Early cellular events in systemic autoimmunity driven by chromatin-reactive T cells

Cellular Immunology

Volumn 208, Issue 2, 2001, Pages 125-136

  Kretz Rommel, Anke ^a   Rubin, Robert L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Antigen presenting cell function of B cells; Autoreactive T and B cells; Fas effects in vivo; Lupus like autoimmunity

Indexed keywords

ANIMAL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; C57BL MOUSE; CELL DIVISION; CHROMATIN; DISEASE MODEL; IMMUNOLOGY; LUPUS VULGARIS; MOUSE; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; AUTOIMMUNITY; B-LYMPHOCYTES; CELL DIVISION; CHROMATIN; DISEASE MODELS, ANIMAL; LUPUS; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES;

EID: 0035021305     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2001.1774     Document Type: Article

References (51)

1. Kretz-Rommel, A., Duncan, S. R., and Rubin, R. L., Autoimmunity caused by disruption of central T cell tolerance: A murine model of drug-induced lupus. J. Clin. Invest. 99, 1888-1896, 1997.
2. Kretz-Rommel, A., and Rubin, R. L., Disruption of positive selection of thymocytes causes autoimmunity. Nat. Med. 6, 298-305, 2000.
3. Kretz-Rommel, A., and Rubin, R. L., Persistence of autoreactive T cell drive is required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus. J. Immunol. 162, 813-820, 1999.
4. +/+ mouse. J. Immunol. 148, 1561-1569, 1992.
5. Shlomchik, M., Mascelli, M., Shan, H., Radic, M. Z., Pisetsky, D., Marshak-Rothstein, A., and Weigert, M., Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171, 265-297, 1990.
6. Marion, T. N., Tillman, D. M., and Jou, N.-T., Interclonal and intraclonal diversity among anti-DNA antibodies from an (NZB X NZW)F1 mouse. J. Immunol. 145, 2322-2332, 1990.
7. Diamond, B., and Scharff, M. D., Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sc. USA 81, 5841-5844, 1984.
8. O'Keefe, T. L., Datta, S. K., and Imanishi-Kari, T., Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene subfamily. Eu. J. Immunol. 22, 619-624, 1992.
9. Theofilopoulos, A. N., In "Systemic Lupus Erythematosus" (R. G. Lahita, Ed.), pp. 121-194, Churchill, New York, 1992.
10. Mohan, C., Adams, S., Stanik, V., and Datta, S. K., Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177, 1367-1381, 1993.
11. Osborne, B. A., Apoptosis and the maintenance of homeostasis in the immune system. Curr. Opin. Immunol. 8, 245-254, 1996.
12. Suda, T., Takahashi, T., Golstein, P., and Nagata, S., Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75, 1169-1178, 1993.
13. Sytwu, H.-K., Liblau, R. S., and McDevitt, H. O., The roles of Fas/Apo-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 5, 17-30, 1996.
14. Ju, S.-T., Panka, D. J., Cui, H., Ettinger, R., El-Khatib, M., Sherr, D. H., Stanger, B. Z., and Marshak-Rothstein, A., Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373, 444-448, 1995.
15. + T cells. Nature 376, 181-183, 1995.
16. Singer, G. G., and Abbas, A. K., The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371, 1994.
17. Mixter, P. F., Russel, J. Q., and Budd, R. C., Delayed kinetics of T lymphocyte anergy and deletion in lpr mice. J. Autoimmun. 7, 697-710, 1994.
18. Elkon, K. B., and Marshak-Rothstein, A., B cells in systemic autoimmune disease: Recent insights from Fas-deficient mice and men. Curr. Opin. Immunol. 8, 852-859, 1996.
19. Wang, J., and Watanabe, T., Expression and function of Fas during differentiation and activation of B cells. Int. Rev. Immunol. 18, 367-379, 1999.
20. Hahn, B. H., and Tsao, B. P., In "Dubois' Lupus Erythematosus" (D. J. Wallace and B. H. Hahn, Eds.), pp. 407-422, Williams & Wilkins, Baltimore, 1997.
21. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746-749, 1989.
22. Burlingame, R. W., and Rubin, R. L., Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J. Immunol. Methods 134, 187-199, 1990.
23. Rubin, R. L., In "Manual of Clinical Laboratory Immunology" (N. R. Rose, E. C. de Macario, J. D. Folds, H. C. Lane, and R. M. Nakamura, Eds.), pp. 935-941, Am. Soc. Microbiol., Washington, DC, 1997.
