Subclinical neurophysiological effects of lead: A review on peripheral, central, and autonomic nervous system effects in lead workers

American Journal of Industrial Medicine

Volumn 37, Issue 2, 2000, Pages 193-204

  Araki, Shunichi ^a   Sato, Hajime ^b   Yokoyama, Kazuhito ^b   Murata, Katsuyuki ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NONE

Author keywords

Computerized static posturography; Distribution of nerve conduction velocities; Dose effects (and response) relationship; Electrocardiographic R R interval variability; Evoked potentials (SEP, VEP, BAEP); Lead poisoning; Neurotoxicity; P300; Peripheral nerve conduction velocity; Subclinical health effect

Indexed keywords

LEAD;

ARTICLE; AUTONOMIC NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM; EVENT RELATED POTENTIAL; EVOKED AUDITORY RESPONSE; EVOKED VISUAL RESPONSE; HUMAN; LEAD POISONING; NERVE CONDUCTION; NEUROPHYSIOLOGY; NEUROTOXICITY; PERIPHERAL NERVOUS SYSTEM;

AUTONOMIC NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; EVOKED POTENTIALS; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; EVOKED POTENTIALS, SOMATOSENSORY; EVOKED POTENTIALS, VISUAL; HUMANS; LEAD; NERVOUS SYSTEM; NEURAL CONDUCTION; PERIPHERAL NERVOUS SYSTEM;

EID: 0033986182     PISSN: 02713586     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0274(200002)37:2<193::AID-AJIM5>3.0.CO;2-J     Document Type: Article

References (102)

