Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells

Journal of Neurochemistry

Volumn 72, Issue 4, 1999, Pages 1448-1456

  Mason, R Preston ^a   Leeds, Peter R ^b   Jacob, Robert F ^a   Hough, Christopher J ^b   Zhang, Kai Gao ^b   Mason, Pamela E ^a   Chuang, De Maw ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Antioxidants; Apoptosis; Ca2+ channel blockers; Cerebellar granule cells

Indexed keywords

ALPHA TOCOPHEROL; AMLODIPINE; ANTIOXIDANT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; HEMOGLOBIN; MELATONIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE; NIFEDIPINE; NIMODIPINE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHLORIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CEREBELLUM; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG POTENCY; GRANULE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STROKE;

AMLODIPINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL AGING; CELLS, CULTURED; CEREBELLUM; CHROMATIN; DNA FRAGMENTATION; HEMOGLOBINS; ION CHANNEL GATING; LIPID PEROXIDATION; LIPOSOMES; MELATONIN; NEURONS; NIMODIPINE; NITRIC OXIDE; NITROARGININE; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

ANIMALIA;

EID: 0033034786     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.721448.x     Document Type: Article

References (41)

1. Balazs L. and Leon M. (1994) Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem. Res. 19, 1131-1137.
2. Bauerle H. D. and Seelig J. (1991) Interaction of charged and uncharged calcium channel antagonists with phospholipid membranes. Binding equilibrium, binding enthalpy, and membrane location. Biochemistry 30, 7203-7211.
3. Cagnoli C. M., Atabay C. Kharlamova E., and Manev H. (1995) Melatonin protects neurons from singlet oxygen-induced apoptosis. J. Pineal Res. 18, 222-226.
4. Choi J. H. and Yu B. P. (1995) Brain synaptosomal aging: free radicals and membrane fluidity. Free Radic. Biol. Med. 18, 133-139.
5. Chuang D. M., Leeds P., Zhang K. G., Gao X. M., and Ishitani R. (1995) Anti-oxidants and NMDA receptor antagonists protect against age-induced apoptosis in cerebellar granule cells. Soc Neurosci. Abstr. 21, 1553.
6. Cotman C. W., Pike C. J., and Copani A. (1992) β-Amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol. Aging 13, 587-590.
7. Coyle J. T. and Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
8. Deyo R. A., Straube K. T., and Disterhoft J. F. (1989) Nimodipine facilitates associative learning in aging rabbits. Science 243, 809-811.
9. el-Saadani M., Esterbauer H., el-Sayed M., Goher M., Nassar A. Y., and Jurgens G. (1989) A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J. Lipid Res. 30, 627-630.
10. Gallo V., Kingsbury A., Balazs R., and Jorgensen O. S. (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7, 2203-2213.
11. Garthwaite J. (1991) Glutamate, nitric oxide and cell-cell signalling in the nevous system. Trends Neurosci. 14, 60-67.
12. Giusti P., Gusella M., Lipartiti M., Milani D., Zhu W., Vicini S., and Manev H. (1995) Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity. Exp. Neurol. 131, 39-46.
13. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
14. Harman D. (1982) The free radical theory of aging, in Free Radicals in Biology (Pryor W. A., ed), pp. 255-275. Academic Press, New York.
15. Ishitani R., Sunaga K., Hirano A., Saunders P., Katsube N., and Chuang D.-M. (1996) Evidence that glyceraldehyde-3-phosphate dehydrogenease is involved in age-induced apoptosis in mature cerebellar neurons in culture. J. Neurochem. 66, 928-935.
16. +-induced apoptosis but not necrosis of cultured cerebellar granule cells. Mol. Pharmacol. 51, 542-550.
17. Janero D. R. and Burghardt B. (1989) Antiperoxidant effects of dihydropyridine calcium antagonists. Biochem. Pharmacol. 38, 4344-4348.
