2005.12.006     Document Type: Review

References (185)

1. S.F. Cramer, and A. Patel The frequency of uterine leiomyomas Am J Clin Pathol 94 1990 435 438
2. V.C. Buttram Jr, and R.C. Reiter Uterine leiomyomata: etiology, symptomatology, and management Fertil Steril 36 1981 433 445
3. J.P. Rice, H.H. Kay, and B.S. Mahony The clinical significance of uterine leiomyomas in pregnancy Am J Obstet Gynecol 160 5 Pt 1 1989 1212 1216
4. V.L. Katz, D.J. Dotters, and W. Droegemeuller Complications of uterine leiomyomas in pregnancy Obstet Gynecol 73 1989 593 596
5. C. Exacoustos, and P. Rosati Ultrasound diagnosis of uterine myomas and complications in pregnancy Obstet Gynecol 82 1993 97 101
6. D. Muram, M. Gillieson, and J.H. Walters Myomas of the uterus in pregnancy: ultrasonographic follow-up Am J Obstet Gynecol 138 1980 16 19
7. G.D. Coronado, L.M. Marshall, and S.M. Schwartz Complications in pregnancy, labor, and delivery with uterine leiomyomas: a population-based study Obstet Gynecol 95 2000 764 769
8. J.L. Davis, S. Ray-Mazumder, and C.J. Hobel Uterine leiomyomas in pregnancy: a prospective study Obstet Gynecol 75 1990 41 44
9. R.S. Cotran, V. Kumar, and S.L. Robbins Robbins pathologic basis of disease 1989 WB Saunders Philadelphia
10. A.H. John, and R. Martin Growth of leiomyomas with estrogen-progesterone therapy J Reprod Med 6 1997 56 59
11. M.S. Rein, R.L. Barbieri, and A.J. Friedman Progesterone: a critical role in the pathogenesis of uterine myomas Am J Obstet Gynecol 172 1 Pt 1 1995 14 18
12. M. Miettinen Diagnostic soft tissue pathology 2003 Churchill Livingstone New York
13. C. Zaloudek, and H.J. Norris Mesenchymal tumors of the uterus R.J. Kurman Blaustein's pathology of the female genital tract 1994 Springer-Verlag New York 487 528
14. G.P. Flake, J. Andersen, and D. Dixon Etiology and pathogenesis of uterine leiomyomas: a review Environ Health Perspect 111 2003 1037 1054
15. C.C. Morton Warner-Lambert/Parke-Davis Award lecture. Many tumors and many genes: genetics of uterine leiomyomata Am J Pathol 153 1998 1015 1020
16. L.A. Lepine, S.D. Hillis, and P.A. Marchbanks Hysterectomy surveillance-United States, 1980-1993 MMWR CDC Surveill Summ 46 1997 1 15
17. AHRQ Management of uterine fibroids. Evidence Report. Technology Assessment 2000 Agency for Healthcare Research and Quality of Life London
18. NUFF Statistics Available at: www.nuff.org/health_statistics.htm 2004 Accessed June 15, 2005
19. G.B. Candiani, L. Fedele, and F. Parazzini Risk of recurrence after myomectomy Br J Obstet Gynaecol 98 1991 385 389
20. P. Acien, and F. Quereda Abdominal myomectomy: results of a simple operative technique Fertil Steril 65 1996 41 51
21. L. Fedele, F. Parazzini, and L. Luchini Recurrence of fibroids after myomectomy: a transvaginal ultrasonographic study Hum Reprod 10 1995 1795 1796
22. C.L. Walker, and E.A. Stewart Uterine fibroids: the elephant in the room Science 308 2005 1589 1592
23. G. Pron, J. Bennett, and A. Common The Ontario Uterine Fibroid Embolization Trial. Part 2. Uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids Fertil Steril 79 2003 120 127
24. J.B. Spies, E.H. Warren, and S.D. Mathias Uterine fibroid embolization: measurement of health-related quality of life before and after therapy J Vasc Interv Radiol 10 1999 1293 1303
25. B.S. Hurst, D.J. Stackhouse, and M.L. Matthews Uterine artery embolization for symptomatic uterine myomas Fertil Steril 74 2000 855 869
