Transport mechanisms for organic forms of carbon and nitrogen between source and sink

Annual Review of Plant Biology

Volumn 55, Issue , 2004, Pages 341-372

  Lalonde, Sylvie ^a   Wipf, Daniel ^a,b   Frommer, Wolf B ^a,c  

^a Plant Physiology   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c GEOPHYSICAL LABORATORY   (United States)

Author keywords

Amino acid; Export; Import; Monosaccharide; Nanosensor; Sensor; Sucrose

Indexed keywords

AMINO ACID; CARBON; NITROGEN; ORGANIC COMPOUND; PEPTIDE; SUCROSE;

BIOSYNTHESIS; CARBOHYDRATE METABOLISM; CELL VACUOLE; HUMAN; METABOLISM; PLANT; REVIEW;

AMINO ACIDS; CARBOHYDRATE METABOLISM; CARBON; HUMANS; NITROGEN; ORGANIC CHEMICALS; PEPTIDES; PLANTS; SUCROSE; VACUOLES;

EID: 3242712351     PISSN: 15435008     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.arplant.55.031903.141758     Document Type: Review

References (190)

1. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, et al. 2003. Structure and mechanism of the lactose permease of Escherichia coli. Science 301:610-15
2. Al-Hasani H, Kunamneni RK, Dawson K, Hinck CS, Müller-Wieland D, et al. 2002. Roles of the N- and C-termini of GLUT4 in endocytosis. J. Cell Sci. 115:131-40
3. Anderson JA, Huprikar SS, Kochian LV, Lucas WJ, Gaber RF. 1992. Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 89:3736-40
4. André B. 1995. An overview of membrane transport proteins in Saccharomyces cerevisiae. Yeast 11:1575-611
5. +/hexose cotransporter from Chlorella in Xenopus oocytes and its characterization with respect to sugar specificity, pH and membrane potential. J. Plant Physiol. 141:293-97
6. Arango M, Gevaudant F, Oufattole M, Boutry M. 2003. The plasma membrane proton pump ATPase: the significance of gene subfamilies. Planta 216:355-65
7. Arlt K, Brandt S, Kehr J. 2001. Amino acid analysis in five pooled single plant cell samples using capillary electrophoresis coupled to laser-induced fluorescence detection. J. Chromatogr. A 926:319-25
8. Atkins CA. 2000. Biochemical aspects of assimilate transfers along the phloem path: N-solutes in lupins. Aust. J. Plant Physiol. 27:531-37
9. Barker L, Kühn C, Weise A, Schulz A, Gebhardt C, et al. 2000. SUT2, a putative sucrose sensor in sieve elements. Plant Cell 12:1153-64
10. Barth I, Meyer S, Sauer N. 2003. Pm-SUC3: Characterization of a SUT2/SUC3-type sucrose transporter from Plantago major. Plant Cell 15:1375-85
11. Baxter I, Tchieu J, Sussman MR, Boutry M, Palmgren MG, et al. 2003. Genomic comparison of p-type ATPase ion pumps in Arabidopsis and rice. Plant Physiol. 132:618-28
12. Bernard F, André B. 2001. Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae. FEBS Lett. 496:81-85
13. Bieleski RL. 1960. The physiology of sugar-cane, III. Characteristics of sugar uptake in slices of mature and immature storage tissue. Aust. J. Biol. Sci. 13:203-20
14. Boles E, Hollenberg CP. 1997. The molecular genetics of hexose transport in yeast. FEMS Microbiol. Rev. 21:85-111
15. +/amino acid transporter from Arabidopsis thaliana. J. Biol. Chem. 271:2213-20
16. +/hexose cotransporter (STP1) from Arabidopsis thaliana expressed in Xenopus oocytes. J. Biol. Chem. 269:20417-24
17. +/sucrose cotransporter StSUT1. J. Biol. Chem. 271:25139-44
