Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4] triazine: Synthesis of an α2/3-selective GABA agonist

Journal of Organic Chemistry

Volumn 70, Issue 15, 2005, Pages 5938-5945

  Gauthier Jr , Donald R ^a   Limanto, John ^a   Devine, Paul N ^a   Desmond, Richard A ^a   Szumigala Jr , Ronald H ^a   Foster, Bruce S ^a   Volante, R P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMINE; CATALYSIS; CHROMATOGRAPHY; HALOGENATION; METHANE; PALLADIUM; SYNTHESIS (CHEMICAL);

AROMATIC BROMINATION; CHROMATOGRAPHY-FREE SYNTHESIS; EFFICIENT SYNTHESIS; PALLADIUM-CATALYZED ARYLATION;

AROMATIC COMPOUNDS;

2',6 DIFLUORO 5' [3 (1 HYDROXY 1 METHYLETHYL)IMIDAZO[1,2 B][1,2,4]TRIAZIN 7 YL]BIPHENYL 2 CARBONITRILE; 4 AMINOBUTYRIC ACID A ALPHA2 RECEPTOR; 4 AMINOBUTYRIC ACID A ALPHA3 RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BROMINE DERIVATIVE; IMIDAZO[1,2 B][1,2,4]TRIAZINE; IMIDAZOTRIAZINE; PALLADIUM; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; BROMINATION; CATALYSIS; CHEMICAL REACTION; CHROMATOGRAPHY; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; REACTION ANALYSIS;

ACETALDEHYDE; BROMIDES; CATALYSIS; GABA AGONISTS; HYDROCARBONS, AROMATIC; IMIDAZOLES; PALLADIUM; RECEPTORS, GABA-A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES; TRIAZOLES;

EID: 22244485005     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0507035     Document Type: Article

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