26. J. Hindley, W.M. Gedroyc, and L. Regan MRI guidance of focused ultrasound therapy of uterine fibroids: early results AJR Am J Roentgenol 183 2004 1713 1719
27. W.H. Matta, R.W. Shaw, and M. Nye Long-term follow-up of patients with uterine fibroids after treatment with the LHRH agonist buserelin Br J Obstet Gynaecol 96 1989 200 206
28. A.J. Friedman, M. Daly, and M. Juneau-Norcross Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin add-back for 2 years Hum Reprod 9 1994 1618 1625
29. E.M. Coutinho, and M.T. Goncalves Long-term treatment of leiomyomas with gestrinone Fertil Steril 51 1989 939 946
30. A. Al-Hendy, E.J. Lee, and H.Q. Wang Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice Am J Obstet Gynecol 191 2004 1621 1631
31. A.A. Murphy, L.M. Kettel, and A.J. Morales Regression of uterine leiomyomata in response to the antiprogesterone RU 486 J Clin Endocrinol Metab 76 1993 513 517
32. N. Ohara Selective estrogen receptor modulator and selective progesterone receptor modulator: therapeutic efficacy in the treatment of uterine leiomyoma Clin Exp Obstet Gynecol 32 2005 9 11
33. S.Z. Zhao, J.M. Wong, and L.M. Arguelles Hospitalization costs associated with leiomyoma Clin Ther 21 1999 563 575
34. B.J. Vollenhoven, A.S. Lawrence, and D.L. Healy Uterine fibroids: a clinical review Br J Obstet Gynaecol 97 1990 285 298
35. L.M. Marshall, D. Spiegelman, and R.L. Barbieri Variation in the incidence of uterine leiomyoma among premenopausal women by age and race Obstet Gynecol 90 1997 967 973
36. K.H. Kjerulff, G.M. Guzinski, and P.W. Langenberg Hysterectomy and race Obstet Gynecol 82 1993 757 764
37. E. Faerstein, M. Szklo, and N. Rosenshein Risk factors for uterine leiomyoma: a practice-based case-control study. I. African-American heritage, reproductive history, body size, and smoking Am J Epidemiol 153 2001 1 10
38. Schwartz S., Voigt L., Tickman E. et al. Familial aggregation of uterine leiomyomata. Presented at the Annual Meeting of the Society for Epidemiological Research. Seattle, Washington, June 15-17, 2000
39. E.M. Vikhlyaeva, Z.S. Khodzhaeva, and N.D. Fantschenko Familial predisposition to uterine leiomyomas Int J Gynaecol Obstet 51 1995 127 131
40. S.A. Treloar, N.G. Martin, and L. Dennerstein Pathways to hysterectomy: insights from longitudinal twin research Am J Obstet Gynecol 167 1992 82 88
41. R. Luoto, J. Kaprio, and E.M. Rutanen Heritability and risk factors of uterine fibroids-the Finnish Twin Cohort study Maturitas 37 2000 15 26
42. W.B. Reed, R. Walker, and R. Horowitz Cutaneous leiomyomata with uterine leiomyomata Acta Derm Venereol 53 1973 409 416
43. M.P. Garcia Muret, R.M. Pujol, and A. Alomar Familial leiomyomatosis cutis et uteri (Reed's syndrome) Arch Dermatol Res 280 1988 S29 S32
44. M. Schoenberg Fejzo, H.R. Ashar, and K.S. Krauter Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas Genes Chromosomes Cancer 17 1996 1 6
45. V. Stambolic, A. Suzuki, and J.L. de la Pompa Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN Cell 95 1998 29 39
46. C.P. Pavlovich, and L.S. Schmidt Searching for the hereditary causes of renal-cell carcinoma Nat Rev Cancer 4 2004 381 393
47. M. Kiuru, V. Launonen, and M. Hietala Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology Am J Pathol 159 2001 825 829
48. M. Kiuru, R. Lehtonen, and J. Arola Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families Cancer Res 62 2002 4554 4557
