Sniffing and spatiotemporal coding in olfaction

Chemical Senses

Volumn 31, Issue 2, 2006, Pages 119-130

  Scott, John W ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Electroolfactogram; Flow rate; Odorant hydrophobicity; Sorption

Indexed keywords

AIRFLOW; ARTICLE; BRAIN FUNCTION; FLOW RATE; GENE EXPRESSION; HUMAN; HYDROPHOBICITY; NONHUMAN; NOSE CAVITY; OLFACTORY BULB; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; SMELLING; SNIFFING;

ANIMALS; BRAIN; INHALATION; NOSE; OLFACTORY BULB; SMELL;

AMPHIUMA MEANS; ANURA; RODENTIA;

EID: 32544446043     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/bjj013     Document Type: Article

References (133)

1. Anker, L.S., Jurs, P.C. and Edwards, P.A. (1990) Quantitative structure-retention relationship studies of odor-active aliphatic compounds with oxygen-containing functional groups. Anal. Chem., 62, 2676-2684.
2. Astic, L., Saucier, D. and Holley, A. (1987) Topographical relationships between olfactory receptor cells and glomerular foci in the rat olfactory bulb. Brain Res., 424, 144-152.
3. Balu, R., Larimer, P. and Strowbridge, B.W. (2004) Phasic stimuli evoke precisely timed spikes in intermittently discharging mitral cells. J. Neurophysiol., 92, 743-753.
4. Buonviso, N., Amat, C., Litaudon, P., Roux, S., Royet, J.P., Farget, V. and Sicard, G. (2003) Rhythm sequence through the olfactory bulb layers during the time window of a respiratory cycle. Eur. J. Neurosci., 17, 1811-1819.
5. Buonviso, N.H., Amat, C. and Litaudon, P. (2005) Respiratory modulation of olfactory neurons in the rodent brain. Chem. Senses. 10.1093/chemse/ bjj010.
6. Burke, J. (1984) Solubility parameters: Theory and application. In Jensen, C. (ed.), The Book and Paper Group Annual, vol. 3. The American Institute for Conservation, Ann Arbor, MI, pp. 13-58.
7. Cang, J. and Isaacson, J.S. (2003) In vivo whole-cell recording of odor-evoked synaptic transmission in the rat olfactory bulb. J. Neurosci., 23, 4108-4116.
8. Castillo, K., Bacigalupo, J. and Wolff, D. (2005) Ca2+-dependent K+ channels from rat olfactory cilia characterized in planar lipid bilayers. FEBS Lett., 579, 1675-1682.
9. Chalansonnet, M. and Chaput, M.A. (1998) Olfactory bulb output cell temporal response patterns to increasing odor concentrations in freely breathing rats. Chem. Senses, 23, 1-9.
10. Chaput, M.A. and Panhuber, H. (1982) Effects of long duration odor exposure on the unit activity of olfactory bulb cells in awake rabbits. Brain Res., 250, 41-52.
11. Daval, G., Leveteau, J. and MacLeod, P. (1970) Electro-olfactogramme local et discrimination olfactive chez la grenouille. J. Physiol. (Paris), 62, 477-488.
12. Davis, B.J. and Macrides, F. (1981) The organization of centrifugal projections from the anterior olfactory nucleus, ventral hippocampal rudiment, and piriform cortex to the main olfactory bulb in the hamster: an autoradiographic study. J. Comp. Neurol., 203, 475-493.
13. Delay, R. and Restrepo, D. (2004) Odorant responses of dual polarity are mediated by cAMP in mouse olfactory sensory neurons. J. Neurophysiol., 92, 1312-1319.
14. Duchamp-Viret, P. and Duchamp, A. (1997) Odor processing in the frog olfactory system. Prog. Neurobiol., 53, 561-602.
15. Eccles, R. (2000) Nasal airflow in health and disease. Acta Otolaryngol., 120, 580-595.
16. Egolf, L.M. and Jurs, P.C. (1993) Quantitative structure-retention and structure-odor intensity relationships for a diverse group of odor-active compounds. Anal. Chem., 65, 3119-3126.
