Recent advances in understanding the clinical utility and underlying cause of antinucleosome (antichromatin) autoantibodies

Clinical and Applied Immunology Reviews

Volumn 4, Issue 5, 2004, Pages 351-366

  Burlingame, Rufus W ^a  

^a INOVA DIAGNOSTICS INC   (United States)

Author keywords

Antinucleosome autoantibodies; Chromatin; Systemic lupus erythematosus

Indexed keywords

ABETIMUS; ANTINUCLEOSOME AUTOANTIBODY; AUTOANTIBODY; DEOXYRIBONUCLEASE I; DNA ANTIBODY; HISTONE ANTIBODY; HYDRALAZINE; PROCAINAMIDE; QUINIDINE; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; AUTOIMMUNE HEPATITIS; CHROMATIN; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE MARKER; DRUG INDUCED DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULONEPHRITIS; HUMAN; IMMUNOASSAY; IMMUNOREACTIVITY; IN VITRO STUDY; LUPOID HEPATITIS; LUPUS ERYTHEMATOSUS; MOLECULAR MECHANICS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 3242763856     PISSN: 15291049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cair.2004.04.002     Document Type: Review

References (77)

1. Amoura Z. Piette J.-C. Bach J.-F. Koutouzov S. The key role of nucleosomes in lupus Arthritis Rheum 42 1999 833-843
2. Burlingame R.W. Boey M.L. Starkebaum G. Rubin R.L. The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus J Clin Invest 94 1994 184-192
3. Chabre H. Amoura Z. Piette J.-C. Godeau P. Bach J.-F. Koutouzov S. Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus Arthritis Rheum 38 1995 1485-1491
4. Karsh J. Halbert S.P. Anken M. Klima E. Steinberg A.D. Anti-DNA, anti-deoxyribonucleoprotein and rheumatoid factor measured by ELISA in patients with systemic lupus erythematosus, Sjögren's syndrome and rheumatoid arthritis Int Arch Allergy Appl Immunol 68 1982 60-69
5. Fritzler M.J. Tan E.M. Antibodies to histones in drug-induced lupus and idiopathic lupus erythematosus J Clin Invest 62 1978 560-567
6. Suer W. Dahnrich C. Schlumberger W. Stocker W. Autoantibodies in SLE but not in scleroderma react with protein-stripped nucleosomes J Autoimmun 22 2004 325-334
7. Amoura Z. Koutouzov A. Chabre H. Cacoub P. Amoura I. Musset L. Bach J.F. Piette J.C. Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases Arthritis Rheum 43 2000 76-84
8. Hmida Y. Schmit P. Gilson G. Humbel R.L. Failure to detect antinucleosome antibodies in scleroderma: comment on the article by Amoura et al Arthritis Rheum 46 2002 280-282
9. Bruns A. Blass S. Hausdorf G. Burmester G.R. Hiepe F. Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus Arthritis Rheum 43 2000 2307-2315
10. Min D.J. Kim S.J. Park S.H. Seo Y.I. Kang H.J. Kim W.U. Cho C.S. Kim H.Y. Anti-nucleosome antibody: significance in lupus patients lacking anti-double-stranded DNA antibody Clin Exp Rheumatol 20 2002 13-18
11. Cervera R. Viñas O. Ramos-Casals M. Font J. Garcia-Carrasco M. Siso A. Ramirez F. Machuca Y. Vives J. Ingelmo M. Burlingame R.W. Antichromatin antibodies in systemic lupus erythematosus: a useful marker for lupus nephropathy Ann Rheum Dis 62 2003 431-434
12. Benucci M. Gobbi F.L. Del Rosso A. Cesaretti S. Niccoli L. Cantini F. Disease activity and antinucleosome antibodies in systemic lupus erythematosus Scand J Rheumatol 32 2003 42-45
13. Kiss E. Lakos G. Nemeth J. Sipka S. Szegedi G. Significance of anti-nucleosome (anti-chromatin) auto-antibodies in systemic lupus erythematosus (article in Hungarian) Orv Hetil 142 2001 1731-1736
14. Horak P. Scudla V. Hermanov Z. Pospisil Z. Faltynek L. Budikova M. Kusa L. Clinical utility of selected disease markers in patients with systemic lupus erythematosus Clin Rheumatol 20 2001 337-344
