Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP)

Medical Molecular Morphology

Volumn 38, Issue 3, 2005, Pages 142-154

  Ando, Yukio ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Amyloidosis; Antibody therapy; FAP; Gene therapy; Liver transplantation; TTR

Indexed keywords

1 BROMO 2,5 BIS(3 HYDROXYCARBONYL 4 HYDROXY)STYRYLBENZENE; 4' IODOESORUBICIN; AMYLOID; CHROMIUM; CONGO RED; METAL ION; NONSTEROID ANTIINFLAMMATORY AGENT; OLIGONUCLEOTIDE; PREALBUMIN; SCAVENGER; UNCLASSIFIED DRUG; 1 BROMO 2,5 BIS (3 HYDROXYCARBONYL 4 HYDROXY)STYRYL BENZENE; 1-BROMO-2,5-BIS-(3-HYDROXYCARBONYL-4-HYDROXY)STYRYL-BENZENE; STYRENE DERIVATIVE; SUPEROXIDE DISMUTASE;

AMYLOIDOSIS; CONFERENCE PAPER; DISEASE COURSE; FAMILIAL AMYLOID POLYNEUROPATHY; GENE THERAPY; HUMAN; HUMAN TISSUE; IMMUNIZATION; LIVER TRANSPLANTATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PH; PLASMAPHERESIS; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; RETINA; TRANSGENIC MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENETICS; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN CONFORMATION; REVIEW;

AMYLOID; AMYLOID NEUROPATHIES, FAMILIAL; FREE RADICAL SCAVENGERS; GENE THERAPY; HUMANS; LIVER; LIVER TRANSPLANTATION; MODELS, MOLECULAR; OXIDATIVE STRESS; PREALBUMIN; PROTEIN CONFORMATION; STYRENES; SUPEROXIDE DISMUTASE;

EID: 32944465275     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s00795-005-0288-1     Document Type: Conference Paper

References (101)