17. Ezeh, P.I., Davis, L.M. and Scott, J.W. (1995) Regional distribution of rat electroolfactogram. J. Neurophysiol., 73, 2207-2220.
18. Frank, R.A., Dulay, M.F. and Gesteland, R.C. (2003) Assessment of the Sniff Magnitude Test as a clinical test of olfactory function. Physiol. Behav., 78, 195-204.
19. Frye, R. (1995) Nasal airway dynamics and olfactory function. In Doty, R. (ed.), Handbook of Olfaction and Gustation. Marcel Dekker, Inc., New York, pp. 471-491.
20. Fülle, H.J., Vassar, R., Foster, D.C., Yang, R.B., Axel, R. and Garbers, D.L. (1995) A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc. Natl Acad. Sci. USA, 92, 3571-3575.
21. Fuller, G.H., Steltenkamp, R. and Tisserand, G.A. (1964) The gas chromatograph with human sensor: Perfumer model. Ann. N. Y. Acad. Sci., 116, 711-724.
22. Giraudet, P., Berthommier, F. and Chaput, M. (2002) Mitral cell temporal response patterns evoked by odor mixtures in the rat olfactory bulb. J. Neurophysiol., 88, 829-838.
23. Hague, C., Uberti, M.A., Chen, Z., Bush, C.F., Jones, S.V., Ressler, K.J., Hall, R.A. and Minneman, K.P. (2004) Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor. Proc. Natl Acad. Sci. USA, 101, 13672-13676.
24. Hahn, I., Scherer, P.W. and Mozell, M.M. (1994) A mass transport model of olfaction. J. Theor. Biol., 167, 115-128.
25. Hamana, H., Hirono, J., Kizumi, M. and Sato, T. (2003) Sensitivity-dependent hierarchical receptor codes for odors. Chem. Senses, 28, 87-104.
26. Harrison, T.A. and Scott, J.W. (1986) Olfactory bulb responses to odor stimulation: Analysis of response pattern and intensity relationships. J. Neurophysiol., 56, 1571-1589.
27. Hayar, A., Karnup, S., Shipley, M.T. and Ennis, M. (2004) Olfactory bulb glomeruli: External tufted cells intrinsically burst at theta frequency and are entrained by patterned olfactory input. J. Neurosci., 24, 1190-1199.
28. Igarashi, K.M. and Mori, K. (2005) Spatial representation of hydrocarbon odorants in the ventrolateral zones of the rat olfactory bulb. J. Neurophysiol., 93, 1007-1019.
29. Imamura, K., Mataga, N. and Mori, K. (1992) Coding of odor molecules by mitral/tufted cells in rabbit olfactory bulb. I. Aliphatic compounds. J. Neurophysiol., 68, 1986-2002.
30. Iwema, C.L., Fang, H., Kurtz, D.B., Youngentob, S.L. and Schwob, J.E. (2004) Odorant receptor expression patterns are restored in lesion-recovered rat olfactory epithelium. J. Neurosci., 24, 356-369.
31. Jiang, M., Griff, E.R., Ennis, M., Zimmer, L.A. and Shipley, M.T. (1996) Activation of locus coeruleus enhances the responses of olfactory bulb mitral cells to weak olfactory nerve input. J. Neurosci., 16, 6319-6329.
32. Johnson, B.A., Ho, S.L., Xu, Z., Yihan, J.S., Yip, S., Hingco, E.E. and Leon, M. (2002) Functional mapping of the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features. J. Comp. Neurol., 449, 180-194.
33. Johnson, B.A. and Leon, M. (2000) Odorant molecular length: One aspect of the olfactory code. J. Comp. Neurol., 426, 330-338.
34. Johnson, B.N., Mainland, J.D. and Sobel, N. (2003) Rapid olfactory processing implicates subcortical control of an olfactomotor system. J. Neurophysiol., 90, 1084-1094.
