Insulin as a primary autoantigen for type 1A diabetes

Clinical and Developmental Immunology

Volumn 12, Issue 3, 2005, Pages 181-186

  Jasinski, J M ^a,b   Eisenbarth, G S ^b,c  

^a Human Medical Genetics Program Aurora   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Autoantigen; Autoimmune; Insulin; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CARBOXYPEPTIDASE H; EPITOPE; GLUCOSE 6 PHOSPHATASE; GLUTAMATE DECARBOXYLASE 65; INSULIN; INSULIN B[9-23]; INSULIN DERIVATIVE; INSULINOMA ASSOCIATED ANTIGEN; PREPROINSULIN; PROINSULIN; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; AUTOIMMUNITY; CATALYSIS; CELL TYPE; DISEASE COURSE; EFFECTOR CELL; GENETIC MANIPULATION; GENETIC POLYMORPHISM; HUMAN; IMMUNIZATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULINOMA; LANGERHANS CELL; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; REVIEW; VARIABLE NUMBER OF TANDEM REPEAT;

ANIMALS; ANTIGEN PRESENTATION; AUTOANTIBODIES; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; EPITOPES; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; PROINSULIN; PROTEIN PRECURSORS; TISSUE DISTRIBUTION;

EID: 32144433232     PISSN: 17402522     EISSN: None     Source Type: Journal    
DOI: 10.1080/17402520500078204     Document Type: Review

References (58)

