Codon Substitution Mutations at Two Positions in the L Polymerase Protein of Human Parainfluenza Virus Type 1 Yield Viruses with a Spectrum of Attenuation In Vivo and Increased Phenotypic Stability In Vitro

Journal of Virology

Volumn 78, Issue 4, 2004, Pages 2029-2036

  McAuliffe, Josephine M ^a   Surman, Sonja R ^a   Newman, Jason T ^a   Riggs, Jeffrey M ^a   Collins, Peter L ^a   Murphy, Brian R ^a   Skiadopoulos, Mario H ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HPIV3CP45 VACCINE; L POLYMERASE; TYROSINE; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS VACCINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ATT GENE; ATTENUATION; CODON; CONTROLLED STUDY; DNA MODIFICATION; GENE; GENE MUTATION; GENETIC STABILITY; HAMSTER; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PARAINFLUENZA VIRUS 1; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTITUTION REACTION; TEMPERATURE SENSITIVE MUTANT; TS GENE; VIRUS ATTENUATION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CODON; CRICETINAE; DNA-DIRECTED DNA POLYMERASE; HUMANS; PARAINFLUENZA VACCINES; PARAINFLUENZA VIRUS 1, HUMAN; PHENOTYPE; RESPIRATORY SYSTEM; RESPIROVIRUS INFECTIONS; TEMPERATURE; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0842282802     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.4.2029-2036.2004     Document Type: Article

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