35. Kashiwadani, H., Sasaki, Y.F., Uchida, N. and Mori, K. (1999) Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb. J. Neurophysiol., 82, 1786-1792.
36. Kauer, J.S. and Moulton, D.G. (1974) Responses of olfactory bulb neurones to odour stimulation of small nasal areas in the salamander. J. Physiol., 243, 717-737.
37. Kauer, J.S. and Shepherd, G.M. (1977) Analysis of the onset phase of olfactory bulb unit responses to odour pulses in the salamander. J. Physiol., 272, 495-516.
38. Kay, L.M. (2003) Two species of gamma oscillations in the olfactory bulb: Dependence on behavioral state and synaptic interactions. J. Integr. Neurosci., 2, 31-44.
39. Kay, L.M. (2005) Theta oscillations and sensorimotor performance. Proc. Natl Acad. Sci. USA, 102, 3863-3868.
40. Kendal-Reed, M., Walker, J.C., Morgan, W.T., LaMacchio, M. and Lutz, R.W. (1998) Human responses to propionic acid. I. Quantification of within- and between-participant variation in perception by normosmics and anosmics. Chem. Senses, 23, 71-82.
41. Kent, P.F., Mozell, M.M., Murphy, S.J. and Hornung, D.E. (1996) The interaction of imposed and inherent olfactory mucosal activity patterns and their composite representation in a mammalian species using voltage-sensitive dyes. J. Neurosci., 16, 345-353.
42. Kent, P.F., Mozell, M.M., Youngentob, S.L. and Yurco, P. (2003) Mucosal activity patterns as a basis for olfactory discrimination: Comparing behavior and optical recordings. Brain Res., 981, 1-11.
43. Kent, P.F., Youngentob, S.L. and Sheehe, P.R. (1995) Odorant-specific spatial patterns in mucosal activity predict perceptual differences among odorants. J. Neurophysiol., 74, 1777-1781.
44. Kimbell, J.S., Godo, M.N., Gross, E.A., Joyner, D.R., Richardson, R.B. and Morgan, K.T. (1997) Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol. Appl. Pharmacol., 145, 388-398.
45. Komisaruk, B.R. (1970) Synchrony between limbic system theta activity and rhythmical behavior in rats. J. Comp. Physiol. Psychol., 70, 482-492.
46. Kurtz, D.B., Zhao, K., Hornung, D.E. and Scherer, P. (2004) Experimental and numerical determination of odorant solubility in nasal and olfactory mucosa. Chem. Senses, 29, 763-773.
47. Land, L.J. (1973) Localized projection of olfactory nerves to rabbit olfactory bulb. Brain Res., 63, 153-166.
48. Larsson, M.C., Domingos, A.I., Jones, W.D., Chiappe, M.E., Amrein, H. and Vosshall, L.B. (2004) Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron, 43, 703-714.
49. Leon, M. and Johnson, B.A. (2003) Olfactory coding in the mammalian olfactory bulb. Brain Res. Brain Res. Rev., 42, 23-32.
50. Linster, C., Wyble, B.P. and Hasselmo, M.E. (1999) Electrical stimulation of the horizontal limb of the diagonal band of Broca modulates population EPSPs in piriform cortex. J. Neurophysiol., 81, 2737-2742.
51. Lobel, D., Jacob, M., Volkner, M. and Breer, H. (2002) Odorants of different chemical classes interact with distinct odorant binding protein subtypes. Chem. Senses, 27, 39-44.
52. Luskin, M.B. and Price, J.L (1983) The topographic organization of associational fibers of the olfactory system in the rat, including centrifugal fibers to the olfactory bulb. J. Comp. Neurol., 216, 264-291.
53. Ma, M. and Shepherd, G.M. (2000) Functional mosaic organization of mouse olfactory receptor neurons. Proc. Natl Acad. Sci. USA, 97, 12869-12874.
54. Mackay-Sim, A. and Kesteven, S. (1994) Topographic patterns of responsiveness to odorants in the rat olfactory epithelium. J. Neurophysiol., 71, 150-160.
