Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels

Toxicology and Industrial Health

Volumn 12, Issue 5, 1996, Pages 723-735

  Foster, Warren G ^a   McMahon, Avril ^a   Rice, Deborah C ^b  

^a Environmental Health Centre Ottawa   (Canada)

^b TOXICOLOGY RESEARCH DIVISION   (Canada)

Author keywords

Acridine orange; analysis of variance; and T; ANOVA; AO; BLL; blood lead level; cells outside the main population; COMP; deoxyribonucleic acid; DNA; EDTA; ethylenediaminetetraacetic acid; PI; propidium iodide; SCSA; serum testosterone; sperm chromatin structure assay

Indexed keywords

ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; LEAD BLOOD LEVEL; LEAD POISONING; MALE; MALE STERILITY; MONKEY; NONHUMAN; SPERMATOZOON COUNT; SPONTANEOUS ABORTION;

ANIMALS; CHROMATIN; DISEASE MODELS, ANIMAL; ENVIRONMENTAL EXPOSURE; FLOW CYTOMETRY; LEAD; LEAD POISONING; MACACA FASCICULARIS; MALE; RADIOIMMUNOASSAY; REFERENCE VALUES; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTOSTERONE;

EID: 0030443041     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/074823379601200509     Document Type: Article

References (36)

1. Al-Hakkak, Z.S., Zahid, Z.R., Ibrahim, D.K., Al-Jumaily, I.S., and Bazzaz, A.A. (1988) “Effects of ingestion of lead monoxide alloy on male mouse reproduction.” Arch. Toxicol. 62:97-100.
2. Assennato, G., Paci, C., Baser, M.E., Molinni, R., Candela, R.G., Altamura, B.M. and Giorgino, R. (1987). “Sperm count suppression without endocrine dysfunction in lead exposed men.” Arch. Environ. Health 42:124-127.
3. Agency For Toxic Substances And Disease Registry (Atsdr) (1990). “Nature and extent of lead exposure in children in the United States.” Atlanta, GA. U. S. Public Health Service, Washington, DC.
4. Ballachey, B.E., Hohenboken, W.D., and Evenson, D.P. (1988). “Heterogeneity of sperm nuclear chromatin structure and its relationship to fertility of bulls.” Biol. Reprod. 36:915-925.
5. Braunstein, G., Dahlgren, J., and Loriaux, D.L. (1978). “Hypogonadism in chronically lead-poisoned men. “ Infertility 1:33-51.
6. Cullen, M.R., Kayne, R.D., and Robins, J.M. (1984). “Endocrine and reproductive dysfunction in men associated with occupational inorganic lead intoxication.” Arch. Environ. Health. 39:431-440.
7. El-Zohairy, E.A., Youssef, A.F., Abul-Nasr, S.M., Fahmy, I.M., Salem, D., Kahil, A.K., and Madkour, M.K. (1996). “Reproductive hazards of lead exposure among urban Egyptian men.” Reprod. Toxicol. 10:145-151.
8. Evenson, D.P. (1990). “Flow cytometric analysis of male germ cell quality. “ Methods Cell Biol. 33:40-410.
9. Evenson, D.P. and Jost, L.K. (1993). “Hydroxyurea exposure alters mouse testicular kinetics and sperm chromatin structure.” Cell Prolif. 26:147-159.
10. Evenson D.P., Higgins, P.H., Gruenberg, D., and Ballachey, B.E. (1985). “Flow cytometric analysis of mouse spermatogenic function following exposure to ethylnitrosurea.” Cytometry 6:238-253.
11. Evenson, D.P., Baer, R.K., Jost, L.K., and Gesch, R.W. (1986). “Toxicity of thiotepa on mouse spermatogenesis determined by dual-parameter flow cytometry.” Toxicol. Appl. Pharamacol. 82:151-163.
12. Evenson, D.P., Janca, F.C., Jost, L.K., Baer, R.K., and Karabinus, D.S. (1989). “Flow cytometric analysis of effects of 1,3-dinitrobenzene on rat spermatogenesis.” J. Toxicol. Environ. Health. 28:81-98.
13. Evenson, D.P., Jost, L.K., and Gandy, J. (1993a). “Glutathione depletion potentiates ethyl methanesulfonate-induced damage to sperm chromatin structure.” Reprod. Toxicol. 7:297-304.
14. Evenson, D.P., Jost, L.K., and Baer, R.K. (1993b). “Effects of methanesulfonate on mouse sperm chromatin structure and testicular cell kinetics.” Environ. Mol. Mut. 21:144-153.
