Gene transfer approaches to enhancing bone healing

Bone Regeneration and Repair: Biology and Clinical Applications

Volumn , Issue , 2005, Pages 157-168

  Betz, Oliver ^a   Vrahas, Mark ^a   Baltzer, Axel ^b   Lieberman, Jay R ^c   Robbins, Paul D ^d   Evans, Christopher H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Praxis und Klink für Orthopaedie   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 31844454899     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1385/1-59259-863-3:157     Document Type: Chapter

References (72)

1. Fernandez, D. L., Ring, D., and Jupiter, J. B. (2001) Surgical management of delayed union and nonunion of distal radius fractures. J. Hand Surg. 26(2), 201-209. (Pubitemid 32244873)
2. Rommens, P. M., Coosemans, W., and Broos, P. L. (1989) The difficult healing of segmental fractures of the tibial shaft. Arch. Orthop. Trauma Surg. 108(4), 238-242. (Pubitemid 19179001)
3. Buchler, U. and Nagy, L. (1995) The issue of vascularity in fractures and non-union of the scaphoid. J. Hand Surg. [Br.] 20(6), 726-735. (Pubitemid 26011103)
4. Einhorn, T. A. and Lane, J. M. (1998) Fracture Healing Enhancement. Clin. Orthop. Rel. Res. 335 S, 365.
5. Arrington, E. D., et al. (1996) Complications of iliac crest bone graft harvesting. Clin. Orthop. 329, 300-309. (Pubitemid 26274684)
6. Colterjohn, N. R. and Bednar, D. A. (1997) Procurement of bone graft from the iliac crest. An operative approach with decreased morbidity. J. Bone Joint Surg. 79(5), 756-759. (Pubitemid 27215411)
7. Kwong, L. M., Jasty, M., and Harris, W. H. (1993) High failure rate of bulk femoral head allografts in total hip acetabular reconstructions at 10 years. J. Arthroplasty 8(4), 341-346. (Pubitemid 23246167)
8. Bonnarens, F. and Einhorn, T. A. (1984) Production of a standard closed fracture in laboratory animal bone. J. Orthop. Res. 2(1), 97-101. (Pubitemid 14034681)
9. Einhorn, T. A. (1998) The cell and molecular biology of fracture healing. Clin. Orthop. 355(Suppl), S7-S21.
10. Reddi, A. H. (2001) Bone morphogenetic proteins: from basic science to clinical applications. J. Bone Joint Surg. 83 A (Suppl 1, pt 1), S1-S6.
11. Li, R. H. and Wozney, J. M. (2001) Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol. 19(7), 255-265. (Pubitemid 32537763)
12. Lieberman, J. R., Daluiski, A., and Einhorn, T. A. (2002) The role of growth factors in the repair of bone. Biology and clinical applications. J. Bone Joint Surg. 84 A (6), 1032-1044.
13. Valentin-Opran, A., et al. (2002) Clinical evaluation of recombinant human bone morphogenetic protein-2. Clin. Orthop. 395, 110-120. (Pubitemid 34136661)
14. Salkeld, S. L., et al. (2001) The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone. J. Bone Joint Surg. 83 A (6), 803-816. (Pubitemid 32523799)
15. Bouxsein, M. L., et al. (2001) Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J. Bone Joint Surg. 83 A (8), 1219-1230. (Pubitemid 32735073)
16. Uludag, H., et al. (2001) Delivery systems for BMPs: factors contributing to protein retention at an application site. J. Bone Joint Surg. 83 A (Suppl 1, pt 2), S128-S135.
17. Talwar, R., et al. (2001) Effects of carrier release kinetics on bone morphogenetic protein-2-induced periodontal regeneration in vivo. J. Clin. Periodontol. 28(4), 340-347. (Pubitemid 33761344)
18. Niyibizi, C., et al. (1998) Potential role for gene therapy in the enhancement of fracture healing. Clin. Orthop. 355(Suppl), S148-S153.
19. Lieberman, J., Ghivizzani, S., and Evans, C. (2002) Gene transfer approaches to the healing of bone and cartilage. Mol. Ther. 6(2), 141.
20. Lieberman, J. R. (2000) Orthopaedic gene therapy. Fracture healing and other nongenetic problems of bone. Clin. Orthop. 379(Suppl), S156-S158.