55. Mackay-Sim, A. and Shaman, P. (1984) Topographic coding of odorant quality is maintained at different concentrations in the salamander olfactory epithelium. Brain Res., 297, 207-216.
56. Mackay-Sim, A., Shaman, P. and Moulton, D.G. (1982) Topographic coding of olfactory quality: Odorant-specific patterns of epithelial responsivity in the salamander. J. Neurophysiol., 48, 584-596.
57. Macrides, F. (1975) Temporal relationships between hippocampal slow waves and exploratory sniffing in hamsters. Behav. Biol., 14, 295-308.
58. Macrides, F. (1977) Dynamic aspects of central olfactory processing. In Muller-Schwarze, D. and Mozell, M.M. (eds), Chemical Signals in Vertebrates. Plenum Press, New York, pp. 499-514.
59. Macrides, F. and Chorover, S.L. (1972) Olfactory bulb units: Activity correlated with inhalation cycles and odor quality. Science, 175, 84-87.
60. Macrides, F., Eichenbaum, H.B. and Forbes, W.B. (1982) Temporal relationship between sniffing and the limbic theta rhythm during odor discrimination reversal learning. J. Neurosci., 2, 1705-1717.
61. Marchand, J.E., Yang, X., Chikaraishi, D., Krieger, J., Breer, H. and Kauer, J.S. (2004) Olfactory receptor gene expression in tiger salamander olfactory epithelium. J. Comp. Neurol., 474, 453-467.
62. Margrie, T.W. and Schaefer, A.T. (2003) Theta oscillation coupled spike latencies yield computational vigour in a mammalian sensory system. J. Physiol., 546, 363-374.
63. McQuiston, A.R. and Katz, L.C. (2001) Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb. J. Neurophysiol., 86, 1899-1907.
64. Miyamichi, K., Serizawa, S., Kimura, H.M. and Sakano, H. (2005) Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb. J. Neurosci., 25, 3586-3592.
65. Mombaerts, P., Wang, F., Dulac, C., Chao, S.K., Nemes, A., Mendelsohn, M., Edmondson, J. and Axel, R. (1996) Visualizing an olfactory sensory map. Cell, 87, 675-686.
66. Moulton, D.G. (1976) Spatial patterning of response to odors in the peripheral olfactory system. Physiol. Rev., 56, 578-593.
67. Mozell, M.M. (1964) Evidence for sorption as a mechanism of the olfactory analysis of vapours. Nature, 203, 1181-1182.
68. Mozell, M.M. (1966) The spatiotemporal analysis of odorants at the level of the olfactory receptor sheet. J. Gen. Physiol., 50, 25-41.
69. Mozell, M.M. (1970) Evidence for a chromatographic model of olfaction. J. Gen. Physiol., 56, 46-63.
70. Mozell, M.M. and Jagodowicz, M. (1973) Chromatographic separation of odorants by the nose: Retention times measured across in vivo olfactory mucosa. Science, 181, 1247-1249.
71. Mozell, M.M., Kent, P.F. and Murphy, S.J. (1991) The effects of flow-rate upon the magnitude of the olfactory response differs for different odorants. Chem. Senses, 16, 631-649.
72. Mozell, M.M., Sheehe, P.R., Hornung, D.E., Kent, P.F., Youngentob, S.L. and Murphy, S.J. (1987) "Imposed" and "inherent" mucosal activity patterns. Their composite representation of olfactory stimuli. J. Gen. Physiol., 90, 625-650.
73. Mustaparta, H. (1971) Spatial distribution of receptor-responses to stimulation with different odours. Acta Physiol. Scand., 82, 154-166.
74. Nagao, H., Yamaguchi, M., Takahash, Y. and Mori, K. (2002) Grouping and representation of odorant receptors in domains of the olfactory bulb sensory map. Microsc. Res. Tech., 58, 168-175.
75. Nakashima, M., Mori, K. and Takagi, S.F. (1978) Centrifugal influence on olfactory bulb activity in the rabbit. Brain Res., 154, 301-306.