49. V. Launonen, O. Vierimaa, and M. Kiuru Inherited susceptibility to uterine leiomyomas and renal cell cancer Proc Natl Acad Sci U S A 98 2001 3387 3392
50. H. Hashimoto, and B. Quade Angioleiomyoma 2001 World Health Organization Geneva
51. A. Vaillo-Vinagre, C. Ballestin-Carcavilla, and S. Madero-Garcia Primary angioleiomyoma of the iliac bone: clinical pathological study of one case with flow cytometric DNA content and S-phase fraction analysis Skeletal Radiol 29 2000 181 185
52. B.J. Quade, C.M. McLachlin, and V. Soto-Wright Disseminated peritoneal leiomyomatosis: clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation Am J Pathol 150 1997 2153 2166
53. D.E. Townsend, R.S. Sparkes, and M.C. Baluda Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis by glucose-6-phosphate dehydrogenase Am J Obstet Gynecol 107 1970 1168 1173
54. R.D. Mashal, M.L. Fejzo, and A.J. Friedman Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata Genes Chromosomes Cancer 11 1994 1 6
55. K. Hashimoto, C. Azuma, and S. Kamiura Clonal determination of uterine leiomyomas by analyzing differential inactivation of the X-chromosome-linked phosphoglycerokinase gene Gynecol Obstet Invest 40 1995 204 208
56. K.L. Gross, and C.C. Morton The genetics of fibroids: cytogenetics and inheritance Infert Reprod Clin N Am 13 2002 283 302
57. D. Linder, and S.M. Gartler Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas Science 150 1965 67 69
58. Wong I.L., Nelson L.M., Ward K. Uterine leiomyomata are clonal tumors as determined by an X chromosome methylation sensitive DNA polymorphism. In: Proceedings of the 39th Annual Meeting of the Society for Gynecologic Investigation. San Antonio (TX); 1992
59. Y.Y. Ozisik, A.M. Meloni, and A.A. Sandberg Cytogenetic findings in a symplastic leiomyoma Cancer Genet Cytogenet 67 1993 79 80
60. Y.P. Xing, W.L. Powell, and C.C. Morton The del(7q) subgroup in uterine leiomyomata: genetic and biologic characteristics. Further evidence for the secondary nature of cytogenetic abnormalities in the pathobiology of uterine leiomyomata Cancer Genet Cytogenet 98 1997 69 74
61. K.L. Gross, and C.C. Morton Genetics and the development of fibroids Clin Obstet Gynecol 44 2 2001 335 349
62. Y.Y. Hsieh, C.C. Chang, and F.J. Tsai Androgen receptor trinucleotide polymorphism in leiomyoma J Assist Reprod Genet 21 2004 453 457
63. M. Nibert, and S. Heim Uterine leiomyoma cytogenetics Genes Chromosomes Cancer 2 1990 3 13
64. M.S. Rein, A.J. Friedman, and R.L. Barbieri Cytogenetic abnormalities in uterine leiomyomata Obstet Gynecol 77 1991 923 926
65. N. Pandis, S. Heim, and H. Willen Histologic-cytogenetic correlations in uterine leiomyomas Int J Gynecol Cancer 1 1991 163 168
66. I. Brosens, E. Johannisson, and P. Dal Cin Analysis of the karyotype and desoxyribonucleic acid content of uterine myomas in premenopausal, menopausal, and gonadotropin-releasing hormone agonist-treated females Fertil Steril 66 1996 376 379
67. M.S. Rein, W.L. Powell, and F.C. Walters Cytogenetic abnormalities in uterine myomas are associated with myoma size Mol Hum Reprod 4 1998 83 86
68. C.C. Morton Genetic approaches to the study of uterine leiomyomata Environ Health Perspect 108 Suppl 5 2000 775 778
69. I. Brosens, J. Deprest, and P. Dal Cin Clinical significance of cytogenetic abnormalities in uterine myomas Fertil Steril 69 1998 232 235
70. K.J. Ryan, R.S. Berkowitz, and R.L. Barbieri Leiomyomas 5th edition 1990 Year Book Medical Publishers Chicago