1. Andrade C (1952) A peculiar form of peripheral neuropathy: familial generalized amyloidosis with special involvement of the peripheral nerves. Brain 75:408-427.
2. Araki S (1984) Type I familial amyloidotic polyneuropathy (Japanese type). Brain Dev 6:128-133
3. Benson MD (1989) Familial amyloidotic polyneuropathy. Trends Neurosci 12:88-92
4. Benson MD, Uemichi T (1996) Transthyretin amyloidosis. Amyloid Int J Clin Invest 3:44-56
5. Ando Y, Araki S, Ando M (1993) Transthyretin related amyloidosis. Intern Med 32:920-922
6. Ando Y, Suhr O (1998) Autonomic dysfunction in familial amyloidotic polyneuropathy (FAP). Amyloid 5:288-300
7. Holmgren G, Ericzon BG, Groth CG, Steen L, Suhr O, Andersen O, Wallin BG, Seymour A, Richardson S, Hawkins PN, Pepys MB (1993) Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Lancet 341:113-116
8. Ericzon BG, Holmgren G, Lundgren E, Suhr OB (1999) New structural information and update on liver transplantation in transthyretin-associated amyloidosis. Report from the 4th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders & the 3rd International Workshop on Liver Transplantation in Familial Amyloid Polyneuropathy, Umea, Sweden. Amyloid 7:145-147
9. Skinner M, Lewis WD, Jones LA, Kasirsky J, Kane K, Ju ST, Jenkins R, Falk RH, Simms RW, Cohen AS (1994) Liver transplantation as a treatment for familial amyloidotic polyneuropathy. Ann Intern Med 120:133-134
10. Takei Y, Ikeda S, Hashikura Y, Ikegami T, Kawasaki S (1999) Partial-liver transplantation to treat familial amyloid polyneuropathy: follow-up of 11 patients. Ann Intern Med 131:592-595
11. Ando Y, Tanaka Y, Ando E, Yamashita T, Nishida Y, Tashima K, Suga M, Uchino M, Ando M (1995) Effect of liver transplantation on autonomic dysfunction in familial amyloidotic polyneuropathy type I. Lancet 345:195-196
12. Suhr O, Danielsson A, Rydh A, Nyhlin N, Hietala SO, Steen L (1996) Impact of gastrointestinal dysfunction on survival after liver transplantation for familial amyloidotic polyneuropathy. Dig Dis Sci 41:1909-1914
13. Lendoire J, Trigo P, Aziz H, Cueto G, Ando Y, Tashima K, Ohlsson PI, Cederquist K, Holmgren G, Suhr OB (1999) Liver transplantation in transthyretin familial amyloid polyneuropathy: first report from Argentina. Amyloid 6:297-300
14. Ando Y, Terazaki H, Haraoka K, Tajiri T, Nakamura M, Obayashi K, Misumi S, Shoji S, Hata K, Nakagawa K, Ishizaki T, Uemoto S, Inomata Y, Tanaka K, Okabe H (2002) Presence of autoantibody against ATTRVal30Met after sequential liver transplantation. Transplantation 73:674-675
15. Ando E, Ando Y, Haraoka K (2001) Ocular amyloid imvolvement after liver transplantation for polyneuropathy. Ann Intern Med 135:931-932
16. Sales-Luis ML, Galvao M, Carvalho M, Sousa G, Alves MM, Serrao R (1991) Treatment of familial amyloidotic polyneuropathy (Portuguese type) by plasma exchange. Muscle Nerve 14:377-378
17. Continho P, Macedo E, Estacio A, Saraiva A, Costa PP, Saraiva MJM (1988) Periodic plasma exchanges in treatment of familial amyloid polyneuropathy: preliminary results. In: Isobe T, Araki S, Uchino F, Kito S, Tsubura E (eds) Amyloid and amyloidosis. Plenum Press, New York, pp 845-849
18. Ikegawa S, Tanase S, Morino Y, Yi S, Ando Y, Miyazaki A, Araki S (1988) Evaluation of serum variant prealbumin levels, and its behavior after plasma exchange for familial amyloidotic polyneuropathy (type 1). In: Isobe T, Araki S, Uchino F, Kito S, Tsubura E (eds) Amyloid and amyloidosis. Plenum Press, New York, pp 839-844
19. Regnault V, Costa PM, Teixeira A, Rivat C, Stoltz JF, Saraiva MJ, Costa PP (1992) Specific removal of transthyretin from plasma of patients with familial amyloidotic polyneuropathy: optimization of an immunoadsorption procedure. Int J Artif Organs 15:249-255
20. Costa PMP, Costa PP (1998) The future of selective apheresis in FAP. Amyloid 5:143-144
21. Tokuda T, Kondo T, Hanaoka N, Takei Y, Kametani F, Yamada Y, Tamura Y, Yoshida M, Yamawaki N, Ikeda S (1998) A selective transthyretin-adsorption column for the treatment of patients with familial amyloid polyneuropathy. Amyloid 5:111-116
22. Jouquan J, Pennec Y, Mottier D, Boles JM, Morin JF, Youinou P, Garre M (1983) Retinol carrier protein, prealbumin and transferrin. Influence of age and sex on the serum concentration of proteins with a short half-life. Presse Med 12:1877
