Stop the killer: How to inhibit the anthrax lethal factor metalloprotease

Trends in Biochemical Sciences

Volumn 29, Issue 6, 2004, Pages 282-285

  Montecucco, Cesare ^a   Tonello, Fiorella ^b   Zanotti, Giuseppe ^a  

^a Istituto Veneto di Medicina Molecolare   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; ANTIBIOTIC AGENT; CATECHIN; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; HYDROXAMIC ACID DERIVATIVE; ILOMASTAT; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; NSC 12155; NSC 357756; NSC 369721; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTHRAX; BACILLUS ANTHRACIS; BACTEREMIA; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; LETHAL GENE; MEMBRANE PERMEABILITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SCREENING; TOXEMIA;

ANTHRAX; BACILLUS ANTHRACIS; POSIBACTERIA;

EID: 3242804491     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2004.04.011     Document Type: Short Survey

References (24)

1. Mock M., Fouet A. Anthrax. Annu. Rev. Microbiol. 55:2001;647-671
2. Dixon T.C., et al. Anthrax. New Engl. J. Med. 341:1999;815-826
3. Atlas R.M. Bioterriorism: from threat to reality. Annu. Rev. Microbiol. 56:2002;167-185
4. Bradley K.A., Young J.A. Anthrax toxin receptor proteins. Biochem. Pharmacol. 65:2003;309-314
5. Molloy S.S., et al. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J. Biol. Chem. 267:1992;16396-16402
6. Lacy D.B., Collier R.J. Structure and function of anthrax toxin. Curr. Top. Microbiol. Immunol. 271:2002;61-85
7. Abrami L., et al. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J. Cell Biol. 160:2003;321-328
8. Menard A., et al. The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxin. FEBS Lett. 386:1996;161-164
9. Leppla S.H. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc. Natl. Acad. Sci. U. S. A. 79:1982;3162-3166
10. Duesbery N.S., et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science. 280:1998;734-737
11. Vitale G., et al. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem. Biophys. Res. Commun. 248:1998;706-711
12. Vitale G., et al. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem. J. 352:2000;739-745
13. Pannifer A.D., et al. Crystal structure of the anthrax lethal factor. Nature. 414:2001;229-233
14. Pearson G., et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22:2001;153-183
15. Tanoue T., Nishida E. Molecular recognitions in the MAP kinase cascades. Cell Signal. 15:2003;455-462
16. Biondi R.M., Nebreda A.R. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem. J. 372:2003;1-13
17. Chaudry G.J., et al. Quickening the pace of anthrax research: three advances point towards possible therapies. Trends Microbiol. 10:2002;58-62
18. Tonello F., et al. Screening inhibitors of anthrax lethal factor. Nature. 418:2002;386
19. Cummings R.T., et al. A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease. Proc. Natl. Acad. Sci. U. S. A. 99:2002;6603-6606
20. Soelaiman S., et al. Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J. Biol. Chem. 278:2003;25990-25997
21. Turk B.E., et al. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat. Struct. Mol. Biol. 11:2004;60-66
22. Panchal R.G., et al. Identification of small molecule inhibitors of anthrax lethal factor. Nat. Struct. Mol. Biol. 11:2004;67-72
23. Roques B.P. Novel approaches to targeting neuropeptide systems. Trends Pharmacol. Sci. 21:2000;475-483
24. Dell'Aica I., et al. Potent inhibitors of anthrax lethal factor from green tea. EMBO Rep. 5:2004;418-422