71. A.A. Sandberg Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma Cancer Genet Cytogenet 158 2005 1 26
72. A.M. Meloni, U. Surti, and A.M. Contento Uterine leiomyomas: cytogenetic and histologic profile Obstet Gynecol 80 1992 209 217
73. J. Hu, and U. Surti Subgroups of uterine leiomyomas based on cytogenetic analysis Hum Pathol 22 1991 1009 1016
74. B. Kazmierczak, S. Wanschura, and K. Meyer-Bolte Cytogenetic and molecular analysis of an aggressive angiomyxoma Am J Pathol 147 1995 580 585
75. G. Calabrese, C. Di Virgilio, and E. Cianchetti Chromosome abnormalities in breast fibroadenomas Genes Chromosomes Cancer 3 1991 202 204
76. P. Dal Cin, R. Vanni, and S. Marras Four cytogenetic subgroups can be identified in endometrial polyps Cancer Res 55 1995 1565 1568
77. N. Mandahl, C. Orndal, and S. Heim Aberrations of chromosome segment 12q13-15 characterize a subgroup of hemangiopericytomas Cancer 71 1993 3009 3013
78. C. Turc-Carel, P. Dal Cin, and U. Rao Cytogenetic studies of adipose tissue tumors. I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14) Cancer Genet Cytogenet 23 1986 283 289
79. J.A. Fletcher, J. Longtine, and K. Wallace Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas Genes Chromosomes Cancer 12 1995 220 223
80. J. Bullerdiek, S. Bartnitzke, and M. Weinberg Rearrangements of chromosome region 12q13 - q15 in pleomorphic adenomas of the human salivary gland (PSA) Cytogenet Cell Genet 45 1987 187 190
81. M.S. Fejzo, S.J. Yoon, and K.T. Montgomery Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma, and lipoma: physical mapping of the 12q14-q15 breakpoint region in uterine leiomyomata Genomics 26 1995 265 271
82. H.R. Ashar, M.S. Fejzo, and A. Tkachenko Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains Cell 82 1995 57 65
83. M.J. Justice, L.D. Siracusa, and D.J. Gilbert A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross Genetics 125 1990 855 866
84. H.R. Ashar, L. Cherath, and K.M. Przybysz Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas Genomics 31 1996 207 214
85. E.F. Schoenmakers, S. Wanschura, and R. Mols Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours Nat Genet 10 1995 436 444
86. V. Giancotti, B. Pani, and P. D'Andrea Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes EMBO J 6 1987 1981 1987
87. V. Giancotti, E. Buratti, and L. Perissin Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures Exp Cell Res 184 1989 538 545
88. M.T. Berlingieri, G. Manfioletti, and M. Santoro Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells Mol Cell Biol 15 1995 1545 1553
89. A.H. Ligon, S.D. Moore, and M.A. Parisi Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas Am J Hum Genet 76 2005 340 348
90. B. Bhugra, T.A. Smolarek, and R.A. Lynch Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma Cancer Lett 126 1998 119 126
91. K. Hug, M.K. Doney, and M.J. Tyler Physical mapping of the uterine leiomyoma t(12;14)(q13-15;q24.1) breakpoint on chromosome 14 between SPTB and D14S77 Genes Chromosomes Cancer 11 1994 263 266
92. S. Mosselman, J. Polman, and R. Dijkema ER beta: identification and characterization of a novel human estrogen receptor FEBS Lett 392 1996 49 53
93. E. Enmark, M. Pelto-Huikko, and K. Grandien Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern J Clin Endocrinol Metab 82 1997 4258 4265