23. Dickson PW, Howlett GJ, Schreiber G (1982) Metabolism of prealbumin in rats and changes induced by acute inflammation. Eur J Biochem 129:289-293
24. Ando Y, Tanaka Y, Nakazato M, Ericzon BG, Yamashita T, Tashima K, Sakashita N, Suga M, Uchino M, Ando M (1995) Change in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation. Biochem Biophys Res Commun 211:354-358
25. Skinner M, Lewis WD, Jones LA, Kasirsky J, Kane K, Ju ST, Jenkins R, Falk RH, Simms RW, Cohen AS (1994) Liver transplantation as a treatment for familial amyloidotic polyneuropathy. Ann Intern Med 120:133-134
26. Ando Y, Tanaka Y, Nakazato M, Ericzon BG, Yamashita T, Tashima K, Sakashita N, Suga M, Uchino M, Ando M (1995) Change in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation. Biochem Biophys Res Commun 211:354-358
27. Monteiro E, Perdigoto R, Furtado AL (1998) Liver transplantation for familial amyloid polyneuropathy. Hepatogastroenterology 45:1375-1380
28. Golling M, Singer R, Weiss G, Mehrabi A, Zapletal C, Kraus T, Herfarth C, Klar E (2000) Sequential (domino) transplantation of the liver in a transthyretin-50 familial amyloid polyneuropathy. Special reference to cardiological diagnosis and complications. Langenbecks Arch Surg 385:21-26
29. Kelly JW, Lansbury PT Jr (1994). A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid formation. Amyloid 1:186-205
30. Colon W, Kelley JW (1992) Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry 31:8654-8660
31. McCutchen SL, Colon W, Kelley JW (1993) Transthyretin mutation Leu-55-Pro alters tetrameric stability and increases amyloidogenicity. Biochemistry 32:12119-12127
32. Alves IL, Divino CM, Schussler GC, Altland K, Almeida MR, Palha JA, Coelho T, Costa PP, Saraiva MJ (1993) Thyroxine binding in a TTR Met 119 kindred. J Clin Endocrinol Metab 77:484-488
33. Longo Alves I, Hays MT, Saraiva MJ (1997) Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin. Eur J Biochem 249:662-668
34. Almeida MR, Damas AM, Lans MC, Brouwer A, Saraiva MJ (1997) Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis. Endocrine 6:309-315
35. Terazaki H, Ando Y, Misumi S, Nakamura M, Ando E, Matsunaga N, Shoji S, Okuyama M, Ideta H, Nakagawa K, Ishizaki T, Ando M, Saraiva MJ (1999) A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels. Biochem Biophys Res Commun 264:365-370
36. Almeida MR, Alves IL, Terazaki H, Ando Y, Saraiva MJ (2000) Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M. Biochem Biophys Res Commun 270:1024-1028
37. Baures PW, Oza VB, Peterson SA, Kelly JW (1999) Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorg Med Chem 7:1339-1347
38. Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW (1998) Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proc Natl Acad Sci USA 95:12956-12960
39. 3+. 5th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders I-P-04 (abstract)
40. Guy CD, Jones CK (2001) Abdominal fat pad aspiration biopsy for tissue confirmation of systemic amyloidosis: specificity, positive predictive value, and diagnostic pitfalls. Diagn Cytopathol 24:181-185
41. Kaplan B, Vidal R, Kumar A, Ghiso J, Gallo G (1999) Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat. Am J Clin Pathol 112:403-407
42. Masouye I (1997) Diagnostic screening of systemic amyloidosis by abdominal fat aspiration: an analysis of 100 cases. Am J Dermatopathol 19:41-45
43. Westermark GT, Westermark P (2000) Endocrine amyloid - a subject of increasing interest for the next century. Amyloid 7:19-22
44. 123I-labeled serum amyloid P component. N Engl J Med 323:508-513
45. 99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy. Eur J Nucl Med 29:376-379
46. Giger M, Baumgartner HR, Zbinden G (1974) Toxicological effects of Evans blue and Congo red on blood platelets. Agents Actions 4:173-180
47. Klunk WE, Debnath ML, Pettegrew JW (1995) Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging 16:541-548
48. Klunk WE, Debnath ML, Koros AM, Pettegrew JW (1998) Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci 63:1807-1814
49. 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis. Nucl Med Commun 22:553-558
50. 99mTc-MAMA- chrysamine G as an in vivo probe for amyloidosis. Amyloid 8:202-214
