Potent DNA gyrase inhibitors; novel 5-vinylpyrazole analogues with Gram-positive antibacterial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2863-2866

  Tanitame, Akihiko ^a   Oyamada, Yoshihiro ^a   Ofuji, Keiko ^a   Suzuki, Kenji ^a   Ito, Hideaki ^a   Kawasaki, Motoji ^a   Wachi, Masaaki ^b   Yamagishi, Jun Ichi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

5 Vinylpyrazole analogues; DNA gyrase inhibitor; Multi drug resistant strains

Indexed keywords

GYRASE INHIBITOR; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENTEROCOCCUS; GRAM POSITIVE BACTERIUM; LIPOPHILICITY; MOLECULAR INTERACTION; NONHUMAN; STAPHYLOCOCCUS;

ANTI-BACTERIAL AGENTS; DNA GYRASE; DRUG DESIGN; ENTEROCOCCUS FAECALIS; ENZYME INHIBITORS; GRAM-POSITIVE BACTERIA; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; PYRAZOLES; STAPHYLOCOCCACEAE; STRUCTURE-ACTIVITY RELATIONSHIP;

POSIBACTERIA;

EID: 2342467510     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.045     Document Type: Article

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