Frequency and significance of antibodies to chromatin in autoimmune hepatitis

Digestive Diseases and Sciences

Volumn 48, Issue 8, 2003, Pages 1658-1664

  Czaja, Albert J ^a   Shums, Zakera ^b   Binder, Walter L ^b   Lewis, Stephen J ^b   Nelson, Vicki J ^b   Norman, Gary L ^b  

^a MAYO CLINIC   (United States)

^b INOVA DIAGNOSTICS INC   (United States)

Author keywords

Autoantibodies; Autoimmunity; Chromatin; Hepatitis

Indexed keywords

ANTIBODY; AZATHIOPRINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PREDNISONE;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNE HEPATITIS; BLOOD SAMPLING; CHROMATIN; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FREQUENCY ANALYSIS; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RELAPSE; SERODIAGNOSIS; SERUM; TOXICITY;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; AZATHIOPRINE; CHROMATIN; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-GLOBULINS; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PREDNISONE; PROGNOSIS; RECURRENCE; RISK FACTORS; TREATMENT OUTCOME;

EID: 0043202638     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024748714580     Document Type: Article

References (46)

1. Czaja AJ, Homburger HA: Autoantibodies in liver disease. Gastroenterology 120:239-249, 2001
2. Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, Chapman RW, Cooksley WGE, Czaja AJ, Desmet VJ, Donaldson PT, Eddleston ALWF, Fainboim L, Heathcote J, Homberg J-C, Hoofnagle JH, Kakumu S, Krawitt EL, Mackay IR, MacSween RNM, Maddrey WC, Manns MP, McFarlane IG, Meyer zum Buschenfelde K-H, Mieli-Vergani G, Nakanuma Y, Nishioka M, Penner E, Porta G, Portmann BC, Reed WD, Rodes J, Schalm SW, Scheuer PJ, Schrumpf E, Seki T, Toda G, Tsuji T, Tygstrup N, Vergani D, Zeniya M: International Autoimmune Hepatitis Group report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 31:929-938, 1999
3. Czaja AJ, Freese DK: Diagnosis and treatment of autoimmune hepatitis. Hepatology 36:479-497, 2002
4. Czaja AJ: Behavior and significance of autoantibodies in type 1 autoimmune hepatitis. J Hepatol 30:394-401, 1999
5. Targan SR, Landers C, Vidrich A, Czaja AJ: High-titer antineutrophil cytoplasmic antibodies in type 1 autoimmune hepatitis. Gastroenterology 108:1159-1166, 1995
6. Zauli D, Ghetti S, Grassi A, Descovich C, Cassani F, Ballardini G, Muratori L, Bianchi FB: Antineutrophil cytoplasmic antibodies in type 1 and type 2 autoimmune hepatitis. Hepatology 25:1105-1107, 1997
7. Czaja AJ, Ming C, Shirai M, Nishioka M: Frequency and significance of antibodies to histones in autoimmune hepatitis. J Hepatol 23:32-38, 1995
8. Chen M, Shirai M, Czaja AJ, Kurokohchi K, Arichi T, Arima K, Kodama T, Nishioka M: Characterization of anti-histone antibodies in patients with type 1 autoimmune hepatitis. J Gastroenterol Hepatol 13:483-489, 1998
9. Fritzler MJ: Autoantibodies: diagnostic fingerprints and etiologic perplexities. Clin Invest Med 20:50-66, 1997
10. Czaja AJ, Cassani F, Cataleta M, Valentini P, Bianchi FB: Frequency and significance of antibodies to actin in type 1 autoimmune hepatitis. Hepatology 24:1068-1073, 1996
11. Czaja AJ, Morshed SA, Parveen S, Nishioka M: Antibodies to single-stranded and double-stranded DNA in antinuclear antibody-positive type 1-autoimmune hepatitis. Hepatology 26:567-572, 1997
12. McFarlane IG, Hegarty JE, McSorley CG, McFarlane BM, Williams R: Antibodies to liver-specific protein predict outcome of treatment withdrawal in autoimmune chronic active hepatitis. Lancet 2:954-956, 1984
13. Czaja AJ, Pfeifer KD, Decker RH, Vallari AS: Frequency and significance of antibodies to asialoglycoprotein receptor in type 1 autoimmune hepatitis. Dig Dis Sci 41:1733-1740, 1996
14. Czaja AJ, Donaldson PT, Lohse AW: Antibodies to soluble liver antigen/liver pancreas and HLA risk factors in type 1 autoimmune hepatitis. Am J Gastroenterol 97:413-419, 2002
15. Baeres M, Herkel J, Czaja AJ, Wies I, Kanzler S, Cancado ELR, Porta G, Nishioka M, Simon T, Daehnrich C, Schlumberger W, Galle PR, Lohse AW: Establishment of standardized SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence and clinical characteristics. Gut 51:259-264, 2002
16. Li L, Chen M, Huang DY, Nishioka M: Frequency and significance of antibodies to chromatin in autoimmune hepatitis type 1. J Gastroenterol Hepatol 15:1176-1782, 2000
17. Doenecke D, Albig W, Bode C, Drabent B, Franke K, Gavenis K, Witt O: Histones: genetic diversity and tissue-specific gene expression. Histochem Cell Biol 107:1-10, 1997