76. Neville, K.R. and Haberly, L.B. (2003) Beta and gamma oscillations in the olfactory system of the urethane-anesthetized rat. J. Neurophysiol., 90, 3921-3930.
77. Nickell, W.T. and Shipley, M.T. (1988) Neurophysiology of magnocellular forebrain inputs to the olfactory bulb in the rat: Frequency potentiation of field potentials and inhibition of output neurons. J. Neurosci., 8, 4492-4502.
78. Norlin, E.M., Alenius, M., Gussing, F., Hagglund, M., Vedin, V. and Bohm, S. (2001) Evidence for gradients of gene expression correlating with zonal topography of the olfactory sensory map. Mol. Cell. Neurosci., 18, 283-295.
79. Norlin, E.M. and Berghard, A. (2001) Spatially restricted expression of regulators of G-protein signaling in primary olfactory neurons. Mol. Cell. Neurosci., 17, 872-882.
80. Norlin, E.M., Vedin, V., Bohm, S. and Berghard, A. (2005) Odorant-dependent, spatially restricted induction of c-fos in the olfactory epithelium of the mouse. J. Neurochem., 93, 1594-1602.
81. Ohtake, P.J., Torres, J.E., Gozal, Y.M., Graff, G.R. and Gozal, D. (1998) NMDA receptors mediate peripheral chemoreceptor afferent input in the conscious rat. J. Appl. Physiol., 84, 853-861.
82. Onoda, N. and Mori, K. (1980) Depth distribution of temporal firing patterns in olfactory bulb related to air-intake cycles. J. Neurophysiol., 44, 29-39.
83. Ottoson D. (1956) Analysis of the electrical activity of the olfactory epithelium. Acta Physiol. Scand., 35(Suppl. 122), 1-83.
84. Paolini, A.G. and McKenzie, J.S. (1996) Lesions in the magnocellular preoptic nucleus decrease olfactory investigation in rats. Behav. Brain Res., 81, 223-231.
85. Paolini, A.G. and McKenzie, J.S. (1997a) Effects of inactivation of the magnocellular preoptic nucleus of olfactory bulb processing. Neuroreport, 8, 929-935.
86. Paolini, A.G. and McKenzie, J.S. (1997b) Intracellular recording of magnocellular preoptic neuron responses to olfactory brain. Neuroscience, 78, 229-242.
87. Philpot, S.D., Foster, T.C. and Brunjes, P.C. (1997) Mitral/tufted cell activity is attenuated and becomes uncoupled from respiration following naris closure. J. Neurobiol., 33, 374-386.
88. Ravel, N., Caille, D. and Pager, J. (1987) A centrifugal respiratory modulation of olfactory bulb unit activity: A study on acute rat preparation. Exp. Brain Res., 65, 623-628.
89. Ravel, N. and Pager, J. (1990) Respiratory patterning of the rat olfactory bulb unit activity: Nasal versus tracheal breathing. Neurosci Lett, 115, 213-218.
90. Rawson, N.E., Eberwine, J., Dotson, R., Jackson, J., Ulrich, P. and Restrepo, D. (2000) Expression of mRNAs encoding for two different olfactory receptors in a subset of olfactory receptor neurons. J. Neurochem., 75, 185-195.
91. Ressler, K.J., Sullivan, S.L. and Buck, L.B. (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell, 73, 597-609.
92. Ressler, K.J., Sullivan, S.L. and Buck, L.B. (1994) Information coding in the olfactory system: Evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell, 79, 1245-1255.
93. Rubin, B.D. and Katz, L.C. (1999) Optical imaging of odorant representations in the mammalian olfactory bulb. Neuron, 23, 499-511.
94. Saito, H., Kubota, M., Roberts, R.W., Chi, Q. and Matsunami, H. (2004) RTP family members induce functional expression of mammalian odorant receptors. Cell, 119, 679-691.
95. Sanhueza, M., Schmachtenberg, O. and Bacigalupo, J. (2000) Excitation, inhibition, and suppression by odors in isolated toad and rat olfactory receptor neurons. Am. J. Physiol. Cell Physiol., 279, C31-C39.
