메뉴 건너뛰기




Volumn 21, Issue 3, 2006, Pages 587-606

Dopaminergic properties and function after grafting of attached neural precursor cultures

Author keywords

6 OHDA lesioned rats; Calcium imaging; Dopaminergic progenitors; In vitro differentiation; Parkinson's disease; Proliferated cells of the ventral mesencephalon; Transplantation; Tyrosine hydroxylase

Indexed keywords

AMPA RECEPTOR; CALCIUM;

EID: 33244481518     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.09.003     Document Type: Article
Times cited : (39)

References (64)
  • 1
    • 84914639435 scopus 로고
    • Estimation of nuclear population from microtome sections
    • M. Abercrombie Estimation of nuclear population from microtome sections Anat. Rec. 94 1946 239 247
    • (1946) Anat. Rec. , vol.94 , pp. 239-247
    • Abercrombie, M.1
  • 2
    • 0033694768 scopus 로고    scopus 로고
    • Parkinson disease gene therapy moves toward the clinic
    • A. Bjorklund, and O. Lindvall Parkinson disease gene therapy moves toward the clinic Nat. Med. 6 2000 1207 1208
    • (2000) Nat. Med. , vol.6 , pp. 1207-1208
    • Bjorklund, A.1    Lindvall, O.2
  • 3
    • 0021021418 scopus 로고
    • Intracerebral grafting of neuronal cell suspensions: I. Introduction and general methods of preparation
    • A. Bjorklund, U. Stenevi, R.H. Schmidt, S.B. Dunnett, and F.H. Gage Intracerebral grafting of neuronal cell suspensions: I. Introduction and general methods of preparation Acta Physiol. Scand. Suppl. 522 1983 1 7
    • (1983) Acta Physiol. Scand. Suppl. , vol.522 , pp. 1-7
    • Bjorklund, A.1    Stenevi, U.2    Schmidt, R.H.3    Dunnett, S.B.4    Gage, F.H.5
  • 4
    • 0032196206 scopus 로고    scopus 로고
    • Survival of expanded dopaminergic precursors is critical for clinical trials
    • P. Brundin, and A. Bjorklund Survival of expanded dopaminergic precursors is critical for clinical trials Nat. Neurosci. 1 1998 537
    • (1998) Nat. Neurosci. , vol.1 , pp. 537
    • Brundin, P.1    Bjorklund, A.2
  • 5
    • 0026811150 scopus 로고
    • Patchclamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: Membrane properties and ionic currents
    • J. Bufler, F. Zufall, C. Franke, and H. Hatt Patchclamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: membrane properties and ionic currents J. Comp. Physiol., A 170 1992 145 152
    • (1992) J. Comp. Physiol., a , vol.170 , pp. 145-152
    • Bufler, J.1    Zufall, F.2    Franke, C.3    Hatt, H.4
  • 6
    • 0029927943 scopus 로고    scopus 로고
    • Open channel block by physostigmine and procaine in embryonic like nicotinic receptors of mouse muscle
    • J. Bufler, C. Franke, H. Parnas, and J. Dudel Open channel block by physostigmine and procaine in embryonic like nicotinic receptors of mouse muscle Eur. J. Neurosci. 8 1996 677 687
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 677-687
    • Bufler, J.1    Franke, C.2    Parnas, H.3    Dudel, J.4
  • 8
    • 0027314998 scopus 로고
    • A hypothermic miniaturized stereotaxic instrument for surgery in newborn rats
    • M.G. Cunningham, and R.D. McKay A hypothermic miniaturized stereotaxic instrument for surgery in newborn rats J. Neurosci. Methods 47 1-2 1993 (Apr) 105 114
    • (1993) J. Neurosci. Methods , vol.47 , Issue.1-2 , pp. 105-114
    • Cunningham, M.G.1    McKay, R.D.2
  • 10
    • 0025273605 scopus 로고
    • Rapid activation, desensitization and resensitization of synaptic channels on crayfish muscle after glutamate pulses
    • J. Dudel, C. Franke, and H. Hatt Rapid activation, desensitization and resensitization of synaptic channels on crayfish muscle after glutamate pulses Biophys. J. 57 1990 533 545
    • (1990) Biophys. J. , vol.57 , pp. 533-545
