Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart

British Journal of Pharmacology

Volumn 142, Issue 4, 2004, Pages 627-634

  Liu, Hui Rong ^a   Gao, Feng ^b   Tao, Ling ^a   Yan, Wen Li ^b   Gao, Erhe ^a   Christopher, Theodore A ^a   Lopez, Bernard L ^a   Hu, Aihua ^a   Ma, Xin L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Calcium; Reperfusion injury

Indexed keywords

BENIDIPINE; CALCIUM CHANNEL BLOCKING AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DRUG VEHICLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; RECEPTOR; SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; MITOCHONDRION; MOLECULE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; STAINING;

ANIMALS; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CASPASE 8; CASPASE 9; CASPASES; CORONARY VESSELS; CYTOCHROMES C; DIHYDROPYRIDINES; FLAVONOIDS; MALE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 3242779223     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705847     Document Type: Article

References (37)

1. ARNOULT, D., PARONE, P., MARTINOU, J.C., ANTONSSON, B., ESTAQUIER, J. & AMEISEN, J.C. (2002). Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J. Cell Biol., 159, 923-929.
2. BAGCHI, D., WETSCHER, G.J., BAGCHI, M., HINDER, P.R., PERDIKIS, G., STOHS, S.J., HINDER, R.A. & DAS, D.K. (1997). Interrelationship between cellular calcium homeostasis and free radical generation in myocardial reperfusion injury. Chem. Biol. Interact., 104, 65-85.
3. BRENNER, C. & KROEMER, G. (2000). Apoptosis. Mitochondria - the death signal integrators. Science, 289, 1150-1151.
4. BUCKLEY, S., DRISCOLL, B., BARSKY, L., WEINBERG, K., ANDERSON, K. & WARBURTON, D. (1999). ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2. Am. J. Physiol., 277, L159-L166.
5. CHEN, S.J., BRADLEY, M.E. & LEE, T.C. (1998). Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: modulation by calcium-regulated proteases and protein kinases. Mol. Cell Biochem., 178, 141-149.
6. CLERK, A., FULLER, S.J., MICHAEL, A. & SUGDEN, P.H. (1998). Stimulation of 'stress-regulated' mitogen-activated protein kinases (stress-activated protein kinases c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses. J. Biol. Chem., 273, 7228-7234.
7. DAS, D.K., ENGELMAN, R.M. & MAULIK, N. (1999). Oxygen free radical signaling in ischemic preconditioning. Ann. N. Y. Acad. Sci., 874, 49-65.
8. FEUERSTEIN, G.Z. & YOUNG, P.R. (2000). Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc. Res., 45, 560-569.
9. GAO, F., GAO, E., YUE, T.L., OHLSTEIN, E.H., LOPEZ, B.L., CHRISTOPHER, T.A. & MA, X.L. (2002). Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation, 105, 1497-1502.
10. GAO, F., GONG, B., CHRISTOPHER, T.A., LOPEZ, B.L., KARASAWA, A. & MA, X.L. (2001). Anti-apoptotic effect of benidipine, a long-lasting vasodilating calcium antagonist, in ischaemic/reperfused myocardial cells. Br. J. Pharmacol., 132, 869-878.
11. GOTTLIEB, R.A. & ENGLER, R.L. (1999). Apoptosis in myocardial ischemia-reperfusion. Ann. N.Y. Acad. Sci., 874, 412-426.
12. GREEN, D.R. & REED, J.C. (1998). Mitochondria and apoptosis. Science, 281, 1309-1312.
13. GROSS, A., MCDONNELL, J.M. & KORSMEYER, S.J. (1999). BCL-2 family members and the mitochondria in apoptosis. Genes Dev., 13, 1899-1911.
14. HANEDA, M., SUGIMOTO, T. & KIKKAWA, R. (1999). Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade. Eur. J. Pharmacol., 365, 1-7.
15. INOMATA, K. & TANAKA, H. (2003). Protective effect of benidipine against sodium azide-induced cell death in cultured neonatal rat cardiac myocytes. J. Pharmacol. Sci., 93, 163-170.
16. KAJSTURA, J., CHENG, W., REISS, K., CLARK, W.A., SONNENBLICK, E.H., KRAJEWSKI, S., OLIVETTI, G. & ANVERSA, P. (1996). Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest., 74, 86-107.
