A high inorganic phosphate diet perturbs brain growth, alters Akt-ERK signaling, and results in changes in cap-dependent translation

Toxicological Sciences

Volumn 90, Issue 1, 2006, Pages 221-229

  Jin, Hua ^a   Hwang, Soon Kyung ^a   Yu, Kyungnam ^a   Anderson, Hanjo K ^a   Lee, Yeon Sook ^a   Lee, Kee Ho ^b   Prats, Anne Catherine ^c   Morello, Dominique ^d   Beck Jr , George R ^e   Cho, Myung Haing ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c CHU RANGUEIL   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt; Brain growth; Cap dependent translation; ERK; Inorganic phosphate

Indexed keywords

ACTIN; CALCIUM; CYCLIN D1; CYCLINE; INITIATION FACTOR 4E BINDING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATE; PROTEIN KINASE B; SERINE; SODIUM PHOSPHATE COTRANSPORTER; THREONINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN CELL; BRAIN FUNCTION; BRAIN GROWTH; BRAIN WEIGHT; CALCIUM BLOOD LEVEL; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIET; ENZYME PHOSPHORYLATION; INTERNAL RIBOSOME ENTRY SITE; MALE; MOUSE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE INTAKE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

ANIMALS; BODY WEIGHT; CELL PROLIFERATION; CEREBELLUM; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EUKARYOTIC INITIATION FACTOR-4E; MALE; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHATES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE III; TELENCEPHALON;

ANIMALIA; EUKARYOTA; HOMO SAPIENS; MURINAE;

EID: 33144473951     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfj066     Document Type: Article

References (45)

