Y2, the smallest of the Sendai virus C proteins, is fully capable of both counteracting the antiviral action of interferons and inhibiting viral RNA synthesis

Journal of Virology

Volumn 75, Issue 8, 2001, Pages 3802-3810

  Kato, A ^a   Ohnishi, Y ^a   Kohase, M ^a   Saito, S ^a   Tashiro, M ^a   Nagai, Y ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; PROTEIN C; VIRUS PROTEIN; VIRUS RNA;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REPORTER GENE; RNA SYNTHESIS; SENDAI VIRUS; TRANSCRIPTION TERMINATION; VIRUS ASSEMBLY; VIRUS INHIBITION; VIRUS TRANSCRIPTION;

ANTIVIRAL AGENTS; GENES, REPORTER; HELA CELLS; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERONS; RESPIROVIRUS; RNA, MESSENGER; RNA, VIRAL; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0035082273     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.8.3802-3810.2001     Document Type: Article

References (47)

1. Respiratory syncytial virus A2 is resistant to the antiviral effects of type 1 interferons and human MxA
2. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion
3. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
4. The Sendai virus nonstructural C proteins specifically inhibit viral mRNA synthesis
5. Sendai virus and simian virus 5 block activation of interferon-responsive genes: Importance for virus pathogenesis
6. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation
7. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
8. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
9. A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: Generation of a novel copy-back nondefective interfering virus
10. Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state
11. Sendai virus C proteins must interact directly with cellular components to interfere with interferon action
12. Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-α/β-mediated responses
13. ACG, the initiator codon for Sendai virus C protein
14. Versatility of the accessory C proteins of Sendai virus: Contribution to virus assembly as an additional role
15. The IRF-3 transcription factor mediates Sendai virus-induced apoptosis
16. The Sendai virus C protein binds the L polymerase protein to inhibit viral RNA synthesis
17. Involvement of the zinc-binding capacity of Sendai virus V protein in viral pathogenesis
18. Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity
19. Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense
20. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for viral pathogenesis
21. Importance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis
22. Sendai virus gene start signals are not equivalent in reinitiation capacity: Moderation at the fusion protein gene
23. STAT1 is inactivated by a caspase
24. Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription
25. Selection of initiation sites by eucaryotic ribosomes: Effect of inserting AUG triplets upstream from the coding sequence for preproinsulin
26. The paramyxovirus, Sendai virus, C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis
27. Paramyxoviridae: The viruses and their replication
28. The various Sendai virus C proteins are not functionally equivalent and exert both positive and negative effects on viral RNA accumulation during the course of infection
29. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
30. pEF-BOS, a powerful mammalian expression vector
31. Paramyxovirus replication and pathogenesis. Reverse genetics transforms understanding
32. Paramyxovirus reverse genetics is coming of age
33. The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions
34. Viral strategies of immune evasion
35. Localization and characterization of Sendai virus nonstructural C and C′ proteins by antibodies against synthetic peptides
36. Antiviral actions of interferon: Interferon regulated cellular proteins and their surprisingly selective antiviral activities
37. Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response
38. Interferon induced antiviral actions and their regulation
39. Virus strategies for evasion of the host response to infection
40. Interferon induced proteins and the antiviral state
41. How cells respond to interferons
42. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
43. A stuttering model for paramyxovirus P mRNA editing
44. Interferon regulatory factors and TFIIB cooperatively regulate interferon-responsive promoter activity in vivo and in vitro
45. Replication-incompetent Sendai virus can suppress the antiviral action of type I interferon
46. Poor induction of interferon induced 2′,5′-oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1 alpha
47. Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response