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Volumn 18, Issue 3, 2004, Pages 393-406

The role of insulin and insulin-like growth factor-I in mammalian ageing

Author keywords

Caloric restriction; Dwarf mice; Insulin; Insulin like growth factor I

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN SH2; PROTEIN TYROSINE KINASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

EID: 3342907109     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2004.02.002     Document Type: Article
Times cited : (58)

References (76)
  • 1
    • 0031919552 scopus 로고    scopus 로고
    • Insulin signal transduction through protein kinase cascades
    • Avruch J. Insulin signal transduction through protein kinase cascades Molecular and Cellular Biochemistry 182 1998 31-48
    • (1998) Molecular and Cellular Biochemistry , vol.182 , pp. 31-48
    • Avruch, J.1
  • 2
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura K.D. Tissenbaum H.A. Liu Y. et al. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans Science 277 1997 942-946
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3
  • 3
    • 0033151613 scopus 로고    scopus 로고
    • PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
    • Paradis S. Ailion M. Toker A. et al. PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans Genes and Development 13 1999 1438-1452
    • (1999) Genes and Development , vol.13 , pp. 1438-1452
    • Paradis, S.1    Ailion, M.2    Toker, A.3
  • 4
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • Paradis S. Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor Genes and Development 12 1998 2488-2498
    • (1998) Genes and Development , vol.12 , pp. 2488-2498
    • Paradis, S.1    Ruvkun, G.2
  • 5
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C. elegans life-span by insulin-like signaling in the nervous system
    • Wolkow C.A. Kimura K.D. Lee M.S. et al. Regulation of C. elegans life-span by insulin-like signaling in the nervous system Science 290 2000 147-150
    • (2000) Science , vol.290 , pp. 147-150
    • Wolkow, C.A.1    Kimura, K.D.2    Lee, M.S.3
  • 6
    • 0035853552 scopus 로고    scopus 로고
    • Regulation of longevity and stress resistance by Sch9 in yeast
    • Fabrizio P. Pozza F. Pletcher S.D. et al. Regulation of longevity and stress resistance by Sch9 in yeast Science 29 2001 288-290
    • (2001) Science , vol.29 , pp. 288-290
    • Fabrizio, P.1    Pozza, F.2    Pletcher, S.D.3
  • 7
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar M. Kopelman A. Epstein D. et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function Science 292 2001 107-110
    • (2001) Science , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3
  • 8
    • 0035815414 scopus 로고    scopus 로고
    • Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    • Clancy D.J. Gems D. Harshman et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein Science 292 2001 104-106
    • (2001) Science , vol.292 , pp. 104-106
    • Clancy, D.J.1    Gems, D.2    Harshman, A.3
  • 9
    • 0024656069 scopus 로고
    • The effect of retarded growth upon the length of life span and upon the ultimate body size
    • 1935
    • McCay C.M. Crowell M.F. Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935 Nutrition 5 1989 155-171
    • (1989) Nutrition , vol.5 , pp. 155-171
    • McCay, C.M.1    Crowell, M.F.2    Maynard, L.A.3
  • 10
    • 0000817678 scopus 로고
    • Nutrition and longevity in the rat: II. Longevity and onset of disease with different levels of food intake
    • Berg B.N. Simms H.S. Nutrition and longevity in the rat: II. Longevity and onset of disease with different levels of food intake Journal of Nutrition 71 1960 255-263
    • (1960) Journal of Nutrition , vol.71 , pp. 255-263
    • Berg, B.N.1    Simms, H.S.2
  • 14
    • 0037008501 scopus 로고    scopus 로고
    • Biomarkers of caloric restriction may predict longevity in humans
    • Roth G.S. Lane M.A. Ingram D.K. et al. Biomarkers of caloric restriction may predict longevity in humans Science 297 2002 811
    • (2002) Science , vol.297 , pp. 811