    • Dudel, J.1    Franke, C.2    Hatt, H.3
  • 12
    • 0024326213 scopus 로고
    • A thin slice preparation for patch clamp recordings from neurons of the mammalian central nervous system
    • F.A. Edwards, A. Konnerth, B. Sakmann, and T. Takahashi A thin slice preparation for patch clamp recordings from neurons of the mammalian central nervous system Pflugers Arch. 414 1989 600 612
    • (1989) Pflugers Arch. , vol.414 , pp. 600-612
    • Edwards, F.A.1    Konnerth, A.2    Sakmann, B.3    Takahashi, T.4
  • 14
    • 0024242712 scopus 로고
    • Mesocorticolimbic dopamine systems and reward
    • H.C. Fibiger, and A.G. Phillips Mesocorticolimbic dopamine systems and reward Ann. N. Y. Acad. Sci. 537 1988 206 215
    • (1988) Ann. N. Y. Acad. Sci. , vol.537 , pp. 206-215
    • Fibiger, H.C.1    Phillips, A.G.2
  • 15
    • 0023655008 scopus 로고
    • Liquid filament switch for ultra fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle
    • C. Franke, H. Hatt, and J. Dudel Liquid filament switch for ultra fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle Neurosci. Lett. 77 1987 199 204
    • (1987) Neurosci. Lett. , vol.77 , pp. 199-204
    • Franke, C.1    Hatt, H.2    Dudel, J.3
  • 17
    • 0030743111 scopus 로고    scopus 로고
    • Use of cell ELISA for the screening of neurotrophic activities on minor cell populations in retinal monolayer cultures
    • S. Fuhrmann, M. Kirsch, K. Wewetzer, and H.D. Hofmann Use of cell ELISA for the screening of neurotrophic activities on minor cell populations in retinal monolayer cultures J. Neurosci. Methods 75 2 1997 199 205 Aug. 22
    • (1997) J. Neurosci. Methods , vol.75 , Issue.2 , pp. 199-205
    • Fuhrmann, S.1    Kirsch, M.2    Wewetzer, K.3    Hofmann, H.D.4
  • 18
    • 0034618804 scopus 로고    scopus 로고
    • The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro
    • C. Grothe, A. Schulze, I. Semkova, F. Muller-Ostermeyer, A. Rege, and K. Wewetzer The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro Neuroscience 100 2000 73 86
    • (2000) Neuroscience , vol.100 , pp. 73-86
    • Grothe, C.1    Schulze, A.2    Semkova, I.3    Muller-Ostermeyer, F.4    Rege, A.5    Wewetzer, K.6
  • 19
    • 0035806345 scopus 로고    scopus 로고
    • In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia
    • C. Grothe, C. Meisinger, and P. Claus In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia J. Comp. Neurol. 434 2001 342 357
    • (2001) J. Comp. Neurol. , vol.434 , pp. 342-357
    • Grothe, C.1    Meisinger, C.2    Claus, P.3
  • 22
    • 0019441262 scopus 로고
    • Improved patchclamp techniques for high resolution current recordings from cells and cell free patches
    • O.P. Hamill, A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth Improved patchclamp techniques for high resolution current recordings from cells and cell free patches Pflugers Arch. 391 1981 85 100
    • (1981) Pflugers Arch. , vol.391 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3    Sakmann, B.4    Sigworth, F.J.5
  • 23
    • 0029793180 scopus 로고    scopus 로고
    • Kinetics of homomeric GluR6 glutamate receptor channels
    • M. Heckmann, J. Bufler, C. Franke, and J. Dudel Kinetics of homomeric GluR6 glutamate receptor channels Biophys. J. 71 1996 1743 1750
    • (1996) Biophys. J. , vol.71 , pp. 1743-1750
    • Heckmann, M.1    Bufler, J.2    Franke, C.3    Dudel, J.4
  • 24
    • 0344442712 scopus 로고    scopus 로고
    • Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR
    • M.J. Hurley, D.C. Mash, and P. Jenner Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR Eur. J. Neurosci. 18 9 2003 (Nov) 2668 2672
    • (2003) Eur. J. Neurosci. , vol.18 , Issue.9 , pp. 2668-2672
