Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates

Vaccine

Volumn 24, Issue 14, 2006, Pages 2674-2684

  Bartlett, Emmalene J ^a   Amaro Carambot, Emerito ^a   Surman, Sonja R ^a   Collins, Peter L ^a   Murphy, Brian R ^a   Skiadopoulos, Mario H ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Attenuating mutations; Human parainfluenza virus; Interferon antagonist; Non human primate study; Vaccine candidates

Indexed keywords

GLYCINE CLEAVAGE SYSTEM; HN PROTEIN; LIVE VACCINE; PARAINFLUENZA VACCINE; PROTEIN C; RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 1 VACCINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CERCOPITHECIDAE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; GENE DELETION; GENE MUTATION; GENETIC STABILITY; HAMSTER; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARAINFLUENZA VIRUS 1; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; REVERTANT; RNA VIRUS INFECTION; VIRUS GENE; VIRUS REPLICATION; VIRUS TITRATION;

ANIMALS; CELL LINE; CRICETINAE; HUMANS; PARAINFLUENZA VACCINES; PARAINFLUENZA VIRUS 1, HUMAN; POINT MUTATION; VACCINES, ATTENUATED;

EID: 33344468778     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.10.047     Document Type: Article

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