Direct in vitro evidence of extracellular Ca2+-induced amino-terminal truncation of human parathyroid hormone (1-84) by human parathyroid cells

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 10, 2005, Pages 5774-5778

  Kawata, Takehisa ^a   Imanishi, Yasuo ^a   Kobayashi, Keisuke ^a   Onoda, Naoyoshi ^a   Takemoto, Yoshiaki ^a   Tahara, Hideki ^a   Okuno, Senji ^b   Ishimura, Eiji ^a   Miki, Takami ^a   Ishikawa, Tetsuro ^a   Inaba, Masaaki ^a   Nishizawa, Yoshiki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PARATHYROID HORMONE; PARATHYROID HORMONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CASE REPORT; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; HORMONE INHIBITION; HORMONE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; PARATHYROID ADENOMA; PARATHYROID CELL; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SECONDARY HYPERPARATHYROIDISM; UREMIA;

CALCIUM; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYPERPARATHYROIDISM, SECONDARY; PARATHYROID GLANDS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; UREMIA;

EID: 26244448040     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0243     Document Type: Article

References (38)

1. 2+-sensing receptor from bovine parathyroid. Nature 366:575-580
2. Hofer AM, Brown EM 2003 Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 4:530-538
3. Bell O, Gaberman E, Kilav R, Levi R, Cox KB, Molkentin JD, Silver J, Naveh-Many T 2005 The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. Mol Endocrinol 19:516-526
4. Habener JF, Rosenblatt M, Potts Jr JT 1984 Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev 64:985-1053
5. o-sensing receptor (CaR): roles in cell signaling and control of diverse cellular functions. Adv Pharmacol 47:209-253
6. Segre GV, Niall HD, Habener JF, Potts Jr JT 1974 Metabolism of parathyroid hormone: physiologic and clinical significance. Am J Med 56:774-784
7. Morrissey JJ, Hamilton JW, MacGregor RR, Cohn DV 1980 The secretion of parathormone fragments 34-84 and 37-84 by dispersed porcine parathyroid cells. Endocrinology 107:164-171
8. Mayer GP, Keaton JA, Hurst JG, Habener JF 1979 Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood. Endocrinology 104:1778-1784
9. D'Amour P, Labelle F, Lecavalier L, Plourde V, Harvey D 1986 Influence of serum Ca concentration on circulating molecular forms of PTH in three species. Am J Physiol 251:E680-E687
10. D'Amour P, Palardy J, Bahsali G, Mallette LE, DeLean A, Lepage R 1992 The modulation of circulating parathyroid hormone immunoheterogeneity in man by ionized calcium concentration. J Clin Endocrinol Metab 74:525-532
11. Hanley DA, Takatsuki K, Sultan JM, Schneider AB, Sherwood LM 1978 Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro. J Clin Invest 62:1247-1254
12. Nguyen-Yamamoto L, Rousseau L, Brossard JH, Lepage R, Gao P, Cantor T, D'Amour P 2002 Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays. Eur J Endocrinol 147:123-131
13. Chu LL, MacGregor RR, Anast CS, Hamilton JW, Cohn DV 1973 Studies on the biosynthesis of rat parathyroid hormone and proparathyroid hormone: adaptation of the parathyroid gland to dietary restriction of calcium. Endocrinology 93:915-924
14. Habener JF, Kemper B, Potts Jr JT 1975 Calcium-dependent intracellular degradation of parathyroid hormone: a possible mechanism for the regulation of hormone stores. Endocrinology 97:431-441
15. Morrissey JJ, Cohn DV 1979 Secretion and degradation of parathormone as a function of intracellular maturation of hormone pools. Modulation by calcium and dibutyryl cyclic AMP. J Cell Biol 83:521-528
16. MacGregor RR, Bansal DD 1989 Inhibitors of cellular proteolysis cause increased secretion from parathyroid cells. Biochem Biophys Res Commun 160:1339-1343
17. Setoguti T, Inoue Y, Wild P 1995 The biological significance of storage granules in rat parathyroid cells. Microsc Res Tech 32:148-163
