Developmental immunotoxicology of lead

Toxicology and Applied Pharmacology

Volumn 198, Issue 2, 2004, Pages 86-94

  Dietert, Rodney R ^a   Lee, Ji Eun ^b   Hussain, Irshad ^a   Piepenbrink, Michael ^a  

^a Department of Obstetrics Gynecology   (United States)

^b CHEVRON PHILLIPS CHEMICAL COMPANY LP   (United States)

Author keywords

Hyper susceptibility; Immunotoxicity; Lead

Indexed keywords

LEAD;

ASTHMA; DISEASE PREDISPOSITION; EMBRYO DEVELOPMENT; ENVIRONMENTAL FACTOR; EXPERIMENTATION; EXPOSURE; GESTATIONAL AGE; HEREDITY; IMMUNE SYSTEM; IMMUNITY; IMMUNOTOXICITY; LIFE CYCLE; NONHUMAN; PRENATAL EXPOSURE; QUANTITATIVE ANALYSIS; REVIEW; RISK FACTOR;

ANIMALIA;

EID: 3242679814     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.08.020     Document Type: Article

References (102)

1. Anetor J.L., Adeniyi F.A. Decreased immune status in Nigerian workers occupationally exposed to lead. Afr. J. Med. Med. Sci. 27:1998;169-172
2. Araki S., Sato H., Yokoyama K., Murata K. Subclinical neurophysiological effects of lead: a review on peripheral, central, and autonomic nervous system effects in lead workers. Am. J. Ind. Med. 37:2000;193-204
3. Aykin-Burns N., Laegeler A., Kellogg G., Ercal N. Oxidative effects of lead in young and adult Fischer 344 rats. Arch. Environ. Contam. Toxicol. 44:2003;417-420
4. Bellinger D.C. Interpreting the literature on lead and child development: the neglected role of the "Experimental System" Neurotoxicol. Teratol. 17:1995;201-212
5. Bellinger D.C., Needleman H.L. Lead and the relationship between maternal and child intelligence. J. Pediatr. 102:1983;523-527
6. Bunn T.L., Marsh J.A., Dietert R.R. Gender differences in developmental immunotoxicity to lead in the chicken: analysis following a single early low-level exposure in ovo. J. Toxicol. Environ. Health, Part A. 61:2000;677-693
7. Bunn T.L., Ladics G.S., Holsapple M.P., Dietert R.R. Developmental immunotoxicology assessment in the rat: age, gender and strain comparisons after exposure to Pb. Toxicol. Methods. 11:2001;41-58
8. Bunn T.L., Parsons P.J., Kao E., Dietert R.R. Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender. Toxicol. Sci. 64:2001;57-66
9. Bunn T.L., Parsons P.J., Kao E., Dietert R.R. Gender-based profiles of developmental immunotoxicity to lead in the rat: assessment in juveniles and adults. J. Toxicol. Environ. Health, Part A. 64:2001;101-118
10. Burger J., Gochfeld M. Effects of lead on birds (Laridae): a review of laboratory and field studies. J. Toxicol. Environ. Health, Part B. 3:2000;59-78
11. Chapin R.E., Harris M.W., Davis B.J., Ward S.M., Wilson R.E., Mauney M.A., Lockhart A.C., Smialowicz R.J., Moser V.C., Burka L.T., Collins B.J. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune and reproductive system function. Fundam. Appl. Toxicol. 40:1997;138-157
12. Chen S., Miller T.E., Golemboski K.A., Dietert R.R. Suppression of macrophage metabolite production by lead glutamate in vitro is reversed by meso-2,3-dimercaptosuccinic acid (DMSA). In Vitro Toxicol. 10:1997;351-357
13. Chen S., Golemboski K.A., Sanders F.S., Dietert R.R. Persistent effect of in utero meso-2,3-dimercaptosuccinic acid (DMSA) on immune function and lead-induced immunotoxicity. Toxicology. 132:1999;67-79
14. Cohen N., Modai A., Weissgarten J., Peller S., Katz A., Aveburk Z., Shaked U. Increased con A-induced suppressor cell activity in humans with occupational lead exposure. Environ. Res. 48:1989;1-6
15. Cohen M.D., Yang Z., Zelikoff J.T. Immunotoxicity of particulate lead: in vitro exposure alters pulmonary macrophage tumor necrosis factor production and activity. J. Toxicol. Environ. Health. 42:1994;377-392
