Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration

Gene Therapy

Volumn 10, Issue 24, 2003, Pages 2013-2019

  Chang, S C N ^a   Chuang, H L ^b   Chen, Y R ^a   Chen, J K ^c   Chung, H Y ^c   Lu, Y L ^c   Lin, H Y ^c   Tai, C L ^a   Lou, J ^d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone regeneration; Stem cells; Tissue engineering

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; BONE MORPHOGENETIC PROTEIN 2; EOSIN; HEMATOXYLIN; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; BIOMECHANICS; BONE MINERALIZATION; BONE REGENERATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FACE MALFORMATION; FEMALE; GENE THERAPY; GENE TRANSFER; IMMUNOHISTOCHEMISTRY; MAXILLOFACIAL SURGERY; MESENCHYME CELL; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STROMA CELL; SURGICAL TECHNIQUE; SWINE; THREE DIMENSIONAL IMAGING; TISSUE ENGINEERING; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; BIOMECHANICS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BONE MORPHOGENETIC PROTEINS; BONE PLATES; BONE REGENERATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MAXILLA; STROMAL CELLS; SWINE, MINIATURE; TISSUE ENGINEERING; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRIDAE; ANIMALIA; SUS SCROFA;

EID: 0242440883     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302106     Document Type: Article

References (49)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993; 920: 260-266.
2. Rabic AB, Chay SH, Wong AM. Healing of autogenous intramembranous bone in the presence and absence of homologous demineralized intramembranous bone. Am J Orthod Dentofacial Orthop 2000; 117: 288-297.
3. Furukawa T, Matsusue Y, Yasunaga T. Histomorphometric study on high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures. J Biomed Mater Res 2000; 50: 410-419.
4. Pittenger MF, Mackay AM, Beck SC. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147.
5. Goshima J, Goldberg VM, Caplan AI. The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop 1991; 262: 298-311.
6. Goshima J, Goldberg VM, Caplan AI. The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop 1991; 269: 274-283.
7. Mardon HJ, Bee J, von der Mark K. Development of osteogenic tissue in diffusion chambers from early precursor cells in bone marrow of adult rats. Cell Tissue Res 1987; 250: 157-165.
8. Owen ME, Friedenstein AJ In: Evered D, Harnett S (eds). Cell and Molecular Biology of Vertebrate Hard Tissues. Wiley: Chichester, 1988, pp 42-60.
9. Ohgushi H, Goldberg VM, Caplan AI. Heterotopic osteogenesis in porous ceramics induced by marrow cells. J Orthop Res 1989; 74: 568-578.
10. Ohgushi H, Goldberg VM, Caplan AI. Repair of bone defects with marrow cells and porous ceramic. Experiments in rats. Acta Orthop Scand 1989; 60: 334-339.
11. Lou J, Xu F, Merkel K. Gene therapy: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo. J Orthop Res 1999; 17: 43-50.
12. Lou J, Manske PR, Aoki M. Adenovirus-mediated gene transfer into tendon and tendon sheath. J Orthop Res 1996; 14: 513-517.
13. Hogan BL, Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 1996; 10: 1580-1594.
14. Reddi AH. Bone and cartilage differentiation. Curr Opin Gene Dev 1994; 4: 737-744.
15. Horwitz MS et al. Model systems for studying the effects of adenovirus E3 genes on virulence in vivo. Curr Top Microbiol Immunol 1995; 199: 195-211.
16. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Academic Press: New York, 1977, pp 284-288.
17. Yasko AW, Lane JM, Fellinger EJ. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg 1992; 74: 659-670.
18. Gerhart TN, Kirker-Head CA, Kriz MJ. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop 1993; 293: 317-326.
19. Rosen V, Nove J, Song JJ. Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes. Bone Miner Res 1994; 9: 1759-1768.
20. Muschler GF, Hyodo A, Manning T. Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin Orthop 1994; 308: 229-240.
21. Toriumi DM, Kotler HS, Luxenberg DP. Mandibular reconstruction with a recombinant bone-inducing factor: functional, histologic, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 1991; 117: 1101-1112.
