Identification and characterization of two novel splicing isoforms of human estrogen-related receptor β

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 2, 2006, Pages 569-579

  Zhou, Wei ^a   Liu, Zhilin ^a   Wu, Jianbo ^c   Liu, Jing Hua ^a,c   Hyder, Salman M ^c   Antoniou, Eric ^a   Lubahn, Dennis B ^a,b,c  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; ESTROGEN RELATED RECEPTOR BETA; ESTROGEN RELATED RECEPTOR BETA2; LUCIFERASE; RECEPTOR SUBTYPE; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; DNA FLANKING REGION; ESTROGEN RESPONSIVE ELEMENT; FEMALE; GENE CONTROL; GENE IDENTIFICATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TESTIS; TRANSCRIPTION INITIATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, WESTERN; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

ANIMALIA; PRIMATES;

EID: 32544441388     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1957     Document Type: Article

References (35)

1. Giguere V 2002 To ERR in the estrogen pathway. Trends Endocrinol Metab 13:220-225
2. Giguere V, Yang N, Segui P, Evans RM 1988 Identification of a new class of steroid hormone receptors. Nature 331:91-94
3. Luo J, Sladek R, Bader JA, Matthyssen A, Rossant J, Giguere V 1997 Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β. Nature 388:778-782
4. Lu D, Kiriyama Y, Lee KY, Giguere V 2001 Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors. Cancer Res 61:6755-6761
5. Trapp T, Holsboer F 1996 Nuclear orphan receptor as a repressor of glucocorticoid receptor transcriptional activity. J Biol Chem 271:9879-9882
6. Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM 1999 Constitutive activation of transcription and binding of coactivator by estrogenrelated receptors 1 and 2. Mol Endocrinol 13:2151-2162
7. Vanacker JM, Pettersson K, Gustafsson JA, Laudet V 1999 Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ. EMBO J 18:4270-4279
8. Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguere V 2001 Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERRβ. Genes Dev 15:833-838
9. Tremblay GB, Bergeron D, Giguere V 2001 4-Hydroxytamoxifen is an isoformspecific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors β and γ. Endocrinology 142:4572-4575
10. Coward P, Lee D, Hull MV,Lehmann JM 2001 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ. Proc Natl Acad Sci USA 98:8880-8884
11. Suetsugi M, Su L, Karisberg K, Yuan Y, Chen S 2003 Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptor. Mol Cancer Res 1:981-991
12. Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT 1999 Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene 228:101-109
13. Pettersson K, Svensson K, Mattsson R, Carlsson B, Ohlsson R, Berkenstam A 1996 Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev 54:211-223
14. Oesterreich S, Zhang P, Guler RL, Sun X, Curran EM, Welshons WV, Osborne CK, Lee AV 2001 Re-expression of estrogen receptor α in estrogen receptor α-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Res 61:5771-5777
15. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D 2002 The human genome browser at UCSC. Genome Res 12:996-1006
16. Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu YT, Roskin KM, Schwartz M, Sugnet CW, Thomas DJ, Weber RJ, Haussler D, Kent WJ 2003 The UCSC genome browser database. Nucleic Acids Res 31:51-54
17. Ansell PJ, Espinosa-Nicholas C, Curran EM, Judy BM, Philips BJ, Hannink M, Lubahn DB 2004 In vitro and in vivo regulation of antioxidant response elementdependent gene expression by estrogens. Endocrinology 145:311-317
18. Welshons WV, Lieberman ME, Gorski J 1984 Nuclear localization of unoccupied oestrogen receptors. Nature 307:747-749
19. Picard D, Kumar V, Chambon P, Yamamoto KR 1990 Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors. Cell Regul 1:291-299
20. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, et al 2001 Initial sequencing and analysis of the human genome. Nature 409:860-921
21. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, et al 2001 The sequence of the human genome. Science 291:1304-1351
22. Mironov AA, Fickett JW, Gelfand MS 1999 Frequent alternative splicing of human genes. Genome Res 9:1288-1293
23. Croft L, Schandorff S, Clark F, Burrage K, Arctander P, Mattick JS 2000 ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome. Nat Genet 24:340-341
24. Brett D, Hanke J, Lehmann G, Haase S, Delbruck S, Krueger S, Reich J, Bork P 2000 EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. FEBS Lett 474:83-86
25. Lou H, Gagel RF 2001 Alternative ribonucleic acid processing in endocrine systems. Endocr Rev 22:205-225
26. Flouriot G, Griffin C, Kenealy M, Sonntag-Buck V, Gannon F 1998 Differentially expressed messenger RNA isoforms of the human estrogen receptor-α gene are generated by alternative splicing and promoter usage. Mol Endocrinol 12:1939-1954
27. Petersen DN, Tkalcevic GT, Koza-Taylor PH, Turi TG, Brown TA 1998 Identification of estrogen receptor β2, a functional variant of estrogen receptor β expressed in normal rat tissues. Endocrinology 139:1082-1092
28. Lu B, Leygue E, Dotzlaw H, Murphy LJ, Murphy LC, Watson PH 1998 Estrogen receptor-β mRNA variants in human and murine tissues. Mol Cell Endocrinol 138:199-203
29. Yang N, Shigeta H, Shi H, Teng CT 1996 Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J Biol Chem 271:5795-5804
30. Johnston SD, Liu X, Zuo F, Eisenbraun TL, Wiley SR, Kraus RJ, Mertz JE 1997 Estrogen-related receptor α1 functionally binds as a monomer to extended halfsite sequences including ones contained within estrogen-response elements. Mol Endocrinol 11:342-352
31. Heard DJ, Norby PL, Holloway J, VissingH2000 Human ERRγ, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol Endocrinol 14:382-392
32. Ariazi EA, Clark GM, Mertz JE 2002 Estrogen-related receptor α and estrogenrelated receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res 62:6510-6518
33. Montano MM, Muller V, Trobaugh A, Katzenellenbogen BS 1995 The carboxyterminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists. Mol Endocrinol 9:814-825
34. Nichols M, Rientjes JM, Stewart AF 1998 Different positioning of the ligandbinding domain helix 12 and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists. EMBO J 17:765-773
35. Schwartz JA, Zhong L, Deighton-Collins S, Zhao C, Skafar DF 2002 Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-α alter its response to estradiol and 4-hydroxytamoxifen. J Biol Chem 277:13202-13209