18. Brossard JH, Whittom S, Lepage R, D'Amour P 1993 Carboxyl-terminal fragments of parathyroid hormone are not secreted preferentially in primary hyperparathyroidism as they are in other hypercalcemic conditions. J Clin Endocrinol Metab 77:413-419
19. MacGregor RR, Jilka RL, Hamilton JW 1986 Formation and secretion of fragments of parathormone. Identification of cleavage sites. J Biol Chem 261:1929-1934
20. Hanley DA, Ayer LM 1986 Calcium-dependent release of carboxyl-terminal fragments of parathyroid hormone by hyperplastic human parathyroid tissue in vitro. J Clin Endocrinol Metab 63:1075-1079
21. Brossard JH, Cloutier M, Roy L, Lepage R, Gascon-Barre M, D'Amour P 1996 Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values. J Clin Endocrinol Metab 81:3923-3929
22. Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C, D'Amour P 1998 A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin Chem 44:805-809
23. Hatakeyama Y, Mizunashi K, Furukawa Y, Yabuki S, Sato Y, Igarashi T 2003 Plasma levels of parathyroid hormone (1-84) whole molecule and parathyroid hormone (7-84)-like fragments in pseudohypoparathyroidism type I. J Clin Endocrinol Metab 88:2250-2255
24. Inaba M, Nakatsuka K, Imanishi Y, Watanabe M, Mamiya Y, Ishimura E, Nishizawa Y 2004 Technical and clinical characterization of the Bio-PTH (1-84) immunochemiluminometric assay and comparison with a second-generation assay for parathyroid hormone. Clin Chem 50:385-390
25. Inaba M, Okuno S, Imanishi Y, Ueda M, Yamakawa T, Ishimura E, Nishizawa Y 2005 Significance of Bio-intact PTH(1-84) assay in hemodialysis patients. Osteoporos Int 16:517-525
26. Bilezikian JP, Potts Jr JT, Fuleihan Gel H, Kleerekoper M, Neer R, Peacock M, Rastad J, Silverberg SJ, Udelsman R, Wells SA 2002 Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century. J Clin Endocrinol Metab 87:5353-5361
27. K/DOQI Work Group, Shaul G, Massry M 2003 Clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 42(Suppl 3):S1-S201
28. Imanishi Y, Inaba M, Nishizawa Y, Morii H, Otani S 1995 Involvement of polyamines in the proliferation of bovine parathyroid cells. Miner Electrolyte Metab 21:197-200
29. Imanishi Y, Inaba M, Seki H, Koyama H, Nishizawa Y, Morii H, Otani S 1999 Increased biological potency of hexafluorinated analogs of 1,25- dihydroxyvitamin D3 on bovine parathyroid cells. J Steroid Biochem Mol Biol 70:243-248
30. 2+ concentration on the clearance and circulating levels of intact and carboxy-terminal iPTH in pentobarbital-anesthetized dogs. J Bone Miner Res 11:1075-1085
31. Slatopolsky E, Finch J, Clay P, Martin D, Sicard G, Singer G, Gao P, Cantor T, Dusso A 2000 A novel mechanism for skeletal resistance in uremia. Kidney Int 58:753-761
32. Antonsen JE, Sherrard DJ, Andress DL 1998 A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Kidney Int 53:223-227
33. Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, Hercz G, Cunningham J, Abu-Alfa AK, Messa P, Coyne DW, Locatelli F, Cohen RM, Evenepoel P, Moe SM, Fournier A, Braun J, McCary LC, Zani VJ, Olson KA, Drueke TB, Goodman WG 2004 Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 350:1516-1525
34. Silverberg SJ, Bone 3rd HG, Marriott TB, Locker FG, Thys-Jacobs S, Dziem G, Kaatz S, Sanguinetti EL, Bilezikian JP 1997 Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. N Engl J Med 337:1506-1510
35. Shoback DM, Bilezikian JP, Turner SA, McCary LC, Guo MD, Peacock M 2003 The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. J Clin Endocrinol Metab 88:5644-5649
36. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 81:1598-1606
37. Gogusev J, Duchambon P, Hory B, Giovannini M, Goureau Y, Sarfati E, Drueke TB 1997 Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 51:328-336
38. Nemeth EF, Steffey ME, Hammerland LG, Hung BC, Van Wagenen BC, DelMar EG, Balandrin MF 1998 Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci USA 95:4040-4045