Gender-based profiles of developmental immunotoxicity to lead in the rat: Assessment in juveniles and adults

Journal of Toxicology and Environmental Health - Part A

Volumn 64, Issue 3, 2001, Pages 223-240

  Bunn, T L ^a   Parsons, P J ^b   Kao, E ^a   Dietert, R R ^a  

^a Department of Obstetrics Gynecology   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD; NITRITE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOPHIL; CHICKEN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DEVELOPMENTAL DISORDER; DOSE TIME EFFECT RELATION; EMBRYO DEVELOPMENT; FEMALE; FETUS; GENDER; GESTATIONAL AGE; IMMUNE DEFICIENCY; IMMUNOTOXICITY; LEAD POISONING; LYMPHOCYTE COUNT; MALE; MAXIMUM PERMISSIBLE DOSE; MONOCYTE; NEUTROPHIL; NEWBORN; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; SPLEEN WEIGHT;

AGING; ANIMALS; ANTIBODY FORMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HYPERSENSITIVITY, DELAYED; IMMUNITY; LEAD; MALE; NITRIC OXIDE; ORGAN SIZE; PREGNANCY; RATS; RATS, INBRED F344; SEX CHARACTERISTICS; SPLEEN;

EID: 0035851009     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390152543708     Document Type: Article

References (44)

1. Subclinical neurophysiological effects of lead: A review on peripheral, central, and autonomic nervous system effects in lead workers
2. The relationship between fatigue, psychological and immunological variables in acute infectious illness
3. Gender differences in developmental immunotoxicity to Pb in the chicken: Analysis following a single early low-level exposure in ovo
4. Developmental immunotoxicology assessment in the rat: Age, gender and strain comparisons after exposure to Pb
5. Persistent effect of in utero meso-2,3-dimercaptosuccinic acid (DMSA) on immune function and Pb-induced immunotoxicity
6. Reproductive and developmental toxicity of metals
7. Immunotoxicity testing in the rat: An improved multiple assay model
8. Gill endocrine cells in the goldfish Carassius carassius var. auratus and their impairment following experimental lead intoxication
9. Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
10. 15N] nitrite in biological fluids
11. The heavy metal lead modulates the expression of both TNF-alpha and TNF-alpha receptors in lipopolysaccharide-activated human peripheral blood mononuclear cells
12. Regulation of HLA-DR and invariant chain expression by human peripheral blood mononuclear cells with lead, interferon-gamma, or interleukin-4
13. Lead differentially modifies cytokine production in vitro and in vivo
14. Differential effects of lead and cAMP on development and activities of Th1- and Th2-lymphocytes
15. Ontogeny of GH mRNA and GH secretion in male and female rats: Regulation by GH-releasing hormone
16. Selective vulnerability of the developing brain to lead
17. Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds
18. Estrogen-receptor expression and function in thymocytes in relation to gender and age
19. Acute effects of cadmium on delayed-type hypersensitivity in mice
20. Immunosuppression produced by lead, cadmium, and mercury
21. Early effects of lead on bone marrow cell responsiveness in mice challenged with Listeria monocytogenes
22. In vivo and in vitro effects of lead on humoral and cell-mediated immunity
23. Developmental windows of differential Pb-induced immunotoxicity in chickens
24. Risk assessment in immunotoxicology I. Sensitivity and predictability of immune tests
25. Elevated immunoglobulin E (IgE) levels in children with exposure to environmental lead
26. The heavy metal lead exhibits B cell-stimulatory factor activity by enhancing B cell ia expression and differentiation
27. Lead, a major environmental pollutant, is immunomodulatory by its differential effects on CD4+ T cells subsets
28. Lead influences translational or posttranslational regulation of la expression and increases invariant chain expression in mouse B cells
29. Lead intoxication impairs the generation of a delayed type hypersensitivity response
30. Developmental exposure to Pb causes persistent immunotoxicity in Fischer 344 rats
31. A rapid Zeeman graphite furnace atomic absorption spectrophotometric method for the determination of Pb in blood
32. Clinical outcome of seriously ill surgical patients with intraabdominal infection depends on both physiologic (APACHE II score) and immunologic (DTH score) alterations
33. The role of chemical-induced stress responses in immunosuppression: A review of quantitative associations and cause-effect relationships between chemical-induced stress responses and immunosuppression
34. Reproductive toxicity and growth effects in rats exposed to lead at different periods during development
35. Endocrine mechanisms underlying reproductive toxicity in the developing rat chronically exposed to dietary lead
36. Serum immunoglobulins and lymphocyte subset distributions in children living in communities assessed for lead and cadmium exposure
37. Low-level lead exposure and children's IQ: A meta-analysis and search for a threshold
38. The efficiency of maternal transfer of Pb and its influence on plasma IgE and splenic cellularity of mice
39. Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations
40. Metal-induced modulation of nitric oxide production in vitro by murine macrophages: Lead, nickel, and cobalt utilize different mechanisms
41. Effects of lead on the male reproductive system in mice
42. Lead administration during pregnancy and lactation affects steroidogenesis and hormone receptors in testes of offspring
43. Accurate and precise measurement of lead in bone using electrothermal atomic absorption spectrometry with Zeeman-effect background correction