21. Makarov, S. S., et al. (1996) Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA. Proc. Natl. Acad. Sci. USA 93(1), 402-406. (Pubitemid 26038167)
22. Baltzer, A. W. A. and Lieberman, J. (2004) Regional gene therapy to enhance bone repair. Gene Ther. 11, 344-350. (Pubitemid 38263084)
23. Marshall, E. (2003) Gene therapy. Second child in French trial is found to have leukemia. Science 299(5605), 320. (Pubitemid 36120006)
24. Evans, C. H., et al. (2004) Orthopaedic gene therapy. Clin. Orthop. Rel. Res. (in press).
25. Evans, C. H. and Robbins, P. D. (1999) Genetically augmented tissue engineering of the musculoskeletal system. Clin. Orthop. 367(Suppl), S410-S418. (Pubitemid 29501520)
26. Evans, C. H. and Robbins, P. D. (1995) Possible orthopaedic applications of gene therapy. J. Bone Joint Surg. 77 A (7), 1103-1114.
27. Evans, C. H., et al. (2004) Gene therapy for the treatment of musculoskeletal diseases. J. Am. Acad. Orthop. Surg. (in press).
28. Oligino, T. J., et al. (2000) Vector systems for gene transfer to joints. Clin. Orthop. 379(Suppl), S17-S30.
29. Lieberman, J. R., et al. (1998) Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J. Orthop. Res. 16(3), 330-339. (Pubitemid 28337629)
30. Lieberman, J. R., et al. (1999) The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J. Bone Joint Surg. 81 A (7), 905-917. (Pubitemid 29354999)
31. Lee, J. Y., et al. (2002) Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum. Gene Ther. 13(10), 1201-1211. (Pubitemid 34746700)
32. Gysin, R., et al. (2002) Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats. Gene Ther. 9(15), 991-999.
33. Alden, T. D., et al. (2000) The use of bone morphogenetic protein gene therapy in craniofacial bone repair. J. Craniofac. Surg. 11(1), 24-30. (Pubitemid 30064158)
34. Dragoo, J. L., et al. (2003) Bone induction by BMP-2 transduced stem cells derived from human fat. J. Orthop. Res. 21(4), 622-629. (Pubitemid 36758206)
35. Franceschi, R. T., et al. (2000) Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J. Cell Biochem. 78(3), 476-486. (Pubitemid 30491075)
36. Viggeswarapu, M., et al. (2001) Adenoviral delivery of LIM mineralization protein-1 induces new-bone formation in vitro and in vivo. J. Bone Joint Surg. 83 A (3), 364-376. (Pubitemid 32221566)
37. Krebsbach, P. H., et al. (2000) Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. Hum. Gene Ther. 11(8), 1201-1210. (Pubitemid 30331585)
38. Gugala, Z., et al. (2003) Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type. Gene Ther. 10(16), 1289-1296. (Pubitemid 36987119)
39. Tsuda, H., et al. (2003) Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector. Mol. Ther. 7(3), 354-365. (Pubitemid 36503859)
40. Olmsted-Davis, E. A., et al. (2002) Use of a chimeric adenovirus vector enhances BMP2 production and bone formation. Hum. Gene Ther. 13(11), 1337-1347. (Pubitemid 35034513)
41. Abe, N., et al. (2002) Enhancement of bone repair with a helper-dependent adenoviral transfer of bone morphogenetic protein-2. Biochem. Biophys. Res. Commun. 297(3), 523-527.
42. Gysin, R., et al. (2002) Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats. Gene Ther. 9(15), 991-999.
43. Chen, Y., et al. (2003) Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors. Gene Ther. 10(16), 1345-1353. (Pubitemid 36987125)
44. Luk, K. D., et al. (2003) Adeno-associated virus-mediated bone morphogenetic protein-4 gene therapy for in vivo bone formation. Biochem. Biophys. Res. Commun. 308(3), 636-645. (Pubitemid 36945540)
45. Park, J., et al. (2003) Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther. 10(13), 1089-1098. (Pubitemid 36850231)
46. Tsuchida, H., et al. (2003) Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats. J. Orthop. Res. 21(1), 44-53. (Pubitemid 36157619)
