A point mutation in the Sendai virus accessory C proteins attenuates virulence for mice, but not virus growth in cell culture

Virology

Volumn 238, Issue 2, 1997, Pages 424-431

  Garcin, Dominique ^a   Itoh, Masae ^b   Kolakofsky, Daniel ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C;

ANIMAL EXPERIMENT; ARTICLE; MALE; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SENDAI VIRUS; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS VIRULENCE;

EID: 0031585531     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8836     Document Type: Article

References (40)

1. Alkhatib G., Massie B., Briedis D. J. Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: Levels of C protein synthesizedin vivo. J. Virol. 62:1988;4059-4069.
2. Barr J., Chambers P., Harriott P., Pringle C. R., Easton A. J. Sequence of the phosphoprotein gene of pneumonia virus of mice: Expression of multiple proteins from two overlapping reading frames. J. Virol. 68:1994;5330-5334.
3. Bellini W. J., Englund G., Rozenblatt S., Arnheiter H., Richardson C. D. Measles virus P gene codes for two proteins. J. Virol. 53:1985;908-919.
4. Cadd T., Garcin D., Tapparel C., Itoh M., Homma M., Roux L., Curran J., Kolakofsky D. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion. J. Virol. 70:1996;5067-5074.
5. Curran J. Reexamination of the Sendai virus P protein domains required for RNA synthesis: A possible supplemental role for the P protein. Virology. 221:1996;130-140.
6. Curran J., Kolakofsky D. Sendai virus P gene produces multiple proteins from overlapping open reading frame. Enzyme. 44:1990;244-249.
7. Curran J., Boeck R., Kolakofsky D. The Sendai virus P gene expresses both an essential protein and an inhibitor of RNA synthesis by shuffling modules via mRNA editing. EMBO J. 10:1991;3079-3085.
8. Curran J., Marq J.-B., Kolakofsky D. The Sendai virus nonstructural C proteins specifically inhibit viral mRNA synthesis. Virology. 189:1992;647-656.
9. Curran J., Marq J.-B., Kolakofsky D. An N-terminal domain of the Sendai virus P protein acts as a chaperone for NP protein during the nascent chain assembly step of genome replication. J. Virol. 69:1995;849-855.
10. Engelhorn M., Stricker R., Roux L. Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. J. Gen. Virol. 74:1993;137-141.
11. Fuerst T. R., Niles E. G., Studier F. W., Moss B. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA. 83:1986;8122-8126.
12. Galinski M. S., Troy R. M., Banerjee A. K. RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3. Virology. 186:1992;543-550.
13. Garcin D., Pelet T., Calain P., Roux L., Curran J., Kolakofsky D. A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: Generation of a novel copy-back nondefective interfering virus. EMBO J. 14:1995;6087-6094.
14. Giorgi C., Blumberg B. M., Kolakofsky D. Sendai virus contains overlapping genes expressed from a single mRNA. Cell. 35:1983;829-836.
15. Hamaguchi M., Yoshida T., Nishikawa K., Naruse H., Nagai Y. Transcriptive complex of NDV: Both L and p proteins are required to reconstitute an active complex. Virology. 128:1983;105-117.
16. Horikami S. M., Curran J., Kolakofsky D., Moyer S. A. Complexes of Sendai virus NP-P and P-L proteins are required for defective interfering particle genome replication in vitro. J. Virol. 66:1992;4901-4908.
17. M. Itoh, M. Homma, 1993, A mechanism of adaptation of Sendai virus to LLC-MK2 cells: Single point mutation of C protein elevated the level of viral mRNA, IXth International Congress of Virology, Glasgow.
