Human responses to propionic acid. I. Quantification of within- and between-participant variation in perception by normosmics and anosmics

Chemical Senses

Volumn 23, Issue 1, 1998, Pages 71-82

  Kendal Reed, Martin ^a   Walker, James C ^b   Morgan, Walter T ^b   LaMacchio, Michelle ^b   Lutz, Richard W ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b R J REYNOLDS TOBACCO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROPIONIC ACID;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; FEMALE; HUMAN; MALE; NERVE STIMULATION; NORMAL HUMAN; ODOR; OLFACTORY NERVE; PERCEPTIVE DISCRIMINATION; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; SMELLING;

EID: 0031944768     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/23.1.71     Document Type: Article

References (47)

1. Abraham, M.H., Whiting, G.S., Alarie, Y., Morris, J.J., Taylor, P.J., Doherty, R.M., Taft, R.W. and Nielsen, G.D. (1990) Hydrogen bonding 12. A new QSAR for upper respiratory tract irritation by airborne chemicals in mice. Quant. Struct. Act. Relat., 9, 6-10.
2. Abraham, M.H., Andonian-Haftvan, J., Cometto-Muñiz, J.E. and Cain, W.S. (1996) An analysis of nasal irritation thresholds using a new solvation equation. Fundam. Appl. Toxicol., 31, 71-76.
3. Alarie, Y. (1981) Dose-response analysis in animal studies: prediction of human responses. Environ. Hlth Perspect., 42, 9-13.
4. Allen, W. (1929) Effect of various labeled vapours on respiration and blood pressure in anesthetized and unanesthetized, sleeping and anosmic subjects. Am. J. Physiol., 88, 620-632.
5. Amoore, J.E. and Steinle, S. (1991) A graphic history of specific anosmia. In Wysocki, C.J. and Kare, M.R. (eds), Chemical Senses, Vol. 3. Genetics of Perception and Communication. Marcel Dekker Inc., New York, pp. 331-351.
6. Amoore, J.E., Venstrom, D. and Davis, A.R. (1968) Measurement of specific anosmia. Percept. Motor Skills, 26, 143-164.
7. Benignus, V.A. and Prah, J.D. (1980) Flow thresholds of nonodorous air through the human naris as a function of temperature and humidity. Percept. Psychophys., 27, 569-573.
8. Buck, L. and Axel, R. (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell, 65, 175-187.
9. Burdach, K.J., Köster, E.P. and Kroeze, J.H.A. (1985) Interindividual differences in acuity for odor and aroma. Percept. Motor Skills, 60, 723-730.
10. Cain, W.S. and Cometto-Muniz, J.E. (1995) Irritation and odor as indicators of indoor pollution. Occ. Med., 10, 133-145.
11. Cometto-Muñiz, J.E. and Cain, W.S. (1994) Sensory reactions of nasal pungency and odor to volatile organic compounds: the alkylbenzenes. Am. Indust. Hyg. Assoc. J., 55, 811-817.
12. Devos, M., Patte, F., Rouault, J., Laffort, P. and Van Gemmert, L.J. (1990) Standardized Human Olfactory Thresholds. IRL Press, Oxford.
13. Doty, R.L. and Kobal, G. (1995) Current trends in the measurement of olfactory function. In Doty, R.L. (ed.), Handbook of Olfaction and Gustation. Marcel Dekker, New York, pp. 191-225.
14. Doty, R.L., Brugger, W.E., Jurs, P.C., Orndorff, M.A., Snyder, P.J. and Lowry, L.D. (1978) Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol. Behav., 20, 175-185.
15. Elsberg, C.A., Levy, I. and Brewer, E.D. (1935) The sense of smell VI. The trigeminal effects of odorous substances. Bull. Neurol. Inst. NY 4, 270-285.
16. Efron, B. (1982) The Jackknife, the Bootstrap and Other Resampling Plans. Society for Industrial and Applied Mathematics, Philadelphia, PA.
17. Gori, S., Massetani, R. and Murri, L. (1995) Evaluation of olfactory function by topographic EEG analysis in patients with Parkinson's disease. Ital. J. Neurol. Sci., 16, 595-601.
18. Gudziol, H. and Gramowski, K-H. (1987) Respirations-Olfaktometrie: eine objektivierende Methode zur quantativen Bewertung einer Hyposmie. Laryngol. Rhinol. Otol., 66, 570-572.
19. Gudziol, H. and Schubert, M. (1996) Investigations of trigeminal sensations by use of respiratory behavior. Poster presented at ECRO XII, Zürich.
20. Hyman, A.M. (1977) Factors influencing the psychophysical function for odor intensity. Sens. Process., 1, 273-291.
21. 2T) to evaluate nasal irritation. Poster presented to the XIXth Annual Meeting of the Association for Chemoreception Sciences, San Diego, CA, July 1997.
22. Kendal-Reed, M. and Van Toller, S. (1992) Brain electrical activity mapping: an exploratory study of infant response to odours. Chem. Senses, 17, 765-777.
23. Kendal-Reed, M. and Walker, J.C. (1996) Human respiratory responses to odorants. Chem. Senses, 21, 486.
24. Keverne, E.B., Murphy, C.L., Silver, W.L., Wysocki, C.J. and Meredith, M. (1986) Non-olfactory chemoreceptors of the nose: recent advances in understanding the vomeronasal and trigeminal systems. Chem. Senses, 11, 119-133.