94. F. Pedeutour, B.J. Quade, and S. Weremowicz Localization and expression of the human estrogen receptor beta gene in uterine leiomyomata Genes Chromosomes Cancer 23 1998 361 366
95. T. Takahashi, N. Nagai, and H. Oda Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma Genes Chromosomes Cancer 30 2001 196 201
96. Z. Shu, S. Smith, and L. Wang Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can be partially rescued in a p53(-/-) background Mol Cell Biol 19 1999 8686 8693
97. E.F. Schoenmakers, C. Huysmans, and W.J. Van de Ven Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas Cancer Res 59 1999 19 23
98. K. Kurose, N. Mine, and D. Doi Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma Genes Chromosomes Cancer 27 2000 303 307
99. B. Kazmierczak, Y. Hennig, and S. Wanschura Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene Cancer Res 55 1995 6038 6039
100. N. Mine, K. Kurose, and H. Konishi Fusion of a sequence from HEI10 (14q11) to the HMGIC gene at 12q15 in a uterine leiomyoma Jpn J Cancer Res 92 2001 135 139
101. B. Kazmierczak, Y. Pohnke, and J. Bullerdiek Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations Genomics 38 1996 223 226
102. N. Pandis, S. Heim, and G. Bardi Chromosome analysis of 96 uterine leiomyomas Cancer Genet Cytogenet 55 1991 11 18
103. M. Nilbert, S. Heim, and N. Mandahl Different karyotypic abnormalities, t(1;6) and del(7), in two uterine leiomyomas from the same patient Cancer Genet Cytogenet 42 1989 51 53
104. Y.Y. Ozisik, A.M. Meloni, and O. Altongoz Translocation (6;10)(p21;q22) in uterine leiomyomas Cancer Genet Cytogenet 79 1995 136 138
105. M. Kiechle-Schwarz, C. Sreekantaiah, and C.S. Berger Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract: a report of 35 cases Cancer Genet Cytogenet 53 1991 125 136
106. K.S. Sornberger, S. Weremowicz, and A.J. Williams Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6 Cancer Genet Cytogenet 114 1999 9 16
107. P. Dal Cin, B.J. Quade, and S. Weremowicz Primary parauterine leiomyoma with a t(6;14) Genes Chromosomes Cancer 26 1999 385 386
108. B. Kazmierczak, P. Dal Cin, and S. Wanschura HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors Genes Chromosomes Cancer 23 1998 279 285
109. G. Tallini, P. Dal Cin, and K.J. Rhoden Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations Am J Pathol 151 1997 37 43
110. S. Xiao, M.L. Lux, and R. Reeves HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma Am J Pathol 150 1997 901 910
111. P. Dal Cin, S. Wanschura, and M.R. Christiaens Hamartoma of the breast with involvement of 6p21 and rearrangement of HMGIY Genes Chromosomes Cancer 20 1997 90 92
112. P. Dal Cin, H. Van Den Berghe, and I. Brosens Involvement of 6p in an endometrial polyp Cancer Genet Cytogenet 51 1991 279 280
113. B. Kazmierczak, S. Bol, and S. Wanschura PAC clone containing the HMGI(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line Genes Chromosomes Cancer 17 1996 191 193
114. A.J. Williams, W.L. Powell, and T. Collins HMGI(Y) expression in human uterine leiomyomata: involvement of another high-mobility group architectural factor in a benign neoplasm Am J Pathol 150 1997 911 918
115. P. Rogalla, K. Drechsler, and G. Frey HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors Am J Pathol 149 1996 775 779
116. G.J. Gattas, B.J. Quade, and R.A. Nowak HMGIC expression in human adult and fetal tissues and in uterine leiomyomata Genes Chromosomes Cancer 25 1999 316 322
