A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly

EMBO Reports

Volumn 4, Issue 1, 2003, Pages 76-81

  Schwake, Michael ^a,c   Jentsch, Thomas J ^a   Friedrich, Thomas ^b  

^a ZMNH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KCNQ; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; POTASSIUM CHANNEL KCNQ;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE CONDUCTANCE; CELL SPECIFICITY; CHIMERA; CONTROLLED STUDY; CYTOPLASM; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN INTERACTION; PROTEIN TRANSPORT; SEQUENCE ALIGNMENT; XENOPUS; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; PROTEIN DOMAIN; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; DNA, COMPLEMENTARY; FEMALE; HUMANS; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; OOCYTES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

ANIMALIA; CHIMAERA;

EID: 0037219281     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor715     Document Type: Article

References (27)

1. Ks cardiac potassium current. Nature, 384, 78-80.
2. Biervert, C. et al. (1998) A potassium channel mutation in neonatal human epilepsy. Science, 279, 403-406.
3. Charlier, C. et al. (1998) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nature Genet., 18, 53-55.
4. Ks activation through interactions with Isk. Cardiovasc. Res., 45, 971-980.
5. Jentsch, T.J. (2000) Neuronal KCNQ potassium channels: physiology and role in disease. Nature Rev. Neurosci., 1, 21-30.
6. Kubisch, C. et al. (1999) KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell, 96, 437-446.
7. Li, M., Jan, Y.N. & Jan, L.Y. (1992) Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science, 257, 1225-1230.
8. Ludwig, J., Owen, D. & Pongs, O. (1997) Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-a-go-go potassium channel. EMBO J., 16, 6337-6345.
9. Marx, S.O. et al. (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science, 295, 496-499.
10. Neyroud, N. et al. (1997) A novel mutation in the potassium channel gene KvLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nature Genet., 15, 186-189.
11. Papazian, D.M. (1999). Potassium channels: some assembly required. Neuron, 23, 7-10.
12. Pusch, M. (1998) Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK. Pflügers Arch., 437, 172-174.
13. Ks, potassium channel. Nature, 384, 80-83.
14. Schmitt, N. et al. (2000) A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J., 19, 332-340.
15. + channels causes epilepsy. Nature, 396, 687-690.
16. Schroeder, B.C., Hechenberger, M., Weinreich, F., Kubisch, C. & Jentsch, T.J. (2000a) KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J. Biol. Chem., 275, 24089-24095.
17. Schroeder, B.C., et al. (2000b) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature, 403, 196-199.
18. + channels involved in epilepsy. J. Biol. Chem., 275, 13343-13348.
19. Selyanko, A.A., Hadley, J.K. & Brown, D.A. (2001) Properties of single M-type KCNQ2/KCNQ3 potassium channels expressed in mammalian cells. J. Physiol. (Lond.), 534, 15-24.
20. Ks channels and channels formed with two minK mutants that cause long QT syndrome. J. Gen. Physiol., 112, 651-663.
21. Singh, N.A. et al. (1998) A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nature Genet., 18, 25-29.
22. Tinker, A., Jan, Y.N. & Jan, L.Y. (1996) Regions responsible for the assembly of inwardly rectifying potassium channels. Cell, 87, 857-868.
23. Wang, H.S. et al. (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science, 282, 1890-1893.
24. Wang, Q. et al. (1996) Positional cloning of a novel potassium channel gene: KvLQT1 mutations cause cardiac arrhythmias. Nature Genet., 12, 17-23.
25. + channel mutations found in inherited cardiac arrhythmias. Hum. Mol. Genet., 6, 1943-1949.
26. Yang, W.P. et al. (1998) Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. J. Biol. Chem., 273, 19419-19423.
27. ATP channels. Neuron, 22, 537-548.