Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 25990-25997

  Soelaiman, Sandriyana ^a   Wei, Binqing Q ^b   Bergson, Pamela ^a   Lee, Young Sam ^a   Shen, Yuequan ^a   Mrksich, Milan ^a   Shoichet, Brian K ^c   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DATABASE SYSTEMS; DISEASE CONTROL; MOLECULAR WEIGHT; SURFACE PLASMON RESONANCE; TOXIC MATERIALS;

PATHOGENS;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ADENYLYLCYCLASE 1; ADENYLYLCYCLASE 2; ADENYLYLCYCLASE 5; ANTITOXIN; CALMODULIN; ETHYL 5 AMINOPYRAZOLO[1,5 A]QUINAZOLINE 3 CARBOXYLATE; QUINAZOLINE DERIVATIVE; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTHRAX; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; NONHUMAN; PERTUSSIS; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; BACILLUS ANTHRACIS; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; CALMODULIN; CATALYTIC DOMAIN; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; LIGHT; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; PYRAZOLES; QUINAZOLINES; SCATTERING, RADIATION; SOFTWARE; SURFACE PLASMON RESONANCE; VIPER VENOMS;

ANIMALIA; ANTHRAX; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0037493019     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301232200     Document Type: Article

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