1. Abiru N, Wegmann D, Kawasaki E, Gottlieb P, Simone E, Eisenbarth GS. 2000. Dual overlapping peptides recognized by insulin peptide B:9-23 reactive T cell receptor AV13S3 T cell clones of the NOD mouse. J Autoimmun 14:231-237.
2. Alleva DG, Crowe PD, Jin L, et al. 2001. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Investig 107:173-180.
3. Anderson MS, Venanzi ES, Klein L, et al. 2002. Projection of an immunological self-shadow within the thymus by the aire protein. Science 298:1395-1401.
4. Anjos S, Polychronakos C. 2004. Mechanisms of genetic susceptibility to type I diabetes: Beyond HLA. Mol Genet Metab 81:187-195.
5. Arif S, Tree TI, Astill TP, et al. 2004. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Investig 113:451-463.
6. Chen W, Bergerot I, Elliott JF, et al. 2001. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 167:4926-4935.
7. Chentoufi AA, Polychronakos C. 2002. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51:1383-1390.
8. Daaboul J, Schatz D. 2003. Overview of prevention and intervention trials for type 1 diabetes. Rev Endocr Metab Disord 4:317-323.
9. Daniel D, Wegmann DR. 1996. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 93:956-960.
10. Devendra D, Paronen J, Moriyama H, Miao D, Eisenbarth GS, Liu E. 2004. Differential immune response to B:9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. J Autoimmun 23:17-26.
11. Dotta F, Gianani R, Previti M, et al. 1996. Autoimmunity to the GM2-1 islet ganglioside before and at the onset of type I diabetes. Diabetes 45:1193-1196.
12. Durinovic-Bello I, Maisel N, Schlosser M, et al. 2003. Relationship between T and B cell responses to proinsulin in human type 1 diabetes. Ann NY Acad Sci 1005:288-294.
13. Eisenbarth GS, Nayak RC, Rabinowe SL. 1988. Type I diabetes as a chronic autoimmune disease. J Diabetes Complicat 2:54-58.
14. Eskola V, Vahasalo P, Akerblom HK, Knip M. 2003. Increased frequency of islet cell antibodies in unaffected brothers of children with type 1 diabetes. Horm Res 59:195-200.
15. Faideau B, Briand JP, Lotton C, et al. 2004. Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice. J Immunol 172:25-33.
16. French MB, Allison J, Cram DS, et al. 1997. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 46:34-39.
17. Gotfredsen CF, Buschard K, Frandsen EK. 1985. Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabetologia 28:933-935.
18. Graves PM, Rotbart HA, Nix WA, et al. 2003. Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). Diabetes Res Clin Pract 59:51-61.
19. Greeley SA, Katsumata M, Yu L, et al. 2002. Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat Med 8:399-402.
20. Gregersen JW, Holmes S, Fugger L. 2004. Humanized animal models for autoimmune diseases. Tissue Antigens 63:383-394.
21. Halbout P, Briand JP, Becourt C, Muller S, Boitard C. 2002. T cell response to preproinsulin I and II in the nonobese diabetic mouse. J Immunol 169:2436-2443.
22. Herold KC. 2004. Treatment of type 1 diabetes mellitus to preserve insulin secretion. Endocrinol Metab Clin North Am 33:93.
23. von Herrath M, Bach JR 2002. Juvenile autoimmune diabetes: A pathogenic role for maternal antibodies? Nat Med 8:331-333.
24. Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. 2004. Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 140:882-886.
25. Hutton JC, Eisenbarth GS. 2003. A pancreatic {beta}-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes. Proc Natl Acad Sci USA 100:8626-8628.
26. Hutton J, Wasmeier C, Amaria R, Bright N, Creemers J, Proprotein processing and pancreatic islet function. Type 1 Diabetes: Molecular, Cellular and Clinical Immunology
27. Juhl K, Hutton J, Stimulus-secretion coupling in the pancreatic beta-cell. Type 1 Diabetes: Molecular, Cellular and Clinical Immunology. http://www.uchsc.edu/misc/diabetes/ books.html
28. Kent S, Chen Y, Breglio L, et al. 2005. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nat 435:224-228.
29. Lieberman SM, Evans AM, Han B, et al. 2003. Identification of the {beta} cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci USA 100:8384-8388.
30. Liu E, Moriyama H, Paronen J, et al. 2003. Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B: 9-23 immunization in the NOD mouse. J Autoimmun 21:213-219.
31. Marner B, Lernmark A, Ludvigsson J, et al. 1985. Islet cell antibodies in insulin-dependent (type 1) diabetic children treated with plasmapheresis. Diabetes Res 2:231-236.
32. Martin S, Wolf-Eichbaum D, Duinkerken G, et al. 2001. Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med 345:1036-1040.
33. Matejkova-Behanova M, Vankova M, Hill M, et al. 2004. Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age. Physiol Res 53:187-190.
34. Milgrom F, Witebsky E. 1962. Autoantibodies and autoimmune disease. JAMA 181:706-716.
35. Moriyama H, Wen L, Abiru N, et al. 2002. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci USA 99:5539-5544.
36. Moriyama H, Abiru N, Paronen J, et al. 2003. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the NOD mouse. Proc Natl Acad Sci USA 100:10376-10381.
37. Nakayama M, Abiru N, Wegmann D, et al. 2005. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nat 435:220-223.
38. Noorchashm H, Greeley SA, Naji A. 2003. The role of T/B lymphocyte collaboration in the regulation of autoimmune and alloimmune responses. Immunol Res 27:443-450.
39. Norris JM, Barriga K, Klingensmith G, et al. 2003. Timing of cereal exposure in infancy and risk of islet autoimmunity. The Diabetes Autoimmunity Study in the Young (DAISY). JAMA 290:1713-1720.
40. Ott PA, Dittrich MT, Herzog BA, et al. 2004. T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol 24:327-339.
41. Redondo MJ, Kawasaki E, Mulgrew CL, et al. 2000. DR and DQ associated protection from type 1 diabetes: Comparison of DRB1*1401 and DQA1*0102-DQB1*0602. J Clin Endocrinol Metab 85:3793-3797.
42. Robles DT, Eisenbarth GS, Dailey NJM, Peterson LB, Wicker LS. 2002. Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice. Diabetes 52:882-886.
43. Sairenji T, Daibata M, Sorli CH, et al. 1991. Relating homology between the Epstein-Barr virus BOLF1 and HLA-DQw8 beta chain to recent onset type 1 (insulin-dependent) diabetes mellitus. Diabetologia 34:33-39.
44. Schloot NC, Willemen S, Duinkerken G, De Vries RRP, Roep BO. 1998. Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain. J Autoimmun 11:169-175.
45. Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tisch RM. 1998. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 161:3912-3918.
46. Skyler J, Krischer J, Wolfsdorf J, Coure C, Palmer J, Greenbaum C, Cathbertson D, Rafkin-Mervis E, Chase H, Leschek, E. 2005. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1. Diabetes Care May 28(5): 1068-1076.
47. Stene LC, Barriga K, Norris JM, et al. 2004. Perinatal factors and development of islet autoimmunity in early childhood: The diabetes autoimmunity study in the young. Am J Epidemiol 160:3-10.
48. Tait KF, Collins JE, Heward JM, et al. 2004. Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity. Diabet Med 21:267-270.
49. Thebault-Baumont K, Dubois-LaForgue D, Krief P, et al. 2003. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J Clin Invest 111:851-857.
50. Verge CF, Gianani R, Kawasaki E, et al. 1996. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933.
51. Verge CF, Stenger D, Bonifacio E, et al. 1998. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial islet autoantibody workshop. Diabetes 47:1857-1866.
52. Wegmann DR, Norbury-Glaser M, Daniel D. 1994. Insulin-specific T-cells are a predominant component of islet infiltrates in prediabetic NOD mice. Eur J Immunol 24:1853-1857.
53. Wong FS, Karttunen J, Dumont C, et al. 1999. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med 5:1026-1031.
54. Wucherpfennig KW 2003. MHC-Linked susceptibility to type 1 diabetes a structural perspective, p 119-127.
55. Yu L, Eisenbarth GS, Humoral Autoimmunity in Type 1 Diabetes: Cellular, Molecular and Clinical Immunology. Type 1 Diabetes: Molecular, Cellular and Clinical Immunology http://www.uchsc. edu/misc/diabetes/books.html
56. Yu L, Rewers M, Gianani R, et al. 1996. Anti-islet autoantibodies develop sequentially rather than simultaneously. J Clin Endocrinol Metab 81:4264-4267.
57. Zekzer D, Wong FS, Wen L, et al. 1997. Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse. Diabetes 46:1124-1132.
58. Zimmet P, Turner R, McCarty D, Rowley M, Mackay I. 1999. Crucial points at diagnosis - Type 2 diabetes or slow type 1 diabetes. Diabetes Care 22:B59-B64.