16. Cook J.A., Hoffman E.O., DiLuzio N.R. Influence of lead and cadmium on the susceptibility of rats to bacterial challenge. Proc. Soc. Exp. Biol. Med. 150:1975;741-747
17. Coscia G.C., Discalzi G., Ponzetti C. Immunological aspects of occupational lead exposure. Med. Lav. 78:1987;360-364
18. De Francisco N., Ruiz Troya J.D., Aguera E.I. Lead and lead toxicity in domestic and free living birds. Avian Pathol. 32:2003;2-13
19. DeMent S.H., Chisolm J.J. Jr., Barber J.C., Strandberg J.D. Lead exposure in an "urban" peregrine falcon and its avian prey. J. Wildl. Dis. 22:1986;238-244
20. Dietert R.R., Etzel R.A., Chen D., Halonen M., Holladay S.D., Jarabek A.M., Landreth K., Peden D.B., Pinkerton K., Smialowicz R.J., Zoetis T. Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. Environ. Health Perspect. 108(Suppl. 3):2000;483-490
21. Dietert R.R., Lee J.-E., Bunn T.L. Developmental immunotoxicology: emerging issues. Hum. Exp. Toxicol. 21:2002;479-485
22. Dunnon D., Allioli N., Vainio O., Ody C., Imhof B.A. Quantification of T-cell progenitors during ontogeny: thymus colonization depends on blood delivery of progenitors. Blood. 93:1999;2234-2243
23. Dyatlov V.A., Lawrence D.A. Neonatal lead exposure potentiates sickness behavior induced by Listeria monocytogenes in mice. Brain Behav. Immun. 16(4):2002;477-492
24. Ewers U., Stiller-Winkler R., Idel H. Serum immunoglobulin, complement C3 and salivary IgA levels in lead workers. Environ. Res. 29:1982;352-357
25. Faith R.E., Luster M.I., Kimmel C.A. Effect of chronic developmental lead exposure on cell-mediated immune functions. Clin. Exp. Immunol. 35:1979;413-420
26. Fernandez-Cabezudo M.J., Hasan M.Y., Mustafa N., El-Sharkawy R.T., Fahim M.A., Al-Ramadi B.K. Alpha tocopherol protects against immunosuppressive and immunotoxic effects of lead. Free Radical Res. 37:2003;437-445
27. Fischbein A., Tsang P., Luo J.-C.J., Roboz J.P., Jiang J.D., Bekesi J.G. Phenotypic aberrations of lymphocytes at low-level occupational exposure to lead. Clin. Immunol. Immunopathol. 66:1993;163-168
28. Foster W.G., McMahon A., Rice D.C. Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels. Toxicol. Ind. Health. 12:1996;723-735
29. Gainer J.H. Lead aggravates viral disease and represses the antiviral activity of interferon inducers. Environ. Health Perspect. 7:1974;113-119
30. Garavan H., Morgan R.E., Levitshy D.A., Herman-Vaquez L., Strupp B.J. Enduring effects of early lead exposure: evidence for a specific deficit in associative ability. Neurotoxicol. Teratol. 22:2000;151-164
31. Gobel T.W.F. The T-dependent immune system. Davidson T.F., Morris T.R., Payne L.N. Poultry Immunology. vol. 24:1996;31-45 Carfax, Abingdon
32. Goyer R.A. Lead toxicity: current concerns. Environ. Health Perspect. 100:1993;177-187
33. Grasman K.A., Scanlon P.F. Effects of acute lead ingestion and diet on antibody and T-cell-mediated immunity in Japanese quail. Arch. Environ. Contam. Toxicol. 28:1995;161-167
34. Guo T.L., Mudzinski S.P., Lawrence D.A. The heavy metal lead modulates the expression of both TNF-alpha and TNF-alpha receptors in lipopolysaccharide- activated human peripheral blood mononuclear cells. J. Leukocyte Biol. 59:1996;932-939
35. Gupta P., Husain M.N., Shankar R., Maheshwari R.K. Lead exposure enhances virus multiplication and pathogenesis in mice. Vet. Hum. Toxicol. 44:2002;205-210
36. Haneef S.S., Swarup D., Kalicharan, Dwivedi S.K. The effect of concurrent lead and cadmium exposure on the cell-mediated immune response in goats. Vet. Hum. Toxicol. 37:1995;428-429
37. He L., Poblenz A.T., Medrano C.J., Fox D.A. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J. Biol. Chem. 275:2000;12175-12184