25. Kobal, G., Kettenmann, B. and Stefan, H. (1995) Olfactory event-related magnetic fields: a new technique in localizing neocortical olfactory areas. Chem. Senses, 20, 164.
26. Laska, M., Distel, H. and Hudson, R. (1997) Trigeminal perception of odorant quality in congenitally anosmic subjects. Chem. Senses, 22, 447-456.
27. Lawless, H.T., Corrigan Thomas, C.J. and Johnston, M. (1995) Variation in odor thresholds for L-carvone and cineole and correlations with suprathreshold intensity ratings. Chem. Senses, 20, 9-17.
28. Leopold, D.A., Schwob, J.E., Hummel, T., Kobal, G., Knecht, M. and Hong, S.C. (1995) Anterior distribution of olfactory neuroepithelium. Paper presented to the XVIIth Annual Meeting of the Association for Chemoreception Sciences, Sarasota, FL, April 19-23, 1995.
29. Lorig, T.S. (1994) EEG and ERP studies of low-level odor exposure in normal subjects. Toxicol. Indust. Hlth, 10, 579-586.
30. Lundberg, J.M., Martling, C.-R. and Lundblad, L. (1988) Cigarette smoke-induced irritation in the airways in relation to peptide-containing, capsaicin-sensitive sensory neurons. Klin. Wochenschr., 66 (Suppl. XI), 151-160.
31. Maiolo, K.C., Walker, J.C. and Ogden, M.W. (1996) Method for calibrating olfactometer output. Part 1. Acetic and propionic acids. Anal. Commun., 33, 199-202.
32. Prah, J.D. and Benignus, V.A. (1984) Trigeminal sensitivity to contact chemical stimulation: a new method and some results. Percept. Psychophys., 35, 65-68.
33. Prah, J.D., Sears, S.B. and Walker, J.C. (1995) Modern approaches to air-dilution olfactometry. In Doty, R.L. (ed.), Handbook of Clinical Olfaction and Gustation. Marcel Dekker, New York, pp. 227-255.
34. Reilly, J.T. and Dalton, P.H. (1997) Stimulus fluctuation in the measurement of odor detection thresholds by static olfactometry. Paper presented to the XIXth Annual Meeting of the Association for Chemoreception Sciences, San Diego, CA, July 1997.
35. Shams Esfandabad, H. (1993) Perceptual Analysis of Odorous Irritants in Indoor Air. Department of Psychology, Stockholm University, Doctoral dissertation.
36. Stevens, J.C., Cain, W.S. and Burke, R.J. (1988) Variability of olfactory thresholds. Chem. Senses, 13, 643-653.
37. Stjärne, P., Lundblad, L., Änggård, A., Hökfelt, T. and Lundberg, J.M. (1989) Tachykinins and calcitonin gene-related peptide: co-existence in the sensory nerves of the nasal mucosa and effects on blood flow. Cell Tissue Res., 56, 439-446.
38. Van Toller, S., Behan, J., Howells, P., Kendal-Reed, M. and Richardson, A. (1993) An analysis of spontaneous human cortical EEG activity to odours. Chem. Senses, 18, 1-16.
39. von Gerhardt, H-J. and Rauh, Ch. (1963) Objektive Olfaktometrie Erfahrungen mit Atmungsregistrierung unter Geruchsreiz. Z. Laryngol. Rhinol. Otol., 42, 658-668.
40. Walker, J.C. and Jennings, R.A. (1991) Comparison of odor perception in humans and animals. In Laing, D.G., Doty, R.L. and Breipohl, W. (eds), The Human Sense of Smell. Springer-Verlag, Berlin, pp. 261-280.
41. Walker, J.C., Warren, D.W., Sidman, J.D., Jennings, R.A. and Reynolds, J.H., IV (1989) Psychophysical and respiratory responses of anosmic humans to odorants. In Døving, K.B. (ed.). Proceedings of the Tenth International Symposium on Olfaction and Taste (ISOT X), Norway. p. 375.
42. Walker, J.C., Kurtz, D.B, Shore, F.M., Ogden, M.W. and Reynolds, J.H., IV (1990a) Apparatus for the automated measurement of the responses of humans to odorants. Chem. Senses, 15, 165-177.
43. Walker, J.C., Reynolds, J.H., IV, Warren, D.W. and Sidman, J.D. (1990b) Responses of normal and anosmic subjects to odorants. In Green, B.G., Mason, J.R. and Kare, M.R.(eds), Chemical Senses, Vol. 2. Irritation. Marcel Dekker Inc., New York, pp. 95-117.
44. Walker, J.C., Jennings, R.A., Nelson, P.R., Morgan, W.T., Heavner, D.L., Robinson, J.H., deBethizy, J.D. and Stancill, M.W. (1993) Sensory responses to environmental tobacco smoke from tobacco-burning and tobacco-heating cigarettes. Indoor Air, 3, 170-180.
45. Walker, J.C., Nelson, P.R., Cain W.S., Utell, M.J., Joyce, M.B., Morgan, W.T., Steichen, T.J., Pritchard, W.S. and Stancill, M.W. (1997) Perceptual and psychophysiological responses of non-smokers to a range of environmental tobacco smoke concentrations. Indoor Air, 7, 173-188.
46. Warren, D., Walker, J.C., Drake, A.F. and Lutz, R. (1992) Assessing the effects of odorants on nasal airway size and breathing. Physiol. Behav., 51, 425-430.
47. Warren, D., Walker, J.C., Drake, A.F. and Lutz, R. (1994) Effects of odorants and irritants on respiratory behavior. Laryngoscope, 104, 623-626.