Parkinson disease gene therapy moves toward the clinic

Nature Medicine

Volumn 6, Issue 11, 2000, Pages 1207-1208

  Bjorklund, A ^a   Lindvall, O ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL PRACTICE; DOPAMINERGIC NERVE CELL; GENE THERAPY; HUMAN; NERVE REGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL; SHORT SURVEY; TREATMENT INDICATION;

GENE THERAPY; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; LENTIVIRUS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE;

PRIMATES;

EID: 0033694768     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/81291     Document Type: Short Survey

References (12)

1. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
2. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
3. Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
4. Neuroprotective and neurorestorative properties of GDNF
5. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
6. Dopaminergic neurons protected from degeneration by GDNF gene therapy
7. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
8. Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease
9. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member Neublastin/Artemin
10. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector
11. Lentiviral vectors: Turning a deadly foe into a therapeutic agent
12. 18F-dopa PET