18. Borisjuk L, Rolletschek H, Wobus U, Weber H. 2003. Differentiation of legume cotyledons as related to metabolic gradients and assimilate transport into seeds. J. Exp. Bot. 54:503-12
19. Borisjuk L, Walenta S, Rolletschek H, Mueller-Klieser W, Wobus U, Weber H. 2002. Spatial analysis of plant metabolism: Sucrose imaging within Vicia faba cotyledons reveals specific developmental patterns. Plant J. 29:521-30
20. Borisjuk L, Walenta S, Weber H, Mueller-Klieser W, Wobus U. 1998. High-resolution histographical mapping of glucose concentrations in developing cotyledons of Vicia faba in relation to mitotic activity and storage processes: glucose as a possible developmental trigger. Plant J. 15:583-91
21. Brandt S, Kloska S, Altmann T, Kehr J. 2002. Using array hybridization to monitor gene expression at the single cell level. J. Exp. Bot. 53:2315-23
22. Braun V, Braun M. 2002. Iron transport and signaling in Escherichia coli. FEBS Lett. 529:78
23. Braun V, Killmann H. 1999. Bacterial solutions to the iron-supply problem. Trends Biochem. Sci. 24:104-9
24. Buckhout TJ. 1989. Sucrose transport in isolated plasma-membrane vesicles from sugar beet (Beta vulgaris L.). Evidence for an electrogenic sucrose-proton symport. Planta 178:393-99
25. +-sucrose cotransporter NtSUT1 is essential for sugar export from tobacco leaves. Plant Physiol. 118:59-68
26. Bush DR. 1989. Proton-coupled sucrose transport in plasmalemma vesicles isolated from sugar beet (Beta vulgaris L. cv Great Western) leaves. Plant Physiol. 89:1318-23
27. Bush DR. 1999. Sugar transporters in plant biology. Curr. Opin. Plant Biol. 2:187-91
28. Büttner M, Sauer N. 2000. Monosaccharide transporters in plants: structure, function and physiology. Biochim. Biophys. Acta 1465:263-74
29. Caspers PJ, Lucassen GW, Puppels GJ. 2003. Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophys. J. 85:572-80
30. Chang HC, Bush DR. 1997. Topology of NAT2, a prototypical example of a new family of amino acid transporters. J. Biol. Chem. 272:30552-57
31. +antiport in Mesembryanthemum crystallinum. Plant J. 24:511-22
32. Chen L, Busch DR. 1997. LHT1, a lysine and histidine specific amino acid transporter in Arabidopsis. Plant Physiol. 115:1127-34
33. Chen L, Ortiz-Lopez A, Jung A, Bush DR. 2001. ANT1, an aromatic and neutral amino acid transporter in Arabidopsis. Plant Physiol. 125:1813-20
34. Chiou TJ, Bush DR. 1998. Sucrose is a signal molecule in assimilate partitioning. Proc. Natl. Acad. Sci. USA 95:4784-88
35. Cho BH, Komor E. 1980. Role of potassium in charge compensation for sucrose-proton symport by cotyledons of Ricinus communis. Plant Sci. Lett. 17:425-35
36. Corbesier L, Lejeune P, Bernier G. 1998. The role of carbohydrates in the induction of flowering in Arabidopsis thaliana: comparison between the wild type and a starchless mutant. Planta 206:131-37
37. Dawson PA, Mychaleckyj JC, Fossey SC, Minic SJ, Craddock AL, et al. 2001. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol. Genet. Metab. 74:186-99
38. Deeken R, Geiger D, Fromm J, Koroleva O, Ache P, et al. 2002. Loss of the AKT2/3 potassium channel affects sugar loading into the phloem of Arabidopsis. Planta 216:334-44
39. Delrot S. 1989. Phloem loading. Transport of Photoassimilates, ed. D Baker, J Milburn, pp. 167-205. London: Longman Sci.