1. Abbate C, Buceti R, Munao F, Giorgianni C, Ferreri G. 1995. Neurotoxicity induced by lead levels. An electrophysiological study. Int Arch Occup Environ Health 66:389-392.
2. Aminoff MJ, editor. 1986. Electrodiagnosis in clinical neurology. 2nd ed. New York: Churchill Livingstone, 822 p.
3. Araki S, Honma T. 1976. Relationships between lead absorption and peripheral nerve conduction velocities in lead workers. Scand J Work Environ Health 4:225-231.
4. Araki S, Murata K. 1993. Determination of evoked potentials in occupational and environmental medicine. A review. Environ Res 63:133-147.
5. Araki S, Honma T, Yanagihara S, Ushio K. 1980. Recovery of slowed nerve conduction velocity in lead-exposed workers. Int Arch Occup Environ Health 46:151-157.
6. Araki S, Murata K, Yanagihara S, Ushio K. 1982. High medical consultation rates of lead workers after industrial dispute over lead effects. Int Arch Occup Environ Health 49:241-250.
7. Araki S, Murata K, Aono H. 1986a. Subclinical cervico-spino-bulbar effects of lead. A study of short-latency somatosensory evoked potentials in workers exposed to lead, zinc, and copper. Am J Ind Med 10:163-175.
8. Araki S, Yokoyama K, Murata K, Aono H. 1986b. Determination of the distribution of conduction velocities in workers exposed to lead, zinc and copper. Br J Ind Med 43:321-326.
9. Araki S, Yokoyama K, Aono H, Murata K. 1986c. Psychological performance in relation to central and peripheral nerve conduction in workers exposed to lead, zinc, and copper. Am J Ind Med 9: 535-542.
10. Araki S, Murata K, Aono H. 1987. Central and peripheral nervous system dysfunction in workers exposed to lead, zinc, and copper. A follow-up study of visual and somatosensory evoked potentials. Int Arch Occup Environ Health 59:177-187.
11. Araki S, Murata K, Yokoyama K, Uchida E. 1992. Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper. Effects of lead on cognitive function and central nervous system. Am J Ind Med 21:539-547.
12. Araki S, Murata K, Uchida E, Aono H, Ozawa H. 1993a. Radial and median nerve conduction velocities in workers exposed to lead, copper, and zinc. A follow-up study for 2 years. Environ Res 61: 308-316.
13. Araki S, Yokoyama K, Murata K. 1993b. Assessment of the effects of occupational and environmental factors on all faster and slower large myelinated nerve fibers. A study of the distribution of nerve conduction velocities. Environ Res 62:325-332.
14. Araki S, Murata K, Yokoyama K. 1994a. Application of neurophysiological methods in occupational medicine in relation to psychological performance. Ann Acad Med Singapore 23:710-718.
15. Araki S, Gilioli R, Landrigan PJ, Yokoyama K, editors. 1994b. Neurobehavioral methods and effects in occupational and environmental health. San Diego: Academic Press, 1020 p.
16. Araki S, Yokoyama K, Murata K. 1997. Neurophysiological methods in occupational and environmental health. Methodology and recent findings. Environ Res 73:42-51.
17. Asahina M, Nakajima M, Kojima S, Hirayama K. 1994. Postural sway in patients with hereditary ataxia. Clin Neurol 34:1105-1110. (In Japanese).
18. Ashby JAS. 1980. A neurological and biochemical study of early lead poisoning. Br J Ind Med 37:133-140.
19. Audesirk G. 1985. Effects of lead exposure on the physiology of neurons. Prog Neurobiol 24:199-231.
20. Azazi ME, Kristensson K, Malm G, Wachtmeister L. 1985. Studies on developmental alterations in the electroretinogram in rats after postnatal exposure to lead. Acta Ophthalmol 63:574-580.
21. Baker EL, Feldman RG, White RA, Harley JP, Niles CA, Dinse GE, Berkey CS. 1984. Occupational lead neurotoxicity. A behavioural and electrophysiological evaluation, study design and year one results. Br J Ind Med 41:352-361.
22. Baloh RW, Spivey GH, Brown CP, Morgan D, Campion DS, Browdy BL, Valentine JL, Gonick HC, Massey FJ, Culver BD. 1979. Subclinical effects of chronic increased lead absorption. A prospective study II. Results of baseline neurologic testing. J Occup Med 21: 490-496.
23. Barker AT, Brown BH, Freeston H. 1979. Determination of the distribution of conduction velocities in human nerve trunks. IEEE Trans Biomed Eng 26:76-81.
24. Bordo BM, Filippini G, Massetto N, Musicco M, Boeri R. 1982. Electrophysiological study of subjects occupationally exposed to lead and with low levels of lead poisoning. Scand J Work Environ Health 8 (Suppl 1):142-147.
25. Buchthal F, Behse F. 1979. Electrophysiology and nerve biopsy in men exposed to lead. Br J Ind Med 36:135-147.
