Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part III: Synthesis of potent antagonists with αvβ3/α IIbβ3 dual activity and improved water solubility

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 7, 2006, Pages 2131-2150

  Ishikawa, Minoru ^a   Hiraiwa, Yukiko ^a   Kubota, Dai ^a   Tsushima, Masaki ^a   Watanabe, Takashi ^a   Murakami, Shoichi ^a   Ouchi, Shokichi ^a   Ajito, Keiichi ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

3 aminopiperidine derivatives; Acute ischemic disease; Integrin IIb 3 antagonist; Integrin v 3 antagonist

Indexed keywords

BENZENESULFONYLAMINO 3 [3 FLUORO 4 (1,4,5,6 TETRAHYDROPYRIMIDIN 2 YLAMINO)PIPERIDIN 1 YL}BENZOYLAMINO]PROPIONIC ACID; BENZENESULFONYLAMINO 3 [4 (1,4,5,6 TETRAHYDROPYRIMIDIN 2 YLAMINO)AZEPAN 1 YL}BENZOYLAMINO]PROPIONIC ACID; BENZENESULFONYLAMINO 3 [4 (1,4,5,6 TETRAHYDROPYRIMIDIN 2 YLAMINO)PYRROLIDIN 1 YL}BENZOYLAMINO]PROPIONIC ACID; BENZENESULFONYLAMINO 3 [4 (PYRIMIDIN 2 YLAMINO)PYRROLIDIN 1 YL}BENZOYLAMINO]PROPIONIC ACID; BENZENESULFONYLAMINO 3 [4 [2 {(1,4,5,6 TETRAHYDROPYRIMIDIN 2 YLAMINO)METHYL}PYRROLIDIN 1 YL]BENZOYLAMINO]PROPIONIC ACID; INTEGRIN; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TOXICITY; HUMAN; HUMAN CELL; ISOMER; NONHUMAN; PHARMACOPHORE; RAT; SCREENING; STRUCTURE ACTIVITY RELATION;

ANIMALS; AORTA; CELL ADHESION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; INTEGRIN ALPHAVBETA3; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYOCYTES, SMOOTH MUSCLE; PIPERIDINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN CONFORMATION; RATS; RATS, WISTAR; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VITRONECTIN; WATER;

ANIMALIA;

EID: 32844469709     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.055     Document Type: Article

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