40. Delrot S, Atanassova R, Maurousset L. 2000. Regulation of sugar, amino acid and peptide plant membrane transporters. Biochim. Biophys. Acta 1465:281-306
41. Delrot S, Bonnemain JL. 1981. Involvement of protons as a substrate for the sucrose carrier during phloem loading in Vicia faba leaves. Plant Physiol. 67:560-64
42. Desimone M, Catoni E, Ludewig U, Hilpert M, Schneider A, et al. 2002. A novel superfamily of transporters for allantoin and other oxo derivatives of nitrogen heterocyclic compounds in Arabidopsis. Plant Cell 14:847-56
43. +-ATPase) in phloem companion cells. Plant Cell 7:2053-67
44. Doering-Saad C, Newbury HJ, Bale JS, Pritchard J. 2002. Use of aphid stylectomy and RT-PCR for the detection of transporter mRNAs in sieve elements. J. Exp. Bot. 53:631-37
45. Dwyer DS. 2001. Model of the 3-D structure of the GLUT3 glucose transporter and molecular dynamics simulation of glucose transport. Proteins 42:531-41
46. Echeverria E. 2000. Vesicle-mediated solute transport between the vacuole and the plasma membrane. Plant Physiol. 123:1217-26
47. Farré EM, Tiessen A, Roessner U, Geigenberger P, Trethewey RN, et al. 2001. Analysis of the compartmentation of glycolytic intermediates, nucleotides, sugars, organic acids, amino acids, and sugar alcohols in potato tubers using a nonaqueous fractionation method. Plant Physiol. 127:685-700
48. Fehr M, Frommer WB, Lalonde S. 2002. Visualization of maltose uptake in living yeast cells by fluorescent nanosensors. Proc. Natl. Acad. Sci. USA 99:9846-51
49. Fehr M, Lalonde S, Lager I, Wolff MW, Frommer WB. 2003. In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors. J. Biol. Chem. 278:19127-33
50. Ferguson AD, Chakraborty R, Smith BS, Esser L, van der Helm D, et al. 2002. Structural basis of gating by the outer membrane transporter FecA. Science 295:1715-19
51. Ferro M, Salvi D, Riviere-Rolland H, Vermat T, Seigneurin-Berny D, et al. 2002. Integral membrane proteins of the chloroplast envelope: identification and subcellular localization of new transporters. Proc. Natl. Acad. Sci. USA 99:11487-92
52. Fiehn O. 2003. Metabolic networks of Cucurbita maxima phloem. Phytochemistry 62:875-86
53. Fischer WN, André B, Rentsch D, Krolkiewicz S, Tegeder M, et al. 1998. Amino acid transport in plants. Trends Plant Sci. 3:188-95
54. +-cotransporters for cellular import of neutral and charged amino acids. Plant J. 29:717-31
55. Fotopoulos V, Gilbert MJ, Pittman JK, Marvier AC, Buchanan AJ, et al. 2003. The monosaccharide transporter gene, AtSTP4, and the cell-wall invertase, Atβfruct1, are induced in Arabidopsis during infection with the fungal biotroph Erysiphe cichoracearum. Plant Physiol. 132:821-29
56. Frommer WB, Hirner B, Kühn C, Harms K, Martin T, et al. 1996. Sugar transport in higher plants. In Membranes: Specialized Functions in Plants, ed. M Smallwood, JP Knox, H Barles, pp. 319-35. Oxford: BIOS Sci.
57. Frommer WB, Hummel S, Riesmeier JW. 1993. Expression cloning in yeast of a cDNA encoding a broad specificity amino acid permease from Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 90:5944-48
58. Frommer WB, Hummel S, Unseld M, Ninnemann O. 1995. Seed and vascular expression of a high-affinity transporter for cationic amino acids in Arabidopsis. Proc. Natl. Acad. Sci. USA 92:12036-40
59. Frommer WB, Ninnemann O. 1995. Heterologous expression of genes in bacterial, fungal, animal and plant cells. Annu. Rev. Plant Physiol. Plant Mol. Biol. 46:419-44
60. Fukamachi S, Shimada A, Shima A. 2001. Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka. Nat. Genet. 28:381-85
61. Gallet O, Lemoine R, Larsson C, Delrot S. 1989. The sucrose carrier of the plant plasma membrane. I. Differential affinity labeling. Biochim. Biophys. Acta 978:56-64
62. Gao Z, Maurousset L, Lemoine R, Yoo SD, van Nocker S, et al. 2003. Cloning, expression, and characterization of sorbitol transporters from developing sour cherry fruit and leaf sink tissues. Plant Physiol. 131:1566-75