15. Ravirajan C.T. Rowse L. MacGowan J.R. Isenberg D.A. An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study Rheumatology (Oxford) 40 2001 1404-1412
16. Tan E.M. Cohen A.S. Fries J.F. Masi A.T. McShane D.J. Rothfield N.F. Schaller J.G. Talal N. Winchester R.J. The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 25 1983 1271-1277
17. Robitaille P. Tan E.M. Relationship between deoxyribonucleoprotein and deoxyribonucleic acid antibodies in systemic lupus erythematosus J Clin Invest 52 1973 316-323
18. Cacoub P. Musset L. Amoura Z. Guilani P. Chabre H. Lunel F. Poynard T. Opolon P. Piette J.C. Anticardiolipin, anti-beta2-glycoprotein I, and antinucleosome antibodies in hepatitis C virus infection and mixed cryoglobulinemia. Multivirc Group J Rheumatol 24 1997 2139-2144
19. Burlingame R.W. Rubin R.L. Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin J Clin Invest 88 1991 680-690
20. Burlingame R.W. The clinical utility of antihistone antibodies. Autoantibodies reactive with chromatin in systemic lupus erythematosus and drug-induced lupus Clin Lab Med 17 1997 367-377
21. Li L. Chen M. Huang D.Y. Nishioka M. Frequency and significance of antibodies to chromatin in autoimmune hepatitis type I J Gastroenterol Hepatol 15 2000 1176-1182
22. Czaja A.J. Shums Z. Binder W.L. Lewis S.J. Nelson V.J. Norman G.L. Frequency and significance of antibodies to chromatin in autoimmune hepatitis Dig Dis Sci 48 2003 1658-1664
23. Holman H.R. Deicher H.R. The reaction of the lupus erythematosus (LE) cell factor with deoxyribonucleoprotein of the cell nucleus J Clin Invest 38 1959 2059-2072
24. Klein F. Hijmans W. Schuit H.R.E. Studies on the LE cell phenomenon II. Adsorption of the LE cell factor Vox Sang 4 1959 367-375
25. Lachmann P.J. An attempt to characterize the lupus erythematosus cell antigen Immunology 4 1961 153-163
26. Rekvig O.P. Hannestad K. Lupus erythematosus (LE) factors recognize both nucleosomes and viable human leukocytes Scand J Immunol 13 1981 597-604
27. Wallace D.J. Lin H.C. Shen G.Q. Peter J.B. Antibodies to histone (H2A-H2B)-DNA complexes in the absence of antibodies to double-stranded DNA or to (H2A-H2B) complexes are more sensitive and specific for scleroderma-related disorders than for lupus Arthritis Rheum 37 1994 1795-1797
28. Stemmer C. Muller S. Histone autoantibodies other than (H2A-H2B)-DNA autoantibodies Peter J.B. Shoenfeld Y. 1996 373 384 Elsevier Science New York
29. Dupois E.L. Drexler E. Arterberry J.D. A latex nucleoprotein test for the diagnosis of systemic lupus erythematosus JAMA 177 1961 131-133
30. Burlingame R.W. Rubin R.L. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays J Immunol Methods 134 1990 187-199
31. Hylkema M.N. van Bruggen M.C. ten Hove T. de Jong J. Swaak A.J. Berden J.H. Smeenk R.J. Histone-containing immune complexes are to a large extent responsible for anti-dsDNA reactivity in the Farr assay of active SLE Patients J Autoimmun 14 2000 159-168
32. Burlingame R.W. Rubin R.L. Balderas R.S. Theofilopoulos A.N. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen J Clin Invest 91 1993 1687-1696
33. Lu L. Kaliyaperumal A. Boumpas D.T. Datta S.K. Major peptide autoepitoppes for nucleosome-specific T cells of human lupus J Clin Invest 104 1999 345-355
34. Kaliyaperumal A. Michaels M.A. Datta S.K. Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: tolerance spreading impairs pathogenic function of autoimmune T and B cells J Immunol 162 1999 5775-5783
35. Amoura Z. Chabre H. Koutouzov S. Lotton C. Cabrespines A. Bach J.F. Jacob L. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria Arthritis Rheum 37 1994 1684-1688
