MHC-linked susceptibility to type 1 diabetes: A structural perspective

Annals of the New York Academy of Sciences

Volumn 1005, Issue , 2003, Pages 119-127

  Wucherpfennig, Kai W ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

DQ8; Humans; I Ag7; MHC class II; NOD mice; Pathogenesis; SDS; Susceptibility; Type 1 diabetes

Indexed keywords

DETERGENT; EPITOPE; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ALLELE; ANTIGEN PRESENTATION; BINDING AFFINITY; BINDING SITE; BIOCHEMISTRY; COMPLEX FORMATION; CONFERENCE PAPER; CRYSTAL STRUCTURE; CRYSTALLIZATION; DENATURATION; DISSOCIATION; GENE LOCUS; GENETIC CODE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULE; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SOLUBILITY; T LYMPHOCYTE;

MURINAE;

EID: 1942475233     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1288.013     Document Type: Conference Paper

References (31)

1. DAVIES, J.L., Y. KAWAGUCHI, S.T. BENNETT et al. 1994. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136.
2. TODD, J.A., J.I. BELL & H.O. MCDEVITT. 1987. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329: 599-604.
3. NOBLE, J.A., A.M. VALDES, M. COOK et al. 1996. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am. J. Hum. Genet. 59: 1134-1148.
4. NEPOM, G.T. & H. ERLICH. 1991. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9: 493-525.
5. ERLICH, H.A., A. ZEIDLER, J. CHANG et al. 1993. HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nat. Genet. 3: 358-364.
6. VAFIADIS, P., S.T. BENNETT, J. TODD et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15: 289-292.
7. PUGLIESE, A., M. ZELLER, A. FERNANDEZ et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15: 293-297.
8. THE FINNISH-GERMAN APECED CONSORTIUM. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17: 399-403.
9. HEINO, M., P. PETERSON, N. SILLANPAA et al. 2000. RNA and protein expression of the murine autoimmune regulator gene (AIRE) in normal, Re1B-deficient and in NOD mouse. Eur. J. Immunol. 30: 1884-1893.
10. WICKER, L.S., J.A. TODD & L.B. PETERSON. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13: 179-200.
11. + nonobese diabetic mice develop insulitis and diabetes. J. Exp. Med. 178: 793-803.
12. ACHA-ORBEA, H. & H.O. MCDEVITT. 1987. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc. Natl. Acad. Sci. USA 84: 2435-2439.
13. HATTORI, M., E. YAMATO, N. ITOH et al. 1999. Homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility gene(s) in nonobese diabetic mice. J. Immunol. 163: 1721-1724.
14. LUND, T., L. O'REILLY, P. HUTCHINGS et al. 1990. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain. Nature 345: 727-729.
15. NOD to the development of insulitis in non-obese diabetic mice. Nature 345: 722-724.
16. g7 molecule: rapid release of CLIP at an endosomal pH. J. Exp. Med. 189: 1723-1734.
17. YU, B., L. GAUTHIER, D.H. HAUSMANN et al. 2000. Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes. Eur. J. Immunol. 30: 2497-2506.
18. LEE, K.H., K.W. WUCHERPFENNIG & D.C. WILEY. 2001. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2: 501-507.
19. g7 molecules from non-obese diabetic mice are poor peptide binders. J. Immunol. 156: 450-458.
20. REICH, E.P., H. VON GRAFENSTEIN, A. BARLOW et al. 1994. Self peptides isolated from MHC glycoproteins of non-obese diabetic mice. J. Immunol. 152: 2279-2288.
21. WEGMANN, D.R., M. NORBURY-GLASER & D. DANIEL. 1994. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. Immunol. 24: 1853-1857.
22. g7 in non-obese diabetic mice. Immunogenetics 46: 29-34.
23. FAIRCHILD, P.J., R. WILDGOOSE, E. ATHERTON et al. 1993. An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction. Int. Immunol. 5: 1151-1158.
24. LAMONT, A.G., A. SETTE, R. FUJINAMI et al. 1990. Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules. J. Immunol. 145: 1687-1693.
25. WONG, F.S., J. KARTTUNEN, C. DUMONT et al. 1999. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat. Med. 5: 1026-1031.
26. ALLEVA, D.G., P.D. CROWE, L. JIN et al. 2001. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J. Clin. Invest. 107: 173-180.
27. STERN, L.J., J.H. BROWN, T. JARDETZKY et al. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368: 215-221.
28. KWOK, W.W., M.E. DOMEIER, M.L. JOHNSON et al. 1996. HLA-DQB1 codon 57 is critical for peptide binding and recognition. J. Exp. Med. 183: 1253-1258.
29. LATEK, R.R., A. SURI, S.J. PETZOLD et al. 2000. Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity 12: 699-710.
30. g7 and autoimmune diabetes. Science 288: 505-511.
31. g7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder. J. Immunol. 165: 3214-3225.