63. Getz HP, Grosclaude J, Kurkdjian A, Lelievre F, Maretzki A, et al. 1993. Immunological evidence for the existence of a carrier protein for sucrose transport in tonoplast vesicles from red beet (Beta vulgaris L.) root storage tissue. Plant Physiol. 102:751-60
64. Giaquinta RT. 1979. Phloem loading of sucrose. Plant Physiol. 63:744-48
65. Giaquinta RT. 1980. Mechanism and control of phloem loading of sucrose. Ber. Dtsch. Bot. Ges. 93:187-201
66. Gogarten JP, Bentrup FW. 1989. Substrate specificity of the hexose carrier in the plasma membrane of Chenopodium suspension cells probes by transmembrane exchange diffusion. Planta 178:52-60
67. Gottwald JR, Krysan PJ, Young JC, Evert RF, Sussman MR. 2000. Genetic evidence for the inplanta role of phloem-specific plasma membrane sucrose transporters. Proc. Natl. Acad. Sci. USA 97:13979-84
68. Hamill S, Cloherty EK, Carruthers A. 1999. The human erythrocyte sugar transporter presents two sugar import sites. Biochemistry 38:16974-83
69. Haritatos E, Ayre BG, Turgeon R. 2000. Identification of phloem involved in assimilate loading in leaves by the activity of the galactinol synthase promoter. Plant Physiol. 123:929-37
70. +-ATPase gene family in Arabidopsis: genomic sequence of AHA10 which is expressed primarily in developing seeds. Mol. Gen. Genet. 244:572-87
71. +-ATPase) of Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 86:1234-38
72. Harrington GN, Nussbaumer Y, Wang XD, Tegeder M, Franceschi VR, et al. 1997. Spatial and temporal expression of sucrose transport-related genes in developing cotyledons of Vicia faba. Protoplasma 200:35-50
73. Havelange A, Lejeune P, Bernier G. 2000. Sucrose/cytokinin interaction in Sinapis alba at floral induction: a shoot-to-root-to-shoot physiological loop. Physiol. Plant. 109:343-50
74. Herbers K, Meuwly P, Frommer WB, Metraux JP, Sonnewald U. 1996. Systemic acquired resistance mediated by the ectopic expression of invertase: Possible hexose sensing in the secretory pathway. Plant Cell 8:793-803
75. Hsu L-C, Chiou T-J, Chen L, Bush DR. 1993. Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant. Proc. Natl. Acad. Sci. USA 90:7441-45
76. Imlau A, Truernit E, Sauer N. 1999. Cell-to-cell and long-distance trafficking of the green fluorescent protein in the phloem and symplastic unloading of the protein into sink tissues. Plant Cell 11:309-22
77. Ishida N, Koizumi M, Kano H. 2000. The NMR microscope: a unique and promising tool for plant science. Ann. Bot. 86:259-78
78. Jaiswal JK, Mattoussi H, Mauro JM, Simon SM. 2003. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotech. 21:47-51
79. Jamai A, Chollet JF, Delrot S. 1994. Proton-peptide co-transport in broad bean leaf tissue. Plant Physiol. 106:1023-31
80. Kaback HR, Sahin-Toth M, Weinglass AB. 2001. The kamikaze approach to membrane transport. Nat. Rev. Mol. Cell Biol. 2:610-20
81. Kang J, Turano FJ. 2003. The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 100:6872-77
82. +/monocarboxylate transporters. J. Biol. Chem. 276:17221-28
83. Knappe S, Flügge UI, Fischer K. 2003. Analysis of the plastidic phosphate translocator gene family in Arabidopsis and identification of new phosphate translocator-homologous transporters, classified by their putative substrate-binding site. Plant Physiol. 131:1178-90
84. Knop C, Voitsekhovskaja O, Lohaus G. 2001. Sucrose transporters in two members of the Scrophulariaceae with different types of transport sugar. Planta 213:80-91
85. +/amino acid symporter StAAP1. Plant J. 33:211-20
86. Köckenberger W. 2001. Functional imaging of plants by magnetic resonance experiments. Trends Plant Sci. 6:286-92
87. Komor E, Rotter M, Tanner W. 1977. A proton-cotransport system in a higher plant: Sucrose transport in Ridnus communis. Plant Sci. Lett. 9:153-62
88. Kühn C, Franceschi VR, Schulz A, Lemoine R, Frommer WB. 1997. Macromolecular trafficking indicated by localization and turnover of sucrose transporters in enucleate sieve elements. Science 275:1298-300