117. A.H. Ligon, and C.C. Morton Genetics of uterine leiomyomata Genes Chromosomes Cancer 28 2000 235 245
118. R. Reeves, T.A. Langan, and M.S. Nissen Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinity Proc Natl Acad Sci U S A 88 1991 1671 1675
119. M.S. Nissen, T.A. Langan, and R. Reeves Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein J Biol Chem 266 1991 19945 19952
120. A.P. Wolffe Architectural transcription factors Science 264 1994 1100 1101
121. R. Reeves Molecular biology of HMGA proteins: hubs of nuclear function Gene 277 2001 63 81
122. Ligon A.H., Morton C.C. Genetics of uterine leiomyomas. In: Sciarra J.J., editor. Gynecology and obstetrics. Philadelphia: Lippincott Williams & Wilkins; 1999. p. Chapter 96, 1-11
123. Y.Y. Ozisik, A.M. Meloni, and U. Surti Deletion 7q22 in uterine leiomyoma: a cytogenetic review Cancer Genet Cytogenet 71 1993 1 6
124. M.S. Sargent, S. Weremowicz, and M.S. Rein Translocations in 7q22 define a critical region in uterine leiomyomata Cancer Genet Cytogenet 77 1994 65 68
125. C.S. Ishwad, R.E. Ferrell, and J. Davare Molecular and cytogenetic analysis of chromosome 7 in uterine leiomyomas Genes Chromosomes Cancer 14 1995 51 55
126. C. Sreekantaiah, and A.A. Sandberg Clustering of aberrations to specific chromosome regions in benign neoplasms Int J Cancer 48 1991 194 198
127. P. Dal Cin, H. Van den Berghe, and R. Sciot Deletion of the long arm of chromosome 7 in lipoma Cancer Genet Cytogenet 96 1997 85 86
128. Y. Davidovitz, R. Zimlichman, and E. Rosner Deletion of the long arm of chromosome 7 in myelomonocytic leukemia with bone marrow eosinophilia Cancer Genet Cytogenet 97 1997 122 124
129. S.N. Sait, P. Dal Cin, and S. Ovanessoff A uterine leiomyoma showing both t(12;14) and del(7) abnormalities Cancer Genet Cytogenet 37 1989 157 161
130. Y. Hennig, P. Rogalla, and S. Wanschura HMGIC expressed in a uterine leiomyoma with a deletion of the long arm of chromosome 7 along with a 12q14-15 rearrangement but not in tumors showing del(7) as the sole cytogenetic abnormality Cancer Genet Cytogenet 96 1997 129 133
131. L. Boghosian, P. Dal Cin, and A.A. Sandberg An interstitial deletion of chromosome 7 may characterize a subgroup of uterine leiomyoma Cancer Genet Cytogenet 34 1988 207 208
132. N. Pandis, S. Heim, and G. Bardi Parallel karyotypic evolution and tumor progression in uterine leiomyoma Genes Chromosomes Cancer 2 1990 311 317
133. S.X. Fan, C. Sreekantaiah, and C.S. Berger Cytogenetic findings in nine leiomyomas of the uterus Cancer Genet Cytogenet 47 1990 179 189
134. S.M. Sell, C. Tullis, and D. Stracner Minimal interval defined on 7q in uterine leiomyoma Cancer Genet Cytogenet 157 2005 67 69
135. rd, and E.M. Davis Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases Blood 88 1996 1930 1935
136. K. Fischer, S. Frohling, and S.W. Schere Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias Blood 89 1997 2036 2041
137. H. Liang, J. Fairman, and D.F. Claxton Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci Proc Natl Acad Sci U S A 95 1998 3781 3785
138. S.M. Sell, O. Altungoz, and A.A. Prowse Molecular analysis of chromosome 7q21.3 in uterine leiomyoma: analysis using markers with linkage to insulin resistance Cancer Genet Cytogenet 100 1998 165 168
139. O. van der Heijden, H.C. Chiu, and T.C. Park Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q Mol Carcinog 23 1998 243 247
