Non-peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-amino acids as aspartic acid replacements

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 1, 2002, Pages 31-34

  Coleman, Paul J ^a   Brashear, Karen M ^a   Hunt, Cecilia A ^a   Hoffman, William F ^a   Hutchinson, John H ^a   Breslin, Michael J ^a   McVean, Carol A ^a   Askew, Ben C ^a   Hartman, George D ^a   Rodan, Sevgi B ^a   Rodan, Gideon A ^a   Leu, Chih Tai ^a   Prueksaritanont, Thomayant ^a   Fernandez Metzler, Carmen ^a   Ma, Bennett ^a   Libby, Laura A ^a   Merkle, Kara M ^a   Stump, Gary L ^a   Wallace, Audrey A ^a   Lynch, Joseph J ^a   Lynch, Robert ^a   Duggan, Mark E ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; ASPARTIC ACID; BETA ALANINE; BETA AMINO ACID; RECEPTOR BLOCKING AGENT;

ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG POTENCY; HUMAN; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; PHYSICAL CHEMISTRY;

AMINO ACIDS; ANIMALS; ASPARTIC ACID; BINDING, COMPETITIVE; DOGS; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; OLIGOPEPTIDES; OSTEOPOROSIS; PROTEIN BINDING; RECEPTORS, VITRONECTIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244391742     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00666-7     Document Type: Article

References (24)

1. 3-Pyridinyl
2. 5-Benzodioxole
3. Dihydrobenzofuranyl