    • Roth, G.S.1    Lane, M.A.2    Ingram, D.K.3
  • 15
    • 0023838776 scopus 로고
    • The influences of dietary protein source on longevity and age-related disease processes of Fischer rats
    • Iwasaki K. Gleiser C.A. Masoro E.J. et al. The influences of dietary protein source on longevity and age-related disease processes of Fischer rats Journal of Gerontology 43 1988 B5-B12
    • (1988) Journal of Gerontology , vol.43
    • Iwasaki, K.1    Gleiser, C.A.2    Masoro, E.J.3
  • 19
    • 0032903935 scopus 로고    scopus 로고
    • Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats
    • Wetter T.J. Gazdag A.C. Dean D.J. Cartee G.D. Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats American Journal of Physiology 276 1999 E728-E738
    • (1999) American Journal of Physiology , vol.276
    • Wetter, T.J.1    Gazdag, A.C.2    Dean, D.J.3    Cartee, G.D.4
  • 20
    • 0035979492 scopus 로고    scopus 로고
    • Caloric restriction alters the feeding response of key metabolic enzyme genes
    • Dhahbi J.M. Mote P.L. Wingo J. et al. Caloric restriction alters the feeding response of key metabolic enzyme genes Mechanisms of Ageing and Development 122 2001 1033-1048
    • (2001) Mechanisms of Ageing and Development , vol.122 , pp. 1033-1048
    • Dhahbi, J.M.1    Mote, P.L.2    Wingo, J.3
  • 21
    • 0033377625 scopus 로고    scopus 로고
    • Calorie restriction in nonhuman primates: Effects on diabetes and cardiovascular disease risk
    • Lane M.A. Ingram D.K. Roth G.S. Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk Toxicology Science 52 supplement 2 1999 41-48
    • (1999) Toxicology Science , vol.52 , Issue.SUPPL. 2 , pp. 41-48
    • Lane, M.A.1    Ingram, D.K.2    Roth, G.S.3
  • 22
  • 23
    • 0000567961 scopus 로고    scopus 로고
    • Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
    • Barzilai N. Banerjee S. Hawkins M. et al. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat Journal of Clinical Investigation 101 1998 1353-1361
    • (1998) Journal of Clinical Investigation , vol.101 , pp. 1353-1361
    • Barzilai, N.1    Banerjee, S.2    Hawkins, M.3
  • 24
    • 3342884328 scopus 로고
    • Effects of dietary restriction on glucose utilization of skeletal muscle of Fischer 344 rats
    • McCarter R.J. Masoro E.J. Mejia W.J. Effects of dietary restriction on glucose utilization of skeletal muscle of Fischer 344 rats The Gerontologist 34 1994 356
    • (1994) The Gerontologist , vol.34 , pp. 356
    • McCarter, R.J.1    Masoro, E.J.2    Mejia, W.J.3
  • 25
    • 0025933857 scopus 로고
    • Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins
    • Breese C.R. Ingram R.L. Sonntag W.E. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins Journal of Gerontology 46 1991 B180-B187
    • (1991) Journal of Gerontology , vol.46
    • Breese, C.R.1    Ingram, R.L.2    Sonntag, W.E.3
  • 26
    • 0026793913 scopus 로고
    • Effects of aging and dietary restriction on tissue protein synthesis: Relationship to plasma insulin-like growth factor-1
    • Sonntag W.E. Lenham J.E. Ingram R.L. Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1 Journal of Gerontology 47 1992 B159-B163
    • (1992) Journal of Gerontology , vol.47
    • Sonntag, W.E.1    Lenham, J.E.2    Ingram, R.L.3
  • 27
    • 0032584997 scopus 로고    scopus 로고
    • Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway(Fischer 344 rat brain
    • Niblock M.M. Brunso-Bechtold J.K. Lynch C.D. et al. Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway(Fischer 344 rat brain Brain Research 804 1998 79-86
    • (1998) Brain Research , vol.804 , pp. 79-86
    • Niblock, M.M.1    Brunso-Bechtold, J.K.2    Lynch, C.D.3
  • 28
    • 0033450849 scopus 로고    scopus 로고
    • Pleitropic effects of growth hormone and insulin-like growth factor (IGF)-I on biological aging: Inferences from moderate caloric-restricted animals
    • Sonntag W.E. Lynch C.D. Cefalu W.T. Pleitropic effects of growth hormone and insulin-like growth factor (IGF)-I on biological aging: inferences from moderate caloric-restricted animals Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 54A 1999 B521-B538
