Species variations in the biliary and urinary excretion of arsenate, arsenite and their metabolites

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 131, Issue 3, 2002, Pages 355-365

  Csanaky, Iván ^a   Gregus, Zoltán ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Arsenic; Biliary excretion; Guinea pig; Hamster; Methylation; Monomethylarsonous acid; Mouse; Rabbit; Rat; Species variations; Urinary excretion

Indexed keywords

ARSENIC ACID; ARSENIC TRIOXIDE; BILE ACID; CACODYLIC ACID; METHANEARSONIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BILE FLOW; CONTROLLED STUDY; GUINEA PIG; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLITE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SPECTROFLUOROMETRY; TOXICOKINETICS; URINARY EXCRETION; URINE LEVEL;

ANIMALIA; CAVIA; CAVIA PORCELLUS; CRICETINAE; MAMMALIA; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0036131143     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1532-0456(02)00018-2     Document Type: Article

References (38)

1. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity
2. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic
3. DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine
4. Study of inorganic arsenic methylation by rat liver in vitro: Relevance for the interpretation of observations in man
5. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RARα/PML proteins
6. In vitro effect of arsenical compounds on glutathione-related enzymes
7. Effect of phosphate transporter and methylation inhibitor drugs on the disposition of arsenate and arsenite in rats
8. The metabolism of methylarsine oxide and sulfide
9. The separation of dimethylarsinic acid, methylarsonous acid, methylarsonic acid, arsenate and dimethylarsinous acid on the Hamilton PRP-X100 anion-exchange column
10. Interrelations of arsenate and phosphate transport in the dog kidney
11. The enigma of arsenic carcinogenesis: Role of metabolism
12. Evaluation of atomic fluorescence spectrometry as a sensitive detection technique for arsenic speciation
13. Role of glutathione in the biliary excretion of the arsenical drugs trimelarsen and melarsoprol
14. Biliary and urinary excretion of inorganic arsenic. Monomethylarsonous acid as a major biliary metabolite in rats
15. Effect of arsenicals on biliary excretion of glutathione and xenobiotics undergoing conjugation with glutathione
16. Glutathione-dependent biliary excretion of arsenic
17. Resistance to the phosphaturic effect of parathyroid hormone in the hamster
18. Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig
19. Radioactive tracer studies on arsenic injected as potassium arsenite
20. Species differences in the transport activity for organic anions across the bile canalicular membrane
21. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
22. Tissue distribution of inorganic arsenic (iAs) and its methylated metabolites in mice following oral administration of arsenate (AsV)
23. Biliary excretion of arsenic in rats, rabbits and dogs
24. Speciation of key arsenic metabolic intermediates in human urine
25. The metabolism of arsenite and arsenate by the rat
26. Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase
27. Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India
28. Methylated trivalent arsenic species are genotoxic
29. Monomethylarsonous acid (MMAIII) is more toxic than arsenite in Chang human hepatocytes
30. Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase
31. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide
32. Species variations in biliary excretion of glutathione-related thiols and methylmercury
33. Comparative in vitro methylation of trivalent and pentavalent arsenicals
34. Mono- and dimethylation of arsenic in rat liver cytosol in vitro
35. Metabolism of arsenic in primary cultures of human and rat hepatocytes
36. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells
37. Species differences in the metabolism of arsenic
38. Metabolism and excretion of orally and intraperitoneally administered methylarsonic acid in the hamster