The development of an europium-GTP assay to quantitate chemokine antagonist interactions for CXCR4 and CCR5

Assay and Drug Development Technologies

Volumn 3, Issue 6, 2005, Pages 637-648

  Labrecque, Jean ^a   Anastassov, Virginia ^a   Lau, Gloria ^a   Darkes, Marilyn ^a   Mosi, Renee ^a   Fricker, Simon P ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); 4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; EUROPIUM; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; RANTES; STROMAL CELL DERIVED FACTOR 1ALPHA; SULFUR 35;

ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

ANTI-HIV AGENTS; CALCIUM; CELL LINE; CELL MEMBRANE; CHEMOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EUROPIUM; FLUORESCENCE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HETEROCYCLIC COMPOUNDS; HUMANS; RECEPTORS, CCR5; RECEPTORS, CXCR4; REPRODUCIBILITY OF RESULTS; SAPONINS; SIGNAL TRANSDUCTION; SODIUM CHLORIDE; TEMPERATURE; TIME FACTORS;

EID: 32944470681     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2005.3.637     Document Type: Article

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