51. 99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer's disease. Eur J Nucl Med 26:1392-1399
52. Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM (2000) In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 97:7609-7614
53. Schmidt ML, Schuck T, Sheridan S, Kung MP, Kung H, Zhuang ZP, Bergeron C, Lamarche JS, Skovronsky D, Giasson BI, Lee VM, Trojanowski JQ (2001) The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3- hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. Am J Pathol 159:937-943
54. Klunk WE, Debnath ML, Pettegrew JW (1994) Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease. Neurobiol Aging 15:691-698
55. Zhuang ZP, Kung MP, Hou C, Plossl K, Skovronsky D, Gur TL, Trojanowski JQ, Lee VM, Kung HF (2001) IBOX(2-(4′-dimethylaminophenyl)-6- iodobenzoxazole): a ligand for imaging amyloid plaques in the brain. Nucl Med Biol 28:887-894
56. Okahata Y, Niikura K, Sugiura Y, Sawada M, Morii T (1998) Kinetic studies of sequence-specific binding of GCN4-bZIP peptides to DNA strands immobilized on a 27-MHz quartz-crystal microbalance. Biochemistry 37:5666-5672
57. Matsuno H, Niikura K, Okahata Y (2001) Direct monitoring kinetic studies of DNA polymerase reactions on a DNA-immobilized quartz-crystal microbalance. Chemistry 7:3305-3312
58. Merlini G, Ascari E, Amboldi N, Bellotti V, Arbustini E, Perfetti V, Ferrari M, Zorzoli I, Marinone MG, Garini P, Diegori M, Trizio D, Ballinari D (1995) Interaction of the anthracycline 4′-iodo-4′-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis. Proc Natl Acad Sci USA 92:2959-2963
59. Gertz MA, Lacy MQ, Dispenzieri A, Cheson BD, Barlogie B, Kyle RA, Palladini G, Geyer SM, Merlini G (2002) A multicenter phase II trial of 4′-iodo-4′-deoxydoxorubicin (IDOX) in primary amyloidosis (AL). Amyloid 9:24-30
60. Sebastiao MP, Merlini G, Saraiva MJ, Damas AM (2000) The molecular interaction of 4′-iodo-4′-deoxydoxorubicin with Leu-55Pro transthyretin "amyloid-like" oligomer leading to disaggregation. Biochem J 351:273-279
61. McCord JM (1980) Oxygen free radicals: Release and activities. Agents Actions 10:522-527
62. Hirota M, Inoue M, Ando Y, Hirayama K, Mirono Y, Sakamoto K, Mori K, Akagi M (1989) Inhibition of stress induced gastric injury in the rat by glutathione. Gastroenterology 97:853-859
63. Ando E, Ando Y, Kamata R, Inoue M, Morino Y, Okamura R (1990) Inhibition of corneal inflammation by an acylated superoxide dismutase derivation. Invest Ophthalmol Vis Sci 31:1963-1967
64. Ando Y, Ikegawa S, Miyazaki A, Inoue M, Morino Y, Araki S (1989) Role of variant prealbumin in the pathogenesis of familial amyloidotic polyneuropathy: rate of normal and variant prealbumin in circulation. Arch Biochem Biophys 274:87-92
65. Granger D (1988) Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255:H1269-H1275
66. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330:1029-1035
67. Banwell BL, Engel AG (2000) AlphaB-crystallin immunolocalization yields new insights into inclusion body myositis. Neurology 54:1033-1041
68. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12:376-389
69. Capeillere-Blandin C, Delaveau T, Descamps-Latscha B (1991) Structural modifications of human beta 2 microglobulin treated with oxygen-derived radicals. Biochem J 277:175-182
70. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, Stadtman ER (1994) Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA 91:2616-2620
71. Mark RJ, Lovell MA, Markesbery WR, Uchida K, Mattson MP (1997) A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide. J Neurochem 68:255-264
72. Sagara Y, Dargusch R, Klier FG, Schubert D, Behl C (1996) Increased antioxidant enzyme activity in amyloid β proteinsresistant cells. J Neurosci 16:497-505
73. Skinner M, Stone P, Shirahama T, Connors L, Calore J, Cohen A (1986) The association of an elastase with amyloid fibrils. Proc Soc Exp Biol Med 181:211-214
74. Stone P, Camistol J, Abraham CR, Rodgers O, Shirahama T, Skinner M (1993) Neutrophil proteases associated with amyloid fibrils. Biochem Biophys Res Commun 30:130-136
75. Benedetti A, Comporti M, Esterbauer H (1980) Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids. Biochim Biophys Acta 620:281-296