    • Hurley, M.J.1    Mash, D.C.2    Jenner, P.3
  • 25
    • 0028179583 scopus 로고
    • 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression
    • 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression Neuron 12 1994 1281 1289
    • (1994) Neuron , vol.12 , pp. 1281-1289
    • Jonas, P.1    Racca, C.2    Sakmann, B.3    Seeburg, P.H.4    Monyer, H.5
  • 30
    • 0024209765 scopus 로고
    • The functional output of the mesolimbic dopamine system
    • G.F. Koob, and N.R. Swerdlow The functional output of the mesolimbic dopamine system Ann. N. Y. Acad. Sci. 537 1988 216 227
    • (1988) Ann. N. Y. Acad. Sci. , vol.537 , pp. 216-227
    • Koob, G.F.1    Swerdlow, N.R.2
  • 31
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
    • S.H. Lee, N. Lumelsky, L. Studer, J.M. Auerbach, and R.D. McKay Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells Nat. Biotechnol. 18 2000 675 679
    • (2000) Nat. Biotechnol. , vol.18 , pp. 675-679
    • Lee, S.H.1    Lumelsky, N.2    Studer, L.3    Auerbach, J.M.4    McKay, R.D.5
  • 32
    • 0034589755 scopus 로고    scopus 로고
    • Clinical observations after neural transplantation in Parkinson's disease
    • O. Lindvall, and P. Hagell Clinical observations after neural transplantation in Parkinson's disease Prog. Brain Res. 127 2000 299 320
    • (2000) Prog. Brain Res. , vol.127 , pp. 299-320
    • Lindvall, O.1    Hagell, P.2
  • 33
    • 3142521479 scopus 로고    scopus 로고
    • Stem cell therapy for human neurodegenerative disorders-How to make it work
    • O. Lindvall, Z. Kokaia, and A. Martinez-Serrano Stem cell therapy for human neurodegenerative disorders-How to make it work Nat. Med. 10 2004 S42 S50 Suppl
    • (2004) Nat. Med. , vol.10
    • Lindvall, O.1    Kokaia, Z.2    Martinez-Serrano, A.3
  • 34
    • 0032007097 scopus 로고    scopus 로고
    • Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines
    • Z.D. Ling, E.D. Potter, J.W. Lipton, and P.M. Carvey Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines Exp. Neurol. 149 1998 411 423
    • (1998) Exp. Neurol. , vol.149 , pp. 411-423
    • Ling, Z.D.1    Potter, E.D.2    Lipton, J.W.3    Carvey, P.M.4
  • 36
    • 0029927145 scopus 로고    scopus 로고
    • In vivo and in vitro effect of glucocorticoids on fibroblast growth factor (FGF)-2 and FGF receptor 1 expression
    • C. Meisinger, C. Zeschnigk, and C. Grothe In vivo and in vitro effect of glucocorticoids on fibroblast growth factor (FGF)-2 and FGF receptor 1 expression J. Biol. Chem. 271 1996 16520 16525
    • (1996) J. Biol. Chem. , vol.271 , pp. 16520-16525
    • Meisinger, C.1    Zeschnigk, C.2    Grothe, C.3
  • 37
    • 0035689768 scopus 로고    scopus 로고
    • Distinctive effects of rat fibroblast growth factor-2 isoforms on PC12 and Schwann cells
    • F. Müller-Ostermeyer, P. Claus, and C. Grothe Distinctive effects of rat fibroblast growth factor-2 isoforms on PC12 and Schwann cells Growth Factors 19 2001 175 191
    • (2001) Growth Factors , vol.19 , pp. 175-191
    • Müller-Ostermeyer, F.1    Claus, P.2    Grothe, C.3
  • 39
    • 0028084486 scopus 로고
    • Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model
    • G. Nikkhah, M.G. Cunningham, A. Jodicke, U. Knappe, and A. Bjorklund Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model Brain Res. 633 1994 133 143
    • (1994) Brain Res. , vol.633 , pp. 133-143
    • Nikkhah, G.1    Cunningham, M.G.2    Jodicke, A.3    Knappe, U.4    Bjorklund, A.5
  • 40
    • 0028138846 scopus 로고
    • A microtransplantation approach for cell suspension grafting in the rat Parkinson model: A detailed account of the methodology