24. McHeyzer-Williams, M. G., and Nossal, G. J. V., Clonal analysis of autoantibody-producing cell precursors in the preimmune B cell repertoire. J. Immunol. 141, 4118-4123, 1988.
25. Fraenkel-Conrad, H., and Olcott, H. S., Esterification of proteins with alcohols of low molecular weight. J. Biol. Chem. 161, 259-268, 1945.
26. Pollard, K. M., Jones, J. E., Tan, E. M., Theofilopoulos, A. N., Dixon, F. J., and Rubin, R. L., Polynucleotide specificities of murine monoclonal anti-DNA antibodies. Clin. Immunol. Immunopathol. 40, 197-208, 1986.
27. + T cells to protein antigens in vivo. J. Immunol. 155, 3734-3741, 1995.
28. + T cell priming in vivo. J. Immunol. 162, 5695-5703, 1999.
29. Foote, L. C., Howard, R. G., Marshak-Rothstein, A., and Rothstein, T. J., Il-4 induces Fas resistance in B cells. J. Immunol. 157, 2749-2753, 1996.
30. Foote, L. C., Marshak-Rothstein, A., and Rothstein, T. J., Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded. J. Exp. Med. 187, 847-853, 1999.
31. Gilkeson, G. S., Grudier, J. P., and Pisetsky, D. S., The antibody response of normal mice to immunization with single-stranded DNA of various species origin. Clin. Immunol. Immunopathol. 51, 362-371, 1989.
32. Conger, J. D., Pike, B. L., and Nossal, G. J., Clonal analysis of the anti-DNA repertoire of murine B lymphocytes. Proc. Natl. Acad. Sci. USA 84, 2931-2935, 1987.
33. Pisetsky, D. S., and Caster, S. A., The B-cell repertoire for autoantibodies: Frequency of precursor cells for anti-DNA antibodies. Cell. Immunol. 72, 294-305, 1982.
34. Avrameas, S., and Ternynck, T., The natural autoantibodies system: Between hypotheses and facts. Mol. Immunol. 30, 1133-1142, 1993.
35. Morris, S. C., Lees, A., and Finkelman, F. D., In vivo activation of naive T cells by antigen-presenting B cells. J. Immunol. 152, 3777-3783, 1994.
36. Croft, M., Joseph, S. B., and Miner, K. T., Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells. J. Immunol. 159, 3257-3265, 1997.
37. + T cells. J. Exp. Med. 179, 1539-1549, 1994.
38. + T cells in vitro: Characteristics and antigen-presenting cell requirements. J. Exp. Med. 176, 1431-1437, 1992.
39. Evans, D. E., Munks, M. W., Purkerson, J. M., and Parker, D. C., Resting B lymphocytes as APC for naive T lymphocytes: Dependence on CD40 ligand/CD40. J. Immunol. 164, 688-697, 2000.
40. Wang, J., Taniuchi, Y., Maekawa, Y., Howard, M., Cooper, M. D., and Watanabe, T., Expression and function of Fas antigen on activated murine B cells. J. Immunol. 26, 92-96, 1996.
41. Dhein, J., Walczak, H., Baumler, C., Debatin, K. M., and Krammer, P. H., Autocrine T-cell suicide mediated by APO-1/(Fas/ CD95). Nature 373, 438-441, 1995.
42. lpr mice. J. Immunol. 160, 3805-3811, 1998.
43. Sobel, E. S., Katagiri, T., Katagiri, K., Morris, S. C., Cohen, P. L., and Eisenberg, R. A., An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J. Exp. Med. 173, 1441-1449, 1991.
44. Katagiri, T., Azuma, S., Toyoda, Y., Mori, S., Kano, K., Cohen, P. L., and Eisenberg, R. A., Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene. J. Immunol. 148, 430-438, 1992.
45. Eisenberg, R. A., Sobel, E. S., Reap, E. A., Halpern, M. D., and Cohen, P. L., The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice. Semin. Immunol. 6, 49-54, 1994.
46. lpr/lpr disease: Theories meet Fas. Semin. Immunol. 6, 55-69, 1994.
47. Craxton, A., Otipoby, K. L., Jiang, A., and Clark, E. A., Signal transduction pathways that regulate the fate of B lymphocytes. Adv. Immunol. 73, 79-152, 1999.
48. Goodnow, C. C., Crosbie, J., Jorgensen, H., Brink, R. A., and Basten, A., Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342, 385-391, 1989.
49. Kouskoff, V., Lacaud, G., and Nemazee, D., T cell-independent rescue of B lymphocytes from peripheral immune tolerance. Science 287, 2501-2503, 2000.
50. Chen, C., Nagy, Z., Radic, M. Z., Hardy, R. R., Huszar, D., Camper, S. A., and Weigert, M., The site and stage of anti-DNA B-cell deletion. Nature 373, 252-255, 1995.
51. Mandik-Nayak, L., Seo, S., Eaton-Bassiri, A., Allman, D., Hardy, R. R., and Erikson, J., Functional consequences of the developmental arrest and follicular exclusion of anti-doublestranded DNA B cells. J. Immunol. 164, 1161-1168, 2000.