Production of dopaminergic neurons for cell therapy in the treatment of Parkinson's disease

Journal of Neuroscience Methods

Volumn 124, Issue 1, 2003, Pages 61-74

  Peaire, A E ^a   Takeshima, T ^b,c   Johnston, J M ^b,d   Isoe, K ^c   Nakashima, K ^c   Commissiong, John W ^a  

^a Prescient NeuroPharma Inc   (Canada)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c TOTTORI UNIVERSITY   (Japan)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cell therapy; Dopaminergic neuron; Expansion; Neuronal aggregates; Neuronal progenitor; Parkinson's disease

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; MESENCEPHALON; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; STEM CELL; STORAGE; STORAGE TEMPERATURE; ANIMAL; BIOLOGICAL THERAPY; CELL DIVISION; CELL SURVIVAL; CELL TRANSPLANTATION; CLASSIFICATION; CULTURE TECHNIQUE; CYTOLOGY; METABOLISM; METHODOLOGY; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; TRANSPLANTATION; XENOGRAFT;

DOPAMINE;

ANIMALS; CELL AGGREGATION; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL SURVIVAL; CELL TRANSPLANTATION; DOPAMINE; FEMALE; MESENCEPHALON; NEURONS; PARKINSON DISEASE; PREGNANCY; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; TISSUE THERAPY; TRANSPLANTATION, HETEROLOGOUS;

EID: 0242380790     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(02)00364-3     Document Type: Article

References (55)