47. Okubo, Y., et al. (2001) In vitro and in vivo studies of a bone morphogenetic protein-2 expressing adenoviral vector. J. Bone Joint Surg. 83 A (Suppl 1, pt 2), S99-S104.
48. Okubo, Y., et al. (2000) Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression. Biochem. Biophys. Res. Commun. 267(1), 382-387. (Pubitemid 30072560)
49. Fang, J., et al. (1996) Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc. Natl. Acad. Sci. USA 93(12), 5753-5758. (Pubitemid 26190752)
50. Bonadio, J., et al. (1999) Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat. Med. 5(7), 753-759. (Pubitemid 29318608)
51. Musgrave, D. S., et al. (1999) Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone 24(6), 541-547. (Pubitemid 29234066)
52. Baltzer, A. W., et al. (1999) A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model. Knee Surg. Sports Traumatol. Arthrosc. 7(3), 197-202.
53. Baltzer, A. W., et al. (2000) Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther. 7(9), 734-739. (Pubitemid 30255754)
54. Sonobe, J., et al. (2004) Osteoinduction by bone morphogenetic protein-2 expressing adenoviral vector: application of biomaterial to mask the host immune response. Hum. Gene Ther. 15, 659-668. (Pubitemid 38925218)
55. Ito, T., et al. (2003) Coxsackievirus and adenovirus receptor (CAR)-positive immature osteoblasts as targets of adenovirusmediated gene transfer for fracture healing. Gene Ther. 10(18), 1623-1628. (Pubitemid 37063269)
56. Kawai, M., et al. (2004) Ectopic bone formation by human bone morphogenetic protein-2 gene transfer to skeletal muscle using transcutaneous electroporation. Hum. Gene Ther. 14, 1547-1556.
57. Li, J. Z., et al. (2004) Osteogenic potential of five different recombinant human bone morphogenetic protein (BMP) adenoviral vectors in the rat. Gene Ther. (in press).
58. Boden, S. D., et al. (1998) LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation. Endocrinology 139(12), 5125-5134. (Pubitemid 28533461)
59. Minamide, A., et al. (2003) Mechanism of bone formation with gene transfer of the cDNA encoding for the intracellular protein LMP-1. J. Bone Joint Surg. 85 A (6), 1030-1039. (Pubitemid 36644783)
60. Peng, H., et al. (2002) Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J. Clin. Invest. 110(6), 751-759.
61. Wang, J. C., et al. (2003) Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J. Bone Joint Surg. 85 A (5), 905-911. (Pubitemid 36548641)
62. Alden, T. D., et al. (1999) Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy. J. Neurosurg. 90(1 Suppl), 109-114. (Pubitemid 29037142)
63. Helm, G. A., et al. (2000) Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. J. Neurosurg. 92(2 Suppl), 191-196. (Pubitemid 30207415)
64. Chang, S. C., et al. (2003) Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration. Gene Ther. 10(24), 2013-2019. (Pubitemid 37407097)
65. Carmody, E. E., et al. (2002) Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Rheum. 46(5), 1298-1308. (Pubitemid 34525839)
66. Childs, L. M., et al. (2001) Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis. J. Bone Joint Surg. 83 A (12), 1789-1797. (Pubitemid 33134432)
67. Sud, S., et al. (2001) Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch. Inflammation 25(6), 361-372. (Pubitemid 33139696)
68. Yang, S., et al. (2002) IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model. Inflamm. Res. 51(7), 342-350. (Pubitemid 34743628)
69. Robbins, P. D., Evans, C. H., and Chernajovsky, Y. (2003) Gene therapy for arthritis. Gene Ther. 10(10), 902-911. (Pubitemid 36656633)
70. Gouze, E., et al. (2001) Gene therapy for rheumatoid arthritis. Curr. Rheumatol. Rep. 3(1), 79-85.
71. Evans, C. H. and Robbins, P. D. (1999) Gene therapy of arthritis. Intern. Med. 38(3), 233-239.
72. Evans, C. H., et al. (1999) Gene therapy for rheumatic diseases. Arthritis Rheum. 42(1), 1-16. (Pubitemid 29042564)