    • (1999) Journals of Gerontology. Series A: Biological Sciences and Medical Sciences , vol.54 A
    • Sonntag, W.E.1    Lynch, C.D.2    Cefalu, W.T.3
  • 29
    • 0030906744 scopus 로고    scopus 로고
    • Up-regulation of IGF binding protein-1 as an anticarcinogenic strategy: Relevance to caloric restriction, exercise, and insulin sensitivity
    • McCarty M.F. Up-regulation of IGF binding protein-1 as an anticarcinogenic strategy: relevance to caloric restriction, exercise, and insulin sensitivity Medical Hypotheses 48 1997 297-308
    • (1997) Medical Hypotheses , vol.48 , pp. 297-308
    • McCarty, M.F.1
  • 30
    • 0025888306 scopus 로고
    • Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice
    • Spindler S.R. Grizzle J.M. Walford R.L. Mote P.L. Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice Journal of Gerontology 46 1991 B233-B237
    • (1991) Journal of Gerontology , vol.46
    • Spindler, S.R.1    Grizzle, J.M.2    Walford, R.L.3    Mote, P.L.4
  • 35
    • 0024382014 scopus 로고
    • Regulation by fasting of rat insulin-like growth factor-I and its receptor. Effects on gene expression and binding
    • Lowe W.L. Jr. Adamo M. Werner H. et al. Regulation by fasting of rat insulin-like growth factor-I and its receptor. Effects on gene expression and binding Proceedings of the National Academy of Science of the USA 84 1988 619-626
    • (1988) Proceedings of the National Academy of Science of the USA , vol.84 , pp. 619-626
    • Lowe Jr., W.L.1    Adamo, M.2    Werner, H.3
  • 36
    • 0029608970 scopus 로고
    • The Ames dwarf gene is required for Pit-1 gene activation
    • Andersen B. Pearse R.V.2nd Jenne K. et al. The Ames dwarf gene is required for Pit-1 gene activation Developmental Biology 172 1995 495-503
    • (1995) Developmental Biology , vol.172 , pp. 495-503
    • Andersen, B.1    Pearse II, R.V.2    Jenne, K.3
  • 37
    • 0025014024 scopus 로고
    • Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
    • Li S. Crenshaw B.E.I.I.I. Rawson E.J. Simmons D.M. et al. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1 Nature 347 1990 528-533
    • (1990) Nature , vol.347 , pp. 528-533
    • Li, S.1    Crenshaw, B.E.I.I.I.2    Rawson, E.J.3    Simmons, D.M.4
  • 38
    • 0020617471 scopus 로고
    • Etiology of growth hormone deficiency in little. Ames and Snell dwarf mice
    • Cheng T.C. Beamer W.G. Phillip J.A. et al. Etiology of growth hormone deficiency in little. Ames and Snell dwarf mice Endocrinology 113 1983 1669-1678
    • (1983) Endocrinology , vol.113 , pp. 1669-1678
    • Cheng, T.C.1    Beamer, W.G.2    Phillip, J.A.3
  • 42
    • 12644257576 scopus 로고    scopus 로고
    • A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
    • Zhou Y. Xu B.C. Maheshwari H.G. et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse) Proceedings of the National Academy of Sciences of the USA 4 1997 3215-13220
    • (1997) Proceedings of the National Academy of Sciences of the USA , vol.4 , pp. 3215-13220
    • Zhou, Y.1    Xu, B.C.2    Maheshwari, H.G.3
  • 46
    • 0019305553 scopus 로고
    • New mouse dw allele: Genetic location and effects on lifespan and growth hormone levels
    • Eicher E.M. Beamer W.G. New mouse dw allele: genetic location and effects on lifespan and growth hormone levels Journal of Heredity 71 1980 187-190
    • (1980) Journal of Heredity , vol.71 , pp. 187-190
    • Eicher, E.M.1    Beamer, W.G.2
  • 47
    • 0036237480 scopus 로고    scopus 로고
    • Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
    • Dominici F.P. Hauck S. Argentino D.P. et al. Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice Journal of Endocrinology 173 2002 81-94
    • (2002) Journal of Endocrinology , vol.173 , pp. 81-94
    • Dominici, F.P.1    Hauck, S.2    Argentino, D.P.3
  • 48
    • 0032836611 scopus 로고    scopus 로고
    • Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-2 knockout mice
    • Gazdag A.C. Dumke C.L. Kahn C.R. Cartee G.D. Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-2 knockout mice Diabetes 48 1999 1930-1936