    • G. Nikkhah, M. Olsson, J. Eberhard, C. Bentlage, M.G. Cunningham, and A. Bjorklund A microtransplantation approach for cell suspension grafting in the rat Parkinson model: a detailed account of the methodology Neuroscience 63 1994 57 72
    • (1994) Neuroscience , vol.63 , pp. 57-72
    • Nikkhah, G.1    Olsson, M.2    Eberhard, J.3    Bentlage, C.4    Cunningham, M.G.5    Bjorklund, A.6
  • 41
    • 0002573716 scopus 로고    scopus 로고
    • Microtransplantation of nigral dopaminergic neurons: A "step by step" recipe
    • The Humana Press Totowa
    • G. Nikkhah, C. Winkler, and A. Rödter Microtransplantation of nigral dopaminergic neurons: a "step by step" recipe Cell and Tissue Transplantation in the CNS 1999 The Humana Press Totowa
    • (1999) Cell and Tissue Transplantation in the CNS
    • Nikkhah, G.1    Winkler, C.2    Rödter, A.3
  • 42
    • 0037226224 scopus 로고    scopus 로고
    • Potential use of embryonic stem cells for the treatment of mouse parkinsonian models: Improved behavior by transplantation of in vitro differentiated dopaminergic neurons from embryonic stem cells
    • F. Nishimura, M. Yoshikawa, S. Kanda, M. Nonaka, H. Yokota, A. Shiroi, H. Nakase, H. Hirabayashi, Y. Ouji, J. Birumachi, S. Ishizaka, and T. Sakaki Potential use of embryonic stem cells for the treatment of mouse parkinsonian models: improved behavior by transplantation of in vitro differentiated dopaminergic neurons from embryonic stem cells Stem Cells 21 2003 171 180
    • (2003) Stem Cells , vol.21 , pp. 171-180
    • Nishimura, F.1    Yoshikawa, M.2    Kanda, S.3    Nonaka, M.4    Yokota, H.5    Shiroi, A.6    Nakase, H.7    Hirabayashi, H.8    Ouji, Y.9    Birumachi, J.10    Ishizaka, S.11    Sakaki, T.12
  • 43
    • 0030041034 scopus 로고    scopus 로고
    • Fetal nigral transplantation as a therapy for Parkinson's disease
    • C.W. Olanow, J.H. Kordower, and T.B. Freeman Fetal nigral transplantation as a therapy for Parkinson's disease Trends Neurosci. 19 1996 102 109
    • (1996) Trends Neurosci. , vol.19 , pp. 102-109
    • Olanow, C.W.1    Kordower, J.H.2    Freeman, T.B.3
  • 48
    • 0030272506 scopus 로고    scopus 로고
    • Epigenetic factors and midbrain dopaminergic neurone development
    • C. Perrone-Capano, and U. di Porzio Epigenetic factors and midbrain dopaminergic neurone development BioEssays 18 1996 817 824
    • (1996) BioEssays , vol.18 , pp. 817-824
    • Perrone-Capano, C.1    Di Porzio, U.2
  • 49
    • 0030298512 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts
    • C. Rosenblad, A. Martinez-Serrano, and A. Bjorklund Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts Neuroscience 75 1996 979 985
    • (1996) Neuroscience , vol.75 , pp. 979-985
    • Rosenblad, C.1    Martinez-Serrano, A.2    Bjorklund, A.3
  • 50
  • 52
    • 0033453218 scopus 로고    scopus 로고
    • Dopamine cells in nigral grafts differentiate prior to implantation
    • S.R. Sinclair, J.W. Fawcett, and S.B. Dunnett Dopamine cells in nigral grafts differentiate prior to implantation Eur. J. Neurosci. 11 1999 4341 4348
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 4341-4348
    • Sinclair, S.R.1    Fawcett, J.W.2    Dunnett, S.B.3
  • 53
    • 0034871846 scopus 로고    scopus 로고
    • Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
    • A. Storch, G. Paul, M. Csete, B.O. Boehm, P.M. Carvey, A. Kupsch, and J. Schwarz Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells Exp. Neurol. 170 2001 317 325
    • (2001) Exp. Neurol. , vol.170 , pp. 317-325
    • Storch, A.1    Paul, G.2    Csete, M.3    Boehm, B.O.4    Carvey, P.M.5    Kupsch, A.6    Schwarz, J.7
  • 54
    • 0141673859 scopus 로고    scopus 로고
    • Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells
    • A. Storch, H.A. Lester, B.O. Boehm, and J. Schwarz Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells J. Chem. Neuroanat. 26 2003 133 142
    • (2003) J. Chem. Neuroanat. , vol.26 , pp. 133-142
    • Storch, A.1    Lester, H.A.2    Boehm, B.O.3    Schwarz, J.4
  • 55
    • 33644684826 scopus 로고    scopus 로고
    • Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats
    • L. Studer, V. Tabar, and R.D. McKay Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats Nat. Neurosci. 1 1998 290 295
    • (1998) Nat. Neurosci. , vol.1 , pp. 290-295
    • Studer, L.1    Tabar, V.2    McKay, R.D.3
  • 56
    • 0034307725 scopus 로고    scopus 로고
    • Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen
    • L. Studer, M. Csete, S.H. Lee, N. Kabbani, J. Walikonis, B. Wold, and R. McKay Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen J. Neurosci. 20 2000 7377 7383
    • (2000) J. Neurosci. , vol.20 , pp. 7377-7383
    • Studer, L.1    Csete, M.2    Lee, S.H.3    Kabbani, N.4    Walikonis, J.5    Wold, B.6    McKay, R.7
  • 57
    • 1842664149 scopus 로고    scopus 로고
    • Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms
    • M. Timmer, F. Muller-Ostermeyer, V. Kloth, C. Winkler, C. Grothe, and G. Nikkhah Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms Exp. Neurol. 187 2004 118 136
    • (2004) Exp. Neurol. , vol.187 , pp. 118-136
    • Timmer, M.1    Muller-Ostermeyer, F.2    Kloth, V.3    Winkler, C.4    Grothe, C.5    Nikkhah, G.6
  • 58
    • 49349130454 scopus 로고
    • 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine pathway: The turning syndrome
    • U. Ungerstedt 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine pathway: the turning syndrome Pharmacol. Ther., B 2 1976 37 40
    • (1976) Pharmacol. Ther., B , vol.2 , pp. 37-40
    • Ungerstedt, U.1
  • 59
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system
    • U. Ungerstedt, and G.W. Arbuthnott Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system Brain Res. 24 1970 485 493
    • (1970) Brain Res. , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.W.2
  • 61
    • 0029803454 scopus 로고    scopus 로고
    • Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
    • C. Winkler, H. Sauer, C.S. Lee, and A. Bjorklund Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease J. Neurosci. 16 1996 7206 7215
    • (1996) J. Neurosci. , vol.16 , pp. 7206-7215
    • Winkler, C.1    Sauer, H.2    Lee, C.S.3    Bjorklund, A.4
  • 62
    • 13144259693 scopus 로고    scopus 로고
    • Cell transplantation in Parkinson's disease: How can we make it work?
    • C. Winkler, D. Kirik, and A. Björklund Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci. 28 2 2005 86 92 (Review)
    • (2005) Trends Neurosci. , vol.28 , Issue.2 , pp. 86-92
    • Winkler, C.1    Kirik, D.2    Björklund, A.3
  • 63
    • 0035172717 scopus 로고    scopus 로고
    • Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors
    • J. Yan, L. Studer, and R.D. McKay Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors J. Neurochem. 76 2001 307 311
    • (2001) J. Neurochem. , vol.76 , pp. 307-311
    • Yan, J.1    Studer, L.2    McKay, R.D.3
  • 64
    • 0032498835 scopus 로고    scopus 로고
    • Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats
    • W.M. Zawada, D.J. Zastrow, E.D. Clarkson, F.S. Adams, K.P. Bell, and C.R. Freed Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats Brain Res. 786 1998 96 103
    • (1998) Brain Res. , vol.786 , pp. 96-103
    • Zawada, W.M.1    Zastrow, D.J.2    Clarkson, E.D.3    Adams, F.S.4    Bell, K.P.5    Freed, C.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.