Non-peptide αvβ3 antagonists. Part 4: Potent and orally bioavailable chain-shortened RGD mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2463-2465

  Coleman, Paul J ^a   Askew, Ben C ^a   Hutchinson, John H ^a   Whitman, David B ^a   Perkins, James J ^a   Hartman, George D ^a   Rodan, Gideon A ^a   Leu, Chih Tai ^a   Prueksaritanont, Thomayant ^a   Fernandez Metzler, Carmen ^a   Merkle, Kara M ^a   Lynch, Robert ^a   Lynch, Joseph J ^a   Rodan, Sevgi B ^a   Duggan, Mark E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ARGINYLGLYCYLASPARTIC ACID DERIVATIVE; INTEGRIN; PEPTIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; OLIGOPEPTIDE; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; LIPOPHILICITY; NONHUMAN; PEPTIDE SYNTHESIS; PLASMA CLEARANCE; STRUCTURE ACTIVITY RELATION; ANIMAL; BIOAVAILABILITY; DRUG ANTAGONISM; HALF LIFE TIME; IC 50; METABOLIC CLEARANCE RATE; MOLECULAR MIMICRY; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; HALF-LIFE; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHAVBETA3; METABOLIC CLEARANCE RATE; MOLECULAR MIMICRY; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4243299683     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00396-7     Document Type: Article

References (18)

1. WO 99/30709