Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin

Anesthesiology

Volumn 84, Issue 6, 1996, Pages 1435-1442

  Müller, Claudia M ^a,f   Scierka, Annette ^b   Stiller, Richard L ^c   Kim, Yong Myeong ^a   Cook, D Ryan ^b   Lancaster Jr , Jack R ^d,e   Buffington, Charles W ^a   Watkins, W David ^a  

^a Dept of Anesth/Critical Care Med ^*

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c Department of Anesthesiology

^d Depts Surg Anesth/Critical C   (Turkey)

^e LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Biotransformation: hydroxylation; induction; microspinal; N demethylation; Enzymes, cytochrome P450: CYP 2B1; CYP2C6 11; CYP3A1 2; Interactions, drug: nitric oxide; sepsis; Metabolism, drug: ethylmorphine; midazolam

Indexed keywords

AMINOGUANIDINE; BACTERIUM LIPOPOLYSACCHARIDE; CYTOCHROME P450; ENDOTOXIN; ETHYLMORPHINE; MIDAZOLAM; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENOBARBITAL;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME INDUCTION; ENZYME INHIBITION; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS;

ANIMALS; ARGININE; CYTOCHROME P-450 ENZYME SYSTEM; GUANIDINES; LIPOPOLYSACCHARIDES; MALE; MICROSOMES, LIVER; NITRIC OXIDE; OMEGA-N-METHYLARGININE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029953771     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199606000-00020     Document Type: Article

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