    • (1999) Diabetes , vol.48 , pp. 1930-1936
    • Gazdag, A.C.1    Dumke, C.L.2    Kahn, C.R.3    Cartee, G.D.4
  • 49
    • 0029551663 scopus 로고
    • Change in insulin action and insulin secretion in the rat after dietary restriction early in life: Influence of food restriction versus low-protein food restriction
    • Piarel-Blanchot F. Alvarez C. Bailbe D. Pascual-Leone A.M. Portha B. Change in insulin action and insulin secretion in the rat after dietary restriction early in life: influence of food restriction versus low-protein food restriction Metabolism 44 1995 1519-1526
    • (1995) Metabolism , vol.44 , pp. 1519-1526
    • Piarel-Blanchot, F.1    Alvarez, C.2    Bailbe, D.3    Pascual-Leone, A.M.4    Portha, B.5
  • 50
    • 0036103401 scopus 로고    scopus 로고
    • Implications for the insulin signaling pathway in Snell dwarf mouse longevity: A similarity with the C. elegans longevity paradigm
    • Hsieh C.C. DeFord J.H. Flurkey K. Harrison D.E. Papaconstantinou J. Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm Mechanisms of Aging and Development 123 2002 1229-1244
    • (2002) Mechanisms of Aging and Development , vol.123 , pp. 1229-1244
    • Hsieh, C.C.1    DeFord, J.H.2    Flurkey, K.3    Harrison, D.E.4    Papaconstantinou, J.5
  • 51
    • 13344277357 scopus 로고    scopus 로고
    • Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    • Accili D. Drago J. Lee E.J. et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene Nature Genetics 12 1996 106-109
    • (1996) Nature Genetics , vol.12 , pp. 106-109
    • Accili, D.1    Drago, J.2    Lee, E.J.3
  • 52
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning J.C. Michael M.D. Winnay J.N. et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance Molecular Cell 2 1998 559-569
    • (1998) Molecular Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1    Michael, M.D.2    Winnay, J.N.3
  • 53
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael M.D. Kulkarni R.N. Postic C. et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Molecular Cell 6 2000 87-97
    • (2000) Molecular Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 54
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni R.N. Bruning J.C. Winnay J.N. et al. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes Cell 96 1999 329-339
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3
  • 55
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • Blüher M. Michael M.D. Peroni O.D. et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance Developmental Cell 3 2002 25-38
    • (2002) Developmental Cell , vol.3 , pp. 25-38
    • Blüher, M.1    Michael, M.D.2    Peroni, O.D.3
  • 56
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Blüher M. Kahn B.B. Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572-574
    • (2003) Science , vol.299 , pp. 572-574
    • Blüher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 58
    • 0032527626 scopus 로고    scopus 로고
    • Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression
    • Butler A.A. Blakesley V.A. Tsokos M. et al. Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression Cancer Research 58 1998 3021-3027
    • (1998) Cancer Research , vol.58 , pp. 3021-3027
    • Butler, A.A.1    Blakesley, V.A.2    Tsokos, M.3
  • 59
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu J.-P. Baker J. Perkins A.S. et al. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) Cell 75 1993 59-72
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.-P.1    Baker, J.2    Perkins, A.S.3
  • 60
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • Holzenberger M. Dupont J. Ducos B. et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 2003 182-187
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3
  • 61
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente L. Kenyon C. Genetic pathways that regulate ageing in model organisms Nature Reviews 408 2000 255-262
    • (2000) Nature Reviews , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 62
    • 0036245337 scopus 로고    scopus 로고
    • Mechanisms of ageing: Public or private?