38. Heinz G.H., Hoffman D.J., Sileo L., Audet D.J., LeCaptain L.J. Toxicity of lead-contaminated sediment to mallards. Arch. Environ. Contam. Toxicol. 36:1999;323-333
39. Hemphill F.E., Kaeberle M.L., Buck W.B. Lead suppression of mouse resistance to Salmonella typhimurium. Science. 172:1971;1031-1032
40. Heo Y., Parsons P.J., Lawrence D.A. Lead differentially modifies cytokine production in vitro and in vivo. Toxicol. Appl. Pharmacol. 138:1996;149-157
41. Heo Y., Lee W.T., Lawrence D.A. In vivo the environmental pollutants lead and mercury induce oligoclonal T cell responses skewed toward type-2 reactivities. Cell. Immunol. 179:1997;185-195
42. Heo Y., Lee W.T., Lawrence D.A. Differential effects of lead and cAMP on development and activities of Th1- and Th2-lymphocytes. Toxicol. Sci. 43:1998;172-185
43. Hoffman D.J., Heinz G.H., Sileo L., Audet D.J., Campbell J.K., LeCaptain L.J., Obrecht H.H. III Developmental toxicity of lead-contaminated sediment in Canada geese (Branta canadensis). J. Toxicol. Environ. Health. 59:2000;235-252
44. Holladay S.D., Smialowicz R.J. Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure. Environ. Health Perspect. 108(Suppl. 3):2000;463-473
45. Hudson C.A., Cao L., Kasten-Joly J., Kirkwood J.N., Lawrence D.A. Susceptibility of lupus-prone NZM mouse strains to lead exacerbation of systemic lupus erythematous symptoms. J. Toxicol. Environ. Health, Part A. 66:2003;895-918
46. Holsapple M.P. Developmental immunotoxicology and risk assessment: a workshop summary. Hum. Exp. Toxicol. 21:2002;473-478
47. Karpuzoglu-Sahin E., Hissong B.D., Ansar Ahmed S. Interferon-gamma levels are upregulated by 17-beta-estradiol and diethylstilbestrol. J. Reprod. Immunol. 52:2001;113-127
48. Kerkvliet N.I., Baecher-Steppan L. Immunotoxicology studies on lead: effects of exposure on tumor growth and cell-mediated tumor immunity after syngeneic or allogeneic stimulation. Immunopharmacology. 4:1982;213-224
49. Kim D., Lawrence D.A. Immunotoxic effects of inorganic lead on host resistance of mice with different circling behavior preferences. Brain Behav. Immun. 14:2000;305-317
50. Kimber I., Jackson J.A., Stonard M.D. Failure of inorganic lead exposure to impair natural killer (NK) cell and T lymphocyte function in rats. Toxicol. Lett. 31:1986;211-218
51. Knowles S.O., Donaldson W.F. Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds. Biol. Trace Elem. Res. 60:1997;13-26
52. Kobayashi N., Okamoto T. Effects of lead oxide on the induction of lung tumors in Syrian hamsters. J. Natl. Cancer Inst. 52:1974;1605-1610
53. Koller L.D. Immunosuppression produced by lead, cadmium, and mercury. Am. J. Vet. Res. 34:1973;1457-1458
54. Koller L.D., Kovacs S. Decreased antibody formation in mice exposure to lead. Nature. 250:1977;148-150
55. Koller L.D., Roan J.G. Effects of lead and cadmium on mouse peritoneal macrophages. J. Reticuloendothel. Soc. 21:1977;7-12
56. Kowolenko M., Tracy L., Mudzinski S., Lawrence D.A. Effect of lead on macrophage function. J. Leukocyte Biol. 43:1988;357-364
57. Kowolenko M., Tracy L., Lawrence D.A. Early effects of lead on bone marrow cell responsiveness in mice challenged with Listeria monocytogenes. Fundam. Appl. Toxicol. 17:1991;75-82
58. Landreth K.S. Critical windows in development of the rodent immune system. Hum. Exp. Toxicol. 21:2002;493-498
59. Lawrence D.A. In vivo and in vitro effect of lead on humoral and cell-mediated and cell-mediated immunity. Infect. Immun. 31:1981;136-143
60. Lawrence D.A., McCabe M.J. Jr. Immunomodulation by metals. Int. Immunopharmacol. 2:2002;293-302