26. Chen Z-Q, Chan Q-I, Par C-C, Qu J-Y. 1985. Peripheral nerve conduction velocity in workers occupationally exposed to lead. Scand J Work Environ Health 11 (Suppl 4):26-28.
27. Chia SE, Chua LH, Ng TP, Foo SC, Jeyaratnam J. 1994. Postural stability of workers exposed to lead. Occup Environ Med 51:768-771.
28. Dichgans J, Fetter M. 1993. Computerized cerebellar functions upon the stabilization of body posture. Rev Neurol 149:654-664.
29. Diener HC, Dichgans J, Bacher M, Gompf B. 1984. Quantification of postural sway in normals and patients with cerebellar diseases. Electroencephalogr Clin Neurophysiol 57:134-142.
30. Eisen A, Aminoff MJ. 1986. Somatosensory evoked potentials. In: Aminoff MJ, editor. Electrodiagnosis in clinical neurology. 2nd ed. New York: Churchill Livingstone, p 535-573.
31. Feldman FG, Hayes MK, Younes R, Aldrich FD. 1977. Lead neuropathy in adults and children. Arch Neurol 34:481-488.
32. Feldman RG. 1998. Occupational and environmental neurotoxicology. Philadelphia: Lippincott-Raven Publishers, p 30-68.
33. Fitzpatrick RC, Gorman RB, Burke D, Gandevia SC. 1992. Postural proprioceptive reflexes in standing human subjects. Band width of response and transmission characteristics. J Physiol 458:69-83.
34. Fox DA, Sillman AJ. 1979. Heavy metals affect rod, but not cone, photoreceptors. Science 206:78-80.
35. Fujimura Y, Araki S, Murata K, Sakai T. 1998. Assessment of peripheral, central and autonomic nervous system functions in two lead smelters with high blood lead concentrations. A follow-up study. J Occup Health 40:9-15.
36. Gennart J-P, Bernard A, Lauwerys R. 1992. Assessment of thyroid, testes, kidney and autonomic nervous system function in lead-exposed workers. Int Arch Occup Environ Health 64:49-57.
37. Goodin DS. 1986. Event-related (endogenous) potentials. In: Aminoff MJ, editor. Electrodiagnosis in clinical neurology. 2nd ed. New York: Churchill Livingstone, p 575-595.
38. Grandjean P, Arnvig E, Beckmann J. 1978. Psychological dysfunctions in lead-exposed workers. Relation to biological parameters of exposure. Scand J Work Environ Health 4:295-303.
39. Haegar-Aronsen B, Schutz A. 1976. Antagonistic effect in vivo of zinc on inhibition of δ-aminolevulinic acid dehydratase by lead. Arch Environ Health 31:215-220.
40. Haenninen H, Hernberg S, Mantere P, Vesnato R, Jalkanen M. 1978. Psychological performance of subjects with low exposure to lead. J Occup Med 20:683-689.
41. Hazemann P, Jeftic M, Lille F. 1987. Somatosensory evoked potentials in alcoholics and patients occupationally exposed to solvents and lead. Electromyogr Clin Neurophysiol 27:183-187.
42. He F-S, Zhang S-L, Li G, Zhang S-C, Huang J-X, We Y-Q. 1988. An electroneurographic assessment of subclinical lead neurotoxicity. Int Arch Occup Environ Health 61:141-146.
43. Hirata M, Kosaka H. 1993. Effects of lead exposure on neurophysiological parameters. Environ Res 63:60-69.
44. Holdstein Y, Pratt H, Goldsher M, Rosen G, Shenhav R, Linn S, Mor A, Barkai A. 1986. Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects. J Laryngol Otol 100:1031-1036.
45. Horiguchi S, Kubo M, Nakano H, Endo G, Teramoto K, Mitsutake H, Harima M, Kurosawa K. 1988. Subclinical cases of lead poisoning specifically concerned with the central and peripheral neurologic findings. Osaka City Med J 34:237-243. (In Japanese with English abstract).
46. Jeyaratnam J, Devathasan G, Ong CN, Phoon WO, Wong PK. 1985. Neurophysiological studies on workers exposed to lead. Br J Ind Med 42:173-177.
47. Jeyaratnam J, Boey KW, Ong CN, Chia CB, Phoon WO. 1986. Neuropsychological studies on lead workers in Singapore. Br J Ind Med 43:626-629.
48. Kajiyama K, Doi R, Sawada J, Hashimoto K, Hazama T, Nakata S, Hirata M, Yoshida T, Miyajima K. 1993. Significance of subclinical entrapment of nerves in lead neuropathy. Environ Res 60:248-253.
49. Kimura J. 1989. Electrodiagnosis in diseases of nerve and muscle: principles and practice. 2nd ed. Philadelphia: FA Davis, 672 p.
50. Landrigan PJ. 1989. Toxicity of lead at low dose. Br J Ind Med 46:593-596.
51. Landrigan PJ, Baker EL Jr, Feldman RG, Cox DH, Eden KV, Orenstein WA, Mather JA, Yankel AJ, von Lindern IH. 1976. Increased lead absorption with anemia and slowed nerve conduction in children near a lead smelter. J Pediatr 89:904-910.
52. Lilis R, Fischbein A, Eisinger J, Blumberg WE, Diamond S, Anderson HA, Rom W, Rice C, Sarkozi L, Kon S, Selikoff IJ. 1977. Prevalence of lead disease among secondary lead smelter workers and biological indicators of lead exposure. Environ Res 14:255-285.