17. KITAKAZE, M., KARASAWA, A., KOBAYASHI, H., TANAKA, H., KUZUYA, T. & HORI, M. (1999). Benidipine: a new calcium channel blocker with a cardioprotective effect. Cardiovasc. Drug Rev., 17, 1-15.
18. KONOPLEVA, M., ZHAO, S., XIE, Z., SEGALL, H., YOUNES, A., CLAXTON, D.F., ESTROV, Z., KORNBLAU, S.M. & ANDREEFF, M. (1999). Apoptosis. Molecules and mechanisms. Adv. Exp. Med. Biol., 457, 217-236.
19. KRIJNEN, P.A., NIJMEIJER, R., MEIJER, C.J., VISSER, C.A., HACK, C.E. & NIESSEN, H.W. (2002). Apoptosis in myocardial ischaemia and infarction. J. Clin. Pathol., 55, 801-811.
20. LEFER, A.M., POLANSKY, E.W., BIANCHI, C.P. & NARAYAN, S. (1979). Influence of verapamil on cellular integrity and electrolyte concentrations of ischemic myocardial tissue in the cat. Basic Res. Cardiol., 74, 555-567.
21. LORENZO, H.K., SUSIN, S.A., PENNINGER, J. & KROEMER, G. (1999). Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ., 6, 516-524.
22. MA, X.L., KUMAR, S., GAO, F., LOUDEN, C.S., LOPEZ, B.L., CHRISTOPHER, T.A., WANG, C.L., LEE, J.C., FEUERSTEIN, G.Z. & YUE, T.L. (1999). Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation, 99, 1685-1691.
23. MASON, R.P., LEEDS, P.R., JACOB, R.F., HOUGH, C.J., ZHANG, K.G., MASON, P.E. & CHUANG, D.M. (1999). Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. J. Neurochem., 72, 1448-1456.
24. MCCONKEY, D.J. & ORRENIUS, S. (1997). The role of calcium in the regulation of apoptosis. Biochem. Biophys. Res. Commun., 239, 357-366.
25. MORISHIMA, N., NAKANISHI, K., TAKENOUCHI, H., SHIBATA, T. & YASUHIKO, Y. (2002). An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem., 277, 34287-34294.
26. OTT, M., ROBERTSON, J.D., GOGVADZE, V., ZHIVOTOVSKY, B. & ORRENIUS, S. (2002). Cytochrome c release from mitochondria proceeds by a two-step process. Proc. Natl. Acad. Sci. U.S.A., 99, 1259-1263.
27. PEITSCH, M.C., POLZAR, B., STEPHAN, H., CROMPTON, T., MACDONALD, H.R., MANNHERZ, H.G. & TSCHOPP, J. (1993). Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J., 12, 371-377.
28. RAAFAT, A.M., MURRAY, M.T., MCGUIRE, T., DEFRAIN, M., FRANKO, A.P., ZAFAR, R.S., PALMER, K., DIEBEL, L. & DULCHAVSKY, S.A. (1997). Calcium blockade reduces renal apoptosis during ischemia reperfusion. Shock, 8, 186-192.
29. SCHEID, M.P., SCHUBERT, K.M. & DURONIO, V. (1999). Regulation of Bad phosphorylation and association with Bcl-xL by the MAPK/Erk kinase. J. Biol. Chem., 274, 31108-31113.
30. TAFANI, M., KARPINICH, N.O., HURSTER, K.A., PASTORINO, J.G., SCHNEIDER, T., RUSSO, M.A. & FARBER, J.L. (2002). Cytochrome c release upon Fas receptor activation depends on translocation of full-length Bid and the induction of the mitochondrial permeability transition. J. Biol. Chem., 277, 10073-10082.
31. THORNBERRY, N.A. & LAZEBNIK, Y. (1998). Caspases: enemies within. Science, 281, 1312-1316.
32. YAMAMOTO, M., GOTOH, Y., IMAIZUMI, Y. & WATANABE, M. (1990). Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells. Br. J. Pharmacol., 100, 669-676.
33. YANG, J.C. & CORTOPASSI, G.A. (1998). Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radic. Biol. Med., 24, 624-631.
34. YANG, J., LIU, X., BHALLA, K., KIM, C.N., IBRADO, A.M., CAI, J., PENG, T.I., JONES, D.P. & WANG, X. (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science, 275, 1129-1132.
35. YUAN, Z., KISHIMOTO, C. & SHIOJI, K. (2003). Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase. Circ. J., 67, 545-550.
36. YUE, T.L., WANG, C., GU, J.L., MA, X.L., KUMAR, S., LEE, J.C., FEUERSTEIN, G.Z., THOMAS, H., MALEEFF, B. & OHLSTEIN, E.H. (2000). Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ. Res., 86, 692-699.
37. ZHOU, B., WANG, Z.X., ZHAO, Y., BRAUTIGAN, D.L. & ZHANG, Z.Y. (2002). The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J. Biol. Chem., 277, 31818-31825.