    • Partridge L. Gems D. Mechanisms of ageing: public or private? Nature Genetics 3 2002 165-178
    • (2002) Nature Genetics , vol.3 , pp. 165-178
    • Partridge, L.1    Gems, D.2
  • 63
    • 0035216820 scopus 로고    scopus 로고
    • Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes
    • Paolisso G. Barbieri M. Rizzo M.R. et al. Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes Experimental Gerontology 37 2001 149-156
    • (2001) Experimental Gerontology , vol.37 , pp. 149-156
    • Paolisso, G.1    Barbieri, M.2    Rizzo, M.R.3
  • 67
    • 3342892927 scopus 로고    scopus 로고
    • Epidemiologic appraoches to evaluating insulin-like growth factor and cancer risk
    • D.Le Roith, W. Zumkeller, & R.C. Baxter (Eds.), New York/Georgetown, TX: Kluwer/Plenum andLandes Bioscience/Eurekah.Com
    • Schernhammer E.S. Hankinson S.E. Epidemiologic appraoches to evaluating insulin-like growth factor and cancer risk in: Le Roith D. Zumkeller W. Baxter R.C. eds. Insulin-Like Growth Factors 2003 Kluwer/Plenum andLandes Bioscience/Eurekah.Com New York/Georgetown, TX
    • (2003) Insulin-Like Growth Factors
    • Schernhammer, E.S.1    Hankinson, S.E.2
  • 68
    • 0013072999 scopus 로고    scopus 로고
    • Calorie restriction, aging, and cancer prevention: Mechanisms of action and applicability to humans
    • Hursting S.D. Lavigne J.A. Berrigan D. et al. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans Annual Review of Medicine 54 2003 131-152
    • (2003) Annual Review of Medicine , vol.54 , pp. 131-152
    • Hursting, S.D.1    Lavigne, J.A.2    Berrigan, D.3
  • 69
    • 0037014743 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
    • Sandhu M.S. Dunger D.B. Giovannucci E.L. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer Journal of the National Cancer Institute 94 2002 972-980
    • (2002) Journal of the National Cancer Institute , vol.94 , pp. 972-980
    • Sandhu, M.S.1    Dunger, D.B.2    Giovannucci, E.L.3
  • 70
    • 0035990351 scopus 로고    scopus 로고
    • Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
    • Johnson T.E. Henderson S. Murakami S. et al. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease Journal of Inherited Metabolic Disease 25 2002 197-206
    • (2002) Journal of Inherited Metabolic Disease , vol.25 , pp. 197-206
    • Johnson, T.E.1    Henderson, S.2    Murakami, S.3
  • 71
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal R.S. Weindruch R. Oxidative stress, caloric restriction, and aging Science 273 1996 59-63
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 72
    • 0032111884 scopus 로고    scopus 로고
    • Influence of caloric intake on aging on the response to stressors
    • Masoro E.J. Influence of caloric intake on aging on the response to stressors Journal of Toxicology and Environmental Health 1 1998 243-257
    • (1998) Journal of Toxicology and Environmental Health , vol.1 , pp. 243-257
    • Masoro, E.J.1
  • 73
    • 0027154719 scopus 로고
    • Expression of heat shock protein 70 is altered by age and diet at the level of transcription
    • Heydari A. Wu B. Takahashi R. et al. Expression of heat shock protein 70 is altered by age and diet at the level of transcription Molecular and Cellular Biology 13 1993 2909-2918
    • (1993) Molecular and Cellular Biology , vol.13 , pp. 2909-2918
    • Heydari, A.1    Wu, B.2    Takahashi, R.3


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