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Volumn 13, Issue 6, 2003, Pages 1071-1074

Biphenyls as potent vitronectin receptor antagonists. Part 2: Biphenylalanine ureas

Author keywords

[No Author keywords available]

Indexed keywords

4 BROMOPHENYLALANINE; BIPHENYL DERIVATIVE; FUNCTIONAL GROUP; PHENYLALANINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UREA DERIVATIVE; VITRONECTIN RECEPTOR ANTAGONIST;

EID: 0037463755     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00023-4     Document Type: Article
Times cited : (22)

References (20)
  • 4
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    • Recent reviews:
    • (d) Hoelzemann G. Idrugs. 40:2001;72.
    • (2001) Idrugs , vol.40 , pp. 72
    • Hoelzemann, G.1
  • 6
    • 0000318966 scopus 로고    scopus 로고
    • All compounds synthesized on Wang resin (Rapp Polymere, Tübingen, loading: 1.08 mmol/g) were obtained in good yields (50-80%). The purity was >90% as determined by HPLC (UV) in all cases. For further details of the syntheses see: WO 0035864, 2000,
    • All compounds synthesized on Wang resin (Rapp Polymere, Tübingen, loading: 1.08 mmol/g) were obtained in good yields (50-80%). The purity was >90% as determined by HPLC (UV) in all cases. For further details of the syntheses see: Urbahns K., Härter M., Albers M., Vaupel A., Schmidt D., Stelte-Ludwig B., Gerdes C., Lustig K. WO 0035864, 2000, Chem. Abstr. 133:2000;43809.
    • (2000) Chem. Abstr. , vol.133 , pp. 43809
    • Urbahns, K.1    Härter, M.2    Albers, M.3    Vaupel, A.4    Schmidt, D.5    Stelte-Ludwig, B.6    Gerdes, C.7    Lustig, K.8
  • 9
    • 85031204629 scopus 로고    scopus 로고
    • Experimental details in: US 2002095050, 2002;
    • Experimental details in: Vaupel A. US 2002095050, 2002; Chem. Abstr. 137:2002;94007.
    • (2002) Chem. Abstr. , vol.137 , pp. 94007
    • Vaupel, A.1
  • 10
    • 85031196609 scopus 로고    scopus 로고
    • The 2,4,6-trimethyl phenyl sulfonyl residue has been incorporated into vitronectin receptor antagonists before: WO 9637492, 1996;
    • The 2,4,6-trimethyl phenyl sulfonyl residue has been incorporated into vitronectin receptor antagonists before: Voss E.J., Jadhav P.K., Smallheer J.M., Batt D.G., Pitts W.J., Wityak J. WO 9637492, 1996; Chem. Abstr. 126:1997;89360.
    • (1997) Chem. Abstr. , vol.126 , pp. 89360
    • Voss, E.J.1    Jadhav, P.K.2    Smallheer, J.M.3    Batt, D.G.4    Pitts, W.J.5    Wityak, J.6
  • 14
    • 9544258252 scopus 로고    scopus 로고
    • Integrin purification: Wong A., Hwang S.M., McDevitt P., McNulty D., Stadel J.M., Johanson K. Mol. Pharm. 50:1996;529 (b) . Echistatin as radioligand: Kumar C.C., Nie H.M., Rogers C.P., Malkowski M., Maxwell E., Catino J.J., Armstrong L. J. Pharm. Exp. Ther. 283:1997;843.
    • (1996) Mol. Pharm , vol.50 , pp. 529
    • Wong, A.1    Hwang, S.M.2    McDevitt, P.3    McNulty, D.4    Stadel, J.M.5    Johanson, K.6
  • 19
    • 85031206165 scopus 로고    scopus 로고
    • note
    • 2+ ions, the ion chelating amino acids as well as all distant residues (5 Å) were kept constant. The docking procedure was performed using SYBYL 6.8 (Tripos Inc., MO, USA).
  • 20
    • 0029778085 scopus 로고    scopus 로고
    • A similar effect is known for c-RGDfV. Substitution of the glycine residue by L- or D-alanine leads to loss of activity:
    • A similar effect is known for c-RGDfV. Substitution of the glycine residue by L- or D-alanine leads to loss of activity: Haubner R., Gratias R., Diefenbach B., Goodman S.L., Jonczyk A., Kessler H. J. Am. Chem. Soc. 118:1996;7461.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 7461
    • Haubner, R.1    Gratias, R.2    Diefenbach, B.3    Goodman, S.L.4    Jonczyk, A.5    Kessler, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.