HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53

Apoptosis

Volumn 11, Issue 2, 2006, Pages 221-233

  Hallgren, O ^a   Gustafsson, L ^a,b   Irjala, H ^a,c   Selivanova, G ^d   Orrenius, S ^d   Svanborg, C ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND INSTITUTE OF TECHNOLOGY   (Sweden)

^c UNIVERSITY OF TURKU   (Finland)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

lactalbumin; HAMLET; p53 and Bcl 2; Programmed cell death

Indexed keywords

ALPHA LACTALBUMIN; CASPASE; ETOPOSIDE; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CHROMATIN CONDENSATION; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; GENE DELETION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CACO-2 CELLS; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HT29 CELLS; HUMANS; JURKAT CELLS; K562 CELLS; LACTALBUMIN; LEUKEMIA L1210; LUNG NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53; U937 CELLS;

EID: 33344455153     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10495-006-3607-7     Document Type: Article

References (49)

1. Jaattela M. Programmed cell death: Many ways for cells to die decently. Ann Med 2002; 34: 480-488.
2. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
3. Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell 1986; 44: 817-829.
4. Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 2001; 412: 95-99.
5. Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 1997; 91: 627-637.
6. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000; 6: 513-519. 1.
7. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
8. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899-1911.
9. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis [see comments]. Science 1997; 275: 1132-1136.
10. Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked [see comments]. Science 1997; 275: 1129-1132.
11. Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. Embo J 1998; 17: 37-49.
12. Reed JC. Dysregulation of apoptosis in cancer. J Clin Oncol 1999; 17: 2941-2953.
13. Real PJ, Cao Y, Wang R, et al. Breast cancer cells can evade apoptosis- mediated selective killing by a novel small molecule inhibitor of Bcl-2. Cancer Res 2004; 64: 7947-7953.
14. Huang Z. Bcl-2 family proteins as targets for anticancer drug design. Oncogene 2000; 19: 6627-6631.
15. Lane DP. Cancer. A death in the life of p53 [news; comment]. Nature 1993; 362: 786-787.
16. Bates S, Vousden KH. Mechanisms of p53-mediated apoptosis. Cell Mol Life Sci 1999; 55: 28-37.
17. Cheng J, Haas M. Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines. Mol Cell Biol. 1990; 10: 5502-5509.
18. Lowe SW, Bodis S, McClatchey A, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994; 266: 807-810.
19. Roemer K. Mutant p53: Gain-of-function oncoproteins and wild-type p53 inactivators. Biol Chem 1999; 380: 879-887.
20. Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 2002; 277: 29803-29809.
21. Robertson JD, Gogvadze V, Kropotov A, et al. Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep 2004; 5: 643-648.
22. Enoksson M, Robertson JD, Gogvadze V, et al. Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J Biol Chem 2004.
23. Bykov VJ, Issaeva N, Shilov A, et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 2002; 8: 282-288.
24. Håkansson A, Zhivotovsky B, Orrenius S, Sabharwal H, Svanborg C. Apoptosis induced by a human milk protein. Proc Natl Acad Sci USA 1995; 92: 8064-8068.
25. Fischer W, Gustafsson L, Mossberg AK, et al. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res 2004; 64: 2105-2112.
26. Gustafsson L, Leijonhufvud I, Aronsson A, Mossberg AK, Svanborg C. Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. N Engl J Med 2004; 350: 2663-2672.
27. Duringer C, Hamiche A, Gustafsson L, Kimura H, Svanborg C. HAMLET interacts with histones and chromatin in tumor cell nuclei. J Biol Chem 2003; 278: 42131-42135.
28. Svensson M, Hakansson A, Mossberg AK, Linse S, Svanborg C. Conversion of alpha-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci USA 2000; 97: 4221-4226.
29. Kohler C, Håkansson A, Svanborg C, Orrenius S, Zhivotovsky B. Protease activation in apoptosis induced by MAL. Exp Cell Res 1999; 249: 260-268.
30. Håkansson A, Kidd A, Wadell G, Sabharwal H, Svanborg C. Adenovirus infection enhances in vitro adherence of Streptococcus pneumoniae. Infect Immun 1994; 62: 2707-2714.
31. 2+ and endonuclease activation in radiation-induced lymphoid cell death. Exp Cell Res 1993; 207: 163-170 issn: 0014-4827.
32. Armstrong RC, Aja T, Xiang J, et al. Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors. J Biol Chem 1996; 271: 16850-16855.
33. Boise LH, Gonzalez-Garcia M, Postema CE, et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-608.
34. Pugacheva EN, Ivanov AV, Kravchenko JE, et al. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Oncogene 2002; 21: 4595-4600.
35. Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497-1501.
36. Nicholson DW, Ali A, Thornberry NA, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995; 376: 37-43.
37. Håkansson A, Andreasson J, Zhivotovsky B, et al. Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei. Exp Cell Res 1999; 246: 451-460.
38. Kimura H, Cook PR. Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B. J Cell Biol 2001; 153: 1341-1353.
39. Blandino G, Levine AJ, Oren M. Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 1999; 18: 477-485.
40. Leist M, Jaattela M. Four deaths and a funeral: From caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001; 2: 589-598.
41. Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003; 4: 416-423.
42. Kohler C, Gogvadze V, Hakansson A, et al. A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria. Eur J Biochem 2001; 268: 186-191.
43. Johnson AJ, Smith LL, Zhu J, et al. A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism. Blood 2005; 105: 2504-2509.
44. Jendrossek V, Handrick R, Belka C. Celecoxib activates a novel mitochondrial apoptosis signaling pathway. Faseb J 2003; 17: 1547-1549.
45. Elliott K, Ge K, Du W, Prendergast GC. The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program. Oncogene 2000; 19: 4669-4684.
46. Chi S, Kitanaka C, Noguchi K, et al. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Oncogene 1999; 18: 2281-2290.
47. Yamaki M, Umehara T, Chimura T, Horikoshi M. Cell death with predominant apoptotic features in Saccharomyces cerevisiae mediated by deletion of the histone chaperone ASF1/CIA1. Genes Cells 2001; 6: 1043-1054.
48. Monney L, Otter I, Olivier R, et al. Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2. J Biol Chem 1998; 273: 6121-6131.
49. Mathiasen IS, Sergeev IN, Bastholm L, et al. Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem 2002; 277: 30738-30745.