53. Lille F, Hazemann P, Garnier R, Dally S. 1988. Effects of lead and mercury intoxications on evoked potentials. Clin Toxicol 26: 103-106.
54. ++-EDTA chelation for mild lead intoxication. J Occup Med 34:638-641.
55. Malliani A, Pagani M, Lombardi F, Cerutti S. 1991. Cardiovascular neural regulation explored in the frequency domain. Circulation 84:482-492.
56. Mantere P, Haenninen H, Hernberg S, Luukkonen R. 1984. A prospective follow-up study on psychological effects in workers exposed to low levels of lead. Scand J Work Environ Health 10: 43-50.
57. Mauritz KH, Dichgans J, Hufschmidt A. 1979. Quantitative analysis of stance in late cortical cerebellar atrophy of the anterior lobe and other forms of cerebellar ataxia. Brain 102:461-482.
58. Muijser H, Hoogendijk EMG, Hooisma J, Twisk DAM. 1987. Lead exposure during demolition of a steel structure coated with lead-based paints. Scand J Work Environ Health 13:56-61.
59. Murata K, Araki S. 1991. Autonomic nervous system dysfunction in workers exposed to lead, zinc, and copper in relation to peripheral nerve conduction. A study of R-R interval variability. Am J Ind Med 20:663-671.
60. Murata K, Araki S. 1996. Assessment of autonomic neurotoxicity in occupational and environmental health as determined by ECG R-R interval variability. A review. Am J Ind Med 30:155-163.
61. Murata K, Araki S, Aono H. 1987a. Effects of lead, zinc and copper absorption on peripheral nerve conduction in metal workers. Int Arch Occup Environ Health 59:11-20.
62. Murata K, Araki S, Aono H. 1987b. Visual and brainstem auditory evoked potentials in lead-exposed workers. Japan J EEG EMG 15:16-21. (In Japanese with English abstract).
63. Murata K, Landrigan PJ, Araki S. 1992. Effects of age, heart rate, gender, tobacco and alcohol ingestion on R-R interval variability in human ECG. J Auton Nerv Syst 37:199-206.
64. Murata K, Araki S, Yokoyama K, Uchida E, Fujimura Y. 1993. Assessment of central, peripheral, and autonomic nervous system functions in lead workers. Neuroelectrophysiological studies. Environ Res 61:323-336.
65. Murata K, Araki S, Yokoyama K, Nomiyama K, Nomiyama H, Tao Y-X, Liu S-J. 1995. Autonomic and central nervous system effects of lead in female glass workers in China. Am J Ind Med 28:233-244.
66. Nielsen CJ, Nielsen VK, Kirkby H, Gyntelberg F. 1982. Absence of peripheral neuropathy in long-term lead-exposed subjects. Acta Neurol Scandinav 65:241-247.
67. Otto DA, Hudnell HK. 1993. The use of visual and chemosensory evoked potentials in environmental and occupational health. Environ Res 62:159-171.
68. Otto DA, Fox DA. 1993. Auditory and visual dysfunction following lead exposure. Neurotoxicology 14:191-208.
69. Otto DA, Benignus VA, Muller KE, Barton CN. 1981. Effects of age and body lead burden on CNS function in young children. I. Slow cortical potentials. Electroencephalogr Clin Neurophysiol 52:229-239.
70. Otto DA, Robinson G, Baumann S, Schroeder S, Mushak P, Kleinbaum D, Boone L. 1985. 5-year follow-up study of children with low-to-moderate lead absorption. Electrophysiological evaluation. Environ Res 38:168-186.
71. Pasternak G, Becker CE, Lash A, Bowler R, Estrin WJ, Law D. 1989. Cross-sectional neurotoxicology study of lead-exposed cohort. Clin Toxicol 27:37-51.
72. Paulev P-E, Gry C, Dossing M. 1979. Motor nerve conduction velocity in asymptomatic lead workers. Int Arch Occup Environ Health 43:37-43.
73. Purser DA, Berrill KR, Majeed SK. 1983. Effects of lead exposure on peripheral nerve in the cynomolgus monkey. Br J Ind Med 40:402-412.
74. Repko JD, Corum CR, Jones PD, Garcia LS Jr. 1978. The Effects of inorganic lead on behavioral and neurologic function. Cincinnati: US Government Printing Office, 92 p.
75. Rosen I, Wildt K, Gullberg B, Berlin M. 1983. Neurophysiological effects of lead exposure. Scand J Work Environ Health 9:431-441.
76. Sata F, Araki S, Murata K, Fujimura Y, Uchida E. 1993. Are faster or slower large myelinated nerve fibers more sensitive to chronic lead exposure? A study of the distribution of conduction velocities. Environ Res 62:333-338.
77. Sborgia G, Assennato G, L'Abbate N, DeMarinis L, Paci C, DeNicola M, DeMarinis G, Montrone N, Ferrannini E, Specchio L, Masi G, Olivieri G. 1983. Comprehensive neurophysiological evaluation of lead-exposed workers. In: Gilioli R, Cassito M, Foa V, editors. Neurobehavioral methods in occupational health. New York: Pergamon Press, p 283-294.