18. Johnson E. M. Jr., Greenlund L. J., Atkins P. T., and Hsu C. Y. (1995) Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury. J. Neurotrauma 12, 843-852.
19. Kass R. S. and Arena J. P. (1989) Influence of pH on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor. J. Gen Physiol. 93, 1109-1127.
20. Kowalska M. and Disterhoft J. F. (1994) Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits Exp. Neurol. 127, 159-166.
21. Lin W. W., Wang C. W., and Chuang D.-M. (1997) Effects of depolarization and NMDA antagonists on the survival of cerebellar granule cells: a pivotal role of protein kinase C isoforms. J. Neurochem. 68, 2577-2586.
22. Mak I. T., Boehme P., and Weglicki W. B. (1992) Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels. Circ. Res. 70, 1099-1103.
23. Manev H., Kharlamov E., Uz T., Mason R. P., Cagnoli C. M. (1997) Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells. Exp. Neurol. 146, 171-178.
24. Margolis R. L., Chuang D. M., and Post R. M. (1994) Programmed cell death: implications for neuropsychiatric disorders. Biol. Psychiatry 35, 946-956.
25. Markesbery W. R. (1992) Alzheimer's disease, in Diseases of the Nervous System: Clinical Neurobiology, pp. 795-803. W. B. Saunders, Philadelphia.
26. Mason R. P. (1994) Probing membrane bilayer interactions of 1,4-dihydropyridine calcium channel blockers. Implications for aging and Alzheimer's disease. Ann. NY Acad. Sci. 747, 125-139.
27. Mason R. P., Campbell S. F., Wang S. D., and Herbette L. G. (1989) Comparison of location and binding for the positively charged 1,4-dihydropyridine calcium channel antagonist amlodipine with uncharged drugs of this class in cardiac membranes. Mol. Pharmacol. 36, 634-640.
28. 2+ channel blockers to the membrane lipid bilayer. Mol. Pharmacol. 41, 315-321.
29. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
30. Narula J., Haider N., Virmani R., DiSalvo T. G., Kolodgie F. D., Hajjar R. J., Schmidt U., Semigran M. J., Dec G. W., and Khaw B. A. (1996) Apoptosis in myocytes in end-stage heart failure. N. Engl. J. Med. 335, 1182-1189.
31. Nonaka S., Hough C. J., and Chuang D. M. (1998) Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc. Natl. Acad. Sci. USA 95, 2642-2647.
32. Olivetti G., Abbi R., Quaini F., Kajstura J., Cheng W., Nitahara J. A., Quaini E., DiLoreto C., Beltrami C. A., Krajewski S., Reed J. C., and Anversa P. (1997) Apoptosis in the failing human heart. N. Engl. J. Med. 336, 1131-1141.
33. 2+ in toxic cell killing. Trends Pharmacol. Sci. 10, 281-285.
34. Packer M., O'Connor C. M., Ghali J. K., Pressler M. L., Carson P. E., Belkin R. N., Miller A. B., Neuberg G. W., Frid D., Wertheimer J. H., Cropp A. B., and DeMets D. L. (1996) Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group. N. Engl. J. Med. 335, 1107-1114.
35. Pozo D., Reiter R. J., Calvo J. R., and Guerrero J. M. (1994) Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci. 55, 455-460.
36. Quartermain D., Hawxhurst A., Ermita B., and Puente J. (1993) Effect of the calcium channel blocker amlodipine on memory in mice. Behav. Neural Biol 60, 211-219.
37. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E. R., Floyd R. A., and Markesbery W. R. (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl. Acad. Sci. USA 88, 10540-10543.
38. Sugden D., Pickering H., Teh M. T., and Garratt P. J. (1998) Melatonin receptor pharmacology: toward subtype specificity. Biol. Cell 89, 531-537.
39. Tan D. F., Chen L. D., Poeggeler B., Manchester L. C., and Reiter R. J. (1993) Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr. J. 1, 57-60.
40. Trump B. F. and Berezesky I. K. (1995) Calcium-mediated cell injury and cell death. FASEB J. 92, 219-228.
41. Wyllie A. H., Kerr J. F., and Currie A. R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-306.