Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell

Biochemical and Biophysical Research Communications

Volumn 305, Issue 4, 2003, Pages 1040-1048

  Kim, Tae Eun ^a   Lee, Hack Sup ^a   Lee, Yong Beom ^a   Hong, Seung Hwan ^b   Lee, Young Seek ^c   Ichinose, Hiroshi ^d   Kim, Seung U ^a,e   Lee, Myung Ae ^a  

^a Ajou University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Hanyang University   (South Korea)

^d FUJITA HEALTH UNIVERSITY   (Japan)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Dopaminergic neurogenesis; FGF8; Human fetal astrocyte; Nurr1; Parkinson's disease; Sonic hedgehog; Tyrosine hydroxylase

Indexed keywords

CELL NUCLEUS RECEPTOR; FIBROBLAST GROWTH FACTOR 8; NUCLEAR RECEPTOR RELATED FACTOR 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL FATE; CELL IMMORTALIZATION; CELL LINEAGE; CELL RENEWAL; CELL SPECIFICITY; CELL STIMULATION; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; MESENCEPHALON; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL;

ERINACEIDAE;

EID: 0037566668     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00879-9     Document Type: Article

References (32)

1. Hornykiewics O. Biochemical aspects of Parkinson's disease. Am. Acad. Neurol. 5:1998;2-9.
2. Mallet J. The TIPS/TINS lecture-Catecholamines: from gene regulation to neuropsychiatric disorders. Trends Pharmacol. Sci. 7:1995;129-135.
3. Flax J.D., Aurora S., Yang C., Simonin C., Wills A.M., Billinghurst L.L., Jendoubi M.J., Sidman R.L., Wolfe J.H., Kim S.U., Snyder E.Y. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat. Biotechnol. 16:1998;1033-1039.
4. Ourednik V., Ourednik J., Flax J.D., Zawada W.M., Hutt C., Yang C., Park K.I., Kim S.U., Sidman R.L., Freed C.R., Snyder E.Y. Segregation of human neural stem cells in the developing primate forebrain. Science. 293:2001;1820-1824.
5. Dunnett S.B., Björklund A. Prospects for new restorative and neuroprotective treatment in Parkinson's disease. Nature. 399:1999;A32-A39.
6. Martinez-Serrano A., Björklund A. Immortalized neural stem progenitor cells for CNS gene transfer and repair. Trends Neurosci. 20:1997;530-538.
7. McKay R. Stem cells in the central nervous system. Science. 276:1997;66-71.
8. Yang M., Stull N.D., Berk M.A., Snyder E.Y., Iacovitti L. Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Exp. Neurol. 177:2002;50-60.
9. Ichinose H., Ohye T., Suzuki T., Sumi-Ichinose C., Nomura T., Hagino Y., Nagatsu T. Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs. Gene. 230:2000;233-239.
10. Saucedo-Cardenas O., Quintana-Hau J.D., Le W.D., Smidt M.P., Cox J.J., De Mayo F., Burbach J.P., Conneely O.M. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA. 95:1998;4013-4018.
11. Baffi J.S., Palkovits M., Castillo S.O., Mezey È., Nikodem V.M. Differential expression of tyrosine hydroxylase in catecholaminergic neurons of neonatal wild-type and Nurr1-deficient mice. Neuroscience. 93:1999;631-642.
12. Zetterström R.H., Solomin L., Jansson L., Hoffer B.J., Olson L., Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice. Science. 276:1997;248-250.
13. Lee M.A., Lee H.S., Lee H.S., Cho K.G., Jin B.K., Sohn S., Lee Y.S., Ichinose H., Kim S.U. Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins. Neurosci. Lett. 333:2002;74-78.
14. Poulsen K.T., Armanini M.P., Klein R.D., Hynes M.A., Phillips H.S., Rosenthal A. TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Neuron. 13:1994;1245-1252.
15. Ye W., Shimamura K., Rubenstein J.L.R., Hynes M.A., Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell. 93:1998;755-766.
16. Wagner J., Åkerud P., Castro D.S., Holm P.C., Canals J.M., Snyder E.Y., Perlmann T., Arenas E. Induction of a midbrain dopaminergic phenotypes in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat. Biotechnol. 17:1999;653-659.
17. Matsuura N., Lie D.C., Hoshimaru M., Asahi M., Hojo M., Ishizaki R., Hashimoto N., Noji S., Ohuchi H., Yoshioka H., Gage F.H. Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line. J. Neurosci. 21:2001;4326-4335.
18. Lumsden A., Krumlauf R. Patterning the vertebrate neuraxis. Science. 274:1996;1109-1115.
19. Nusslein-Volhard C., Lohs-Schardin M., Sander K., Cremer C. A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila. Nature. 283:1980;474-476.
20. Palmer T.D., Takahashi J., Gage F.H. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell Neurosci. 8:1997;389-404.
21. Sakurada K., Ohshima-Sakurada M., Palmer T.D., Gage F.H. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development. 126:1999;4017-4026.
22. Takahashi J., Palmer T.D., Gage F.H. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J. Neurobiol. 38:1999;65-81.
23. Chung S., Sonntag K.C., Anderson T., Bjorklund L.M., Park J.-J., Kim D.-W., Kang U.J., Isacson O., Kim K.-S. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. Eur. J. Neurosci. 16:2002;1829-1838.
24. Sasai Y. Generation of dopaminergic neurons from embryonic stem cells. J. Neurol. 249:2002;1141-1144.
25. Satoh J., Kuroda Y. The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines. Neuropathology. 22:2002;219-232.
26. Riaz S.S., Jauniaux E., Stern G.M., Bradford H.F. The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitro. Brain Res. Dev. Brain Res. 136:2002;27-34.
27. Haas S.J., Wree A. Dopaminergic differentiation of the Nurr1-expressing immortalized mesencephalic cell line CSM14.1 in vitro. J. Anat. 201:2002;61-69.
28. Iwawaki T., Kohno K., Kobayashi K. Identification of a potential Nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells. Biochem. Biophys. Res. Commun. 274:2000;590-595.
29. Matsushita N., Okada H., Yasoshima Y., Takahashi K., Kiuchi K., Kobayashi K. Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development. J. Neurochem. 82:2002;295-304.
30. Kawasaki H., Mizuseki K., Nishikawa S., Kanebo S., Kuwana Y., Nakanishi S., Nishikawa S.I., Sasai Y. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron. 28:2000;31-40.
31. Lehmann J.M., Jong L., Fanjul A., Cameron J.F., Lu X.P., Haefner P., Dawson M.I., Pfahl M. Retinoids selective for retinoic X receptor response pathways. Science. 258:1992;1944-1946.
32. Perlmann T., Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 9:1995;769-782.