18. Rubin RL: Autoantibody specificity in drug-induced lupus and neutrophii-mediated metabolism of lupus-inducing drugs. Clin Biochem 25:223-234, 1992
19. Mohan CH, Adams S, Stanik V, Datta SK: Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 177:1367-1381, 1993
20. Amoura Z, Koutouzov S, Piette J-C: The role of nucleosomes in lupus. Curr Opin Rheumatol 12:369-373, 2000
21. Amoura Z, Chabre H, Koutouzov S, Lotton C, Cabrespines A, Bach JF, Jacob L: Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antii-histone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice and are present in kidney eluates. Arthritis Rheum 37:1684-1688, 1994
22. Burlingame RW, Boey ML, Starkebaum G, Rubin RL: The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus. J Clin Invest 94:184-192, 1994
23. Donaldson PT, Doherty DG, Hayllar KM, McFarlane IG, Johson PJ, Williams R: Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors. Hepatology 13:701-706, 1991
24. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB: Significance of HLA DR4 in type 1 autoimmune hepatitis. Gastroenterology 105:1502-1507, 1993
25. Czaja AJ, Nishioka M, Morshed SA, Hachiya T: Patterns of nuclear immunofluorescence and reactivities to recombinant nuclear antigens in autoimmune hepatitis. Gastroenterology 107:200-207, 1994
26. Czaja AJ, Cassani F, Cataleta M, Valentini P, Bianchi FB: Antinuclear antibodies and patterns of nuclear immunofluorescence in type I autoimmune hepatitis. Dig Dis Sci 42:1688-1696, 1997
27. Homburger HA, Cahen YD, Griffiths J, Jacob GL: Detection of antinuclear antibodies. Comparative evaluation of enzyme immunoassay and indirect immunofluorescence methods. Arch Pathol Lab Med 122:993-999, 1998
28. Czaja AJ, Munns MP, Homburger HA: Frequency and significance of antibodies to liver/kidney microsome type I in adults with chronic active hepatitis. Gastroenterology 103:1290-1295, 1992
29. Czaja AJ: Drug therapy in the management of type I autoimmune hepatitis. Drugs 57:49-68, 1999
30. Summerskill WHJ, Korman MG, Ammon HV, Baggenstoss AH: Prednisone for chronic active liver disease: dose titration, standard dose, and combination with azathioprine compared. Gut 16:876-883, 1975
31. Czaja AJ, Wolf AM, Baggenstoss AH: Laboratory assessment of severe chronic active liver disease (CALD): correlation of serum transaminase and gamma globulin levels with histologic features. Gastroenterology 80:687-692. 1981
32. Czaja AJ, Menon KVN, Carpenter HA: Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: a retrospective analysis. Hepatology 35:890-897, 2002
33. Tan EM: Autoantibodies to nuclear antigens: their immunology and meaning. Adv Immunol 33:167-240, 1982
34. Strettell MDJ, Donaldson PT, Thomson LJ, Santrach PJ, Moore SB, Czaja AJ, Williams R: Allelic basis for HLA-encoded susceptibility to type 1 autoimmune hepatitis. Gastroenterology 112:2028-2035, 1997
35. Czaja AJ, Strettell MDJ, Thomson LJ, Santrach PJ, Moore SB, Donaldson PT, Williams R: Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis. Hepatology 25:317-323, 1997
36. Czaja AJ, Santrach PJ, Moore SB: Shared genetic risk factors in autoimmune liver disease. Dig Dis Sci 46:140-147, 2001
37. Hall S, Czaja AJ, Kaufman DK, Markowitz H, Ginsburg WW: How lupoid is lupoid hepatitis? J Rheumatol 13:95-98, 1986
38. Wood JR, Czaja AJ, Beaver SJ, Hall S, Ginsburg WW, Kaufman DK, Markowitz H: Frequency and significance of antibody to double-stranded DNA in chronic active hepatitis. Hepatology 6:976-980, 1986
39. Czaja AJ: Understanding the pathogenesis of autoimmune hepatitis. Am J Gastroenterol 96:1224-1231, 2001
40. Parveen S, Morshed SA, Arima K, Nishioka M, Czaja AJ, Chow C, Ng H-S: Antibodies to Ro/La, Cenp-B, and snRNPs antigens in autoimmune hepatitis of North America versus Asia. Dig Dis Sci 43:1322-1331, 1998
41. Walport MJ: Lupus, DNase and defective disposal of cellular debris. Nature Genet 25:135-136, 2000
42. Doherty DG, Penzotti JE, Koelle DM, Kwok WW, Lybrand TP, Masewicz S, Nepom GT: Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR. J Immunol 161:3527-3535, 1998
43. Czaja AJ, Doherty DG, Donaldson PT: Genetic bases of autoimmune hepatitis. Dig Dis Sci 47:2139-2150, 2002
44. Czaja AJ: Behavior and significance of autoantibodies in type 1 autoimmune hepatitis. J Hepatol 30:394-401, 1999
45. Czaja AJ, Donaldson PT: Gender effects and synergism with histocompatibility leukocyte antigens in type 1 autoimmune hepatitis. Am J Gastroenterol 97:2051-2057, 2002
46. Whitacre CC, Reingold SC, O'Looney PA: A gender gap in autoimmunity. Science 283:1277-1278, 1999