18. Itoh M., Isegawa Y., Hotta H., Homma M. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells. J. Gen. Virol. 1997.
19. Kashiwazaki H., Homma M., Ishida N. Assay of Sendai virus by immunofluorescence and hemadsorbed cell-counting procedures. Proc. Soc. Exp. Biol. Med. 120:1965;134-138.
20. Kast W. M., Bluestone J. A., Heemskerk M. H. M., Spaargaren J., Voordouw A. C., Ellenhorn J. D. I., Melief C. J. M. Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells. J. Immunol. 145:1990;2254-2259.
21. Kato A., Kiyotani K., Sakai Y., Yoshida T., Nagai Y. Importance of the V protein for determining in vitro phenotypes and in vivo pathogenicity of Sendai virus. EMBO J. 16:1997;678-587.
22. Kretzschmar E., Peluso R., Schnell M. J., Whitt M. A., Rose J. K. Normal replication of vesicular stomatitis virus without C proteins. Virology. 216:1996;309-316.
23. Lamb R. A., Paterson R. G. The nonstructural proteins of paramyxoviruses. The Paramyxoviruses. 1991;Plenum, New York. p. 181-210.
24. Liston P., Briedis D. J. Measles virus V protein binds zinc. Virology. 198:1994;399-404.
25. Matsuoka Y., Curran J., Pelet T., Kolakofsky D., Ray R., Compans R. W. The P gene of human parainfluenza type 1 virus encodes P and C proteins, but not a cysteine-rich V protein. J. Virol. 65:1991;3406-3410.
26. Murphy F. A., Fauquet C. M., Bishop D. H. L. Sixth report of the International Committee on Taxonomy of Viruses. Arch. Virol. Suppl. 10:1994;268-274.
27. Nathan C. Natural resistance and nitric oxide. Cell. 82:1995;873-876.
28. Paterson R. G., Leser G. P., Shaughnessy M. A., Lamb R. A. The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions. Virology. 208:1995;121-131.
29. Pelet T., Curran J., Kolakofsky D. The P gene of bovine parainfluenza virus 3 expresses all three reading frames from a single mRNA editing site. EMBO J. 10:1991;443-448.
30. Portner A., Gupta K. C., Seyer J. M., Beachey E. H., Kingsbury D. W. Localization and characterization of Sendai virus nonstructural C and C′ proteins by antibodies against synthetic peptides. Virus Res. 6:1987;109-121.
31. Radecke F., Billeter M. A. The nonstructural C protein is not essential for multiplication of Edmunston B strain measles virus in cultured cells. Virology. 217:1996;418-421.
32. Reed L. J., Muench H. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 23:1938;493-497.
33. Robinson T. W. E., Cureton R. J. R., Heath R. B. The pathogenesis of Sendai virus infection in the mouse lung. J. Med. Microbiol. 1:1968;89-95.
34. Rochat S., Komada H., Kolakofsky D. Loss of V protein expression in human parainfluenza virus type 1 is not a recent event. Virus Res. 24:1992;137-144.
35. Spiropoulou C. F., Nichol S. T. A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus. J. Virol. 67:1993;3103-3110.
36. C. Tapparel, S. Hausmann, T. Pelet, J. Curran, D. Kolakofsky, L. Roux, 1997, When inhibition results from an increased selectivity: A role for the Sendai virus C proteins.
37. Tashiro M., Homma M. Pneumotropism of Sendai virus in relation to protease-mediated activation in mouse lungs. Infect. Immun. 39:1983;879-888.
38. Vidal S., Curran J., Kolakofsky D. Editing of the Sendai virus P/C mRNA by G insertion occurs during mRNA synthesis via a virus-encoded activity. J. Virol. 64:1990;239-246.
39. Wang X.-L., Itoh M., Hotta H., Homma M. A protease activation mutant, MVCES1, as a safe and potent live vaccine derived from currently prevailing Sendai virus. Virology. 68:1994;3369-3373.
40. Yamada H., Hayata S., Omata-Yamada T., Taira H., Mizumoto K., Iwasaki K. Association of the Sendai virus C protein with nucleocapsids. Arch. Virol. 113:1990;245-253.