15. Fahim, M.S., Fahim, Z., and Hall, D.G. (1976). “Effects of subtoxic lead on pregnant women in the state of Missouri.” Res. Comm. Chem. Pathol. Pharmacol. 13:309-330.
16. Foster, W.G., McMahon, A., Younglai, E.V., Hughes, E.G., and Rice, D.C. (1993). “Reproductive endocrine effects of chronic lead exposure in the male cynomolgus monkey.” Reprod. Toxicol. 7:203-209.
17. Johansson, L. and Wide, M. (1986). “Long-term exposure of the male mouse to lead: effects on fertility.” Environ. Res. 41:481-487.
18. Johansson, L. and Pellicciari, C.E. (1988). “Lead-induced changes in the stabilization of the mouse sperm chromatin.” Toxicology 51:11-24.
19. Lancranjan, I. Popescu, H.I., Gavesnescu, O., Kelpsch, I., and Serbanescu, M. (1975). “Reproductive ability of workmen occupationally exposed to lead.” Arch. Environ. Health 30:396-401.
20. Matilsky, M., Battino, S., Ben-Ami, M., Geslevich, Y., Eyali, V., and Shalev, E. (1993). “The effect of ejaculatory frequency on semen characteristics of normozoospermic and oligozoospermic men from an infertile population.” Hum. Reprod. 8:71-73.
21. McGregor, A.J. and Masson, H.J. (1990). “Chronic occupational lead exposure and testicular endocrine function.” Human Exp. Toxicol. 9:371-376.
22. McMichael, A.I., Vimpani, G.V., Robertson, E.F., Baghurst, P.A., and Clark, P.D. (1986). “The Port Pirie cohort study: maternal blood lead and pregnancy outcome.” J. Epidemiol. Comm. Health. 40:18-25.
23. Murthy, R.C., Gupta, S.K., and Saxena, D.K. (1995). “Nuclear alterations during acrosomal cap formation in spermatids of lead-treated rats.” Reprod. Toxicol. 9:483-489.
24. Ng, T.P., Goh, H.H., Ng, Y.L., Ong, H.Y., Ong, C.N., Chia, K.S., Chia, S.E., and Jeyaratnam, J. (1991). “Male endocrine functions in workers with moderate exposure to lead.” Brit. J. Industr. Med. 48:485-491.
25. Rice, D.C. (In Press). “Effects of Long-Term Lead Exposure on Hematology, Blood Biochemistry and Growth Curves in Monkeys.” Neurotoxicol.
26. Rice, D.C. (1990). “Lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys exposed during different periods of development.” Toxicol. Appl. Pharmacol. 106:327-333.
27. Rice, D.C. and Gilbert, S.G. (1990). “Sensitive periods for lead-induced behavioral impairment (nonspatial discrimination reversal) in monkeys.” Toxicol. Appl. Pharamcol. 102:101-109.
28. Singh, A., Cullen, C., Dykeman, A., Rice, D., and Foster, W. (1993). “Chronic lead exposure induces ultrastructural alterations in the monkey testis.” J. Submicr. Cytol. Pathol. 25:479-486.
29. Steel, R.G.D. and Torrie, J.H. (1980). Principles and Procedures of Statistics, A Biometrical Approach. McGraw-Hill Book Co., New York, NY. pp. 539–544.
30. Tepper, A. (1992). “Surveillance of occupational lead exposure in New Jersey: 1986 to 1989.” Am. J. Public Health. 82:275-277.
31. Thomas, J.A. and Brogan, W.C., III. (1983). “Some actions of lead on the sperm and on the male reproductive system.” Am. J. Industr. Med. 4:127-134.
32. Tzalev, D.L. and Zaprianov, Z.K. (1985). “Atomic absorption spectrometry in occupational and environmental health practice.” Vol. 1. CRC Press, pp. 137–150.
33. Vallee, B.L. and Ulmer, D.D. (1972). “Biochemical effects of mercury, cadmium and lead.” Annual Rev. Biochem. 41:91-128.
34. Valerio, D.A., Ellis, E.B., Clark, M.L., and Thompson, G.E. (1969). “Collection of semen from macaques by electroejaculation. “ Lab. Anim. Care 19:250-252.
35. Valerio, D.A., Leverage, W.E., and Munster, J.H. (1970). “Semen evaluation in macaques.” Lab. Anim. Care 20:734-740.
36. Young, R.J., Bodt, B.A., and Heitkamp, D.H. (1995). “Action of metallic ions on the precocious development by rabbit sperm of motion patterns that are characteristic of hyperactivated motility.” Mol. Reprod. Develop. 41:239-248.