89. Kühn C, Hajirezaei M-R, Fernie AR, Roessner-Tunali U, Czechowski T, et al. 2003. The sucrose transporter StSUT1 localizes to sieve elements in potato tuber phloem and influences tuber physiology and development. Plant Physiol. 131:102-13
90. Kühn C, Quick WP, Schulz A, Riesmeier JW, Sonnewald U, Frommer WB. 1996. Companion cell-specific inhibition of the potato sucrose transporter SUT1. Plant Cell Environ. 19:1115-23
91. Lager I, Fehr M, Frommer WB, Lalonde S. 2003. Development of a fluorescent nanosensor for ribose. FEBS Lett. 553:85-89
92. Lalonde S, Boles E, Hellmann H, Barker L, Patrick JW, et al. 1999. The dual function of sugar carriers: Transport and sugar sensing. Plant Cell 11:707-26
93. Lalonde S, Weise A, Panford Walsh R, Ward JM, Frommer WB. 2003. Fusion to GFP blocks intercellular trafficking of the sucrose transporter SUT1 leading to accumulation in companion cells. BMC Plant Biol. 3:8
94. Lam HM, Chiu J, Hsieh MH, Meisel L, Oliveira IC, et al. 1998. Glutamate-receptor genes in plants. Nature 396:125-26
95. Larsson C. 1985. Plasma membranes. In Modern Methods of Plant Analysis, ed. HF Linskens, JF Jackson, pp. 85-104. Berlin: Springer-Verlag
96. Leidreiter K, Kruse A, Heineke D, Robinson DG, Heldt HW. 1995. Subcellular volumes and metabolite concentrations in potato (Solanum tuberosum cv. Désirée) leaves. Bot. Acta 108:439-44
97. Lemoine R. 2000. Sucrose transporters in plants: update on function and structure. Biochim. Biophys. Acta 1465:246-62
98. Lemoine R, Bürkle L, Barker L, Sakr S, Kühn C, et al. 1999. Identification of a pollen-specific sucrose transporter-like protein NtSUT3 from tobacco. FEBS Lett. 454:325-30
99. Lemoine R, Delrot S. 1989. Proton-motive-force-driven sucrose uptake in sugar beet plasma membrane vesicles. FEBS Lett. 248:129-33
100. Li ZC, Bush DR. 1990. ΔpH-dependent amino acid transport into plasma membrane vesicles isolated from sugar beet leaves. I. Evidence for carrier-mediated, electrogenic flux through multiple transport systems. Plant Physiol. 94:268-77
101. Liu JY, Miller PF, Willard J, Olson ER. 1999. Functional and biochemical characterization of Escherichia coli sugar efflux transporters. J. Biol. Chem. 274:22977-84
102. Lohaus G, Pennewiss K, Sattelmacher B, Hussmann M, Muehling KH. 2001. Is the infiltration-centrifugation technique appropriate for the isolation of apoplastic fluid? A critical evaluation with different plant species. Physiol. Plant. 111:457-65
103. Lu C, Koroleva OA, Farrar JF, Gallagher J, Pollock CJ, Tomos AD. 2002. Rubisco small subunit, chlorophyll a/b-binding protein and sucrose:fructan-6- fructosyl transferase gene expression and sugar status in single barley leaf cells in situ. Cell type specificity and induction by light. Plant Physiol. 130:1335-48
104. Magnusson U, Chaudhuri BN, Ko J, Park C, Jones TA, Mowbray SL. 2002. Hinge-bending motion of D-allose-binding protein from Escherichia coli: three open conformations. J. Biol. Chem. 277:14077-84
105. Marchant A, Bhalerao R, Casimiro I, Eklof J, Casero PJ, et al. 2002. AUX1 promotes lateral root formation by facilitating indole-3-acetic acid distribution between sink and source tissues in the Arabidopsis seedling. Plant Cell 14:589-97
106. Martin T, Hellmann H, Schmidt R, Willmitzer L, Frommer WB. 1997. Identification of mutants in metabolically regulated gene expression. Plant J. 11:53-62
107. Maynard JW, Lucas WJ. 1982. Sucrose and glucose uptake into Beta vulgaris leaf tissues. A case for general (apoplastic) retrieval systems. Plant Physiol. 70:1436-43
108. McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM. 1997. Identification and characterization of the vesicular GABA transporter. Nature 389:870-76
109. Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, et al. 2003. Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat. Mater. 2:630-38
110. Meyer S, Melzer M, Truernit E, Hummer C, Besenbeck R, et al. 2000. AtSUC3, a gene encoding a new Arabidopsis sucrose transporter, is expressed in cells adjacent to the vascular tissue and in a carpel cell layer. Plant J. 24:869-82