1. Bauer, M., Alda, M., Priller, J., and Young, L. T. The International Group for the Study of Lithium Treated Patients (IGSLI). (2003). Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. Pharmacopsychiatry 36(Suppl. 3), S250-S254.
2. Beck, G. R., Jr. (2003). Inorganic phosphate as a signaling molecule in osteoblast differentiation. J. Cell. Biochem. 90, 234-243.
3. Beck, G. R., Moran, E., and Knecht, N. (2003). Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2. Exp.Cell Res. 288, 288-300.
4. Bryan, J., Osendarp, S., Hughes, D., Calvaresi, E., Baghurst, K., and van Klinken, J. W. (2004). Nutrients for cognitive development in school-aged children. Nutr. Rev. 62, 295-306.
5. Brywe, K. G., Mallard, C., Gustavsson, M., Hedtjarn, M., Leverin, A. L., Wang, X., Blomgren, K., Isgaard, J., and Hagberg, H. (2005). IGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK2beta? Eur. J. Neurosci. 21, 1489-1502.
6. Calvo, M. S. (1993). Dietary phosphorous, calcium metabolism, and bone. J. Nutr. 123, F1627-F1633.
7. Caverzasio, J., and Bonjour, J. P. (1996). Characteristics and regulation of Pi transport in estrogenic cells for bone metabolism. Kidney Int. 49, 975-980.
8. Conrads, K. A., Yi, M., Simpson, K. A., Lucas, D. A., Camalier, C. E., Yu, L. R., Veenstra, T. D., Stephens, R. M., Conrads, T. P., and Beck, G. R., Jr. (2005). A combined proteome and microarray investigation of inorganic phosphate-induced pre-osteoblast cells. Mol. Cell Proteomics 9, 1284-1296.
9. Cote, A., Chiasson, M., Perelta, M. R., 3rd, Lafortune, K., Pellegrini, L., and Toth, K. (2005). Cell type-specific action of seizure-induced intracellular zinc communication in the rat hippocampus. J. Physiol. 566, 821-837.
10. Créancier, L., Mercier, P., Prats, A., and Morello, D. (2001). C-myc internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice. Mol. Cell. Biol. 21, 1833-1840.
11. Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789.
12. Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M., Szabolcs, M., de Jong, R., Oltersdorf, T., et al. (2005). Role of Akt3/protein kinase B gamma in attainment of normal brain size. Mol. Cell. Biol. 25, 1869-1878.
13. Felderhoff-Mueser, U., Bittigau, P., Sifringer, M., Jarosz, B., Korowicz, E., Mahler, L., Piening, T., Moysich, A., Grune, T., Thor, F., et al. (2004). Oxygen causes cell death in the developing brain. Neurobiol. Dis. 17, 273-282.
14. Glinn, M., Ni, B., and Paul, S. M. (1995). Characterization of Na(+)-dependent phosphate uptake in cultured fetal rat cortical neurons. J. Neurochem. 65, 2358-2365.
15. Hayashi, M., Otsuka, M., Morimoto, R., Hirota, S., Yatsushiro, S., Takeda, J., Yamamoto, A., and Moriyama, Y. (2001). Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems. J. Biol. Chem. 276, 43400-43406.
16. Hisano, S. (2002). The inorganic phosphate transport system in the brain and the potency as vesicular glutamate transporters. Kaibogaku Zasshi 77, 51-58.
17. Hovelmann, S., Beckers, T. L., and Schmidt, M. (2004). Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells. Br. J. Cancer 90, 2370-2377.
18. Kandel, E. S., and Hay, N. (1999). The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229.
19. Kane, L. P., Mollenauer, M. N., Xu, Z., Turck, C. W., and Weiss, A. (2002). Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol. Cell. Biol. 22, 5962-5974.
20. 2+ induced N-terminal truncation of (1-84)hPTH by human parathyroid cells. J. Clin. Endocrinol. Metab. 90, 5774-5778.
21. Kim, H.W., Park, I. K., Cho, C. S., Lee, K. H., Beck, G. R., Colburn, N. H., and Cho, M. H. (2004). Aerosol gene delivery of glucosylated polyethyleneimine (GPEI)/PTEN complex suppresses Akt downstream pathways in the lung of K-ras null mice. Cancer Res. 64, 7971-7976.
22. LaManna, J. C., and Lust, W. D. (1997). Nutrient consumption and metabolic perturbations. Neurosurg Clin North Am. 8, 145-163.
23. Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R., and Pouyssegur, J. (1996). Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271, 20608-20616.
24. Lawlor, M. A., and Alessi, D. R. (2001). PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?. J. Cell Sci. 114, 2903-2910.
25. Mulroney, S. E., Woda, C. B., Halaihel, N., Louie, B., McDonnell, K., Schulkin, J., Haramati, A., and Levi, M. (2004). Central control of renal sodium-phosphate (NaPi-2) transporters. Am. J. Physiol. Renal Cell Physiol. 286, F647-F652.
26. Myhre, O., Sterri, S. H., Bogen, I. L., and Fonnum, F. (2004). ERK1/2 phosphorylation and reactive oxygen species formation via nitric oxide and Akt-1/Raf-1 crosstalk in cultured cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane. Toxicol.Sci. 80, 296-303.
27. +-dependent inorganic phosphate cotransporter. J. Neurochem. 66, 2227-2238.
28. Onyango, I. G., Bennett, J. P., Jr., and Tuttle, J. B. (2005). Endogenous oxidative stress in sporatic Alzheimer/s disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids. Neurobiol. Dis. 19, 312-322.
29. Perkinton, M. S., Ip, J. K., Wood, G. L., Crossthwaite, A. J., and Williams, R. J. (2002). Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signaling to MAP kinase (ERK1/2), Akt/PKB and CREB in striatal neurons. J. Neurochem. 80, 239-254.
30. Pollitt, E., Jacoby, E., and Cueto, S. (1996). School breakfast and cognition among nutritionally at-risk children in the Peruvian Andes. Nutr. Rev. 54, S22-S26.
31. Pyronnet, S., Dosite, J., and Sonnenberg, N. (2001). Suppression of cap-dependent translation in mitosis. Genes Dev. 15, 2083-2093.
32. Reeves, P. G., Nielsen, F. H., and Fahey, G. C., Jr. (1993). AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the Reformulation of the AIN-76A rodent diet. J. Nutr. 123, 1939-1951.
33. Reinert, M., Khaldi, A., Zauner, A., Doppenberg, E., Choi, S., and Bullock, R. (2000). High level of extracellular potassium and its correlates after severe head injury: Relationship to high intracranial pressure. J. Neurosurg. 93, 800-807.
34. Richter, J. D., and Sonenberg, N. (2005). Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433, 477-480.
35. Rolli-Derkinderen, M., Machavoine, F., Baraban, J. M., Grolleau, A., Beretta, L., and Dy, M. (2003). ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1. J. Biol. Chem. 278, 18859-18867.
36. Rosenwald, I. B. (2004). The role of translation in neoplastic transformation from a pathologist's point of view. Oncogene 23, 3230-3237. Scheidenhelm, D. K., Cresswell, J., Haipek, C. A., Fleming, T. P., Mercer,
37. R. W., and Gutmann, D. H. (2005). Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol-3-kinase and Rheb signaling. Mol. Cell. Biol. 25, 3151-3162.
38. Sherr, C. J. (2002). D1 in G2. Cell Cycle 1, 36-38.
39. Shi, Y., Sharma, A., Wu, H., Lichtenstein, A., and Gera, J. (2005). Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by Akt activity and enhanced by rapamycin through a p38 MAPK and ERK-dependent pathway. J. Biol. Chem. 280, 10964-10973.
40. Shoback, D. M., Bilezikian, J. P., Turner, S. A., McCary, L. C., Guo, M. D., and Peacock, M. (2003). The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperthyroidism. J. Clin. Endocrinol. Metab. 88, 5644-5649.
41. Sitara, D., Razzaque, M. S., Hesse, M., Yoganathan, S., Taguchi, T., Erben, R. G., Juppner, H., and Lanske, B. (2004). Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 23, 421-432.
42. Song, G., Ouyang, G., and Bao, S. (2005). The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. 9, 59-71.
43. Takeda, E., Yamamoto, H., Nashiki, K., Sato, T., Arai, H., and Taketani, Y. (2004). Inorganic phosphate homeostasis and the role of dietary phosphorus. J. Cell. Mol. Med. 8, 191-200.
44. S6K-independent signaling in growth factor-stimulated NIH3T3 fibroblasts. Mol. Cell. Biol. 19, 1346-1358.
45. Uluitu, M., Badescu, A., and Chis, R. (1995). Influence of increased sodium intake on cerebral excitability. Rom. J. Physiol. 32, 11-33.