22. Cook SD, Dalton JE, Tan EH. In vivo evaluation of recombinant human osteogenic protein implants as a bone graft substitute for spinal fusions. Spine 1994; 19: 1655-1663.
23. Wang EA, Rosen VD, Alessandro JS. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 1990; 87: 2220-2224.
24. Nakahara H, Bruder SP, Goldberg VM. In vivo osteochondrogenic potential of cultured cells derived from the periosteum. Clin Orthop Res 1990; 259: 223-232.
25. Isogai N, Landis WJ, Mori R. Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells. Plast Reconstr Surg 2000; 105: 953-963.
26. Breitbart AS, Grande DA, Kessler R. Tissue engineered bone repair of calvarial defects using cultured periosteal cells. Plast Reconstr Surg 1998; 101: 567-574, discussion 575-576.
27. Vacanti CA, Kim W, Upton J. The efficacy of periosteal cells compared to chondrocytes in the tissue engineered repair of bone defects. Tissue Eng 1995; 1: 301-389.
28. Lazarus HM, Haynesworth SE, Gerson SL. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant 1995; 16: 557-564.
29. Mason JM, Breitbart AS, Barcia M. Cartilage and bone regeneration using gene-enhanced tissue engineering. Clin Orthop 2000; 1 (Suppl 379): S171-178.
30. Lee JY, Peng H, Usas A. Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum Gene Ther 2002; 13: 1201-1211.
31. Crystal RG. Transfer of genes to humans: early lessons and obstacles to success. Science 1995; 270: 404-410.
32. Roman M, Axelrod JH, Dai Y. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted in murine skeletal muscle. Somat Cell Mol Genet 1992; 18: 247-258.
33. Resenfeld MA, Yoshimura K, Trapnel BC. In vivo transfer of the human cystic fibrosis transmembrane conductance gene to the airway epithelium. Cell 1992; 68: 143-155.
34. Wilson JM. Adenoviruses as gene-delivery vehicles. N Engl J Med 1996; 334: 1185-1187.
35. Beresford JN. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop 1989; 240: 270-280.
36. Caplan AI. Mesenchymal Stem Cells-Mediated Cartilage and Bone Repair. Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Ed. Davidovitch Z., EBSCO Pub., 1992, pp 433-438.
37. Haynesworth SE, Goshima J, Goldberg VM. Characterization of cells with osteogenic potential from human marrow. Bone 1992; 13: 81-88.
38. Mason JM, Grande DA, Barcia M. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Therapy 1998; 5: 1098-1104.
39. Lieberman JR et al. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 1998; 16: 330-339.
40. Alden TD, Pittman DD, Hankins GR. In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector. Hum Gene Ther 1999; 10: 2245-2253.
41. Engstrand T, Daluiski A, Bahamonde ME. Transient production of bone morphogenetic protein 2 by allogeneic transplanted transduced cells induces bone formation. Hum Gene Ther 2000; 11: 205-211.
42. Oakes DA, Lieberman JR. Osteoinductive applications of regional gene therapy: ex vivo gene transfer. Clin Orthop 2000; 1 (Suppl 379): S101-S112.
43. Baltzer AW, Lattermann C, Whalen JD. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Therapy 2000; 7: 734-739.
44. Breitbart AS, Grande DA, Kessler R. Tissue engineered bone repair of calvarial defects using cultured periosteal cells. Plast Reconstr Surg 1998; 101: 567-574, discussion 575-576.
45. Hollinger JO, Kleinschmidt JC. The critical size defect as an experimental model to test bone repair materials. J Craniofac Surg 1990; 1: 60-68.
46. Lo LJ, Marsh JL, Vannier MW. Craniofacial computer-assisted surgical planning and simulation. Clin Plast Surg 1994; 21: 501-516.
47. Robb RA, Hanson DP. A software system for interactive and quantitative visualization of multidimensional biomedical images. Australas Phys Eng Sci Med 1991; 14: 9-30.
48. Heise C, Sampson-Johannes A, Williams A. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997; 3: 639-645.
49. Tai CL, Shih CH. Mechanical testing of polymethyl methacrylate bone cement impregnated with bone and hydroxyapatite. Chin J Med Biol Eng 1997; 17: 1-8.