111. 2+ based on green fluorescent proteins and calmodulin. Nature 388:882-87
112. Münch E. 1930. Die Stoffbewegungen in der Pflanze. Jena: Fischer. 234 pp.
113. Nelissen B, De Wachter R, Goffeau A. 1997. Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol. Rev. 21:113-34
114. Nikawa J, Tsukagoshi Y, Yamashita S. 1991. Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae. J. Biol. Chem. 266:11184-91
115. Noiraud N, Maurousset L, Lemoine R. 2001. Identification of a mannitol transporter, AgMaT1, in celery phloem. Plant Cell 13:695-705
116. O'Neal PD, Cote GL, Motamedi M, Chen J, Lin WC. 2003. Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids. J. Biomed. Opt. 8:33-39
117. Oparka KJ, Duckett CM, Prior DAM, Fisher DB. 1994. Real-time imaging of phloem unloading in the root tip of Arabidopsis. Plant J. 6:759-66
118. Özcan S, Dover J, Johnston M. 1998. Glucose sensing and signaling by two glucose receptors in yeast Saccharomyces cerevisiae. EMBO J. 17:2566-73
119. Özcan S, Dover J, Rosenwald AG, Wölfel S, Johnston M. 1996. Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl. Acad. Sci. USA 93:12428-32
120. Patrick J, Offler CE. 2001. Compartmentation of transport and transfer events in developing seeds. J. Exp. Bot. 52:551-64
121. + channel family in higher plants. J. Mol. Evol. 56:418-34
122. Pollock C, Farrar J, Tomos D, Gallagher J, Lu C, et al. 2003. Balancing supply and demand: the spatial regulation of carbon metabolism in grass and cereal leaves. J. Exp. Bot. 54:489-94
123. Quick WP. 1998. Transgenic plants as a tool to analyse the mechanistic basis for variation in plant growth. In Inherent Variation in Plant Growth. Physiological Mechanisms and Inherent Variation, ed. H Lambers, H Poorter, MMI van Vuuren, pp. 1-21. Leiden: Blackhuys
124. Quirino BF, Reiter WD, Amasino RD. 2001. One of two tandem Arabidopsis genes homologous to monosaccharide transporters is senescence-associated. Plant Mol. Biol. 46:447-57
125. Rausch C, Bucher M. 2002. Molecular mechanisms of phosphate transport in plants. Planta 216:23-37
126. Reifenberger E, Boles E, Ciriacy M. 1997. Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression. Eur. J. Biochem. 245:324-33
127. Reinders A, Schulze W, Kühn C, Barker L, Schulz A, et al. 2002. Protein-protein interactions between sucrose transporters of different affinities colocalized in the same enucleate sieve element. Plant Cell 14:1567-77
128. Reinders A, Schulze W, Thaminy S, Stagljar I, Frommer WB, et al. 2002. lntra- and intermolecular interactions in sucrose transporters at the plasma membrane detected by the split-ubiquitin system and functional assays. Structure 10:763-72
129. Reinders A, Ward JM. 2001. Functional characterization of the alpha-glucoside transporter Sut1p from Schizosaccharomyces pombe, the first fungal homologue of plant sucrose transporters. Mol. Microbiol. 39:445-54
130. Rentsch D, Hirner B, Schmelzer E, Frommer WB. 1996. Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutant. Plant Cell 8:1437-46
131. Riesmeier JW, Hirner B, Frommer WB. 1993. Potato sucrose transporter expression in minor veins indicates a role in phloem loading. Plant Cell 5:1591-98
132. Riesmeier JW, Willmitzer L, Frommer WB. 1992. Isolation and characterization of a sucrose carrier cDNA from spinach by functional expression in yeast. EMBO J. 11:4705-13
133. Riesmeier JW, Willmitzer L, Frommer WB. 1994. Evidence for an essential role of the sucrose transporter in phloem loading and assimilate partitioning. EMBO J. 13:1-7
134. Ripp KG, Viitanen PV, Hitz WD, Franceschi VR. 1988. Identification of a membrane protein associated with sucrose transport into cells of developing soybean cotyledons. Plant Physiol. 88:1435-45
135. Ritchie RJ, Fieuw-Makaroff S, Patrick JW. 2003. Sugar retrieval by coats of developing seeds of Phaseolus vulgaris L. and Vicia faba L. Plant Cell Physiol. 44:163-72
136. Roblin G, Sakr S, Bonmort J, Delrot S. 1998. Regulation of a plant plasma membrane sucrose transporter by phosphorylation. FEBS Lett. 424:165-68
137. Rogers S, Docherty SE, Slavin JL, Henderson MA, Best JD. 2003. Differential expression of GLUT12 in breast cancer and normal breast tissue. Cancer Lett. 193:225-33