96. Sato, T., Hirono, J., Tonoike, M. and Takebayashi, M. (1994) Tuning specificities to aliphatic odorants in mouse olfactory receptor neurons and their local distribution. J. Neurophysiol., 72, 2980-2989.
97. Schild, D. and Manzini, I. (2004) Cascades of response vectors of olfactory receptor neurons in Xenopus laevis tadpoles. Eur. J. Neurosci., 20, 2111-2123.
98. Schoenfeld, T.A., Clancy, A.N., Forbes, W.B. and Macrides, F. (1994) The spatial organization of the peripheral olfactory system of the hamster. Part I: Receptor neuron projections to the main olfactory bulb. Brain Res. Bull., 34, 183-210.
99. Schoppa, N.E. and Westbrook, G.L. (2001) Glomerulus-specific synchronization of mitral cells in the olfactory bulb. Neuron, 31, 639-651.
100. Scott, J.W. and Brierley, T. (1999) A functional map in rat olfactory epithelium. Chem. Senses, 24, 679-690.
101. Scott, J.W., Brierley, T. and Schmidt, F.H. (2000) Chemical determinants of the rat electro-olfactogram. J. Neurosci., 20, 4721-4731.
102. Scott, J.W., Davis, L.M., Shannon, D. and Kaplan, C (1996) Relation of chemical structure to spatial distribution of sensory responses in rat olfactory epithelium. J. Neurophysiol., 75, 2036-2049.
103. Scott, J.W., Shannon, D.E., Charpentier, J., Davis, L.M. and Kaplan, C. (1997) Spatially organized response zones in rat olfactory epithelium. J. Neurophysiol., 77, 1950-1962.
104. Scott-Johnson, P.E., Blakley, D. and Scott, J.W. (2000) Effects of air flow on rat electroolfactogram. Chem. Senses, 25, 761-768.
105. Seifert, E.L. and Mortola, J.P. (2002) Circadian pattern of ventilation during prolonged hypoxia in conscious rats. Respir. Physiol. Neurobiol., 133, 23-34.
106. Sobel, E.C. and Tank, D.W. (1993) Timing of odor stimulation does not alter patterning of olfactory bulb unit activity in freely breathing rats. J. Neurophysiol., 69, 1331-1337.
107. Sobel, N., Khan, R.M., Hartley, C.A., Sullivan, E.V. and Gabrieli, J.D. (2000) Sniffing longer rather than stronger to maintain olfactory detection threshold. Chem. Senses, 25, 1-8.
108. Sobel, N., Prabhakaran, V., Desmond, J.E., Glover, G.H., Goode, R.L., Sullivan, E.V. and Gabrieli, J.D. (1998) Sniffing and smelling: Separate subsystems in the human olfactory cortex. Nature, 392, 282-286.
109. Stephenson, R., Liao, K.S., Hamrahi, H. and Horner, R.L. (2001) Circadian rhythms and sleep have additive effects on respiration in the rat. J. Physiol., 536, 225-235.
110. Stewart, W.B. and Pedersen, P.E. (1987) The spatial organization of olfactory nerve projections. Brain Res., 411, 248-258.
111. Strotmann, J., Wanner, I., Helfrich, T., Beck, A., Meinken, C., Kubick, S. and Breer, H. (1994) Olfactory neurones expressing distinct odorant receptor subtypes are spatially segregated in the nasal neuroepithelium. Cell Tissue Res., 276, 429-438.
112. Sullivan, S.L., Adamson, M.C., Ressler, K.J., Kozak, C.A. and Buck, L.B. (1996) The chromosomal distribution of mouse odorant receptor genes. Proc. Natl Acad. Sci. USA, 93, 884-888.
113. Takahashi, Y.K., Kurosaki, M., Hirono, S. and Mori, K. (2004) Topographic representation of odorant molecular features in the rat olfactory bulb. J. Neurophysiol., 92, 2413-2427.