61. Lee J.-E., Dietert R.R. Developmental immunotoxicology of lead: impact on thymic function. Birth Defects Res. Part A. 67:2003;861-867
62. Lee J.-E., Chen S., Golemboski K.A., Parsons P., Dietert R.R. Developmental windows of differential lead-induced immunotoxicity in chickens. Toxicology. 156:2001;161-170
63. Lee J.-E., Naqi S., Kao E., Dietert R.R. Embryonic exposure to lead: comparison of immune and cellular responses in unchallenged and virally stressed chickens. Arch. Toxicol. 75:2002;717-724
64. Lee S.Y., Lee Y.H., Shin C., Shim J.J., Kang K.H., Yoo S.H., In K.H. Association of asthma severity and bronchial hyperreponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene. Chest. 122:2002;171-176
65. Leposavic G., Plecas B., Kosec D. Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats. Immunopharmacology. 46:2000;79-87
66. Ling Z., Gayle D.A., Ma S.Y., Lipton J.W., Tong C.W., Hong J.S., Carvet P.M. In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov. Disord. 17:2002;116-124
67. Loghman-Adman M. Renal effects of environmental and occupational lead exposure. Environ. Health Perspect. 105:1997;928-939
68. Lorenzana R.M., Troast R., Mastriano M., Follansbee M.H., Diamond G.L. Lead intervention and pediatric blood lead levels at hazardous waste sites. J. Toxicol. Environ. Health. 66:2003;871-893
69. Luster M.I., Faith R.E., Kimmel C.A. Depression of humoral immunity in rats following chronic developmental lead exposure. J. Environ. Pathol. Toxicol. 1:1978;397-402
70. Luster M.I., Dean J.H., Germolec D.R. Consensus workshop on methods to evaluate developmental immunotoxicity. Environ. Health Perspect. 111:2003;579-583
71. Lutz P.M., Wilson T.J., Ireland J., Jones A.L., Gorman J.S., Gale N.L., Johnson J.C., Hewett J.E. Elevated immunoglobulin E (IgE) levels in children with exposure to environmental lead. Toxicology. 134:1999;63-78
72. Mas A., Arola L.L. Cadmium and lead toxicity effects on zinc, copper, nickel and iron distribution in the developing chick embryo. Comp. Biochem. Physiol. 80C:1985;185-188
73. McCabe M.J. Jr., Lawrence D.A. Lead, a major environmental pollutant, is immunomodulatory by its differential effects on CD4+ T cell subsets. Toxicol. Appl. Pharmacol. 111:1991;13-23
74. McCabe M.J. Jr., Singh K.P., Reiner J.J. Jr. Lead intoxication impairs the generation of a delayed type hypersensitivity response. Toxicology. 139:1999;255-264
75. McCabe M.J. Jr., Singh K.P., Reiners J.J. Jr. Low level lead exposure in vitro stimulates the proliferation and expansion of alloantigen-reactive CD4 (high) T cells. Toxicol. Appl. Pharmacol. 177:2001;219-231
76. Miller T.E., Golemboski K.A., Ha R.S., Bunn T.L., Sanders F.S., Dietert R.R. Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 Rats. Toxicol. Sci. 42:1998;129-135
77. Misra K.P., Singh V.K., Rani R., Yadav V.S., Chandran V., Srivastava S.P., Seth P.K. Effect of lead exposure on the immune response of some occupationally exposed individuals. Toxicology. 188:2003;251-259
78. Muller S., Gillert K.E., Krause C., Gross U., Age-Stehr J.L., Diamanstein T. Suppression of delayed type hypersensitivity of mice by lead. Experientia. 33:1977;667-668
79. Nolan C.V., Shaikh Z.A. Lead nephrotoxicity and associated disorders: biochemical mechanisms. Toxicology. 73:1992;27-146
80. Peden D.B. Development of atopy and asthma: candidate environmental influences and important periods of exposure. Environ. Health Perspect. 108(Suppl. 3):2000;475-482
81. Pinkerton L.E., Biagini R.E., Ward E.M., Hull R.D., Deadens J.A., Boeniger M.F., Schnorr T.M., Mackenzie B.A., Luster M.I. Immunologic findings among lead-exposed workers. Am. J. Ind. Med. 33:1998;400-408