138. Rosche E, Blackmore D, Tegeder M, Richardson T, Schroeder H, et al. 2002. Seed-specific overexpression of a potato sucrose transporter increases sucrose uptake and growth rates of developing pea cotyledons. Plant J. 30:165-75
139. Ruan YL, Patrick JW, Brady C. 1997. Protoplast hexose carrier activity is a determinate of genotypic difference in hexose storage in tomato fruit. Plant Cell Environ. 20:341-49
140. Ruiz-Medrano R, Xonocostle-Cázares B, Lucas WJ. 1999. Phloem long-distance transport of CmNACP mRNA: implications for supracellular regulation in plants. Development 126:4405-19
141. Russnak R, Konczal D, McIntire SL. 2001. A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J. Biol. Chem. 276:23849-57
142. Saier MH Jr. 2000. Families of transmembrane sugar transport proteins. Mol. Microbiol. 35:699-710
143. Salerno GL, Curatti L. 2003. Origin of sucrose metabolism in higher plants: when, how and why? Trends Plant Sci. 8:63-69
144. Sauer N. 1997. Sieve elements and companion cells - extreme division of labour. Trends Plant Sc. 2:285-86
145. Sauer N, Caspari T, Klebl F, Tanner W. 1990. Functional expression of the Chlorella hexose transporter in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 87:7949-52
146. +-cotransporter. FEBS Lett. 259:43-46
147. Schaller GE, Sussman MR. 1988. Isolation and sequence of tryptic peptides from the proton-pumping ATPase of the oat plasma membrane. Plant Physiol. 86:512-16
148. Schulze W, Frommer WB, Ward JM. 1999. Transporters for ammonium, amino acids and peptides are expressed in pitchers of the carnivorous plant Nepenthes. Plant J. 17:637-46
149. Schulze W, Schulze ED, Stader J, Heilmeier H, Stitt M, et al. 1994. Growth and reproduction of Arabidopsis thaliana in relation to storage of starch and nitrate in the wild-type and in starch-deficient and nitrate-uptake- deficient mutants. Plant Cell Environ. 17:795-809
150. Schulze W, Weise A, Frommer WB, Ward JM. 2000. Function of the cytosolic N-terminus of sucrose transporter AtSUT2 in substrate affinity. FEBS Lett. 485:189-94
151. Schulze WX, Reinders A, Ward J, Lalonde S, Frommer WB. 2003. Interactions between co-expressed Arabidopsis sucrose transporters in the split-ubiquitin system. BMC Plant Biol. 4:3
152. Schwacke R, Schneider A, van der Graaff E, Fischer K, Catoni E, et al. 2003. ARAMEMNON, a novel database for Arabidopsis integral membrane proteins. Plant Physiol. 131:16-26
153. Schwöppe C, Winkler HH, Neuhaus HE. 2002. Properties of the glucose-6-phosphate transporter from Chlamydia pneumoniae (HPTcp) and the glucose-6-phosphate sensor from Escherichia coli (UhpC). J. Bacteriol. 184:2108-15
154. Sentenac H, Bonneaud N, Minet M, Lacroute F, Salmon JM, et al. 1992. Cloning and expression in yeast of a plant potassium ion transport system. Science 256:663-65
155. Shafer-Peltier KE, Haynes CL, Glucksberg MR, Van Duyne RP. 2003. Toward a glucose biosensor based on surface-enhanced Raman scattering. J. Am. Chem. Soc. 125:588-93
156. Sherson SM, Alford HL, Forbes SM, Wallace G, Smith SM. 2003. Roles of cell-wall invertases and monosaccharide transporters in the growth and development of Arabidopsis. J. Exp. Bot. 54:525-31
157. Sopanen T, Burston D, Matthews DM. 1977. Uptake of small peptides by the scutellum of germinating barley. FEBS Lett. 79:4-7
158. Stacey G, Koh S, Granger C, Becker JM. 2002. Peptide transport in plants. Trends Plant Sci. 7:257-63
159. Stadler R, Besenbeck R, Gahrtz M, Sauer N. 1998. Division of labour: two phloem specific sucrose carriers of Plantago major. Presented at 11th Int. Workshop Plant Membr. Biol., Cambridge, UK
160. Stadler R, Brandner J, Schulz A, Gahrtz M, Sauer N. 1995. Phloem loading by the PmSUC2 sucrose carrier from Plantago major occurs into companion cells. Plant Cell 7:1545-54
161. Stadler R, Sauer N. 1996. The Arabidopsis thaliana AtSUC2 gene is specifically expressed in companion cells. Bot. Acta 109:299-306
162. Stadler R, Truernit E, Gahrtz M, Sauer N. 1999. The AtSUC1 sucrose carrier may represent the osmotic driving force for anther dehiscence and pollen tube growth in Arabidopsis. Plant J. 19:269-78
163. Stolz J, Ludwig A, Stadler R, Biesgen C, Hagemann K, et al. 1999. Structural analysis of a plant sucrose carrier using monoclonal antibodies and bacteriophage lambda surface display. FEBS Lett. 453:375-79