1. Armstrong R.J., Harrower T.P., Hurelbrink C.B., McLaughin M., Ratcliffe E.L., Tyers P., Richards A., Dunnett S.B., Rosser A.E., Barker R.A. Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells. Neuroscience. 106:2001;201-216.
2. Armstrong R.J., Hurelbrink C.B., Tyers P., Ratcliffe E.L., Richards A., Dunnett S.B., Rosser A.E., Barker R.A. The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease. Exp. Neurol. 175:2002;98-111.
3. Aubert I., Brana C., Pellevoisin C., Giros B., Caille I., Carles D., Vital C., Bloch B. Molecular anatomy of the development of the human substantia nigra. J. Comp. Neurol. 379:1997;72-87.
4. Barkats M., Nakao N., Grasbon-Frodl E.M., Bilang-Bleuel A., Revah F., Mallet J., Brundin P. Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase. Neuroscience. 78:1997;703-713.
5. Bayer S.A., Wills K.V., Triarhou L.C., Ghetti B. Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Exp. Brain Res. 105:1995;191-199.
6. Bjorklund A., Schmidt R.H., Stenevi U. Functional reinnervation of the neostriatum in the adult rat by the use of intraparenchymal grafting of dissociated cell suspensions from the substantia nigra. Cell. Tissue Res. 212:1980;39-45.
7. Boer G.J. Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research. J. Neurol. 242:1994;1-13.
8. Bottenstein J.E., Sato G.H. Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA. 76:1979;514-517.
9. Cohen B.R., Sladek C.D. Expression of floor plate in dispersed mesencephalic cultures: role in differentiation of tyrosine hydroxylase neurons. Exp. Neurol. 147:1997;525-531.
10. Dahl D., Bignami A. Immunogenic properties of the glial fibrillary acidic protein. Brain Res. 116:1976;150-157.
11. De Camilli P., Miller P.E., Navone F., Theurkauf W.E., Vallee R.B. Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence. Neuroscience. 11:1984;817-846.
12. Deacon T., Schumacher J., Dinsmore J., Thomas C., Plamer P., Kott S., Edge A., Penny D., Kassissieh S., Dempsey P., Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat. Med. 3:1997;350-353.
13. Dong J.-F., Detta A., Hitchcock E.R. Enhanced in vitro survival and growth of foetal human mesencephalic dopaminergic neurones on laminin and collagen: implications for cell banking. Neurosci. Lett. 178:1994;27-31.
14. Espejo E.F., Montoro R.J., Armengol J.A., Lopez-Barneo J. Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron. 20:1998;197-206.
15. Freed C.R. Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease? Proc. Natl. Acad. Sci. USA. 99:2002;1755-1757.
16. Freed C.R., Breeze R.E., Rosenberg N.L., Schneck S.A., Kriek E., Qi J., Lone T., Zhang Y., Snyder J.A., Wells T.H., Olson Ramig L., Thompson L., Mazziotta J.C., Huang S.C., Grafton S.T., Brooks D., Sawle G., Schroter G., Ansari A.A. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. New Engl. J. Med. 327:1992;1549-1555.
17. Freeman T.B., Spence M.S., Boss B.D., Spector D.H., Strecker R.E., Olanow C.W., Kordower J.H. Development of dopaminergic neurons in the human substantia nigra. Exp. Neurol. 113:1991;344-353.
18. Gage F.H. Cell therapy. Nature. 392:1998;18-24.
19. German D.C., Manaye K.F. Midbrain dopaminergic neurons (nuclei A8, A9, and A10): three-dimensional reconstruction in the rat. J. Comp. Neurol. 331:1993;297-309.
20. Hynes M., Porter J.A., Chiang C., Chang D., Tessier-Lavigne M., Beachy P.A., Rosenthal A. Induction of midbrain dopaminergic neurons by sonic hedgehog. Neuron. 15:1995;35-44.
21. Iacovitti L., Stull N.D., Jin H. Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line. Brain Res. 912:2001;99-104.
22. Johe K.K., Hazel T.G., Muller T., Dugich-Djordjevic M.M., McKay R.D.G. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10:1996;3129-3140.
23. Kordower J.H., Rosenstein J.M., Collier T.J., Burke M.A., Chen E.Y., Li J.M., Martel L., Levey A.E., Mufson E.J., Freeman T.B., Olanow C.W. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies. J. Comp. Neurol. 370:1996;203-230.
24. Larsson L.C., Czech K.A., Brundin P., Widner H. Intrastriatal ventral mesencephalic xenografts of porcine tissue in rats: immune responses and functional effects. Cell. Transplant. 9:2000;261-272.
25. Lendahl U., Zimmerman L.B., McKay R.D. CNS stem cells express a new class of intermediate filament protein. Cell. 60:1990;585-595.
26. Mandel R.J., Spratt S.K., Snyder R.O., Leff S.E. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc. Natl. Acad. Sci. USA. 94:1997;14083-14088.
27. Matise M.P., Epstein D.J., Park H.L., Platt K.A., Joyner A.L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 125:1998;2759-2770.
28. Matsuura N., Lie D.C., Hoshimaru M., Asahi M., Hojo M., Ishizaki R., Hashimoto N., Noji S., Ohuchi H., Yoshioka H., Gage F.H. Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line. J. Neurosci. 21:2001;4326-4335.
