Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system

Free Radical Biology and Medicine

Volumn 37, Issue 5, 2004, Pages 682-694

  Warabi, Eiji ^a,b   Wada, Youichiro ^a   Kajiwara, Hiroko ^c   Kobayashi, Mika ^a   Koshiba, Nobuko ^d   Hisada, Toshiaki ^d   Shibata, Masahiro ^e   Ando, Joji ^e   Tsuchiya, Masatoshi ^c   Kodama, Tatsuhiko ^a   Noguchi, Noriko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c Yamato Scientific Company   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Atherosclerosis; BSO; buthionine sulfoximine; Free radicals; Gene expression; glutathione; GSH; heme oxygenase 1; HO 1; Human umbilical endothelial cells; HUVEC; Low density lipoprotein; Nrf 2; Oxygen concentration; Shear stress

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE; LOW DENSITY LIPOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ARTICLE; ATHEROGENESIS; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA MICROARRAY; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; LABORATORY TEST; LAMINAR FLOW; MALE; MICROENVIRONMENT; MONOCYTE; NONHUMAN; OXYGEN CONCENTRATION; PRIORITY JOURNAL; SHEAR STRESS; UMBILICAL VEIN;

BASE SEQUENCE; CELL CULTURE TECHNIQUES; CELL HYPOXIA; CELL LINE; DNA PRIMERS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; KINETICS; LIPOPROTEINS, LDL; OXYGEN; POLYMERASE CHAIN REACTION; STRESS, MECHANICAL; UMBILICAL VEINS;

EID: 3342990076     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.05.020     Document Type: Article

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