36. Kono D.H. Burlingame R.W. Owens D.G. Kuramochi A. Balderas R.S. Balomenos D. Theofilopoulos A.N. Lupus susceptibility loci in New Zealand mice Proc Natl Acad Sci U S A 91 1994 10168-10172
37. Nagata S. Fas-induced apoptosis, and diseases caused by its abnormality Genes Cells 1 1996 873-879
38. Napirei M. Karsunky H. Zevnik B. Stephan H. Mannherz H.G. Moroy T. Features of systemic lupus erythematosus in Dnase1-deficient mice Nat Genet 25 2000 177-181
39. Bickerstaff M.C. Botto M. Hutchinson W.L. Herbert J. Tennent G.A. Bybee A. Mitchell D.A. Cook H.T. Butler P.J. Walport M.J. Pepys M.B. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity Nat Med 5 1999 694-697
40. Vyse T.J. Halterman R.K. Rozzo S.J. Izui S. Kotzin B.L. Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus Proc Natl Acad Sci U S A 96 1999 8098-8103
41. Mohan C. Alas E. Morel L. Yang P. Wakeland E.K. Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes J Clin Invest 101 1998 1362-1372
42. Morel L. Croker B.P. Blenman K.R. Mohan C. Huang G. Gilkeson G. Wakeland E.K. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains Proc Natl Acad Sci U S A 97 2000 6670-6675
43. Morel L. Blenman K.R. Croker B.P. Wakeland E.K. The major murine systemic lupus erythematosus susceptibility locus, SLE1, is a cluster of functionally related genes Proc Natl Acad Sci U S A 98 2001 1787-1792
44. Boackle S.A. Holers V.M. Chen X. Szakonyi G. Karp D.R. Wakeland E.K. Morel L. Cr2, a candidate gene in the murine SLE 1c lupus susceptibility locus, encodes a dysfunctional protein Immunity 15 2001 775-785
45. Yasutomo K. Horiuchi T. Kagami S. Tsukamoto H. Hashimura C. Urushihara M. Kuroda Y. Mutation of DNASE1 in people with systemic lupus erythematosus Nat Genet 28 2001 313-314
46. Barilla-La Barca M.L. Atkinson J.P. Rheumatic syndromes associated with complement deficiency Curr Opin Rheumatol 15 2003 55-60
47. Sen J.W. Recke C. Rahbek L. Skogstrand K. Heegaard N.H. Structural, quantitative and functional comparison of amyloid P component in sera from patients with systemic lupus erythematosus and healthy donors Scand J Immunol 56 2002 645-651
48. Waaler E. On the occurrence of a factor in human serum activating the specific agglutination of sheep red blood corpuscles Acta Pathol Microbiol Scand 17 1940 172-178
49. Rose H.M. Ragan C. Pearce E. Lipman M.O. Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis Proc Soc Exp Biol Med 68 1949 1-11
50. Hargraves M.M. Richmond H. Morton R.J. Presentation of two bone marrow elements, "Tart" cell and "L.E." cell Mayo Clin Proc 23 1948 25-28
51. Cohen A.S. Reynolds W.E. Franklin E.C. Kulka J.P. Ropes M.W. Shulman L.E. Wallace S.L. Preliminary criteria for the classification of systemic lupus erythematosus Bull Rheum Dis 21 1971 643-648
52. Schett G. Rubin R.L. Steiner G. Hiesberger H. Muller S. Smolen J. The lupus erythematosus cell phenomenon: comparative analysis of antichromatin antibody specificity in lupus erythematosus cell- positive and -negative sera Arthritis Rheum 43 2000 420-428
53. Tan E.M. Schur P.H. Carr R.I. Kunkel H.G. Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus J Clin Invest 45 1966 1732-1740
54. Wold R.T. Young F.E. Tan E.M. Farr R.S. Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid Science 161 1968 806-807
55. Aarden L.A. de Groot Els R. Feltkamp T.E.W. Immunology of DNA III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique Ann N Y Acad Sci 254 1975 505-515
56. Hochberg M.C. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 9 1997 1725
57. Werle E. Blazek M. Fiehn W. The clinical significance of measuring different anti-dsDNA antibodies by using the Farr assay, an enzyme immunoassay and a Crithidia luciliae immunofluorescence test Lupus 1 1992 369-377