140. P.J. Bosma, E.A. van den Berg, and T. Kooistra Human plasminogen activator inhibitor-1 gene: promoter and structural gene nucleotide sequences J Biol Chem 263 1988 9129 9141
141. M. Ishiai, F.B. Dean, and K. Okumura Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22 Genomics 46 1997 294 298
142. L.R. Osborne, J.A. Herbrick, and T. Greavette PMS2-related genes flank the rearrangement breakpoints associated with Williams syndrome and other diseases on human chromosome 7 Genomics 45 1997 402 406
143. L.C. Tsui, H. Donis-Keller, and K.H. Grzeschik Report of the second international workshop on human chromosome 7 mapping 1994 Cytogenet Cell Genet 71 1995 2 21
144. V. Yajnik, C. Paulding, and R. Sordella DOCK4, a GTPase activator, is disrupted during tumorigenesis Cell 112 2003 673 684
145. D.G. Quintana, K.C. Thome, and Z.H. Hou ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases J Biol Chem 273 1998 27137 27145
146. A. Sourla, C. Polychronakos, and W.R. Zeng Plasminogen activator inhibitor 1 messenger RNA expression and molecular evidence for del(7)(q22) in uterine leiomyomas Cancer Res 56 1996 3123 3128
147. W.R. Zeng, S.W. Scherer, and M. Koutsilieris Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas Oncogene 14 1997 2355 2365
148. M. Nilbert, S. Heim, and N. Mandahl Ring formation and structural rearrangements of chromosome 1 as secondary changes in uterine leiomyomas with t(12;14)(q14-15;q23-24) Cancer Genet Cytogenet 36 1988 183 190
149. C. Casartelli, M.A.M. Ruzzene, and S.R. Rogatto A cytogenetic study of uterine leiomyomas Cancer Genet Cytogenet 41 1989 279
150. R. Vanni, U. Lecca, and G. Faa Uterine leiomyoma cytogenetics. II. Report of forty cases Cancer Genet Cytogenet 53 1991 247 256
151. G. Havel, B. Wedell, and R. Dahlenfors Cytogenetic relationship between uterine lipoleiomyomas and typical leiomyomas Virchows Arch B Cell Pathol Incl Mol Pathol 57 1989 77 79
152. J. Mark, G. Havel, and C. Grepp Cytogenetical observations in human benign uterine leiomyomas Anticancer Res 8 1988 621 626
153. P. Polito, P. Dal Cin, and B. Kazmierczak Deletion of HMG17 in uterine leiomyomas with ring chromosome 1 Cancer Genet Cytogenet 108 1999 107 109
154. R. Vanni, P. Dal Cin, and H. Van Den Berghe Is the chromosome band 1p36 another hot-spot for rearrangements in uterine leiomyoma? Genes Chromosomes Cancer 2 1990 255 256
155. F. Mitelman, B. Johansson, and F. Mertens Mitelman Database of Chromosome Aberrations in Cancer Available at: http://cgap.nci.nih.gov/Chromsomes/Mitelman Accessed June 15, 2000
156. N. Christacos, B.J. Quade, and P. Dal Cin Uterine leiomyomata with deletions of 1p represent a distinct cytogenetic subgroup associated with unusual histologic features Genes Chromosomes Cancer 45 3 2006 304 312
157. N.A. Alam, S. Bevan, and M. Churchman Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43 Am J Hum Genet 68 2001 1264 1269
158. K.L. Gross, C.I. Panhuysen, and M.S. Kleinman Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studies Genes Chromosomes Cancer 41 2004 183 190
159. I.P. Tomlinson, N.A. Alam, and A.J. Rowan Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer Nat Genet 30 2002 406 410
160. P. Dal Cin, and C.C. Morton 1q42 approximately q44 is rarely cytogenetically involved in sporadic uterine leiomyomata Cancer Genet Cytogenet 138 2002 92 93
161. M.H. Wei, O. Toure, and G. Glenn Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer J Med Genet 43 1 2005 18 27