114. Thommesen, G. and Døving, K.B. (1977) Spatial distribution of the EOG in the rat; a variation with odour quality. Acta Physiol. Scand., 99, 270-280.
115. Tsuboi, A., Yoshihara, S., Yamazaki, N., Kasai, H., Asai-Tsuboi, H., Komatsu, M., Serizawa, S., Ishii, T., Matsuda, Y., Nagawa, F. and Sakano, H. (1999) Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb. J. Neurosci., 19, 8409-8418.
116. Vassar, R., Chao, S.K., Sitcheran, R., Nunez, J.M., Vosshall, L.B. and Axel, R. (1994) Topographic organization of sensory projections to the olfactory bulb. Cell, 79, 981-991.
117. Vassar, R., Ngai, J. and Axel, R. (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell, 74, 309-318.
118. Vedin, V., Slotnick, B. and Berghard, A. (2004) Zonal ablation of the olfactory sensory neuroepithelium of the mouse: Effects on odorant detection. Eur. J. Neurosci., 20, 1858-1864.
119. Wachowiak, M. and Cohen, L.B. (2003) Correspondence between odorant-evoked patterns of receptor neuron input and intrinsic optical signals in the mouse olfactory bulb. J. Neurophysiol., 89, 1623-1639.
120. Walker, J.K., Lawson, B.L. and Jennings, D.B. (1997) Breath timing, volume and drive to breathe in conscious rats: Comparative aspects. Respir. Physiol., 107, 241-250.
121. Welker, W.I. (1964) Analysis of sniffing of the albino rat. Behaviour, 22, 223-244.
122. Wellis, D.P., Scott, J.W. and Harrison, T.A. (1989) Discrimination among odorants by single neurons of the rat olfactory bulb. J. Neurophysiol., 61, 1161-1177.
123. Whitby-Logan, G.K., Weech, M. and Walters, E. (2004) Zonal expression and activity of glutathione S-transferase enzymes in the mouse olfactory mucosa. Brain Res., 995, 151-157.
124. Xu, F., Liu, N., Kida, I., Rothman, D.L., Hyder, F. and Shepherd, G.M. (2003) Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc. Natl Acad. Sci. USA, 100, 11029-11034.
125. Young, T.A. and Wilson, D.A. (1999) Frequency-dependent modulation of inhibition in the rat olfactory bulb. Neurosci. Lett., 276, 65-67.
126. Youngentob, S.L. and Kent, P.F. (1995) Enhancement of odorant-induced mucosal activity patterns in rats trained on an odorant identification task. Brain Res., 670, 82-88.
127. Youngentob, S.L., Kent, P.F., Sheehe, P.R., Schwob, J.E. and Tzoumaka, E. (1995) Mucosal inherent activity patterns in the rat: Evidence from voltage-sensitive dyes. J. Neurophysiol., 73, 387-398.
128. Youngentob, S.L., Mozell, M.M., Sheehe, P.R. and Hornung, D.E. (1987) A quantitative analysis of sniffing strategies in rats performing odor detection tasks. Physiol. Behav., 41, 59-69.
129. Yu, T.T., McIntyre, J.C., Bose, S.C., Hardin, D., Owen, M.C. and McClintock, T.S. (2005) Differentially expressed transcripts from phenotypically identified olfactory sensory neurons. J. Comp. Neurol., 483, 251-262.
130. Zhang, X. and Bruce, E.N. (1998) Response of breathing pattern to flow and pressure in the upper airway of rats. Respir. Physiol., 113, 191-200.
131. Zhang, X. and Firestein, S. (2002) The olfactory receptor gene superfamily of the mouse. Nat. Neurosci., 5, 124-133.
132. Zhao, K., Dalton, P., Yang, G. and Scherer, P.W. (2005) Numerical modeling of turbulent and laminar airflow and odorant transport during sniff in the human and rat nose. Chem. Senses. 10.1093/chemse/bjj008.
133. Zhao, K., Scherer, P.W., Hajiloo, S.A. and Dalton, P. (2004) Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction. Chem. Senses, 29, 365-379.