78. Schwartz J, Landrigan PJ, Feldman RG, Silbergeld EK, Baker EL Jr, von Lindern IH. 1988. Threshold effect in lead-induced peripheral neuropathy. J Pediatr 112:12-17.
79. Seppaelainen AM, Hernberg S. 1972. Sensitive technique for detecting subclinical lead neuropathy. Br J Ind Med 29:443-449.
80. Seppaelainen AM, Hernberg S. 1980. Subclinical lead neuropathy. Am J Ind Med 1:413-420.
81. Seppaelainen AM, Tola S, Hernberg S, Kock B. 1975. Subclinical neuropathy at safe levels of lead exposure. Arch Environ Health 30:180-183.
82. Seppaelainen AM, Hernberg S, Kock B. 1979. Relationship between blood levels and nerve conduction velocities. Neurotoxicology 1:313-332.
83. Seppaelainen AM, Hernberg S, Vesanto R, Kock B. 1983. Early neurotoxic effects of occupational lead exposure. A prospective study. Neurotoxicology 4:181-192.
84. Singer R, Valciukas JA, Lilis R. 1983. Lead exposure and nerve conduction velocity. The differential time course of sensory and motor nerve effects. Neurotoxicology 4:193-202.
85. Sokol S. 1986. Visual evoked potentials. In: Aminoff MJ, editor. Electrodiagnosis in clinical neurology. 2nd ed. New York: Churchill Livingstone, p 441-466.
86. Solliway BM, Schaffer A, Pratt H, Yannai S. 1994. A multidisciplinary study of lead-exposed subjects. I. Delayed target detection P-300 latency, an electrophysiological parameter, correlates with urinary δ-ALA. Environ Res 67:168-182.
87. Spivey GH, Baloh RW, Brown CP, Browdy BL, Campion DS, Valentine JL, Morgan DE, Culver BD. 1980. Subclinical effects of chronic increased lead absorption. A prospective study III. Neurologic findings at follow-up examination. J Occup Med 22:607-612.
88. Stockard JJ, Stockard JE, Sharbrough FW. 1986. Brainstem auditory evoked potentials in neurology. Methodology, interpretation, and clinical application. In: Aminoff MJ, editor. Electrodiagnosis in clinical neurology. 2nd ed. New York: Churchill Livingstone, p 467-503.
89. Stollery BT, Broadbent DE, Banks HA, Lee WR. 1991. Short term prospective study of cognitive functioning in lead workers. Br J Ind Med 48:739-749.
90. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. 1996. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation 93:1043-1065.
91. Teruya K, Sakurai H, Omae K, Higashi T, Muto T, Kaneko Y. 1991. Effect of lead on cardiac parasympathetic function. Int Arch Occup Environ Health 62:549-553.
92. Triebig G, Weltle D, Valentin H. 1984. Investigations on neurotoxicity of chemical substances at the workplace. V. Determination of the motor and sensory nerve conduction velocity in persons occupationally exposed to lead. Int Arch Occup Environ Health 53:189-204.
93. Vasilescu C. 1973. Motor nerve conduction velocity and electromyogram in chronic lead poisoning. Rev Roum Neurol 10:221-226.
94. WHO task group on environmental health criteria for inorganic lead. 1995. Inorganic lead (Environmental health criteria 165). Geneva: WHO, 300 p.
95. Yagi K. 1989. Multivariate statistical analysis in stabilometry in human upright standing (the first report). Age-related factor. Japan J Otorhinolaryngol 92:899-908. (In Japanese with English abstract).
96. Yeh J-H, Chang Y-C, Wang J-D. 1995. Combined electroneurographic and electromyographic studies in lead workers. Occup Environ Med 52:415-419.
97. Yokoyama K, Araki S. 1992. Assessment of slow axonal transport in lead-exposed rats. Environ Res 59:440-446.
98. Yokoyama K, Araki S, Murata K, Aono H. 1987. Distribution of conduction velocities (DCV) in man. Mathematical model, measurement errors, and normal and abnormal values. Japan J EEG EMG 15:282-290. (In Japanese with English abstract).
99. Yokoyama K, Araki S, Aono H. 1988. Reversibility of psychological performance in subclinical lead absorption. Neurotoxicology 9: 405-410.
100. Yokoyama K, Araki S, Murata K, Nomiyama K, Nomiyama H, Tao YX, Liu SJ, Mori N. 1994. Effects of lead on postural balance and psychobehavioral performance in female glass workers in China. Japan J Ind Health 36:471. (Abstract in Japanese).
101. Yokoyama K, Araki S, Murata K, Morita Y, Katsuno N, Tanigawa T, Mori N, Yokota J, Ito A, Sakata E. 1997. Subclinical vestibulocerebellar, anterior cerebellar lobe and spinocerebellar effects in lead workers in relation to concurrent and past exposure. Neurotoxicology 18:371-380.
102. Yokoyama K, Araki S, Aono H, Murata K. 1998. Calcium disodium ethylenediamine tetraacetate-chelated lead as a predictor of subclinical lead neurotoxicity. Follow-up study on gun-metal foundry workers. Int Arch Occup Environ Health 71:459-464.