162. J.P. Fryns, M. Haspeslagh, and A. de Muelenaere 9p Trisomy/18p distal monosomy and multiple cutaneous leiomyomata. Another specific chromosomal site (18pter) in dominantly inherited multiple tumors? Hum Genet 70 1985 284 286
163. S. Heim, N. Mandahl, and U. Kristoffersson Structural chromosome aberrations in a case of angioleiomyoma Cancer Genet Cytogenet 20 1986 325 330
164. H. Sonobe, Y. Ohtsuki, and H. Mizobuchi An angiomyoma with t(X;10)(q22;q23.2) Cancer Genet Cytogenet 90 1996 54 56
165. Y. Hennig, J. Caselitz, and C. Stern Karyotype evolution in a case of uterine angioleiomyoma Cancer Genet Cytogenet 108 1999 79 80
166. M.R. Nucci, S. Weremowicz, and D.M. Neskey Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva Genes Chromosomes Cancer 32 2001 172 176
167. Y.Y. Ozisik, A.M. Meloni, and U. Surti Inversion (X)(p22q13) in a uterine leiomyoma Cancer Genet Cytogenet 61 1992 131 133
168. P. Dal Cin, P. Moerman, and J. Deprest A new cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3 Genes Chromosomes Cancer 13 1995 219 220
169. Y.Y. Ozisik, A.M. Meloni, and U. Surti Involvement of 10q22 in leiomyoma Cancer Genet Cytogenet 69 1993 132 135
170. A.M. Meloni, U. Surti, and A.A. Sandberg Deletion of chromosome 13 in leiomyomas of the uterus Cancer Genet Cytogenet 53 1991 199 203
171. M. Nilbert, S. Heim, and N. Mandahl Trisomy 12 in uterine leiomyomas: a new cytogenetic subgroup Cancer Genet Cytogenet 45 1990 63 66
172. C. Blank, P. Rogalla, and K.H. Tran A novel high mobility group protein gene is a candidate for Xp22 abnormalities in uterine leiomyomas and other benign tumors Cancer Genet Cytogenet 121 2000 172 180
173. C. Turc-Carel, P. Dal Cin, and L. Boghosian Consistent breakpoints in region 14q22-q24 in uterine leiomyoma Cancer Genet Cytogenet 32 1988 25 31
174. R. Vanni, M. Nieddu, and R. Paoli Uterine leiomyoma cytogenetics. I. Rearrangements of chromosome 12 Cancer Genet Cytogenet 37 1989 49 54
175. J. Mark, G. Havel, and C. Grepp Chromosomal patterns in human benign uterine leiomyomas Cancer Genet Cytogenet 44 1990 1 13
176. M. Nilbert, S. Heim, and N. Mandahl Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), + 12, and t(12;14), in 44 uterine leiomyomas Hum Genet 85 1990 605 611
177. P.A. Steck, M.A. Pershouse, and S.A. Jasser Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Nat Genet 15 1997 356 362
178. J. Mollenhauer, S. Wiemann, and W. Scheurlen DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours Nat Genet 17 1997 32 39
179. S.D. Moore, S.R. Herrick, and T.A. Ince Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF Cancer Res 64 2004 5570 5577
180. J. Mark, G. Havel, and R. Dahlenfors Cytogenetics of multiple uterine leiomyomas, parametrial leiomyoma and disseminated peritoneal leiomyomatosis Anticancer Res 11 1991 33 39
181. R.F. Service Proteomics. Can Celera do it again? Science 287 2000 2136 2138
182. R.F. Service Biochemistry: protein arrays step out of DNA's shadow Science 289 2000 1673
183. J.I. Everitt, D.C. Wolf, and S.R. Howe Rodent model of reproductive tract leiomyomata: clinical and pathological features Am J Pathol 146 1995 1556 1567
184. K.J. Field, J.W. Griffith, and C.M. Lang Spontaneous reproductive tract leiomyomas in aged guinea-pigs J Comp Pathol 101 1989 287 294
185. S.R. Howe, M.M. Gottardis, and J.I. Everitt Rodent model of reproductive tract leiomyomata: establishment and characterization of tumor-derived cell lines Am J Pathol 146 1995 1568 1579