76. Siems W, Kowalewski J, Werner A, Schimke I, Gerber G (1989) Radical formation in the rat small intestine during and following ischemia. Free Radic Res Commun 7:347-353
77. Uchida K, Itakura K, Kawakishi S, Hiai H, Toyokuni S, Stadtman ER (1995) Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies. Arch Biochem Biophys 324:241-248
78. Ando Y, Brännström T, Uchida K, Nyhlin N, Näsman B, Suhr O, Yamashita T, Olsson T, Uchino M, Ando M (1998) Histochemical detection of 4-hydroxynonenal protein in Alzheimer disease amyloid. J Neurol Sci 156:172-176
79. Hoff HF, O'Neil JA (1991) Oxidation of LDL: role in atherogenesis. Klin Wochenschr 69:1032-1038
80. Sakashita N, Ando Y, Jinnouchi K, Yoshimatsu M, Terazaki H, Obayashi K, Takeya M (2001) Familial amyloidotic polyneuropathy (ATTR Val30Met) with widespread cerebral amyloid angiopathy and lethal cerebral hemorrhage. Pathol Int 51:476-480
81. Ando Y, Nyhlin N, Suhr O, Holmgren G, Uchida K, El-Salhy M, Yamashita T, Terasaki H, Nakamura M, Uchino M, Ando M (1997) Oxidative stress is found in amyloid deposits in systemic amyloidosis. Biochem Biophys Res Commun 232:497-502
82. Ando Y, Suhr O, El-Salhy M (1998) Oxidative stress and amyloidosis. Histol Histopathol 13:845-850
83. Nyhlin N, Ando Y, Nagai R, Suhr O, El-Salhy M, Terazaki H, Yamashita, Ando M, Horiuchi S (2000) Advanced glycation end product in familial amyloidotic polyneuropathy (FAP). J Intern Med 247:485-492
84. Sakashita N, Ando Y, Marklund SL, Tashima K, Nilsson P, Yamashita T, Takeya M, Takahashi K (1998) Familial amyloidotic polyneuropathy type I with extracellular superoxide dismutase mutation: a case report. Hum Pathol 13:845-850
85. Suhr OB, Lang K, Wikstrom L, Anan I, Ando Y, El-Salhy M, Holmgren G, Tashima K (2001) Scavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients. Scand J Clin Lab Invest 61:11-18
86. Propsting MJ, Blaschke M, Haas RE, Genschel J, Hedrich HJ, Manns MP, Schmidt HH (1999) Inosine(15.1)-hammerhead ribozymes for targeting the transthyretin-30 mutation. Biochem Biophys Res Commun 260:313-317
87. Tanaka K, Yamada T, Ohyagi Y, Asahara H, Horiuchi I, Kira J (2001) Suppression of transthyretin expression by ribozymes: a possible therapy for familial amyloidotic polyneuropathy. J Neurol Sci 183:79-84
88. Yoon K, Cole-Strauss A, Kmiec EB (1996) Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA·DNA oligonucleotide. Proc Natl Acad Sci USA 93:2071-2076
89. Cole-Strauss A, Yoon K, Xiang Y, Byrne BC, Rice MC, Gryn J, Holloman WK, Kmiec EB (1996) Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science 273:1386-1389
90. Kren BT, Cole-Strauss A, Kmiec EB, Steer CJ (1997) Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide. Hepatology 25:1462-1468
91. +-enriched cell population using a chimeric RNA/DNA oligonucleotide. J Mol Med 75:829-835
92. Kren BT, Bandyopadhyay P, Steer CJ (1998) In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotide. Nat Med 4:285-290
93. Alexeev V, Yoon K (1998) Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA/DNA oligonucleotide. Nat Biotechno1 16:1343-1346
94. Kren BT, Parashar B, Bandyopadhyay P, Chowdhury N, Chowdhury JR, Steer CJ (1999) Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler-Najjar syndrome type I with a chimeric oligonucleotide. Proc Natl Acad Sci USA 96:10349-10354
95. Gamper HB Jr, Cole-Strauss A, Metz R, Parekh H, Kumar R, Kmiec EB (2000) A plausible mechanism for gene correction by chimeric oligonucleotides. Biochemistry 39:5808-5816
96. Gamper HB, Parekh H, Rice MC, Bruner M, Youkey H, Kmiec EB (2000) The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts. Nucleic Acids Res 28:4332-4339
97. Kishikawa M, Nakanishi T, Miyazaki A, Shimizu A (1999) Enhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis. Amyloid 6:183-186
98. Altland K, Winter P (1999) Potential treatment of transthyretin-type amyloidoses by sulfite. Neurogenetics 2:183-188
99. Cardoso I, Pereira PJ, Damas AM, Saraiva MJ (2000) Aprotinin binding to amyloid fibrils. Eur J Biochem 267:2307-2311
100. Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW (2000) A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature (Lond) 408:982-985
101. Imbimbo BP (2002) Toxicity of beta-amyloid vaccination in patients with Alzheimer's disease. Ann Neurol 51:794