164. Swofford DL. 1998. PAUP*. Phylogenetic Analysis Using Parsimony (* and Other Methods). Sunderland, MA: Sinauer
165. Tadege M, Bucher M, Stähli W, Suter M, Dupuis I, et al. 1998. Activation of plant defense responses and sugar efflux by expression of pyruvate decarboxylase in potato leaves. Plant J. 16:661-71
166. Tchieu JH, Fana F, Fink JL, Harper J, Nair TM, et al. 2003. The PlantsP and PlantsT functional genomics databases. Nucl. Acids Res. 31:342-44
167. Tegeder M, Wang XD, Frommer WB, Offler CE, Patrick JW. 1999. Sucrose transport into developing seeds of Pisum sativum L. Plant J. 18:151-61
168. Thorens B, Guillam MT, Beermann F, Burcelin R, Jaquet M. 2000. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic β cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J. Biol. Chem. 275:23751-58
169. Toyofuku K, Kasahara M, Yamaguchi J. 2000. Charaterization and expression of monosaccharide transporters (OsMSTs) in rice. Plant Cell Physiol. 41:940-47
170. + symporter gene directs expression of beta-glucuronidase to the phloem: Evidence for phloem loading and unloading by SUC2. Planta 196:564-70
171. Truernit E, Schmid J, Epple P, Illig J, Sauer N. 1996. The sink-specific and stress-regulated Arabidopsis STP4 gene: Enhanced expression of a gene encoding a monosaccharide transporter by wounding, elicitors, and pathogen challenge. Plant Cell 8:2169-82
172. Truernit E, Stadler R, Baier K, Sauer N. 1999. A male gametophyte-specific monosaccharide transporter in Arabidopsis. Plant J. 17:191-201
173. +-myoinositol symporter expressed predominantly in the brain. EMBO J. 20:4467-77
174. Uldry M, Thorens B. 2003. The SLC2 family of facilitated hexose and polyol transporters. Eur. J. Physiol. In press. DOI: 10.1007/s00424-003-1085-0
175. Vaughn MW, Harrington GN, Bush DR. 2002. Sucrose-mediated transcriptional regulation of sucrose symporter activity in the phloem. Proc. Natl. Acad. Sci. USA 99:10876-80
176. Veenhoff LM, Heuberger EHML, Poolman B. 2001. The lactose transport protein is a cooperative dimer with two sugar translocation pathways. EMBO J. 20:3056-62
177. Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ. 2002. Cooperativity in signal transfer through the Uhp system of Escherichia coli. J. Bacteriol. 184:4205-10
178. Ward JM. 2001. Identification of novel families of membrane proteins from the model plant Arabidopsis thaliana. Bioinformatics 17:560-63
179. Ward JM, Kühn C, Tegeder M, Frommer WB. 1997. Sucrose transport in higher plants. Int. Rev. Cytol. 178:41-71
180. Watson A, Wu XY, Bruchez M. 2003. Lighting up cells with quantum dots. BioTechniques 34:296-303
181. Weber A, Servaites JC, Geiger DR, Kofler H, Hille D, et al. 2000. Identification, purification, and molecular cloning of a putative plastidic glucose transocator. Plant Cell 12:787-801
182. Weber H, Borisjuk L, Heim U, Sauer N, Wobus U. 1997. A role for sugar transporters during seed development: Molecular characterization of a hexose and
183. Weise A. 2000. Expression analysis of sucrose transporter genes from Lycopersicon esculentum and Arabidopsis thaliana. PhD thesis. Eberhard-Karls-Universität, Tübingen, Germany
184. Weise A, Barker L, Kühn C, Lalonde S, Buschmann H, et al. 2000. A new subfamily of sucrose transporters, SUT4, with low affinity/high capacity localized in enucleate sieve elements of plants. Plant Cell 12:1345-55
185. Weschke W, Panitz R, Sauer N, Wang Q, Neubohn B, et al. 2000. Sucrose transport into barley seeds: molecular characterization of two transporters and implications for seed development and starch accumulation. Plant J. 21:455-67
186. Williams LE, Lemoine R, Sauer N. 2000. Sugar transporters in higher plants - a diversity of roles and complex regulation. Trends Plant Sci. 5:283-90
187. Wipf D, Ludewig U, Tegeder M, Rentsch D, Koch W, et al. 2002. Conservation of amino acid transporters in fungi, plants and animals. Trends Biochem. Sci. 27:139-47
188. Zhou JJ, Miller AJ. 2000. Comparison of the transport properties of three plant sucrose carriers expressed in Xenopus oocytes. Aust. J. Plant Physiol. 27:725-32
189. +/sucrose cotransporter expressed in Xenopus oocytes. J. Membr. Biol. 159:113-25
190. Zottola RJ, Cloherty EK, Coderre PE, Hansen A, Hebert DN, et al. 1995. Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promoter GLUT1 tetramerization. Biochemistry 34:9734-47