58. Tipping P.G. Buchanan R.C. Riglar A.G. Dimech W.J. Littlejohn G.O. Holdsworth S.R. Measurement of anti-DNA by ELISA: a comparative study with Crithidia and a Farr assay Pathology 23 1991 21-24
59. Suzuki T. Burlingame R.W. Casiano C.A. Boey M.L. Rubin R.L. Antihistone antibodies in systemic lupus erythematosus: patient heterogeneity, assay dependency and direct binding to non-ubiquitinated histones J Rheumatol 21 1994 1081-1091
60. Theophilopoulos A.N. Kono D.H. The genes of systemic autoimmunity Proc Assoc Am Physicians 111 1999 228-240
61. Andreassen K. Bendiksen S. Kjeldsen E. Van Ghelue M. Moens U. Arnesen E. Rekvig O.P. T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system Arthritis Rheum 46 2002 1270-1281
62. Jacob M. Napirei M. Ricken A. Dixkens C. Mannherz H.G. Histopathology of lupus-like nephritis in Dnase1-deficient mice in comparison to NZB/W F1 mice Lupus 11 2002 514-527
63. Pisetsky D.S. The role of bacterial DNA in autoantibody induction Curr Top Microbiol Immunol 247 2000 143-155
64. Mohan C. Liu F. Xie C. Williams Jr. R.C. Anti-subnucleosome reactivities in systemic lupus erythematosus (SLE) patients and their first degree relatives Clin Exp Immunol 123 2001 119-126
65. Van Ghelue M. Moens U. Bendiksen S. Rekvig O.P. Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation J Autoimmun 20 2003 171-182
66. Schneider S. Bruns A. Moewes B. Holzknecht B. Hausdorf G. Riemekasten G. Radbruch A. Hiepe F. Thiel A. Simultaneous cytometric analysis of (auto)antigen-reactive T and B cell proliferation Immunobiology 206 2002 484-495
67. Datta S.K. Major peptide autoepitopes for nucleosome-centered T and B cell interaction in human and murine lupus Ann N Y Acad Sci 987 2003 79-90
68. Duncan S.R. Rubin R.L. Burlingame R.W. Sinclair S.B. Pekny K.W. Theofilopoulos A.N. Intrathymic injection of chromatin delays autoantibody production in BXSB mice Clin Immunol Immunopathol 79 1996 171-181
69. Wu H.Y. Ward F.J. Staines N.A. Histone peptide-induced nasal tolerance: suppression of murine lupus J Immunol 169 2002 1126-1134
70. Alarcon-Segovia D. Tumlin J.A. Furie R.A. McKay J.D. Cardiel M.H. Strand V. Bagin R.G. Linnik M.D. Hepburn B. LJP 394 Investigator Consortium. LJP 394 for prevention of renal flare in patients with systemic lupus erythematosus: results from a randomized, double-blind, placebo-controlled study Arthritis Rheum 48 2003 442-454
71. Williams R.C. Malone C.C. Meyers C. Decker P. Muller S. Detection of nucleosome core particles in serum and plasma from patients with systemic lupus erythematosus using monoclonal antibody 4H7 J Rheumatol 28 2001 81-94
72. Kramers C. Hylkema M.N. van Bruggen M.C. van de Lagemaat R. Dijkman H.B. Assmann K.J. Smeenk R.J. Berden J.H. Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo J Clin Invest 94 1994 568-577
73. Mannik M. Merril C.E. Stamps L.D. Wener M.H. Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus J Rheumatol 30 2003 1495-1504
74. Lachmann P.J. Lupus and desoxyribonuclease Lupus 12 2003 202-206
75. Kretz-Rommel A. Rubin R.L. Early cellular events in systemic autoimmunity driven by chromatin-reactive T cells Cell Immunol 208 2001 125-136
76. Feeney A.J. Lawson B.R. Kono D.H. Theofilopoulos A.N. Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-fas(lpr) mice J Immunol 167 2001 3486-3493
77. Schett G. Smolen J. Zimmermann C. Hiesberger H. Hoefler E. Fournel S. Muller S. Rubin R.L. Steiner G. The autoimmune response to chromatin antigens in systemic lupus erythematosus: autoantibodies against histone H1 are a highly specific marker for SLE associated with increased disease activity Lupus 11 2002 704-715