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Recent reviews:
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(d) Hoelzemann G. Idrugs. 40:2001;72.
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Hoelzemann, G.1
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Urbahns K., Härter M., Albers M., Schmidt D., Stelte-Ludwig B., Brüggemeier U., Vaupel A., Gerdes C. Bioorg. Med. Chem. Lett. 12:2002;205.
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6
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0000318966
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All compounds synthesized on Wang resin (Rapp Polymere, Tübingen, loading: 1.08 mmol/g) were obtained in good yields (50-80%). The purity was >90% as determined by HPLC (UV) in all cases. For further details of the syntheses see: WO 0035864, 2000,
-
All compounds synthesized on Wang resin (Rapp Polymere, Tübingen, loading: 1.08 mmol/g) were obtained in good yields (50-80%). The purity was >90% as determined by HPLC (UV) in all cases. For further details of the syntheses see: Urbahns K., Härter M., Albers M., Vaupel A., Schmidt D., Stelte-Ludwig B., Gerdes C., Lustig K. WO 0035864, 2000, Chem. Abstr. 133:2000;43809.
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0027096411
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3 and related integrins.
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3 and related integrins. Hartman G.D., Egbertson M.S., Halczenko W., Laswell W., Duggan M.E., Smith R.L., Naylor A.M., Manno P.D., Lynch R.J., Zhang G., Chang C.T.-C., Gould R. J. Med. Chem. 35:1992;4640.
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9
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85031204629
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Experimental details in: US 2002095050, 2002;
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Experimental details in: Vaupel A. US 2002095050, 2002; Chem. Abstr. 137:2002;94007.
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Vaupel, A.1
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85031196609
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The 2,4,6-trimethyl phenyl sulfonyl residue has been incorporated into vitronectin receptor antagonists before: WO 9637492, 1996;
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The 2,4,6-trimethyl phenyl sulfonyl residue has been incorporated into vitronectin receptor antagonists before: Voss E.J., Jadhav P.K., Smallheer J.M., Batt D.G., Pitts W.J., Wityak J. WO 9637492, 1996; Chem. Abstr. 126:1997;89360.
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(a) Incorporation of camphor residues into beta 3 integrin antagonists: Diefenbach B., Fittschen C., Gante J., Goodman S., Wiesner M., Rippmann F. DE 95-195548709; Chem. Abstr. 127:1997;95612.
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Incorporation of camphor residues into beta 3 integrin antagonists: DE 95-195548709;
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Integrin purification: Wong A., Hwang S.M., McDevitt P., McNulty D., Stadel J.M., Johanson K. Mol. Pharm. 50:1996;529 (b) . Echistatin as radioligand: Kumar C.C., Nie H.M., Rogers C.P., Malkowski M., Maxwell E., Catino J.J., Armstrong L. J. Pharm. Exp. Ther. 283:1997;843.
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Integrin purification: Echistatin as radioligand:
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Integrin purification: Wong A., Hwang S.M., McDevitt P., McNulty D., Stadel J.M., Johanson K. Mol. Pharm. 50:1996;529 (b) . Echistatin as radioligand: Kumar C.C., Nie H.M., Rogers C.P., Malkowski M., Maxwell E., Catino J.J., Armstrong L. J. Pharm. Exp. Ther. 283:1997;843.
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19
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85031206165
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note
-
2+ ions, the ion chelating amino acids as well as all distant residues (5 Å) were kept constant. The docking procedure was performed using SYBYL 6.8 (Tripos Inc., MO, USA).
-
-
-
-
20
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-
0029778085
-
-
A similar effect is known for c-RGDfV. Substitution of the glycine residue by L- or D-alanine leads to loss of activity:
-
A similar effect is known for c-RGDfV. Substitution of the glycine residue by L- or D-alanine leads to loss of activity: Haubner R., Gratias R., Diefenbach B., Goodman S.L., Jonczyk A., Kessler H. J. Am. Chem. Soc. 118:1996;7461.
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Haubner, R.1
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Kessler, H.6
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