29. Meyer M., Widmer H.R., Wagner B., Guzman R., Evtouchenko L., Seiler R.W., Spenger C. Comparison of mesencephalic free-floating tissue culture grafts and cell suspension grafts in the 6-hydroxydopamine-lesioned rat. Exp. Brain Res. 119:1998;345-355.
30. Patience C., Takeuchi Y., Weiss R.A. Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3:1997;282-286.
31. Perlow M.J., Freed W.J., Hoffer B.J., Sieger A., Olson O., Wyatt R. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science. 204:1979;643-647.
32. Platt J.L. New directions for organ transplantation. Nature (Suppl.). 392:1998;11-17.
33. Riaz S.S., Jauniaux E., Stern G.M., Bradford H.F. The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitro. Brain Res. Dev. Brain Res. 136:2002;27-34.
34. Rodriguez-Pallares J., Rey P., Soto-Otero R., Labandeira-Garcia J.L. N-acetylcysteine enhances production of dopaminergic neurons from mesencephalic-derived precursor cells. NeuroReport. 12:2001;3935-3938.
35. Sanchez-Pernaute R., Studer L., Bankiewicz K.S., Major E.O., McKay R.D. In vitro generation and transplantation of precursor-derived human dopamine neurons. J. Neurosci. Res. 65:2001;284-288.
36. Saucedo-Cardenas O., Quintana-Hau J.D., Le W.D., Smidt M.P., Cox J.J., DeMayo F., Burbach J.P.H., Conneely O.M. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA. 95:1998;4013-4018.
37. Shimoda K., Sauve Y., Marini A., Schwartz J.P., Commissiong J.W. A high percentage yield of tyrosine hydroxylase-positive cells from rat E14 mesencephalic cell culture. Brain Res. 586:1992;319-331.
38. Silani V., Mariani D., Donato F.M., Ghezzi C., Mazzucchelli F., Buscaglia M., Pardi G., Scarlato G. Development of dopaminergic neurons in the human mesencephalon and in vitro effects of basic fibroblast growth factor treatment. Exp. Neurol. 128:1994;59-76.
39. Solberg Y., Silverman W.F., Pollack Y. Prenatal ontogeny of tyrosine hydroxylase gene expression in the rat ventral mesencephalon. Dev. Brain Res. 73:1993;91-97.
40. Sortwell C.E., Pitzer M.R., Collier T.J. Time course of apoptotic cell death within mesencephalic cell suspension grafts: implications for improving grafted dopamine neuron survival. Exp. Neurol. 165:2000;268-277.
41. Sortwell C.E., Camargo M.D., Pitzer M.R., Gyawali S., Collier T.J. Diminished survival of mesencephalic dopamine neurons grafted into aged hosts occurs during the immediate postgrafting interval. Exp. Neurol. 169:2001;23-29.
42. Spencer D.D., Robbins R.J., Naftolin F., Marek K.L., Vollmer T., Leranth C., Roth R.H., Price L.H., Gjedde A., Bunney B.S., Sass K.J., Elsworth J.D., Kier E.L., Makuch R., Hoffer P.B., Redmond D.E. Jr. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. New Engl. J. Med. 327:1992;1541-1548.
43. Stanworth S.J., Newland A.C. Stem cells: progress in research and edging towards the clinical setting. Clin. Med. 1:2001;378-382.
44. Stemple D.L., Anderson D.J. Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell. 71:1992;973-985.
45. Strecker R.E., Miao R., Loring J.F. Survival and function of aggregate cultures of rat fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp. Brain Res. 76:1989;315-322.
46. Studer L., Tabar V., McKay R.D.G. Transplantation of expanded mesencephalic precursors leads to recovery in Parkinsonian rats. Nat. Neurosci. 1:1998;290-295.
47. Takeshima T., Johnston J.M., Commissiong J.W. Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J. Neurosci. 14:1994;4769-4779.
48. Takeshima T., Shimoda K., Johnston J.M., Commissiong J.W. Standardized methods to bioassay neurotrophic factors for dopaminergic neurons. J. Neurosci. Methods. 67:1996;27-41.
49. Tang F.I., Tien L.T., Zhou F.C., Hoffer B.J., Wang Y. Intranigral ventral mesencephalic grafts and nigrostriatal injections of glial cell line-derived neurotrophic factor restore dopamine release in the striatum of 6-hydroxydopamine-lesioned rats. Exp. Brain Res. 119:1998;287-296.
50. Taylor J.R., Elsworth J.D., Roth R.H., Sladek J.R. Jr, Collier T.J., Redmond D.E. Jr. Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls. Exp. Brain Res. 85:1991;335-348.
51. Tepper J.M., Damlama M., Trent F. Postnatal changes in the distribution and morphology of rat substantia nigra dopaminergic neurons. Neuroscience. 60:1994;469-477.
52. Wagner J., Akerud P., Castro D.S., Holm P.C., Canals J.P., Snyder E.Y., Perlmann T., Arenas E. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat. Biotech. 17:1999;653-659.
53. Wang M.Z., Jin P., Bumcrot D.A., Marigo V., McMahon A.P., Wang E.A., Woolf T., Pang K. Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat. Med. 1:1995;1184-1188.
54. Widner H., Tetrud J., Rehncrona S., Snow B., Brundin P., Gustavii B., Björklund A., Lindvall O., Langston J.W. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP). New Engl. J. Med. 327:1992;1556-1563.
55. Zawada W.M., Zastrow D.J., Clarkson E.D., Adams F.S., Bell K.P., Freed C.R. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res. 786:1998;96-103.