82. Rabinowitz M.B., Allred E.N., Bellinger D.C., Levitan A., Needleman H.L. Lead and childhood propensity to infectious and allergic disorders: is there an association? Bull. Environ. Contam. Toxicol. 44:1990;657-660
83. Rocke T.E., Samuel M.D. Effects of lead shot ingestion on selected cells of the mallard immune system. J. Wildl. Dis. 27:1991;1-9
84. Ronis M.J., Badger T.M., Shema S.T., Roberson R.K., Shaikh F. Effects on pubertal growth and reproduction in rats exposed to lead perinatally or continuously throughout development. J. Toxicol. Environ. Health. 53:1998;327-341
85. Sata F., Araki S., Tanigawa T., Morita Y., Sakurai S., Nakata A., Katsuno N. Changes in T cell subpopulations in lead workers. Environ. Res. 76:1998;61-64
86. Sarasua S.M., Vogt R.F., Henderson L.M., Jones P.A., Lybarger J.A. Serum immunoglobins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure. J. Toxicol. Environ. Health, Part A. 60:2000;1-15
87. Sears M.R., Burrow B., Flannery E.M., Hebison G.P., Hewitt C.J., Holdaway M.D. Relationship between airway responsiveness and serum IgE in children with asthma and in apparently normal children. New Engl. J. Med. 325:1991;1067-1071
88. Sengler C., Lau S., Wahn U., Nickle R. Interaction between genes and environmental factors in asthma and atopy: new developments. Respir. Res. 3:2002;7
89. Shabani A., Rabbani A. Lead nitrate induced apoptosis in alveolar macrophages from rat lung. Toxicology. 149:2000;109-114
90. Smialowicz R.J. The rat as a model in developmental immunotoxicology. Hum. Exp. Toxicol. 21:2002;513-519
91. Snyder J.E., Filipov N.M., Parsons P.J., Lawrence D.A. The efficiency of maternal transfer of lead and its influence on plasma IgE and splenic cellularity of mice. Toxicol. Sci. 57:2000;87-94
92. Talcott P.A., Koller L.D. The effect of inorganic lead and/or a polychlorinated biphenyl on the developing immune system of mice. J. Toxicol. Environ. Health. 12:1983;337-352
93. Tian L., Lawrence D.A. Lead inhibits nitric oxide production in vitro by murine splenic macrophages. Toxicol. Appl. Pharmacol. 132:1995;156-163
94. Umetsu D.T., DeKruyff R.H. Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases. Proc. Soc. Exp. Biol. Med. 215:1997;11-20
95. Undeger U., Basaran N., Canpinar H., Kansu E. Immune alterations in lead-exposed workers. Toxicology. 109:1996;167-172
96. Valentino M., Governa M., Marchiseppe I., Visona I. Effects of lead on polymorphonuclear leukocyte (PMN). Arch. Toxicol. 65:1991;685-688
97. Vicente A., Varas A., Acedon R.S., Jimenez E., Munoz J.J., Zapata A.G. Appearance and maturation of T-cell subsets during rat thymus ontogeny. Dev. Immunol. 5:1998;319-331
98. Waalkes M.P., Fox D.A., States C., Patierno S.R., McCabe M.J. Jr. Metals and disorders of cell accumulation: modulation of apoptosis and cell proliferation. Toxicol. Sci. 56:2000;162-255
99. Wayland M., Neugebauer E., Bollinger T. Concentrations of lead in liver, kidney and bone of bald and golden eagles. Arch. Environ. Contam. Toxicol. 37:1999;267-272
100. Youssef S.A.H., El-Sanousi A.A., Afifi N.A., El Brawy A.M. Effect of subclinical lead toxicity on the immune response of chickens to Newcastle disease virus vaccine. Res. Vet. Sci. 60:1996;13-16
101. Zelikoff J.T., Parsons E., Schlesinger R.B. Inhalation of particulate lead oxide disrupts pulmonary macrophage-mediated functions important for host defense and tumor surveillance in the lung. Environ. Res. 62:1993;207-222
102. Zelikoff J.T., Smialowicz R., Bigazzi P.E., Goyer R.A., Lawrence D.A., Maibach H.L., Gardiner D. Immunomodulation by metals. Fundam. Appl. Toxicol. 22:1994;1-7